Image source: China Radio Network

CCTV News:"Family, less idle month, people twice as busy in June. At night, the south wind rises and the wheat is covered with yellow. " It’s the wheat harvest season in a year. Under the blue sky in the distance, golden wheat waves are surging. The newly harvested wheat is ground into fragrant flour and enters the kitchens of various households. ……

One out of every eight steamed buns eaten by more than 1.3 billion people in China comes from the wheat variety "Bainong Aikang 58", which is known as "the first wheat in Huanghuai". It is "Mai Da" Ru Zhengang who successfully cultivated this new wheat variety. He is the vice president of the School of Life Science and Technology of Henan University of Science and Technology, the director of the Henan Hybrid Wheat Engineering Technology Research Center, and the chief expert of wheat disease and pest resistance breeding in Henan Province.

Ru Zhengang often said: "As an agricultural science and technology worker, you can’t help farmers increase production and income. You are nothing!" His lifelong aspiration is to fill the granary of China with the power of science and technology.

Change the world with a "go against the sky wheat seed"

Food is scarce and farming is difficult. These childhood memories make Ru Zhengang have an indescribable feeling for wheat. He has always had a "wheat dream", "We must have enough food in Chinese, and the granary is full of our own wheat".

In 1981, Ru Zhengang, who graduated from agronomy, was selected by Professor Huang Guangzheng, a national expert who was famous in the breeding field at that time and won the second prize of national invention, and "pulled into" the breeding industry. Since then, it has been persistent for 36 years.

In order to find the root of the problem of wheat growth, Ru Zhengang ate and lived in the wheat field for several days. In order to ensure the accuracy of the data, he took the research team to manually thresh one by one; In order to understand the growth of wheat in various places, he traveled almost every wheat producing area in China.

In the process of breeding new wheat varieties such as "Aikang 58", Ru Zhengang explored and created a set of nearly complete scientific methods, theoretical systems and scientific research equipment and breeding platform established from it. In his breeding base, from the molecular biology laboratory to the artificial climate room, to the intelligent greenhouse, and then to the outdoor experimental field, it takes only a few minutes to be fully prepared. It is these few minutes’ path that shortens the time of wheat breeding by six years.

Ruzhengang successively cultivated and popularized many varieties such as "Bainong 62", "Bainong 64", "Bainong 160" and "Bainong Aikang 58", and the wheat varieties with stable and high yield filled the granaries of China, which also made the people happy. Ruzhengang has become an out-and-out "God of Grain".

The inspiration for scientific research propositions comes from ordinary people.

"All my scientific research topics and the inspiration and source of technological innovation come from ordinary people." Ru Zhengang traveled all over the country in most wheat fields, and no matter where he went, he never forgot to ask the villagers to "find fault" with their own seeds.

Can wheat be high-yielding and lodging-resistant? Can wheat be planted whenever it wants? The ears of wheat are big, can you make more grains? There are too many ears, can you make the straw shorter? The wheat straw is short, can it tolerate barren and drought? … … Seemingly harsh problems are thrown at him from time to time, and if Ru Zhengang gets the treasure, it will eventually turn into his most breakthrough and creative scientific research topic.

Many experts believe that the wheat yield in Huanghuai area of China has reached the "ceiling", and it is "even more difficult" to further increase the yield. Ru Zhengang’s thoughts and vision jumped to the northeast and Guangdong, Fujian and other places, hoping to find a record-breaking "artifact" in these places.

He constantly challenges himself and his limits. "Even though the frost of time has stained my temples and the knife of years has carved my forehead, why don’t I change my mind and be as heroic as yesterday?" Ru Zhengang expressed his ambition to charge for hybrid wheat breeding in poetic language.

Loving wheat is like your own daughter.

Ru Zhengang said that after 36 years of research, Wheat is actually like his daughter. It can understand his words, and he knows how it can be good, what it likes, what it doesn’t like, and how to make it happy.

"When you chat with wheat with your heart, you can feel the power of its life. Although the breeding work has to face failure 90% of the time, every improvement is an exploration of life and a spiritual enjoyment." Ru Zhengang said.

In Ru Zhengang’s view, wheat that can give people full returns, like wheat, is not wheat, but wheat of a work of art.. He wants to cultivate better wheat varieties, serve the strategic needs of modern agricultural production and national food security, and make new contributions to China’s food security and agricultural harvest. (Source: Ministry of Science and Technology)

　　The report of the 19th National Congress proposed that we should implement the new development concept and build a modern economic system.

　　In this regard, it is an important content to improve the system and mechanism of promoting consumption and enhance the basic role of consumption in economic development. In recent years, consumption has replaced investment as the first driving force of economic growth. Behind this, the innovation of payment methods brought by technical means has contributed greatly, and installment consumption is one of them. "Spend tomorrow’s money and enjoy today’s resources", whether it is life consumption such as digital electronics, home appliances and furniture, or service consumption such as training, tourism and entertainment, the tentacles of phased consumption have extended to all aspects of life.

　　Can installment consumption really make people enjoy life ahead of schedule easily? In the face of the network staging platform with spurt growth, how should consumers rationally stage and make good use of staging?

　　How hot is the market?

