In August, the temperature rises, the rainfall increases, and the humid and hot weather is conducive to the growth and reproduction of microorganisms and vectors, causing the spread of many infectious diseases.

　　Experts from Henan CDC hereby remind residents to focus on hand-foot-mouth disease, fever with thrombocytopenia syndrome, brucellosis, novel coronavirus infection, monkeypox and food poisoning this month. In addition, special attention should be paid to the prevention of extreme weather events and accidental injuries of children and adolescents during summer vacation.

　　Key tips

　　First, hand, foot and mouth disease

　　Hand, foot and mouth disease (HFMD) is a common infectious disease in children, which is caused by various enterovirus infections. Children under 5 years old are more likely to be infected through close contact, respiratory droplets and digestive tract. Recently, the incidence of hand, foot and mouth disease in our province has decreased, but it is still at a high level, exceeding the level of the same period in the past two years. We should pay attention to the health status of young children, maintain good personal hygiene habits, and regularly clean and disinfect the family and the surrounding environment.

　　Protective measures:

　　1. Pay attention to personal hygiene, especially hand hygiene. Wash your hands with clean water, hand sanitizer or soap before touching your mouth and nose, before eating and defecating, before processing food, after touching herpes/respiratory secretions, after changing diapers or handling items contaminated by feces; Cover your nose and mouth with a handkerchief or paper towel when sneezing or coughing, then wrap the paper towel and throw it into the covered trash can.

　　2. Do not share towels or other personal items with others; Do not contact patients and their contaminated articles, and pollute the environment; Do not swim or play in the unsterilized swimming pool. During the epidemic of hand, foot and mouth disease, try to avoid taking children to participate in group activities.

　　3. Always clean and disinfect the surfaces of articles or objects that are often in contact, such as toys and furniture. After cleaning, wipe them with chlorine-containing disinfectant or soak them for disinfection. After 30 minutes, wipe them with clean water or rinse them off.

　　Second, fever with thrombocytopenia syndrome

　　Fever with thrombocytopenia syndrome is a new infectious disease caused by a new Bunia virus, which is spread by tick bites. The rain increases in August, and the high temperature and humid environment is suitable for the growth and reproduction of ticks. When you are active in parks, fields and other places with dense vegetation, you should be well protected to prevent ticks from biting.

　　Protective measures:

　　1. Personal protection should be done during outdoor activities, such as wearing long-sleeved underwear, tightening trouser legs, and applying repellent to bare skin, so as to avoid sitting and lying for a long time in the main habitats of ticks, such as grass and Woods, and prevent ticks from biting. Don’t pull hard after being bitten by a tick, spray it with alcohol and then clamp the tick head with pointed tweezers to peel off slowly.

　　2. Management of infected persons. In general, it is not necessary to isolate patients. Medical staff and patients’ families in medical institutions should do personal protection when caring for patients, and the patients’ blood, secretions, excreta and the environment and articles polluted by them can be disinfected by means of high temperature, high pressure and chlorine-containing disinfectant.

　　Third, brucellosis

　　Brucellosis (brucellosis) is a zoonotic disease caused by Brucella. The main clinical manifestations are fever, hyperhidrosis, joint pain and so on. Sheep are the main source of infection. People in pastoral areas, aquaculture and other occupations can be infected through skin and mucous membrane contact during slaughter, peeling and milking. Eating undercooked meat, drinking raw milk or inhaling contaminated droplets can also lead to brucellosis. In recent years, brucellosis has also occurred from time to time in non-pastoral areas, so we should pay attention to self-protection.

　　Protective measures:

　　1, sheep breeding, grazing, trading, slaughtering and other professional people should pay attention to daily personal protection, timely medical treatment after illness.

　　2. Try to avoid direct contact with any animals, especially those of unknown origin.

　　3. Do not eat undercooked meat, eggs, milk and other animal products. Choose fresh and safe animal food raw materials, and pay attention to the separation of raw and cooked food when processing.

　　Fourth, monkeypox

　　Monkeypox is a zoonotic disease caused by monkeypox virus infection, and its clinical manifestations are mainly fever, rash and lymphadenopathy. In the past, it mainly occurred in Central Africa and West Africa. Since 2022, monkeypox outbreaks have occurred in many non-endemic areas around the world, with a mortality rate of about 0.1%. Most cases have mild clinical manifestations, and the deaths are mainly people with low immunity such as untreated HIV-infected people. Since June 2023, many provinces in China have reported many cases of monkeypox, most of which are young and middle-aged men, mainly transmitted through sexual contact. Men who have sex with men are the key groups infected with monkeypox. People are generally susceptible to monkeypox virus, and smallpox vaccine has a certain degree of cross-protection against monkeypox virus.

　　Protective measures:

　　1. Entry-exit personnel should pay attention to the epidemic information of monkeypox in destination countries and regions, and avoid contact with monkeypox-like symptoms, rodents, primates and other animals.

　　2. Returnees who have a history of suspicious contact abroad should do a good job in self-health monitoring to avoid close contact with others. In case of monkeypox-like symptoms such as fever, rash and lymphadenopathy, they should take the initiative to see a doctor and truthfully report their epidemiological history.

　　3. Key people need to raise awareness of prevention and reduce high-risk behaviors. If they have a history of suspicious contact, they should consciously monitor their health and take the initiative to see a doctor if symptoms appear.

　　V. novel coronavirus infection

　　Recently, the number of people infected in novel coronavirus in our province has shown a downward trend. The elderly, key people with basic diseases and low immunity still need to adhere to personal protection and actively vaccinate. Those who have not completed basic immunization and are not infected with Covid-19 should complete basic immunization first.

　　Protective measures:

　　1. Actively vaccinate. Elderly people aged 60 and above, people aged 18-59 with serious basic diseases, people with low immune function, people with high risk of infection, and people who have completed basic immunization or have been infected with Covid-19 should be actively vaccinated to further strengthen their autoimmune ability.

　　2. Pay attention to personal protection. Residents should wear masks in their daily trips, minimize unnecessary gatherings and keep social distance. Maintain good personal and environmental hygiene, wash hands frequently, often ventilate, pay attention to rest, pay attention to nutrition and enhance physical fitness.

　　3. Use drugs rationally and see a doctor as needed. After infection, residents should take corresponding treatment measures according to the severity of their own symptoms, implement self-care at home, reduce contact with their roommates, rationally use symptomatic drugs according to relevant guidelines, do a good job in health monitoring, and go to medical institutions in time if the condition worsens.

　　Six, food poisoning

　　In August, the temperature is high and the humidity is high, and food is perishable. Improper food processing or storage can easily lead to food poisoning. Recently, food poisoning incidents have occurred frequently in many parts of the country. People must pay attention to food hygiene when eating at home or out. When they have symptoms such as nausea, vomiting, abdominal pain and diarrhea, they should induce vomiting as soon as possible to reduce the absorption of toxins and send them to the hospital for treatment in time.

　　Protective measures:

　　1. Avoid eating in public places without health protection. Buy food in supermarkets or vegetable markets with health protection. Try not to buy bulk food.

　　2. Fresh food should be fully heated before eating, and attention should be paid to the cleanliness of processed cold and raw foods. Avoid mixing raw and cooked food, mixing chopping boards and kitchen knives, and prevent cross-contamination of raw and cooked food. Try not to leave any food in each meal. Don’t store the leftover food in the refrigerator for too long. It must be heated thoroughly before eating.

　　3. Develop good personal hygiene habits, wash your hands before and after meals and before processing food.

　　VII. Extreme weather events

　　With global warming, extreme weather events occur frequently. Typhoon No.5 "Du Surui" landed in Fujian on July 28, and the residual circulation went all the way north, resulting in large-scale heavy rainfall in Henan, Shandong, Beijing-Tianjin-Hebei and Liaoning, with heavy rain in the local area. Recently, there have been heavy rains in many places in our province, and heavy rains have occurred in some counties and cities, accompanied by complex strong convective weather. At present, the impact of Typhoon Du Surui on Henan Province has ended, but it is still rainy in our province in the near future due to the strengthening of the westward extension of the subtropical high, the uplift of typhoon Kanu and the windward slope in mountainous areas.

　　At present, it is in the critical period of "seven downs and eight highs" (from late July to early August). Due to the influence of typhoon and subtropical high, our province will usher in the humid and sultry weather of "rainfall+high temperature". The public should pay close attention to the warning signals of meteorological disasters, respond in time, and do a good job in heatstroke prevention and cooling.

　　Eight, children and adolescents accidental injury

　　Summer vacation is a period of high incidence of accidental injuries among children and adolescents. While celebrating the holiday, special attention should be paid to preventing accidental injuries such as drowning, traffic accidents, falls, poisoning, burns, electric shock, airway foreign bodies, and animal bites.

　　Protective measures:

　　1. Parents should carry out safety inspection on daily necessities at home, so as to eliminate those foreseeable and avoidable safety hazards, such as hot water bottles, hot water cups and kitchen utensils with hot soup, which should be placed out of children’s reach; Household electrical equipment and power supply should be kept away from children’s reach; Take good care of household chemicals, and it is best to store medicines in safe packages that prevent children from opening them.

　　2. In terms of children’s diet and daily life, it should be fresh and non-toxic to prevent food pollution and deterioration. Teach children not to run or cry when eating, and correct the bad habits of children’s mouth contents.