　　"It is no exaggeration to say that more than 90% of college students around me have used installment consumption, and food, clothing, housing and transportation, leisure and entertainment can all be solved by installment consumption."

　　"With children at home, the requirements for environmental sanitation are relatively high. My British Dyson vacuum cleaner was made of JD.COM white stripes. I often shop in JD.COM, and I can avoid paying interest by installments with coupons. It is much more economical to installment this year than to use a bank credit card. " Hao Yihang, an employee of a large state-owned enterprise in Beijing, is a fan of JD.COM IOUs. In his words, the slogan of "Consumption by stages, so that youth does not leave blank" attracts young people. The service of "Shopping first, paying later" and "30 days interest-free and staging at will" makes life consumption zero obstacles. "Consumption by stages is so cool!"

　　It reduces the pressure of one-time payment, and the relaxed shopping experience of "installment consumption" makes people happy. Hao Yihang said that Apple’s upcoming iPhone X, which he also intends to buy in stages, will not cause economic pressure and keep up with the trend. Staging consumption can make the monthly salary diversified and meet more new consumption needs.

　　The application method is flexible, the application procedure is convenient, there is no need for mortgage guarantee, and the approval speed is fast. With these characteristics, installment consumption quickly wins the favor of young people. The group represented by "post-90 s" grew up in the era of rapid development of the Internet, and accepted new technologies, new things and new products with a high degree. Pursuing efficiency and enjoying the present are their main consumption concepts, and this group is the main force of phased consumption.

　　"It is no exaggeration to say that more than 90% of college students around me have used installment consumption, and food, clothing, housing and transportation, leisure and entertainment can all be solved through installment consumption." Wang Peng is a junior in a university in Beijing. As early as when he first entered school, he began to use installment consumption, which was very convenient.

　　"This year, the money I signed up for the TOEFL training class was solved by stages. A TOEFL class costs more than 30 thousand yuan, and I ask my parents directly. I’m a little embarrassed. After using the staging platform, I will take out some money from the living expenses to repay the loan on schedule every month. Although there is some interest, I think it is worthwhile. " Wang Peng said that installment consumption is very common among college students, ranging from buying computers and mobile phones, education and training, to recharging phone bills and purchasing tickets for movies. They all like to choose installment.

　　In the past two years, the installment consumption platform has developed rapidly, especially the "internet plus installment consumption" platform has made up for the shortcomings of the traditional financial industry and served the groups that it failed to cover. Recently, the industry has welcomed the "regular army", banks have returned to the field of campus installment consumer credit, and the market is gradually standardizing. According to the forecast of relevant institutions, in the past five years, the average annual growth rate of installment consumption loans exceeded 20%.

　　How tempting is it?

　　Some merchants deliberately weaken the intermediary fees and induce consumers with the gimmick of "low threshold, zero interest and zero down payment", while the handling fee and service fee behind the products are actually higher than the interest.

　　"I obviously bought a 5799 yuan mobile phone, but the final repayment was more than 1700 yuan, which means that I spent nearly 8000 yuan on this mobile phone. Although the mobile phone was used more than one year in advance, it also paid a price. " Speaking of installment consumption, Zhao Xiaoxian, a chef in a restaurant in Hefei, Anhui Province, felt quite helpless. "It is very difficult for migrant workers like me who have no stable income to apply for bank credit cards. Online merchants lied to me that installment consumption threshold is low, procedures are convenient and interest is low. However, in the final calculation, the handling fees are higher than the interest. "

　　Dong Ximiao, a senior researcher at Chongyang Financial Research Institute of Renmin University of China, believes that the staged consumer market is developing rapidly, but the good and the bad are mixed, and many services are falsely advertised. The main purpose of staging business on the consumer platform is to expand users’ staging consumption, but the way to expand customers mainly comes from offline, and salesmen are easy to cheat and induce consumers for the sake of performance. Some merchants deliberately weaken the intermediary fees, and basically induce consumers with the gimmick of "low threshold, zero interest and zero down payment", while the handling fee and service fee behind the products are actually higher than the interest, which makes consumers feel miserable.

　　"The development of bank credit card business is relatively mature, and both the bank’s own risk control system and regulatory regulations are relatively perfect. However, the staged market has outstanding problems such as false propaganda and induced sales promotion in a fierce competitive environment. " Dong Ximiao said.

　　The installment consumption business of traditional commercial banks is standardized, mainly for consumers with stable income. Consumers have lower risk in using it and can effectively protect their rights and interests. The market gap that traditional commercial banks can’t cover has inspired the rise of Internet staging platforms, which have low thresholds and are aimed at social groups such as students and migrant workers. Coupled with the lag of regulatory policies, some disadvantages of installment consumption are constantly emerging.

　　For example, it is inevitable that unqualified consumers will default in time on the staging platform. Salespeople usually "salute before soldiers", but the effect of "collection" will be linked to performance. Because there is no standardized and legalized collection supervision policy at present, there are different kinds of violent collection behaviors in the staged market in reality.

　　The risk of disclosure of personal information makes installment consumption a safety hazard. Many people have encountered the problem of "receiving a collection message without a loan" and "being registered under an assumed name without registration". Most people will choose to ignore it, but doing so may affect consumers’ credit information and bring inconvenience to life and work.