　　3. Never leave children alone by the open water source. No matter in the water at home, indoors, outdoors or other places, the distance between parents and children should be within reach and concentrate on nursing. Parents must educate their children not to swim in dangerous waters/water bodies or informal swimming pools to prevent drowning. If you encounter a drowning companion, don’t rescue yourself by force. You should shout for help and ask people around you to help you.

　　4. Pay attention to cultivate children’s safety awareness, guide children to obey traffic rules, don’t chase and fight on the side of the road, and sit in the child safety seat and fasten the seat belt when traveling by car.

　　Transfer from: Henan CDC

　　Ouyang Ziyuan, an academician of China Academy of Sciences and the first chief scientist of China lunar exploration project, walked into Beijing No.2 Middle School Education Group to give a keynote speech to teachers and students, and observed students’ scientific and technological works. Xinhua News Agency (photo by Zhou Liang)

　　Fill in the shortcomings of popular science and improve citizens’ scientific quality ②

　　Encouragement is necessary, but it is more important to make researchers feel that it is beneficial to do it from the heart. At the same time, the scientific community will recognize the behavior of this profession and will not think that scientific researchers are "doing nothing" when doing popular science.

　　Zhonghe Zhou

　　Academician of China Academy of Sciences and researcher of vertebrate paleontology and Paleoanthropology Institute of Chinese Academy of Sciences.

　　"We just want to open a video number and do two short videos about big health and food safety every week, but after talking to a professional shooting and production team, one will cost one or two thousand, and this funding has not yet been settled." After taking office last year, Shen Qi, director of the Institute of Agricultural Products Processing of Jiangsu Academy of Agricultural Sciences, first thought was to promote popular science knowledge of food health to the public.

　　However, it is too difficult for this wish to land. "In addition to funding, the opening of WeChat official account has to be approved at different levels, and an interested scientific researcher has to be responsible for it." Shen Qi said that the recent statements of the central ministries and commissions calling for strengthening popular science work have given him hope. He said: "Maybe there will be funds to build WeChat official account next year."

　　Scientific researchers are considered as "the first starter of scientific communication", and it should be one of their duties to do a good job in popular science. However, for a long time, the proportion of scientific researchers involved in popular science is not high, and the atmosphere of popularizing scientific knowledge to the public has not become popular in scientific research circles. What is the reason for this? Is it a lack of system or a lack of funds? Some researchers’ answers may provide a basis for relevant state departments to formulate policies.

　　People who are most suitable for science popularization can’t let go of their hands and feet

　　Yongchun Zheng, a researcher at the National Astronomical Observatory of the Chinese Academy of Sciences, is now the "online celebrity" in the field of popular science.

　　"I didn’t take the initiative to enter this field, just like when I chose my major before. I didn’t take the initiative to choose, but I didn’t resist it when I had such an opportunity. I was willing to understand it, and I slowly entered through this process." In 2015, an accidental teaching experience brought Yongchun Zheng into contact with the writing of popular science articles, and he became a popular science expert step by step. "After publishing a book, he later registered a blog and had more opportunities to do more things, thus opening up a whole new world."

　　Today, when China has become a strong voice of the times, there are few "online celebrity" scientists like Yongchun Zheng, and it is still controversial whether popular science is the responsibility of researchers.

　　In recent years, a number of investigations and analyses on the participation of scientific researchers in popular science have drawn similar conclusions — — High recognition, strong will and weak mobility. Why can’t researchers who are most suitable for popular science let go?

　　Researcher Wang Yongdong, director of the Science Communication Center of Nanjing Institute of Geology and Paleontology, Chinese Academy of Sciences, told the reporter that there are two main reasons why researchers are absent from popular science work: first, objectively speaking, popular science takes up the time and energy of researchers, but it doesn’t count in the assessment, such as awarding prizes, evaluating professional titles, and there is neither corresponding post setting nor corresponding incentive mechanism. After all, in scientific research units, everyone pays more attention to projects, papers, impact factors, talent hats, etc.

　　Secondly, subjectively speaking, most researchers feel that science popularization work does not need too deep professional knowledge; At the same time, I am worried that science popularization needs to use the achievements of others, resulting in intellectual property disputes. I feel that it is better to concentrate on writing my own paper than to spend time doing unfamiliar science popularization work.

　　The researchers interviewed agreed that in the current scientific research and talent evaluation system, most of the popular science contributions are nameless, unprofitable and thankless. Under the guidance of such a "baton", the collective cognition of attaching importance to scientific research and neglecting popular science has gradually formed.

　　"On the cultural level, although there is only one word difference between scientific research and popular science, they are completely different. The scientific research culture is inward, and it pursues recognition in academic circles and professional circles. The culture of popular science is extroverted, and it pursues public recognition." Yongchun Zheng said.

　　Scientific researchers can’t do "one size fits all" in doing popular science.

　　Since the existing "baton" ignores popular science, will the enthusiasm of researchers be high if the contribution of popular science is increased in the scientific research evaluation system?

　　The reporter learned that in recent years, the state has introduced relevant policies to encourage popular science. For example, "Several Opinions on Opening Scientific Research Institutions and Universities to the Society to Carry out Popular Science Activities" clearly puts forward the suggestion that the performance evaluation method of scientific communication should be regarded as an important basis for the evaluation of scientific researchers’ professional titles and post appointment. However, there are no substantive operating rules and hard rules, which leads to the failure to implement the policy.

　　In the interview, the reporter also found that researchers have different opinions on the proposal of establishing a rigid system for popular science assessment.

　　"I used to think that researchers should be encouraged to do popular science, or some institutionalized incentive mechanisms should be established, but now I feel more and more that we can’t generalize." Yongchun Zheng said that the main business of scientific researchers is scientific research. Doing popular science not only requires scientific research background, wide knowledge and willingness to share, but also takes a lot of time and energy to accumulate experience, which is not suitable for everyone.

　　Zhou Zhonghe, an academician of the China Academy of Sciences and a researcher at the Institute of vertebrate paleontology and Paleoanthropology of the Chinese Academy of Sciences, once said at the 27th National Symposium on Science Popularization Theory that administration is a double-edged sword, and it is impossible to make a one-size-fits-all policy. For example, science popularization should be regarded as the assessment index for all scientific researchers.

　　Shen Qi suggested that a research group, a laboratory and a research institute can be quantitatively assessed, forcing the heads of teams and units to pay attention to popular science work.

　　Zhou Zhonghe said, encouragement is necessary, but it is more important to make researchers feel that it is beneficial to do it from the heart. At the same time, the scientific community will recognize the behavior of this profession and will not think that scientific researchers are "doing nothing" when doing popular science.

　　Luo Jingjia, dean of the Frontier Research Institute of Climate and Application in Nanjing University of Information Science & Technology, has been working abroad for a long time. He told reporters that foreign scientists are very happy to share their scientific research progress and related scientific knowledge. "Isn’t writing papers a kind of popular science? It’s just a popular science for professionals. Since you can share it with insiders, why don’t you bother to spread science to the public? "

　　Luo Jingjia said that different languages need to be translated, and different disciplines are interlaced like mountains. Scientists in other fields are also members of the public and need popular science. Once this kind of cognitive and popular science culture is formed, there is no need for a system to make it hard.

　　The system of popular science should be established as soon as possible.

　　Lack of funds for popular science is the most common voice heard by reporters in interviews. So, do scientific research units have special funds for popular science work?

　　Among the 120 research institutes of Nanjing Institute of Geology and Paleontology, China Academy of Sciences, the scientific communication index is in the forefront. It is said that the institute should invest a lot in people and property to achieve such achievements. Wang Yongdong told reporters that the institute is very supportive of science communication, and the budget of the Science Communication Center alone this year has reached nearly 7.8 million yuan. Expenditure expenses include editing and publishing expenses of several professional magazines, purchasing expenses of library documents and materials, specimen maintenance expenses, operation expenses of Nanjing Paleontology Museum and personnel expenses. The annual income, including financial allocation, is very limited. After making ends meet, the institute will have to subsidize more than 3 million yuan, which is very stressful for a research institute that mainly carries out basic research.

　　At the same time, the scientists in the institute are also very enthusiastic about popular science work. "On May 18 this year, we hired more than 20 researchers in the institute as the first batch of science communication experts." Wang Yongdong said that this group of science communication experts actively participated in the writing of the exhibition outline and exhibition board explanations, the design of booths and exhibits, video shooting, and popular science lectures and activities.

　　Yongchun Zheng suggested that the state should establish a system of popular science as soon as possible, and subsidize popular science as it does scientific research, such as setting up a popular science fund, a popular science talent plan, and awards for popular science achievements. "Researchers can get project funding and national awards, and they can also be recognized by their peers, so they will naturally be willing to join them." Yongchun Zheng said.

　　Wang Yongdong also believes that the state can set up science communication projects in the Natural Science Foundation, and science communication awards can also be set up among the three major science and technology awards.

　　At the same time, respondents generally believe that popular science training and personnel training must be taken seriously. "After doing science popularization and science education, I found that this person is studying high-energy physics, and that person is studying applied mathematics and analytical chemistry. Does anyone study science? We need someone who can connect different disciplines and be compatible, and give these talents the overall scientific nourishment from the perspective of future talent training. " Yongchun Zheng said.

　　Wang Yongdong suggested that the science communication course should be set up as a compulsory course in science and engineering majors in universities, so that students can master the expressive ability of difficult content and the essentials and methods of integrating media communication. Only when they take up their jobs in the future can the results be clearly described and disseminated, so that the whole society and the general public can understand, understand and use them.

Author: Hongge comes from Medical Wechat WeChat official account.