　　In addition, from the consumer’s own point of view, staged consumption increases irrational consumption behavior. The amount of payment is reduced when the installment is consumed, which makes people have the illusion of spending less. The risk monitoring measures of many platforms are not in place, which may easily lead to credit problems such as overdue default by unqualified consumers.

　　How hard is it to choose?

　　By means of digital management and information sharing, we will strengthen the construction of credit system and prevent multi-head lending. Consumers should abandon vanity, comparison and blind obedience.

　　Behind the popularity of installment consumption, how can we rationally use and manage installment consumption?

　　Dong Ximiao believes that from the perspective of regulators, we should continue to carry out the special rectification of Internet finance and increase the cleaning and rectification of various stages of consumption platforms. For the platform with disorderly operation and chaotic management, if it fails to pass the filing in accordance with the regulations, measures should be taken to resolutely close it.

　　"At present, China’s credit information market still needs to be further improved, and the problem of long-term lending in the industry has not been completely solved. I believe that after the sharing of credit information data at the national level in the future, the whole industry will develop more healthily and orderly." Dong Ximiao said.

　　Credit data is an important link in risk control of phased consumption platform. Companies such as Taobao, JD.COM, Ctrip, etc., which have mastered the consumption scenes of hundreds of millions of users, have a large user base and many data resources, and can keenly capture the credit rating of users, and the cost of risk control is low. It is difficult for other financial platforms to accurately judge consumers’ credit information "Facebook".

　　"Now, for installment consumption, we have to put a lot of energy into risk prevention and control. It can be said that if the risk control is done well, the operating cost will be reduced, and the platform installment consumption interest rate will be reduced accordingly, thus attracting more quality customers." Gao Sheng, the public relations director of Staged Music Mall, said, "For example, we are now using artificial intelligence technology to develop ‘ Hawkeye ’ The intelligent risk control engine has more than 6,000 risk control model data variables, which can greatly improve the efficiency of risk control audit. "

　　Dong Ximiao suggested strengthening the construction of credit infrastructure, consolidating and enriching the credit information system by means of digital management and information sharing, improving the risk identification ability and risk prevention efficiency of installment consumption business, and enabling institutions and customers to enjoy more convenience in inclusive finance.

　　Banks and internet platforms should further improve or establish their own risk assessment and monitoring systems, objectively evaluate users’ consumption levels, and reasonably set credit lines; Staging consumption business institutions and platforms should correctly carry out marketing propaganda, put an end to false propaganda and induced propaganda, and set up necessary punishment mechanisms.

　　For consumers, we should carefully choose between bank credit card and installment payment platform, and try to choose a bank credit card with a more formal and perfect management system. If you choose the internet installment consumption platform, you should carefully check how to calculate the installment consumption interest, handling fee and service fee to prevent being charged with high interest and service fee.

　　"Installment consumption is a form of prepayment. If the repayment is overdue, it will not only increase the overdue interest, but also affect their credit rating, and even some financial institutions will terminate the installment business." Dong Ximiao said that consumers should abandon the bad mentality of vanity, comparison and blind obedience, carefully weigh whether the purchase of goods is reasonable, and formulate reasonable consumption and repayment plans to avoid over-consumption and over-consumption.

　　The insiders believe that for platforms with relatively standardized operations, the principle of "same business, same supervision" should be adopted to implement penetrating supervision, safeguard the legitimate rights and interests of financial consumers and protect the security of personal information. At the same time, we will strengthen the monitoring of the installment business it provides in terms of loan purposes and capital flow. Consumers should also enhance their risk awareness, strengthen the study of financial consumption and network security knowledge, and not disclose personal information at will to improve their ability to identify and prevent bad businesses.

　　What are the installment consumption platforms? (link)

　　In the past two years, staged consumption platforms have mushroomed, with different application scenarios and different characteristics.

　　JD.COM White Strip: the first Internet consumer financial product in the industry. You can enjoy a deferred payment period of up to 30 days or a payment by installments of up to 24 days if you use white bars for payment on JD.COM website. In recent years, JD.COM White Bar has been integrated into more consumption scenes, gradually covering the fields of renting, tourism, decoration, education, wedding and so on, extending from credit purchase service to providing credit consumption loans to provide credit consumption services for more consumers.

　　Ant Flower Garden: Born in the e-commerce department, it mainly supports multi-scene shopping. Its main application scenarios are Taobao and Tmall. Recently, it has also settled in most e-commerce shopping platforms, such as Amazon, Suning and local life service websites, such as word of mouth, Meituan, public comment, etc., and also involved some overseas shopping websites.

　　Staging music: Staging music in the staged shopping mall under Lexin Group is a new consumption platform of "e-commerce+finance". The shopping mall consumption scene involves 3C digital, outdoor sports, beauty care, eating, drinking and having fun, etc. It is the official authorized distributor of Apple mobile phones. The platform provides phased consumption services for mainstream consumer groups such as young people and white-collar workers.