　 　　 　　　Recent epidemic situation in ChinaIn the process of getting up, there are some situations that deserve our attention.the most importantIsFalse negatives in nucleic acid detection. Intercepting relevant news, it was found that 8 confirmed patients in Shijiazhuang on the 22nd were repeatedly negative for nucleic acid detection, and 5 confirmed patients in Shijiazhuang on the 24th were repeatedly negative for nucleic acid detection.

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　 　On the 22nd, there were 11 new confirmed cases in Shijiazhuang, including:

Case 1: Male, 52 years old, from Huangjiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 2: Male, 13 years old, Niujiazhuang Village. On the evening of the 21st.Nine times nucleic acid positive;

Case 3: Female, 11 years old, Zhongyao Village. On the evening of the 21st.Nine times nucleic acid positive;

Case 4: Male, 49 years old, Nanqiaozhai Village. On the evening of 21st.Ninth nucleic acid positive;

Case 5: Male, 47 years old, Niujiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 6: Female, 65 years old, Niujiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 7: Male, 11 years old, grandson of Case 6. On the evening of 21st.Ninth nucleic acid positive;

Case 11: Male, 67 years old, Xiaoguozhuang Village, husband of Case 2 on January 7th. On January 3, it was transferred to centralized isolation medical observation; On the evening of 21st.11th nucleic acid detectionFinally positive;

On the 24th, there were 7 new confirmed cases in Shijiazhuang:

Case 1: Female, 65 years old, Nanqiaozhai Village. Centralized isolation on the 11 th.Nucleic acid after 9 times, 22 positive.

Case 2: Female, 4 years old, Nanqiaozhai Village. Centralized isolation on the 11 th.Nucleic acid after 9 times, 22 positive.

Case 3: Female, 4 years old, Mi Jie, Chang ‘an District. Centralized isolation on the 13 th.Nucleic acid after 8 times, 23 positive.

Case 4: Female, 64 years old, Xiaoguozhuang Village. Centralized isolation on the 10 th.After 11 nucleic acids, 24 positive.

Case 5: Male, 34 years old, Xiaoguozhuang Village. Centralized isolation on the 8 th.After 11 nucleic acids, 24 positive.

Case 6: 34-year-old female, Liujiazuo Village, was positive for nucleic acid on the 5th, was diagnosed as asymptomatic infection on the 6th, and was clinically confirmed on the 24th.

Case 7: A 28-year-old male, living in Yuhua District, went to work by car at Zhengding Airport on weekdays. He was diagnosed as asymptomatic infected with nucleic acid on the 5th, and was clinically confirmed on the 24th.

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Since the outbreak of COVID-19 last year, the topic of high false negative rate of nucleic acid detection has been the focus of attention. It has been reported that the positive rate of Covid-19 detection by fluorescence quantitative RT-PCR is only 30%-50% at present, which leads to extremely high false negative rate.

For Hongge, who doesn’t know much about the test, this paper analyzes the relatively high false negative test by searching articles and documents, and summarizes some reasons to discuss with you.

First, the incidence of COVID-19 suggests that it is highly possible to collect positive samples in a proper time.

Academician Yuan Guoyong’s team conducted this cohort study in Hong Kong Princess Margaret Hospital and Queen Mary Hospital. From January 22 to February 12, 2020, 23 hospitalized patients who were diagnosed as COVID-19 by laboratory examination of nasopharyngeal or sputum specimens were screened in the two hospitals.

A total of 173 respiratory specimens were collected from 23 patients. The researchers used RT-QCPR to determine the viral load in the samples. The results showed that the median viral load of respiratory tract samples was 5.2 log10 copies /mL (interquartile range was 4.1-7.0), and only 3 patients (13%) did not detect Covid-19 RNA in saliva samples.

The researchers observed that,The viral load in saliva was the highest in the first week after the patient developed symptoms, and then gradually decreased.Eight days after the patient developed symptoms, airway extracts were collected, and there was no obvious downward trend in viral load. Of the 21 patients who did not die,Seven people (33%) could still detect viral RNA after 20 days of symptoms, but this was not related to the severity of the disease.

▲ Changes of viral load in saliva (blue line) and airway extract (red line) of all 23 patients. Abscissa D- days after symptoms appear; S/E- number of saliva/airway samples.

AprilAccording to a study published in Nature Medicine, COVID-19 patients are most infectious before symptoms appear, and they begin to shed SARS-CoV-2 2 2-3 days before the first symptoms appear.

https://doi.org/10.1038/s41591-020-0869-5

The study, led by Eric Lau of the University of Hong Kong, involved 94 patients with COVID-19 admitted to the Eighth People’s Hospital of Guangzhou, China, 50% of whom were male, with a median age of 47 years. Among them, 61 of 93 patients were mild. Specifically, the researchers collected the throat swabs of 94 COVID-19 patients who were treated in the Eighth People’s Hospital of Guangzhou, China from January 21st to February 14th. From the onset of symptoms to 23 days after onset, 414 throat swabs were collected.

The results show that the researchers areThe high viral load was detected shortly after the patient developed symptoms, and then gradually decreased to the detection limit around the 21st day.There is no significant difference in viral load among different sexes, age groups and disease severity.

In addition, the researchers also analyzed 77 samples of "transmission pairs" from public data to assess how much time passed between the onset of symptoms in each patient. It assumes that the median incubation period (the time from infection to symptoms) is 5.2 days.The research team concluded that infectivity began 2.3 days before symptoms appeared, and peaked 0.7 days before symptoms appeared.

In the sensitivity analysis, the same estimation procedure is used, but assuming that the infectious attack is unchanged 1-7 days before the symptom occurs, thenIt was found that the infectivity reached its peak 0-2 days before the onset of symptoms, and the transmission ratio before the onset of symptoms was 46% to 55%.

The study also found that,The virus may start shedding 2-3 days before the first symptoms appear.After the symptoms appear, the viral load in the patient’s body decreases faster. This is consistent with the results of two recent studies. On April 1st, teams from Munich, Germany, Berlin and Cambridge, England published the article "Viro logical assessment of hospital patients with Covid-2019" on Nature. It was found that the shedding peak of Covid-19 occurred in the early upper respiratory tract infection.This shows that virus carriers may be the most infectious when they have mild symptoms or almost no obvious symptoms.

Brother Hong:From the above two documents, we can draw a conclusion that the virus shed and spread 2-3 days before the symptoms appear after infection, and after the symptoms appear, with the passage of time,The viral load of throat swab decreases gradually, and the viral load detected within 7 days after symptoms. If symptoms have existed for more than 20 days, the reliability of negative conclusion of throat swab is poor.

Solution:We need to publicize the law of the new crown to the people and medical workers, and improve our vigilance against COVID-19. It is best for patients to see a doctor in time, and doctors can also suspect this possibility. Only at the right time can we collect high-content samples and diagnose and control them in time.

Second, accurate sampling strategy is the best means to reduce false negative results.

In February, a study published by Medrxir, a pre-printed website, collected respiratory tract samples such as nasal swab, throat swab, sputum and bronchoalveolar lavage fluid (BALF) from patients diagnosed with COVID-19, and included 213 Covid-19-infected patients admitted to the Third People’s Hospital of Shenzhen from January 11th to February 3rd, 2020, who were diagnosed by Guangdong CDC. A total of 866 respiratory tract samples, including 490 nasal swabs, 205 throat swabs, 142 sputum samples and 29 BALF samples, were collected at the time of admission and after each time point. According to the collection date, the samples were divided into 0~7 days, 8~14 days and ≥15 days after onset. According to the guidelines on prevention and treatment of Covid-19 infection issued by National Health Commission, patients were divided into severe and mild cases.

Three groups were divided according to the sample collection time after onset, and the viral nucleic acid was quantitatively determined.The positive rate of viral nucleic acid in sputum samples was the highest in the group of 0~7 days after onset.The positive rates of severe and mild cases were 88.9% and 82.2% respectively.Followed by a nasal swab.(73.3% and 72.1% respectively),The throat swab again.(60.0% and 61.3% respectively). In mild cases, the positive rate of nasal swab and sputum samples is similar.

The positive rate of BLAF samples collected from 8 to 14 days after the onset of severe cases was 100%.However, the BALF samples of 3 mild cases were negative. In all cases, the positive rate of sputum samples was the highest in the 8~14 days after onset, which was much higher than that of nasal swab and throat swab. It is worth noting that the positive rate of throat swab in severe patients is only 50%, and that in mild patients is only 29.6%.

In the group ≥15 days after onset,The positive rates of BALF, sputum and nasal swab from severe cases were similar. In mild cases, the positive rate of sputum and nasal swab is similar, which is much higher than that of throat swab.

For the diagnosis of viral nucleic acid in COVID-19’s patients,Sputum samples are the most accurate, followed by nasal swabs. It is not recommended to collect throat swabs for diagnosis.

The difference between oropharyngeal swab and nasopharyngeal swab

anusswab

Brother Hong:

1. Oropharyngeal swab is the least painful and most acceptable, but it has to bear the consequences of high false negative results. My suggestion is to use it according to the epidemic risk in the first epidemic area.

2. The positive rate of nasopharyngeal swab is higher than that of oropharyngeal swab, which is why nasopharyngeal swab is introduced into laboratory examination in the fifth edition of Diagnosis and Treatment Plan for Pneumonia Infected by Covid-19 (the fourth edition is still pharyngeal swab). If we want to pursue accuracy, it is suggested to use it, or to use it when screening people in close contact or sub-close contact. At present, the examination of returnees in domestic reports seems to be nasopharyngeal swab method.

3. Alveolar lavage fluid can’t be used for screening in the general population, so it is suggested that hospitals with ICU should use it for screening severe pneumonia patients living in ICU for COVID-19 patients.

4. Deep expectoration seems to be the best sample, but many patients in COVID-19 have a dry cough, which may not be possible.

5、anusSwabs were used in Daxing epidemic in Beijing, which is the first time to use this method in the screening process. In some literatures,anusAlthough the positive rate of swabs is not high, as I remember, it seems to be more than 10%, but it does not seem to coincide with the patients with oropharyngeal swabs, suggesting that the virus may attack the gastrointestinal tract, and also suggesting that there may be the possibility of gastrointestinal transmission in Covid-19. Although the initial symptoms of some patients are gastrointestinal symptoms such as abdominal pain and diarrhea, there are also ACE2 receptors in the digestive tract, which is theoretically possible, but it has not been confirmed at present. So,anusMy suggestion is that swabs can only be used as a supplement to nasopharyngeal swabs, and it is better to select patients whose first symptoms are digestive tract symptoms more accurately, which is unlikely to be used as a means of large-scale screening.

Solution:It is best for National Health Commission to issue a guiding document for large-scale screening, and make detailed regulations on what population and what sampling methods to adopt under what circumstances.,When local governments encounter an outbreak in COVID-19, it’s best to ask professionals to act as consultants and make choices according to the actual situation.

Third, the consistency of sampling ability of sampling personnel affects the sampling results.

Garbage in, garbage out (garbage samples produce garbage results), which is a sentence that inspectors often say.

The sampling team is huge, and the ability of sampling personnel must be uneven. In addition, people may have such fears about sampling, which often leads to unqualified samples.

Generally, there is an internal standard in the molecular diagnostic reagent to monitor the detection process, for example, RNaseP is used as the internal standard. If both the sample response curve and the internal standard response curve displayed by the fluorescence PCR platform do not jump, it means that the quality of the collected samples may have problems or false negatives may occur due to improper experimental operation, which needs to attract the attention of medical workers. The RNaseP internal standard can monitor the sample collection and ensure the accuracy of the test results.

Note: RNaseP is ribonuclease P, which is one of the most important ribozymes in human body. It is ubiquitous in all organs, tissues and cells of human body, and can detect RNA nucleic acid fragments from human body samples, and can also be used as an internal standard.

And I privately asked the relevant person in charge of our city’s temporary inspection center. He told me that every day in our hospital, some samples were told that they needed to be re-sampled because the internal standard did not jump. Imagine that you didn’t wipe down a few cells in your throat swab collection, so will the negative of this nucleic acid be accurate?

Solution:Consistency training for nucleic acid sampling personnel will greatly reduce the human influence, and it is easier to standardize the sampling process by taking such sampling methods as nasopharyngeal swab. Our city seems to have trained the nucleic acid emergency sampling team very early. What about your city?

In addition, if in the environment of large-scale nucleic acid sampling, when testing under the standard of 5-mixed 1 and 10-mixed 1, according to the above principle of internal standard, it seems that there is no single-tube ability in the quality control of internal standard. Therefore, especially those in the emergency sampling team, we must pay attention to the standard sampling methods and remember to collect qualified samples as much as possible.

Fourth, choose the right oneSampling device

The virus preservation tube mainly consists of a sampling swab and a virus nucleic acid preservation tube (containing virus nucleic acid preservation solution). There are many kinds of virus preservation tubes on the market at present.It is very important for epidemic prevention and disease diagnosis to choose the appropriate virus preservation tube, reduce the infection risk of medical inspectors as much as possible, and keep the virus RNA stable without degradation..

The preservation solution UTM used in traditional virus collection tubes is based on Hank’s solution, with gentamicin, fungal antibiotics, BSA (V), cryoprotectant, biological buffer and amino acids added. Its main purpose is to maintain the virus activity within a certain temperature range, so that it is convenient for health and epidemic prevention departments to further isolate, culture and trace the virus and determine the pathogen. This kind of non-inactivated tube, which I call it, is good for further work, but the sameLive virus increases the infection risk of medical staff in the whole process of sample collection, transportation and testing!Personally, I think this kind of sampling tube for inactivated virus should be a better choice for disease control sampling.

And clinicalIn order to achieve the purpose of rapid detection, it is not necessary to cultivate the virus, but only to crack the virus, so as long as the integrity and stability of the virus nucleic acid can be guaranteed.nowCommonly known as inactivation tube.Many inactivation tubes in China are used.The inactivation component is guanidine salt, which is in this inactivation tube in our hospital.Guanidine salt can crack the virus, but it can’t protect the integrity of nucleic acid for a long time.The virus nucleic acid may have been degraded during the delivery of the sample to the laboratory, which will also cause a "false negative" in the detection. Many studies show that both temperature and time can affect the test results, so the COVID-19 Laboratory Testing Guide has clear requirements for samples to be tested within 24 hours after collection and transported at 4 degrees Celsius. If it is necessary to exceed 24 hours, it should be stored at -70 degrees Celsius.

And some manufacturers put forward another inactivation tube, a kind of.containNon-guanidine saltThe virus preservation tube containing protein denaturant can inactivate the virus and ensure the preservation of virus nucleic acid at room temperature.And the virus nucleic acid is stably stored for 7 days.Does not degrade.

Solution:

1, from sampling to testing, it is necessary to mark the time, so that quality control can be carried out on the preservation time, which is basically no problem in a better hospital.

2. For the front-line staff to do the corresponding training, they should know the advantages and disadvantages of various types of preservation tubes and adopt the best sampling tubes suitable for local conditions.

3. It is best for the country to recommend the selection of sampling tubes with the support of relevant experimental data.

5. Failure of reagents caused by virus mutation?

After the virus mutation in South Africa, Britain, Brazil and other places, there have been cases that turned positive after ten tests in various parts of the world, including China.The FDA recently warned that virus mutation has caused some reagents to fail, and listed several kits that may be affected by mutation. This means that virus mutation may have led to the failure of some nucleic acid detection or persistent false negative.

The FDA listed several kits that may be affected by mutation:

Accula SARS-Cov-2 detection (Mesa Biotech): If the virus mutates at the 28881st base (GGG to AAC), the detection of this kit will be affected;

TaqPath COVID-19 Combo Kit (Thermo Fisher Scientific): This kit detects three genes at the same time, and the variant B.1.1.7 appearing in Britain will affect one of the detection results;

Linea COVID-19 detection (Applied DNA Sciences): This kit detects two genes at the same time, and the variant B.1.1.7 appearing in Britain will affect one of the detection results;

Helix, an American company doing nucleic acid detection, also noticed the influence of virus mutation on detection. The company’s nucleic acid detection simultaneously detected three Covid-19 genes: ORF1ab, N, and S. Because the B.1.1.7 strain that appeared in Britain had deletion mutation in S gene, ORF1ab and N could be detected in the detection, but S gene could not be detected (4). This phenomenon is called "S gene withdrawal".

In addition, the sensitivity of reagents from different manufacturers to COVID-19 is different, and the country also organized a national evaluation of reagents last year. butIn an evaluation study on the consistency and detection ability of seven domestic novel coronavirus nucleic acid detection kits published by Chinese Journal of Laboratory Medicine in July, 2020, it was proposed that "some kits have poor detection ability for weakly positive samples,It is suggested that weak positive samples should be rechecked by kits from at least two manufacturers to ensure the accuracy of the results."

Several targets of nucleic acid detection in Covid-19 are ORF1ab gene, N gene and S gene.

In the Technical Guide for Laboratory Detection of Pneumonia Infected in novel coronavirus issued by China CDC (hereinafter referred to as the Technical Guide), the two targets of nucleic acid detection in Covid-19 are ORF1ab gene and N gene respectively.

On January 6th, the Weekly Report of China Center for Disease Control and Prevention published the results of gene sequencing analysis of two cases of Covid-19 infection in Shijiazhuang and Xingtai. According to the published results, the strain prevalent in Gaocheng, Hebei Province, is different from the strain found in other places in China recently, and is homologous to the strain reported in Russia last July, belonging to strain B.1.1.123

Coincidentally, the mutation happened at the 28881 ~ 28883 bases of the virus gene of this strain, and this is exactly the position of the forward primer of the N gene!

This also explains why there were many negative results at that time.

I guess this is one of the reasons why the criteria for judging nucleic acid positivity have also changed.The judgment position that the single target is still positive after retest is positive.

Figure/Current Criteria for Judging Positive Cases in Technical Guide

Solution:

1. Require manufacturers of nucleic acid reagents to conduct confirmatory experiments on the current mutant strains and propose technical solutions.

2, all localities should introduce at least two kinds of better quality detection reagents, for control use.

3. Information about the failure of test reagents that may be caused by mutated viruses should be effectively and widely reported in domestic laboratories.

Six, the standard implementation in the process of laboratory testing

the pastAccording to the guidelines issued by relevant institutions, the collected samples need to be inactivated at 56℃ before nucleic acid detection, which is very likely to degrade the Covid-19 nucleic acid, which will lead to the failure of normal detection and ultimately improve the false negative rate.In the early daysInactivation treatment is carried out for the sake of biological safety, to protect the staff engaged in testing from virus infection.

But later, there were many voices of doubt in the academic circles, becauseViral RNA is easily degraded by ribonuclease, because this enzyme has the highest activity at 60℃. Ribonuclease comes from two aspects, one is the sample cells, and the other is the foreign pollutants in the process of collection, preservation and transportation.