　　Consumer finance company: it is a non-bank financial institution that provides unsecured and unsecured consumer loans. According to the "2017 Internet Consumer Finance Development Report and Outlook" by Suning Financial Research Institute, there are currently 22 licensed consumer finance companies in China, of which banks account for more than 90%. Consumer finance companies have offline channels, and offline outlets basically involve the whole country. Many licensed financial consumer companies have launched in-store consumption business to expand the financial consumer market. With the development of internet finance in recent years, many consumer finance companies have begun to cooperate with e-commerce platforms to develop online consumer credit business.

　　(Song Chao)

Notice on printing and distributing the vaccination work plan to deal with the recent infection situation in Covid-19
Guo Wei Ming Dian [2023] No.46

All provinces, autonomous regions, municipalities directly under the Central Government and Xinjiang Production and Construction Corps should respond to the joint prevention and control mechanism (leading group and headquarters) of novel coronavirus infection, and the State Council should respond to the members of the vaccination coordination group of the joint prevention and control mechanism of novel coronavirus infection:

The "Work Plan for Vaccination in Response to Recent Infections in Covid-19" is hereby printed and distributed to you, please conscientiously implement it according to the actual situation.

The State Council responds to novel coronavirus infection.Comprehensive group of epidemic prevention and control mechanism
April 6, 2023

(Information disclosure form: voluntary disclosure)

Respond to the recent Covid-19 infection epidemic.Vaccination work plan

In order to thoroughly implement the decision-making arrangements of the CPC Central Committee and the State Council, effectively respond to the recent epidemic situation in Covid-19, and ensure and safeguard people’s health, this work plan is formulated in combination with the epidemic situation, vaccine research and development, immune effect evaluation, population immunity level and other factors.

First, the target population

At this stage, the focus of vaccination is to fill the gap in immune level for different target groups and further reduce the risk of severe illness and death. The target population is as follows:

(a) people who are not infected and have not completed the established immunization program. Including uninfected people aged 3-17 who have not completed basic immunization, uninfected people aged over 18 who have not completed the first dose of booster immunization, and uninfected people aged over 18 who have not completed the second dose of booster immunization (high-risk people with infection, elderly people over 60 years old, people with serious basic diseases and people with low immunity).

(two) people who have been infected and have not completed basic immunization.

Second, the time interval and vaccine selection

(1) Time interval.

The uninfected target population completes the follow-up vaccination according to the established immunization program and its time interval requirements. Among them, for people over 18 who have completed basic immunization, the interval of the first dose of booster immunization is adjusted to more than 3 months.

People who have been infected and have not completed basic immunization can be vaccinated with one dose after 3 months of infection.

(2) vaccine selection.

Shenzhou cell recombinant Covid-19 tetravalent S trimer protein vaccine and Unacon Covid-19 mRNA vaccine have been included in emergency use, which can be used for intensive immunization of people over 18 years old.

The vaccines used for basic immunization of uninfected target population shall be implemented with reference to the relevant requirements in the previous period. In order to strengthen immunization, it is recommended to use Shenzhou cell recombinant Covid-19 tetravalent S trimer protein vaccine and Unacon Covid-19 mRNA vaccine. Other recombinant protein vaccines or virus vector vaccines that have been approved for conditional marketing or emergency use can also be selected for sequential enhanced immunization.

People over the age of 18 who have been infected and have not completed basic immunization are recommended to use Shenzhou cell recombinant Covid-19 tetravalent S trimer protein vaccine and Unacon Covid-19 mRNA vaccine, or choose other recombinant protein vaccines or virus vector vaccines that have been approved for conditional marketing or emergency use. For people aged 3-17 who have been infected and have not completed basic immunization, the vaccines used for vaccination shall be implemented according to the relevant requirements of the previous period.

Follow-up will be based on the progress of vaccine research and development, approval, combined with the epidemic situation, virus variation and other conditions, timely research and adjustment of vaccination strategies.

Third, ensure vaccination safety

All localities should continue to give priority to vaccination safety, and organize vaccination implementation in strict accordance with the requirements of the Code for Vaccination Work. Local health departments should implement the "four haves" requirement that vaccination units should have emergency personnel stationed in general hospitals at or above the second level, emergency equipment and medicines, 120 ambulances on duty, and green channels for treatment in general hospitals at or above the second level to ensure vaccination safety. Inoculation units should do a good job in vaccination information registration and vaccine flow management, and update the vaccination records in the immunization planning information system and vaccination vouchers in a timely and accurate manner.

Fourth, strengthen organization and implementation

(1) Strengthening the responsibility of territorial subjects. All localities should implement the responsibility of territorial management, attach great importance to and co-ordinate the vaccination work in Covid-19. It is necessary to strengthen the guidance of vaccination work within the jurisdiction and fully grasp the progress of the work. Relevant local departments should strengthen docking and do a good job of coordination.

(two) to play the role of the competent department of industry. The competent departments of relevant industries should guide the units where the personnel in this industry work to actively cooperate with local unified arrangements and jointly do a good job in organizing and mobilizing.

(3) Strengthen supervision and guidance. It is necessary to closely track and monitor the progress of vaccination in various places, and find and study and solve related problems in time. Improve the traceability system of vaccine flow, improve the safety supervision mechanism of vaccine chain, continuously strengthen the whole process management and safety precautions, and effectively ensure the efficient and smooth transportation of vaccines.