Last February, there was a similar research article.The high-temperature inactivation process before virus nucleic acid extraction significantly reduces the amount of detectable virus nucleic acid templates, which has been pre-published on the platform of scientific papers of China Academy of Sciences.

And last May,The Journal of Clinical Chemistry published the research of Chinese scholars on Covid-19’s false negative test.The study confirmed that,Thermal inactivation can cause the increase of Ct value reflected by PCR and cause false negative results.Specifically, 46.7%(7/15) of the weakly positive samples were false negative after inactivation (a surprising proportion). Another inactivation method is to inactivate the virus by dissolving the virus protein with guanidine hydrochloride. This study confirmed that guanidine hydrochloride had little effect on PCR reaction, and the false negative rate was low, although there was also a false negative rate of 13.3%(2/15).

Related address: https://academic.oup.com/clinchem/article/66/6/794/5815979

I also inquired whether there was a 56-degree inactivation step in the detection process of CDC in the United States. Although my English ability was poor, I didn’t see this step by machine translation.

Including some other documents retrieved, it is also very clear that 56-degree inactivation does have a great influence on weakly positive specimens.

No matter the Manual of Nucleic Acid Detection in Medical Institutions in novel coronavirus (Trial) on July 13th, 2020 or the Manual of Nucleic Acid Detection in Medical Institutions in novel coronavirus (Trial 2nd Edition) on December 30th, 2020, there are corresponding descriptions.For the laboratory that has been inactivated with the sampling tube containing guanidine salt, there is no need to inactivate at 56 degrees for 30 minutes.This is only true if non-inactivated sampling tubes are used.

However, I learned from the familiar laboratory leaders that this is not the case. Many laboratories still require samples to be pretreated at 56 degrees for 30 minutes regardless of whether the tubes are inactivated or not. I can understand that they are worried about hospital infection and laboratory exposure. But generally speaking, reducing the false negative rate, increasing the detection amount and taking corresponding measures to control the epidemic situation as soon as possible, I think the corresponding suggestions in the corresponding guidelines are also the best choice from the overall situation and supported by data.

Our laboratory should not control the occurrence of hospital sensation and laboratory exposure at the expense of reducing the detection rate, but should focus on stricter control of experimental steps, more cautious PPE wear and higher laboratory environment.

Solution:

1. It is suggested that the state give special instructions to laboratories at all levels on this matter.

2. It is suggested that the country should further study the preservation solution of sampling tubes, and if there is any preservation solution that can not reduce the detection rate at 56 degrees for 30 minutes, it can also be recommended.

The above zero zero always said a lot of points, mainly about how to reduce false negative conclusions, hoping to give you a reference.

It’s been many days since I wrote this afternoon, mainly considering Spring Festival travel rush. Although the scale of Spring Festival travel rush is reported to have dropped by more than 75% this year compared with previous years, the population flow is still very strong. We may face the rising trend of an epidemic after Spring Festival travel rush, and how to make the work better may be a more urgent need before us.

　　At 17: 00 on December 28th, the Information Office of Xi ‘an Municipal Government held a press conference on the joint prevention and control of epidemic situation in COVID-19 (Game 39), attended by Lv Yongpeng, deputy director of Xi ‘an Health and Wellness Committee, Yang Yongtao, deputy head of Chang ‘an District Government, and Guo Xiaohui, deputy director of High-tech Zone Management Committee, to report the latest situation of epidemic prevention and control in Xi ‘an.

　　The press conference revealed that starting from December 28, Yanta District, Chang ‘an District and High-tech Zone will conduct a regional nucleic acid screening every day.

　　At the press conference, Lv Yongpeng, deputy director of Xi ‘an Health and Health Commission, introduced that at 12 o’clock on December 27th, Xi ‘an started a new round of nucleic acid screening. By 12 o’clock on the 28th, a total of 12,317,000 people had been sampled, and the result was 11,347,800.

　　In this round of nucleic acid screening, a total of 5,077 sampling points and 11,669 sampling stations were set up, with more than 31,000 sampling personnel and 132,900 service support personnel, with a daily detection capacity of 1.6 million tubes. The workflow of each sampling point is standardized, guiding and persuading the masses to keep "one meter line" and scanning code, so that the sampling work runs efficiently.

　　With the effective organization of staff and the active cooperation of citizens and friends, the efficiency of nucleic acid sampling has been greatly improved. From 12: 00 to 20: 00 on the 27th, a total of 11,080,800 people were sampled, and more than 11 million people were sampled in 8 hours. Yanta District, Chang ‘an District and High-tech Zone will conduct nucleic acid screening once a day from December 28th. According to the situation, Lianhu District will increase the frequency of nucleic acid screening in the whole region; 1250 sampling personnel were transferred from other districts, counties and development zones to support nucleic acid screening in the above four districts, counties and development zones.

Five zang-organs health-preserving method-Shugan method

2020-06-24 11:51:22.0 Source: China Fitness Qigong Association

　 　 　 Liver belongs to wood, which is the official of a general, and forms the liver system with gallbladder, eyes, tendons and claws.

　 　 　 First, the physiological function of liver

　 　 　 The main physiological functions of the liver are: dispersing and storing blood.

　 　 　 1. The liver governs the drainage: the drainage refers to the dredging, and the drainage refers to the smoothness, which means that the liver can dredge the qi, and it has the movements of ascending, descending, exiting and entering, and circulates all over the body everywhere to maintain the physiological functions of the human body. The function of main drainage is embodied in the following two aspects:

　 　 　 (1) Emotion: The emotional activities of the human body are mainly dominated by the heart and the liver. The difference is that the heart storing the spirit refers to the occurrence of mental disorders and various emotional lesions when the mind is in charge of the mental consciousness. The function of the liver governing the discharge refers to regulating emotional activities and helping to think about problems. When this function is normal, people feel comfortable, optimistic and thoughtful. When it is abnormal, it is emotionally disordered, which is mostly manifested as qi depression and rage. Depression of liver qi can be seen as sullen, suspicious and thoughtful, sad and crying, hypochondriac breast swelling and pain, irregular menstruation. Hyperactivity of liver qi can be seen as impatience, dizziness and hypochondriac pain. Liver dysfunction and emotional abnormality are mutually causal. Liver dysfunction and emotional abnormality turn into depression or hyperactivity, and emotional failure leads to liver disease, which is dysfunction, while rage and qi stagnation both hurt the liver. Therefore, the characteristics of the liver are: being happy (feeling comfortable) and being depressed.

　 　 　 (2) Digestion: Digestion is the function of the spleen and stomach, and the drainage of the liver can help the spleen and stomach digest, which is manifested in two aspects: on the one hand, it helps the spleen and stomach to rise and fall. Normal qi movement changes are spleen ascending to clear, stomach descending to turbid. If the drainage of the liver is normal, the qi can be regulated smoothly, so the spleen can be cleared and the stomach can be turbid. If the liver’s drainage is abnormal, the qi will be disordered, and the stomach will drop when the liver’s qi invades the stomach, which is vomiting and belching in the upper body, and abdominal distension and pain in the middle; When liver-qi invades the spleen, the spleen loses its elevation, which is dizziness in the upper part and diarrhea in the lower part. On the other hand, it secretes and excretes bile: bile is secreted by the liver, which is yellow in color and bitter in taste and discharged into the intestine to help digestion. Normal liver drainage, normal bile secretion and excretion, normal digestion; The liver loses its function of dispersing qi, and bile secretion and excretion are abnormal. If it overflows into the stomach, it will cause yellow mouth, bitter water and epigastric pain. If it cannot be discharged into the intestine, abdominal distension will occur. In addition, the liver governs the discharge, which has a close influence on women’s menstruation.

　 　 　 2. The liver holds blood: it means that the liver has the function of storing and regulating blood.

　 　 　 (1) Storage of blood: The liver is known as the "treasury of blood". The liver looks like a warehouse, and there is a saying in Su Wen Wu Zang Gen Pian: "The blood lying in the old man belongs to the liver". Modern medical research has proved that the liver can increase blood flow by 25% when people lie still, and the whole liver system, including venous system, can store 55% of the whole body blood volume.

　 　 　 (2) Regulate the circulating blood volume: Only the blood of human tissues can play a normal role. When the activities of tissues and organs are strengthened, more blood supply is needed, and conversely, less blood supply is needed. At this time, liver blood can be re-divided. If there is insufficient blood stored in the liver, the leader will not be raised and he will feel dizzy; If you are not surplus, you will see less menstrual flow or amenorrhea; I can’t nourish the collaterals, and my limbs are numb.

　 　 　 Liver-governing and blood-storing cooperate with each other in physiology and affect each other in pathology. liver blood deficiency can cause disorder of blood-releasing, resulting in depression or irritability. Conversely, liver depression and qi stagnation can cause blood stasis (chest and hypochondrium, tingling, amenorrhea, lump) when the mood is abnormal; In great anger, the liver qi goes up against the qi, and blood can be seen bleeding with the surge of qi.

　 　 　 Second, self-guided massage for liver disease intervention

　 　 　 It consists of qigong exercises and massage. When exercising and recovering, you can do qigong first and then massage.