(4) Do a good job in publicity and guidance. All localities and relevant departments should, according to the needs of work, formulate targeted publicity measures for vaccination work, focus on the purpose and significance of vaccination, respond to social concerns, sum up and popularize typical experiences and practices, actively guide the target population to take the initiative to vaccinate, and especially guide and improve the vaccination rate of the elderly population.

Note: People aged 3-17 can only use Covid-19 inactivated vaccine of Sinopharm Zhongsheng Beijing Company, Beijing Kexing Company, Sinopharm Zhongsheng Wuhan Company and Zhifeilong Kema recombinant Covid-19 vaccine (CHO cells).

　　Cctv newsAt 15: 00 on April 20th, the State Council Press Office held a press conference to introduce the development of industry and informatization in the first quarter of 2023 and answer questions from reporters.

　　Zhao Zhiguo, chief engineer and spokesperson of the Ministry of Industry and Information Technology, said that overall, the development of industry and information technology achieved a smooth start in the first quarter, showing a trend of stabilization and improvement.

　　First, the industrial economy has maintained a stable operation. It mainly presents three characteristics. First, industrial production has steadily picked up. In the first quarter, the added value of industrial enterprises above designated size increased by 3% year-on-year, which was 0.3 percentage points higher than that in the fourth quarter of last year, reversing the continuous downward trend since October last year. According to the data of China Association of Automobile Manufacturers, the production and sales of automobiles in March increased by 15.3% and 9.7% respectively, and the production and sales of new energy vehicles increased by 44.8% and 34.8% respectively. Second, investment in manufacturing industry continued to grow steadily. In the first quarter, manufacturing investment increased by 7% year-on-year, which was 1.9 percentage points higher than the national fixed assets investment, and maintained a rapid growth rate on the basis of a high base for two consecutive years. Third, the role of industrial provinces is obvious. The industrial growth rate of Hebei, Shandong, Jiangsu and other major industrial provinces is significantly higher than the national level. Since March, the industrial economy of Guangdong, Zhejiang and other provinces has picked up.

　　Second, the advanced manufacturing industry is developing well. Vigorously develop advanced manufacturing industry and promote the high-end, intelligent and green development of manufacturing industry. Solidly promote the industrial base reconstruction project and major technical equipment research projects, and make significant progress in some areas. ARJ21 has safely transported more than 6.55 million passengers and has recently been put into overseas commercial operation. Delivered the world’s largest 24188 TEU super-large container ship, and the first domestic extracorporeal membrane oxygenation machine (ECMO) was successfully developed and certified for listing. Deeply implement intelligent manufacturing engineering and promote the digital transformation of the industry. The three functional systems of industrial internet network, platform and security were completed, and the scale of core industries exceeded 1.2 trillion yuan. Accelerate the transformation and development of green and low-carbon industries. Accelerate the development of new energy vehicles, photovoltaics and other emerging industries. In the first quarter, the investment in fixed assets of high-tech manufacturing industry increased by 15.2% year-on-year, and the output of new energy vehicles, solar cells and other emerging products increased by 22.5% and 53.2% respectively.

　　Third, the empowerment effect of the information and communication industry is constantly emerging. We will fully consolidate new infrastructure and strongly support high-quality economic and social development. In the first quarter, telecom business revenue increased by 7.7% year-on-year. Steadily promote the construction of "double Gigabit" network, with the cumulative number of 5G base stations exceeding 2.64 million, and the number of Gigabit access users exceeding 100 million. Continue to deepen the application of convergence, and 5G is fully integrated into 52 national economic categories. Improve the ability of application services, further enhance the supply of mobile Internet application services, and accelerate the demonstration and promotion of excellent cases of aging and barrier-free transformation of Internet applications. Coordinate development and security, introduce policies to promote the development of data security industry, strengthen the security protection of key information infrastructure in the industry, and ensure the safe and stable operation of basic telecommunications networks.

　　Fourth, the industrial development environment has been further optimized. Adhere to the better combination of effective market and promising government, and strive to create a good ecology conducive to industrial development. In-depth implementation of the "14 th Five-Year Plan" in the field of industry and information technology, and organization and formulation of work plans for steady growth of key industries such as automobiles and electronics. Focusing on the "urgent difficulties and worries" of small and medium-sized enterprises, together with relevant departments, we have issued a series of policy measures to help stabilize growth and adjust structural strength, and started the cultivation of the fifth batch of "little giants" that specialize in specialty and innovation. Convene the 2023 Working Meeting of the Inter-Ministerial Joint Conference on Reducing the Burden of Enterprises in the State Council. Deepen the precise docking of industry and finance, and the national industry-finance integration platform has helped enterprises to raise more than 500 billion yuan.

　　Of course, we must also see that there are still some difficulties and challenges in the current industrial economic development, but the fundamentals of China’s industrial economic development have not changed for a long time, and we are full of confidence in this. In the next step, we will adhere to the guidance of Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, thoroughly implement the decision-making arrangements of the CPC Central Committee and the State Council, strengthen our confidence, be determined to innovate, stabilize the development of key industries, support leading enterprises and specialized new enterprises, work hard to draw long boards, forge new boards and fill short boards, promote the sustained stabilization and improvement of the industrial economy in the second quarter, and accelerate the development of the information and communication industry, thus laying a solid foundation for achieving the objectives and tasks for the whole year.

　　CCTV News:South Korean Presidential Palace Cheongwadae announced on the 8th that Moon Jae in will meet with a visiting high-level delegation from the DPRK on the 10th. Members of the delegation include Jin Yongnan, Chairman of the Standing Committee of the Supreme People’s Assembly of the DPRK, Jin Yuzheng, First Deputy Minister of the Central Committee of the Workers’ Party of Korea, Cui Hui, Chairman of the State Sports Steering Committee, and Li Shanquan, Chairman of the Peaceful Reunification Committee of the Motherland. According to Xinhua News Agency, the DPRK delegation arrived at Incheon Airport in South Korea by special plane at noon on the 9th.

　　Who’s Jin Yuzheng? What is the future trend of the situation on the peninsula? Will the representatives of North Korea, South Korea and the United States interact outside of sports events? The PyeongChang Winter Olympics in 2018 was full of topics before it started.

　　Rare! Kim Jong-un once only took his twin sister to inspect the troops.

　　Jin Yuzheng is the daughter of the late North Korean leader Kim Jong Il and the younger sister of Kim Jong Un.

　　On March 9, 2014, Jin Yuzheng made her first "official appearance" in a report on North Korean national television. At that time, Kim Jong-un was elected as the representative of Baitoushan Constituency No.111 with 100% support rate. Jin Yuzheng, known as "Comrade", appeared for the first time in the report, and a "close-up" of her voting was shown.

　　On November 27th, 2014, Kim Jong-un inspected the 426 Animation Studio. Korean Central News Agency mentioned Jin Yuzheng, Vice Minister of the Central Committee of the Labor Party, when introducing the accompanying personnel. This was the first time that the North Korean media publicized Jin Yuzheng’s position, which attracted the attention of foreign media.

　　After that, Jin Yuzheng can always be seen in Kim Jong-un’s activities reported by North Korea’s official media. From watching performances, to inspecting factories and museums, to inspecting military training activities, Jin Yuzheng’s name can always be found in the list of accompanying persons.

　　From March 9, 2014 to March 12, 2015, Jin Yuzheng accompanied Kim Jong-un on 25 inspections. Since November, 2014, Jin Yuzheng has been accompanying Kim Jong-un to inspect more and more frequently, accounting for more than half of the total times. Generally speaking, Jin Yuzheng’s people’s livelihood and cultural performances are twice as many as her military and political visits. However, since November 2014, her visits to the army have been basically the same as other activities. In January 2015, Jin Yuzheng’s public activities were particularly active, and he accompanied Kim Jong-un on seven inspections.

　　On March 12, 2015, Kim Jong-un, the top leader of North Korea, visited a defense squadron in the front post on the east coast of North Korea. In Korean Central News Agency’s report, only the name of Kim Jong-un’s sister Jin Yuzheng was mentioned, but the names of other accompanying persons were not mentioned. Judging from the pictures released by the Workers’ Party of Korea, Jin Yuzheng not only accompanied Kim Jong-un to inspect the whole process, but also participated in the final photo. This kind of situation is rare. Usually, the entourage of Kim Jong-un does not take part in the group photo during the inspection activities, and it is the first time that only Kim Jong-un’s brother and sister inspect the troops in the official media of North Korea.

　　At present, it is a critical moment for the DPRK and the ROK to release goodwill and improve bilateral relations. Kim Jong-un sent Jin Yuzheng to represent North Korea in the opening ceremony of the PyeongChang Winter Olympics, and the position of the younger sister in North Korea’s political arena is self-evident.

　　The South Korean side also attaches great importance to the first entry of North Korean Kim family members into Korea. A spokesman for South Korea’s Cheongwadae said that all preparations would be made to ensure the smooth visit of the DPRK high-level delegation to South Korea to participate in the Olympic Games, and called Jin Yuzheng’s visit "of great significance". As Jin Yuzheng is an important figure in the Labor Party, the ROK expects that she will have considerable discretion in this trip, which is more important than Jin Yongnan’s coming to hankyung alone, and the ROK and the DPRK may take this opportunity to have a more meaningful dialogue.

　　The close interaction between the DPRK and the ROK, the United States and Japan secretly "make bad"

　　The 23rd Winter Olympics in Pyeongchang, South Korea in 2018 is destined to be an "unusual" Winter Olympics. Before that, the Vice President of the United States invited "special guests" to pour cold water on the relations between the DPRK and the ROK, and then members of the North Korean "Baitoushan family" (Kim family) entered Korea for the first time. During this period, it was reported that Trump’s daughter would attend the closing ceremony of the Winter Olympics and the South Korean Unification Ministry made intensive statements four times in three days … … The "feature film" of the 2018 Winter Olympics has not yet started, and the "trailer" alone is as wonderful as any Hollywood movie.