　 　 　 (A) Fitness Qigong movements

　 　 　 1. save your fist and glare to increase your strength

　 　 　 Key points of action: move your body’s center of gravity to the right, move your left foot to the left, squat down with your legs slowly and knees in a stance, and at the same time, hold your hands firmly, with your fist eyes up and look ahead. The left fist rushes forward slowly and forcefully, shoulder-high, with the fist eye facing up; Stare, depending on the direction of the left fist. Left arm pronation, left fist changing palm, tiger mouth down, visual left palm. The left arm is rotated outward, and the elbow joint is slightly bent. At the same time, the left palm is wrapped to the left, and the palm is turned up and then held, with the thumb included, and the left fist is visually observed. The elbow of the left fist is recovered to the waist, the fist eye is up, and the front is visible. The right potential action is the same as the left potential action, and the potential is left and right once, which is done three times in total.

The role of the achievement method: "the main muscle of the liver, enlighten the eyes." The expression "glaring" in this formula can stimulate the liver meridian, make the liver blood full, relieve the diarrhea of the liver qi, and strengthen the bones and muscles. Squatting with two legs and grasping the ground with ten toes, fist-saving with both hands, wrist-twisting, and finger-grasping with force step by step can stimulate the hands and feet at Shu points and Du Meridian in Yang the twelve meridians, Yin San. At the same time, the muscles and tendons of the whole body are stimulated by static stretching, and long-term exercise can make the muscles and muscles of the whole body firm and increase their strength.

　 　 　 2. Qinglong probe claw

　 　 　 Zuo Qinglong explores the claw potential: the feet are shoulder-width apart, the hands are firmly grasped, the elbows are flexed to the waist, the fist wheel is attached to Zhangmen point, and the fist center is upward; Look down front. Then the right fist changes to palm, the right arm is straight, and it abducts to the right from below, slightly lower than the shoulder, and the palm is up; Move your eyes. The right arm bends elbow and wrist, the right palm turns into a "dragon claw", the fingertips are left, and they extend horizontally to the left side of the body through the chin, and the eyes move easily; The trunk then turns to the left about 90; Look at the direction pointed by the right palm. The "right claw" changes its palm, and then the body bends forward to the left, and the palm is pressed down to the outside of the left foot; Look down. The trunk bends from left to right, and drives the right hand to draw an arc to the outside of the right knee or right foot through the left knee or left foot. The arm is rotated outward, the palm is forward, and the grip is firm; Look down with your eyes. The upper body is lifted and upright; The right fist is raised with the upper body and closed at Zhangmen point, with the heart of the fist upward; Look down front. Right Qinglong claw-probing potential: It is the same as left Qinglong claw-probing potential, but in the opposite direction.

　 　 　 Function of achievement method: "Two threats belong to the liver", which can alternately open and close the two threats by turning around, probing left and right paws and bending forward, so as to achieve the effects of soothing the liver, regulating qi and regulating emotions; It can improve the activity function of waist and lower limb muscles.

　 　 　 3. The formula of "shh"

　 　 　 Action points: release your hands, palm up, little finger lightly attached to your waist, and receive it back to your waist; Look down front. Keep your feet still and turn your body 90 to the left; At the same time, the right palm slowly goes out from the waist to the left, to about shoulder height, and with the word "shh" spoken; Eyes gradually open, visual right palm out direction. The right palm draws back the waist along the original road; At the same time, the body turns back to the front; Look down front. The left and right movements are the same, but in the opposite direction. So wear the palm three times left and right. This type utters the word "shh" six times.

Function of achievement method: Shuzi formula can dredge liver qi, prevent and treat liver diseases, eye diseases, chest tightness, loss of appetite, dizziness and other symptoms, and can intervene reproductive system and gynecological diseases.

　 　 　 4. Wind swings lotus leaves

　 　 　 Action points: Left-handed action: the left foot is open to the side, the two feet are parallel, the distance is about shoulder width, and the legs bend their knees and squat; The waist is turned from right to left by 45 degrees, and the hands are changed from ring grip to tiger’s mouth grip stick, the palms are down, and a flat circle is drawn to the left and front through the abdomen; Stand naturally with your legs stretched out; Hold the staff in both hands, roll the wrist and collect the staff in an arc on the left side of the abdomen; Look at the lower left front. Both legs remain the same; Turn the waist to the right, and the staff will move the lower abdomen horizontally from left to right, with the right hand leading the staff to the back of the right shoulder and the left hand holding the staff to the right rib; Then both legs bend their knees and squat; The waist turns positive, and the left and right hands are crossed to the right and left respectively, and the right arm overlaps the chest at the top and the left arm at the bottom; Look ahead. Stretch your knees with your legs and stand naturally; The left hand holding the stick draws a flat circle from the front of the waist to the left rear of the body, and reaches the extension line to the left from the rear edge of the left heel. The left hand is about waist high, and the right arm is naturally straightened and attached to the right ear. The upper body bends to the left, and the stick stands obliquely and stops at the left rear of the body. Then both hands and fingers naturally straighten, hold the staff, and pause; Look at the direction of the staff. Keep your legs still; The body is upright, the head is raised, the staff is raised upward to the top of the head in an arc shape, the wrist is straight, the fingers are upward, the arms are naturally straight, and the eyes are above; Immediately, the legs bend their knees, the staff falls to the chest, and then it is rubbed down from the breasts to the abdomen, and the palms of both hands are down; Close your left foot and right foot together, stand naturally, hold the staff in both hands and put it in front of your abdomen; Look ahead. Right-handed and left-handed movements are the same, but the left and right directions are opposite. This formula is done once for one left and one right, and it is done twice in total.

　 　 　 Function of achievement method: The body bends sideways, which can effectively stimulate the channels such as gallbladder meridian, pulse impulse and Ren Du meridian, help to soothe the liver and benefit the gallbladder, suppress the hyperactivity of liver yang, and promote the smooth operation of qi and blood in the whole body. According to the practice and theory of chiropractic, the left and right flexion of the spine can prevent or adjust the asymmetry and imbalance of the physiological bending of the spine, and effectively avoid the adverse changes in the shape of the spine.

　 　 　 5. Friction potential

　 　 　 Action points: straighten your legs, lift your arms horizontally from side to side, palm down, fingertips outward, cooperate with inhalation, and look ahead. Move the center of gravity to the right, buckle the left foot by 45, move the center of gravity to the left, slightly bend the left foot, straighten the right leg and tilt the palm toe, take the heel of the right foot as the fulcrum, turn the body about 90, and turn the body right at the same time. The center of gravity leans backward and leans forward to drive the two-arm cube to swing the arm, with the left arm up/forward/down to the tip of the right foot, the left fingertip forward and downward, and the left elbow slightly flexes, at the same time, the right arm is downward. Bend your right arm, put your right palm under your armpit, step back about 30 with your right foot, and move your center of gravity backward. Push the root of your right palm along the midline of your armpit, swing forward in an arc, and lift your left palm up to your armpit in an arc. At the same time, your right foot retreats into a left imaginary step, and your body turns left. With exhalation, look at the direction of your right hand. Step back with your left foot, turn your body right, push your left palm forward, lift your right palm up to your right armpit, and take four steps back. At the end of the fourth step backwards and rib rubbing, the right foot tilts up, leans forward, presses the tip of the right foot under the left palm, and lifts the right arm to the back. Get up, buckle your right foot, tilt your left foot abduction, turn left, and drive your two arms to swing three-dimensionally. Bend over, stick the right palm to the left toe, lift the left arm to the back, cooperate with exhalation, and look at the front and bottom. This formula takes four steps back on the left and four steps back on the right. The actions are the same and the directions are opposite. Do it again on the left and right. When you make the last move on the right side, buckle your left foot, keep your right heel inside, get up and turn positive, drive your arms to extend horizontally, then embrace them upward, inhale, bend your knees and press them with your palms down, which is the same height as your navel.With exhalation, look at the front and bottom.

　 　 　 Function of achievement method: The rubbing rib potential can enhance the flexibility of shoulder joint and lower limbs by swinging arms, climbing feet and flexing legs, and can promote the function of dispersing the liver and transporting the spleen by massaging the big acupoints on both sides and twisting the spine left and right. This type of action requires high physical coordination, which can be improved through practice.

　 　 　 (B) Tuina method

　 　 　 1. Wide-chested method: Sit, put the virtual palm of your right hand above your right breast, slap it with appropriate force and gradually move it to the other side, and go back and forth for 10 times. Then cross your palms and cling to the top and bottom of the breast, and rub them back and forth 29 times. Later, two palms are stuck under two armpits, from the upper side of the waist down to the ilium, and pushed back and forth, with heat as the degree.

　 　 　 2. Sparse intercostal space: Sit, with two palms under your armpits, fingers open, and the gap between fingers and ribs is the same width. First, push the right palm to the left to the sternum, then push it to the sternum with the left palm to the right, from top to bottom, alternately push it to the umbilical level, and repeat 10 times. Pay attention to the fingers should be close to the ribs, and the force should be uniform, especially if the chest ribs have a warm feeling.

　 　 　 3. Straighten the triple energizer: Sit or lie down, with two hands and four fingers crossed, press horizontally on the Shanzhong point, and press with two palms on the inner side of both breasts. From top to bottom, push slightly to the end of the abdomen, counting 20 times.

　 　 　 4. Dial Yanglingquan: when sitting, press two thumbs on Yanglingquan point (the point where human tendons meet) on both sides, and the other four fingers are assisted. Press and knead this point for 1 minute first, and then pluck the tendons at this point 3-5 times with force, so as to feel sore and numb.

　 　 　 5. Binocular movement: Keep your gaze straight, keep your head straight and your waist straight. First, slowly rotate your eyes clockwise for 10 times, then stare forward for a moment, and then operate counterclockwise as usual.

　 　 　 Third, nourishing the liver and taking medicine

　 　 　 Traditional Chinese Medicine: Radix Codonopsis, Ganoderma, Colla Corii Asini, Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Carapax et Plastrum Testudinis and Bupleuri Radix.

　 　 　 Food: crucian carp, lean pork, animal liver, chicken, shellfish, fungus, medlar, mung bean, banana, kiwi fruit, strawberry, etc.

　 　 　 Ganzao Buxue Decoction: pork liver 30g, duck liver 30g, spinach 100g, dried jujube 20g, water fungus 15g, seasoning: ginger 5g, salt 2g, slicing both pork liver and duck liver; Wash spinach and cut into sections; Put the liver, jujube and auricularia auricula into a pot, add appropriate amount of water and cook for 30 minutes on low heat; Add spinach, salt and ginger and cook for 5 minutes. It has the functions of invigorating qi and liver, replenishing essence and blood. It is suitable for dizziness, fatigue, dysphoria, irritability, etc. caused by liver blood deficiency.

　 　 　 Chrysanthemum honey drink: 50g chrysanthemum, 20ml water, simmer for 30 minutes, filter, add appropriate amount of honey, and mix well before drinking. Has the effects of nourishing liver, improving eyesight, promoting fluid production, quenching thirst, clearing heart fire and strengthening brain, and is suitable for blurred vision, vexation, aphtha, etc. caused by liver fire.

Many people have had this feeling that their chest suddenly "thumped" as if their heart had stopped. This situation is likely to be premature beats.

Premature beat is that a heartbeat rhythm is advanced, and there is a long interval after beating ahead. Some patients with less premature beats have no obvious feeling, but occasionally feel some discomfort or slight palpitation in the chest. If premature beats occur frequently, it will cause symptoms such as palpitation, shortness of breath, chest tightness and fatigue, and even worsen the original heart disease, which requires active treatment.

Western medicine treatment of premature beats is mainly "anti-"

For the treatment of premature beats, the traditional western medicine treatment method is to choose antiarrhythmic drugs, which only aim at a certain level and a certain part of arrhythmia, ignoring the interaction between factors at the same level and the interaction between different levels, and then aiming at the single cause of arrhythmia, blindly adopting the "anti-"treatment method can not solve the fundamental problem. Moreover, the side effects of antiarrhythmic drugs are increasingly obvious, which not only has serious extracardiac toxicity and leads to liver and kidney damage, but also may cause more complicated arrhythmia and even worsen the original arrhythmia symptoms. Another point is that western medicine can not effectively treat bradyarrhythmia, so there is no good way to treat arrhythmia such as sinus bradycardia with ventricular premature beats.

The treatment of premature beats with traditional Chinese medicine focuses on "regulating" 　 　 　 　 　 　 　 　 　 　 　 　 　

Shensong Yangxin capsule, a traditional Chinese medicine, has realized the thinking change from "resistance" to "modulation" in clinical treatment of premature beats. "Modulation" is the whole regulation, which takes the integration of various factors and mechanisms for regulating premature beats as the core, and starts from the interrelation among molecules, cells, tissues, the whole heart and even the whole human body, so as to regulate the autonomic nervous function of the heart, block multi-ion channels, improve the metabolism of myocardial cells, and restore the whole function of the heart, and has a good curative effect on all kinds of premature beats.

In the evidence-based medical research of Shensong Yangxin Capsule, which was attended by more than 500 doctors from 36 3A hospitals in China, 188 cases of non-organic ventricular premature beats and 671 cases of organic ventricular premature beats caused by heart diseases such as coronary heart disease and myocarditis were treated with Shensong Yangxin Capsule. Compared with the curative effect of slow heart rhythm, the results of 24-hour dynamic electrocardiogram examination show that Shensong Yangxin capsule has a good therapeutic effect on both non-organic ventricular premature beats and organic ventricular premature beats, and its curative effect is significantly better than that of slow heart rhythm, and there is no adverse cardiac reaction. By taking Shensong Yangxin Capsule, the symptoms such as palpitation, shortness of breath, chest tightness, fatigue, dizziness and sweating disappeared.

In addition, the curative effect of Shensong Yangxin Capsule on sinus bradycardia with ventricular premature beats and heart failure with ventricular premature beats has also been confirmed by evidence-based medical research.

A randomized, double-blind, placebo-controlled, multi-center clinical study of Shensong Yangxin Capsule in the treatment of sinus bradycardia with ventricular premature beats, which was jointly participated by 33 3A hospitals in China, showed that the number of premature beats in the treatment group decreased by 1827 times /24 hours, the rate of decrease of premature beats was 71.01%, the heart rate increased by 6.25 times/minute, and the heart rate percentage increased by 11.38%. The research results show that Shensong Yangxin Capsule can improve ventricular premature beats safely and effectively, and at the same time, it can increase sinus heart rate, thus screening out effective and safe therapeutic drugs for patients with sinus bradycardia and ventricular premature beats at home and abroad.

Evidence-based medical research on Shensong Yangxin Capsule in the treatment of heart failure with ventricular premature beats was completed by 31 domestic 3A hospitals for two years. The results confirmed that Shensong Yangxin Capsule can significantly reduce the number of patients with 24-hour ventricular premature beats and significantly improve the decline rate of 24-hour ventricular premature beats on the basis of standardized treatment of chronic heart failure. At the same time, it can increase the left ventricular ejection fraction, improve the cardiac function classification, reduce the plasma concentration of pro-brain natriuretic peptide (NT-ProBNP), increase the walking distance of 6 minutes, improve the quality of life of patients, and have good safety.

Based on the research results of Shensong Yangxin Capsule in treating premature beats, Shensong Yangxin Capsule was recommended by China Expert Consensus of Ventricular Arrhythmia in 2020.

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When the hybrid car developed into the second half, it was not the user’s taste that became higher, but the user’s eyesight became awkward. It is increasingly found that price is not the only indicator of hybrid cars, and cars with high performance, high intelligence and high safety are worthy of the money in their pockets. Cars are not toys. They will be replaced and eliminated after buying for one or two years, but will bring long-term high-value travel experience. Therefore, cars manufactured with high standards are worth starting with.

The 2025 LECK 08EM-P, which was launched on August 8, is a high-value hybrid SUV choice worthy of users’ travel and life in terms of strength and quality.

Between low price and high value, there are always people who prefer the latter.

In the former automobile market, there were always people who thought that low price was king. As users became more aware of automobiles, they tended to be more value-oriented.

The 2025 LECK 08EM-P has six models: 120 long battery life Plus version, 120 long battery life Pro version, 120 long battery life version, 245 long battery life Pro version, 245 long battery life Halo version and 220 four-wheel drive performance Halo version. The battery life in pure electric mode adopts stricter CLTC working conditions. CLTC is based on the actual driving conditions in China, including urban, suburban and high-speed driving conditions, and the battery life test is more in line with it. On the surface, the LEICK 08EM-P with a low battery life of 120km seems to be equivalent to the 121km Tang DM-i, but the Tang DM-i still uses a relatively loose NEDC working condition count. In terms of comprehensive endurance, the LECK 08EM-P with CLTC working condition of 1400km is obviously more realistic than the Tang DM-i with NEDC working condition of 1100km.

?On the power system level, the Lectra 08EM-P super extended-range electric system consists of P1 and P3 motors +P4 motor +1.5T electric hybrid engine, which together form a high-performance architecture. Specifically, the P1+P3 motor architecture is a rear-wheel drive model, and the P1+P3+P4 motor architecture is a four-wheel drive model. Logically, the engine generates electricity for P1 motor, and the rear-drive vehicle is driven by P3 motor, with a maximum power of 160 kW and a peak torque of 350 N m.. The four-wheel drive model is driven by P3+P4 motor, and the peak power of P4 motor is 156 kW. The comprehensive maximum power of the system is 436 kW, the comprehensive maximum torque is 905 N·m, and the acceleration of 100 kilometers is only 4.6 seconds.

The DHT three-speed transmission of LINKE 08EM-P can realize the flexible switching between engine and motor, and bring more accurate power distribution under different road conditions. In the specific operation experience, the driver of the 08EM-P can choose the appropriate gear in different road environments and match the power with different intensities, thus bringing a precise sense of control. And the shifting logic is very clear, and the power acceleration is not all of a sudden, but a linear acceleration experience.

In contrast, Tang DM-i’s CVT gearbox has the advantages of strong ride comfort, but its disadvantages are also quite obvious: first, CVT gearbox is prone to cold protection problems, and it may take a long time to start in cold environment, which may also lead to the inability of vehicles to speed up effectively. Secondly, the transmission belt of CVT gearbox is fragile and easy to be damaged in harsh driving environment, which requires more frequent maintenance and replacement, and the actual vehicle maintenance cost is higher. Thirdly, CVT gearbox will obviously feel the lack of power on vehicles with strong power, especially on uphill sections, which is one of the reasons why BYD plug-in and hybrid vehicles have not adopted the strategy of high power.

In the era of intelligent flooding, Linke 08EM-P has implemented the user’s needs.

At present, the new energy vehicle market has entered the era of intelligent flooding, which is manifested in the stacking of non-vehicle intelligent configurations, such as the "refrigerator color TV sofa" that people often vomit. On the aspect of integrated intelligence, LEEK 08EM-P upgraded the car system to OTA version 1.6.0. The overall intelligent cockpit performance of the car is different from the current flood era. It follows the principle of "making the car practical and intelligent to the extreme" and implements the needs of users.