　　At the beginning of the new year in 2018, the DPRK and the ROK changed the normal state of "arrogance" and "angry words", shelved the dispute between nuclear weapons and Sadr, and launched active "ice-breaking" talks around the Winter Olympics in a "double pause" posture, which achieved many results. For example, the DPRK and the ROK will jointly hold the flag of the Korean Peninsula at the opening ceremony of the Winter Olympics, the Korean art troupe will perform the opening ceremony in South Korea, and the DPRK and the ROK have expressed their positive will to improve the bilateral relations in the future … …

　　At the same time of close interaction between the DPRK and the ROK, the United States began to "pour cold water" on the slowly warming DPRK-ROK relations.

　　US President Donald Trump confirmed last month that he would send Vice President Burns as the head of the US delegation to attend the PyeongChang Winter Olympics. However, it is not known what attitude Burns will take to intervene in the situation on the Korean Peninsula. A White House official said that Burns believed that the DPRK wanted to use the Winter Olympics to "engage in propaganda activities" and he intended to "show up" at the Winter Olympics to "offset" the DPRK’s influence and self-promotion efforts.

　　According to Washington post, Burns will invite a "special guest", namely Fred, the father of the late American college student Otto Warmbier, to visit Korea. Otto Warmbier was charged and convicted of conspiring to subvert the state in North Korea, and was detained for more than a year. He was released to China in June last year, but he was in a coma and died a few days later. This incident once prompted the State Council to issue a travel ban to the DPRK.

　　It is also reported that US President Trump’s daughter ivanka will lead a presidential delegation to attend the closing ceremony of the 2018 PyeongChang Winter Olympics. Some South Korean media analysts said that if ivanka really attended the closing ceremony of PyeongChang Winter Olympics as reported by CNN, and Kim Jong-un’s younger sister Jin Yuzheng also went south for a pre-meeting, it might be possible for them to meet in the closing ceremony of Winter Olympics.

　　The DPRK, the United States and South Korea are playing hot, and Japan is also joining in the fun. According to the news released by the Japanese government on the 3rd, Prime Minister Shinzo Abe will meet with Burns before attending the opening ceremony of the Winter Olympics, suggesting that the US-South Korea joint military exercise should not be scaled down after the Winter Olympics.

　　… …

　　The Korean Peninsula crisis has lasted for more than 20 years, and the biggest obstacle is the "return to Asia-Pacific strategy" of the United States. However, this "door-to-door talk" between the DPRK and the ROK is a sincere attempt by the DPRK. It is hoped that with the efforts of all parties, the stability of the DPRK and the ROK will be further developed, and the rare "warm drama" between the DPRK and the ROK will not become a "farce" with no end in some countries. (Text/Cheng Xiang)

Author: Hongge comes from Medical Wechat WeChat official account.

　 　　 　　　Recent epidemic situation in ChinaIn the process of getting up, there are some situations that deserve our attention.the most importantIsFalse negatives in nucleic acid detection. Intercepting relevant news, it was found that 8 confirmed patients in Shijiazhuang on the 22nd were repeatedly negative for nucleic acid detection, and 5 confirmed patients in Shijiazhuang on the 24th were repeatedly negative for nucleic acid detection.

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　 　On the 22nd, there were 11 new confirmed cases in Shijiazhuang, including:

Case 1: Male, 52 years old, from Huangjiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 2: Male, 13 years old, Niujiazhuang Village. On the evening of the 21st.Nine times nucleic acid positive;

Case 3: Female, 11 years old, Zhongyao Village. On the evening of the 21st.Nine times nucleic acid positive;

Case 4: Male, 49 years old, Nanqiaozhai Village. On the evening of 21st.Ninth nucleic acid positive;

Case 5: Male, 47 years old, Niujiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 6: Female, 65 years old, Niujiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 7: Male, 11 years old, grandson of Case 6. On the evening of 21st.Ninth nucleic acid positive;

Case 11: Male, 67 years old, Xiaoguozhuang Village, husband of Case 2 on January 7th. On January 3, it was transferred to centralized isolation medical observation; On the evening of 21st.11th nucleic acid detectionFinally positive;

On the 24th, there were 7 new confirmed cases in Shijiazhuang:

Case 1: Female, 65 years old, Nanqiaozhai Village. Centralized isolation on the 11 th.Nucleic acid after 9 times, 22 positive.

Case 2: Female, 4 years old, Nanqiaozhai Village. Centralized isolation on the 11 th.Nucleic acid after 9 times, 22 positive.

Case 3: Female, 4 years old, Mi Jie, Chang ‘an District. Centralized isolation on the 13 th.Nucleic acid after 8 times, 23 positive.

Case 4: Female, 64 years old, Xiaoguozhuang Village. Centralized isolation on the 10 th.After 11 nucleic acids, 24 positive.

Case 5: Male, 34 years old, Xiaoguozhuang Village. Centralized isolation on the 8 th.After 11 nucleic acids, 24 positive.

Case 6: 34-year-old female, Liujiazuo Village, was positive for nucleic acid on the 5th, was diagnosed as asymptomatic infection on the 6th, and was clinically confirmed on the 24th.