If you are installed with the identity of "Leader 08EM-P Owner" now, you don’t need a physical key to get on the bus, and your Apple mobile phone, watch and proximity can open the door for you, realizing a feeling of unlocking/locking, and making your travel life more scientific and technological. When you sit in the driver’s seat, you don’t need to look down at your mobile phone or central control screen navigation when driving, because there is the largest 92-inch AR-HUD mass-produced in the industry, which directly presents three-lane information, AR navigation, ADAS assistance and other information on the front windshield. In terms of car experience, the LYNK Flyme Auto car system of LINKE 08EM-P is the first to take the Antola 1000 Pro computing platform, which integrates two 7nm "Longying No.1" chips independently developed in the industry, and the computing power of a single chip is comparable to that of Qualcomm 8155 car chip, and it has larger running and storage memory, which is smoother and faster in car startup and functional experience.

When you want to watch the video on a big screen, use the 15.4-inch ultra-clear full screen of LTPS LCD display technology, which has a picture quality of 2.5K and a color gamut as high as 85%, which can show more colors. The sound quality experience is even more impressive. As the only SUV model equipped with Harman Kardon 23 plus WANOS panoramic sound within 200,000, the Lectra 08EM-P has brought a million-level extreme sound experience at a price of 200,000. In terms of sound surround telepresence, the top "sky sound" surround channel is added to the Lectra 08EM-P cockpit, which enhances the depth and telepresence of the sound image compared with the two-channel stereo, and it seems to be surrounded by sound when sitting on it. In addition, the car system is equipped with WANOS Panoramic Audio APP, with its high-quality panoramic audio-visual entertainment resources to realize audio-visual synchronization, which can bring you and your family a more immersive and shocking audio-visual experience.

On the intelligent voice level, Aicy voice assistant can support four-tone recognition, which has higher understanding and execution ability, not only supports custom wake-up words, but also can customize a variety of images to make the dialogue more vivid and interesting. Crucially, Aicy voice assistant can realize multiple rounds of communication according to the context of the whole context, which really brings an intelligent experience of "seeing and speaking".

Not only that, LINKE 08EM-P also has innovative functions of sentry mode and car wash mode. Sentinel mode In the parking scene, vehicles can monitor suspicious targets by looking around the fisheye camera, rely on the acceleration sensor to detect the risk of collision, and give a double flash warning to the outside world in time. It can also record and store suspicious scenes and notify the owner. When the car wash mode is turned on, the vehicle will close the window, trunk, charging cap, fuel cap, wiper, etc., and disable the approaching vehicle to unlock and leave the vehicle, effectively preventing water seepage and ensuring vehicle safety.

In intelligent driving, LEEK 08EM-P is equipped with Lynk Co-Pilot Navi intelligent navigation assistance system, which not only performs sensitive and fast in daily adaptive cruising, overtaking, going up and down ramps and other road conditions, but also has various lane-changing functions such as autonomous lane change and voice control lane change, taking into account more scenes. It is worth mentioning that when the Lectra 08EM-P encounters a big car, it will take the initiative to avoid it, deliberately widen the front and rear distance from the big car, and in the process of overtaking, pull the horizontal distance from the big car, reduce the parallel time, relieve the driver’s driving fatigue and pressure, and ensure driving safety.

In terms of road perception, LEEK 08EM-P supports 10 perception cameras and 5 millimeter-wave radars, and relies on centimeter-level precision maps to guide navigation. Together with two black sesame intelligent Huashan A1000 chips with a cost-effective ratio of up to 116 TOPS, it realizes the algorithmic arrangement of road environment and helps vehicles realize the intelligent driving performance of L2+ high-order parking.

Whoever ignores security is the enemy of users.

Consumers want cars with lower prices, but irrational price wars will only harm the interests of users in the end. Some brands take the lead in setting off price involution, which seems to be more cost-effective. In fact, they cut corners on invisible core components and car-making technology, and use iron oil tanks, ultra-thin and ultra-short front and rear anti-collision beams, and chopsticks-slender chassis suspension, which bring great hidden dangers to the safety of the whole vehicle. Such cost-effective is not the price that users want, and such brands can also be regarded as the enemies of users.

In sharp contrast with such a brand model, the price of the Lexus 08EM-P, which is already quite ahead in terms of three-electric system and intelligence, starting from 179,800 yuan may not be cheap, but it is also within the reasonable price of high-value plug-in SUV. Crucially, LEEK 08EM-P is a benchmark in vehicle safety.

The LEICK 08EM-P is made of thermoformed steel with the maximum pressure of 2000MPa, and the proportion of high-strength steel and aluminum alloy in white body is as high as 75%. It is equipped with aerospace-grade 7 series aluminum alloy front crash beam, and the integrated thermoformed boron steel door knocker and superelastic honeycomb filling technology are adopted for the first time, which can alleviate more impact energy, and the performance of materials exceeds that of brand luxury cars.

In addition, the car is equipped with an extended head air curtain with a length of 2000mm, which runs through the ABC column and covers the whole window area. After bouncing off, the pressure can be maintained for 6 seconds, which brings longer personnel protection. Adding 120L super-large passenger airbag can further ensure the safety of the passenger’s head. Finally, in terms of battery safety that people are most concerned about, Linke 08EM-P adopts the first integrated DP1180 bottom guard plate with the tensile strength of 1200MPa, which far exceeds the safety standard of the national standard, and can realize 50ms high-voltage power failure due to collision and bid farewell to the natural danger of battery fire.

Based on its solid performance in safety, LEEK 08EM-P obtained the first domestic certification of "60km/h side impact protection of new energy passenger cars with superimposed side pillars" issued by China Automotive Research Institute.

Jianghu car review:

In the just-concluded platform test, the Lectra 08EM-P stood out among 35 models, and won the first lap time of SUV with 2 minutes and 19.87 seconds, which fully reflected the excellent handling performance of CMA Evo architecture. The 2025 Lectra 08EM-P is not the first model of Lectra 08EM-P. Since it was launched one year ago, the cumulative sales volume has exceeded 80,000, and its high-value travel quality has been recognized by users. Its brand, Linke, also rolled off the production line for the millionth vehicle in less than six years, becoming the fastest high-end automobile brand in China and the truly recognized high-end automobile brand in China. The Lexus 08-EM-P, which is built with heart, advanced technology and solid materials, is a high-end new energy SUV choice that most people can’t avoid.

Some netizens left a message and wanted to see it. Today it came. Next, let’s take a look with Xiaobian.

First of all, from the appearance, LaVida’s front face is beautifully shaped and equipped with a banner net, which looks sporty. Coupled with headlights, the overall look is very deep. The car is equipped with LED daytime running lights, front fog lights, automatic opening and closing, delayed closing and so on. Coming to the side of the car, the body size of the car is 4561MM*1740MM*1470MM, and the car adopts deep and elegant lines, which gives people a very hard-core feeling. With large-sized thick-walled tires, it gives people a very young personality. At the rear of the car, the rear of the car echoes the front of the car, the taillights look very cool, and the exhaust pipe adopts a hidden design, which is simple and fashionable.

Arriving in the car, the interior of LaVida looks very fashionable, simple and functional. The steering wheel of the car uses a three-spoke design and is made of plastic, showing a sense of atmosphere. Let’s take a look at the central control panel, which is decorated with an 8-inch central control panel, which makes the interior design quite layered and conforms to the temperament of the car. The dashboard and seats give people a good feeling, too. Let’s take a look. The dashboard design is remarkable and eye-catching. The car uses a leather-like seat, the seat is wrapped in place, and the overall ride feels soft and comfortable.

LaVida matches the automatic manual transmission (AT) gearbox, with the maximum power of 81KW and the maximum torque of 141N.m, and the power performance is good.

LaVida is equipped with driving mode selection, remote control key, engine start and stop, traction control (ASR/TCS, etc.), CarPlay support, HUAWEI HiCar support and other configurations, which is worthy of praise.

The LaVida introduced today is not only eye-catching in space, but also has reached the mainstream level in various configurations, and there is nothing to be picky about driving experience and space experience. You must also have a look at this car, which will definitely bring you unexpected surprises.

speed up apply the brakes oil consumption second rice rise A self-motivated test of the new Honda Accord 2.4L Evaluation Editor-Wang Ziping:

The most outstanding feature of the new Accord is its cost performance. It has worked very hard to add enough scientific and technological security configurations, which makes it particularly eye-catching among the same price models. But the price is the most lethal weapon, and its price is basically the same as that of the old models, which makes its cost performance suddenly more prominent. Suddenly there are so many rich configurations, I think no one will not like it, and then it is the regret of the owners of the old models.

Evaluation Editor-Liang Haiwen:

The upgrade of the new Accord focuses on the configuration and modeling. It must be admitted that the appearance of the new car is really dazzling, which is very important to attract young consumers, and the blessing of a number of high-tech configurations makes it keep up with the trend. Although the engine has been re-adjusted, its power performance is at the same level as the old one, and its acceleration performance is still better than that of the two main Japanese rivals. The manipulation feeling is still sticking to the original style: it is the most athletic among the Japanese "Three Musketeers" and more comfortable than its European and American rivals.

Evaluation Editor-Huang Rongjia:

As an old car owner, I think the appearance of the new Accord is much more beautiful than the current car. The configuration is much richer, especially the configurations such as inner CarPlay and Honda SENSING system, which are full of highlights. To sum up, compared with the current 2.4L model, the new car has improved a little, which has brought many surprises to my old car owner. To tell the truth, seeing a new car really makes people feel the urge to change cars.

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