Case 7: A 28-year-old male, living in Yuhua District, went to work by car at Zhengding Airport on weekdays. He was diagnosed as asymptomatic infected with nucleic acid on the 5th, and was clinically confirmed on the 24th.

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Since the outbreak of COVID-19 last year, the topic of high false negative rate of nucleic acid detection has been the focus of attention. It has been reported that the positive rate of Covid-19 detection by fluorescence quantitative RT-PCR is only 30%-50% at present, which leads to extremely high false negative rate.

For Hongge, who doesn’t know much about the test, this paper analyzes the relatively high false negative test by searching articles and documents, and summarizes some reasons to discuss with you.

First, the incidence of COVID-19 suggests that it is highly possible to collect positive samples in a proper time.

Academician Yuan Guoyong’s team conducted this cohort study in Hong Kong Princess Margaret Hospital and Queen Mary Hospital. From January 22 to February 12, 2020, 23 hospitalized patients who were diagnosed as COVID-19 by laboratory examination of nasopharyngeal or sputum specimens were screened in the two hospitals.

A total of 173 respiratory specimens were collected from 23 patients. The researchers used RT-QCPR to determine the viral load in the samples. The results showed that the median viral load of respiratory tract samples was 5.2 log10 copies /mL (interquartile range was 4.1-7.0), and only 3 patients (13%) did not detect Covid-19 RNA in saliva samples.

The researchers observed that,The viral load in saliva was the highest in the first week after the patient developed symptoms, and then gradually decreased.Eight days after the patient developed symptoms, airway extracts were collected, and there was no obvious downward trend in viral load. Of the 21 patients who did not die,Seven people (33%) could still detect viral RNA after 20 days of symptoms, but this was not related to the severity of the disease.

▲ Changes of viral load in saliva (blue line) and airway extract (red line) of all 23 patients. Abscissa D- days after symptoms appear; S/E- number of saliva/airway samples.

AprilAccording to a study published in Nature Medicine, COVID-19 patients are most infectious before symptoms appear, and they begin to shed SARS-CoV-2 2 2-3 days before the first symptoms appear.

https://doi.org/10.1038/s41591-020-0869-5

The study, led by Eric Lau of the University of Hong Kong, involved 94 patients with COVID-19 admitted to the Eighth People’s Hospital of Guangzhou, China, 50% of whom were male, with a median age of 47 years. Among them, 61 of 93 patients were mild. Specifically, the researchers collected the throat swabs of 94 COVID-19 patients who were treated in the Eighth People’s Hospital of Guangzhou, China from January 21st to February 14th. From the onset of symptoms to 23 days after onset, 414 throat swabs were collected.

The results show that the researchers areThe high viral load was detected shortly after the patient developed symptoms, and then gradually decreased to the detection limit around the 21st day.There is no significant difference in viral load among different sexes, age groups and disease severity.

In addition, the researchers also analyzed 77 samples of "transmission pairs" from public data to assess how much time passed between the onset of symptoms in each patient. It assumes that the median incubation period (the time from infection to symptoms) is 5.2 days.The research team concluded that infectivity began 2.3 days before symptoms appeared, and peaked 0.7 days before symptoms appeared.

In the sensitivity analysis, the same estimation procedure is used, but assuming that the infectious attack is unchanged 1-7 days before the symptom occurs, thenIt was found that the infectivity reached its peak 0-2 days before the onset of symptoms, and the transmission ratio before the onset of symptoms was 46% to 55%.

The study also found that,The virus may start shedding 2-3 days before the first symptoms appear.After the symptoms appear, the viral load in the patient’s body decreases faster. This is consistent with the results of two recent studies. On April 1st, teams from Munich, Germany, Berlin and Cambridge, England published the article "Viro logical assessment of hospital patients with Covid-2019" on Nature. It was found that the shedding peak of Covid-19 occurred in the early upper respiratory tract infection.This shows that virus carriers may be the most infectious when they have mild symptoms or almost no obvious symptoms.

Brother Hong:From the above two documents, we can draw a conclusion that the virus shed and spread 2-3 days before the symptoms appear after infection, and after the symptoms appear, with the passage of time,The viral load of throat swab decreases gradually, and the viral load detected within 7 days after symptoms. If symptoms have existed for more than 20 days, the reliability of negative conclusion of throat swab is poor.

Solution:We need to publicize the law of the new crown to the people and medical workers, and improve our vigilance against COVID-19. It is best for patients to see a doctor in time, and doctors can also suspect this possibility. Only at the right time can we collect high-content samples and diagnose and control them in time.

Second, accurate sampling strategy is the best means to reduce false negative results.

In February, a study published by Medrxir, a pre-printed website, collected respiratory tract samples such as nasal swab, throat swab, sputum and bronchoalveolar lavage fluid (BALF) from patients diagnosed with COVID-19, and included 213 Covid-19-infected patients admitted to the Third People’s Hospital of Shenzhen from January 11th to February 3rd, 2020, who were diagnosed by Guangdong CDC. A total of 866 respiratory tract samples, including 490 nasal swabs, 205 throat swabs, 142 sputum samples and 29 BALF samples, were collected at the time of admission and after each time point. According to the collection date, the samples were divided into 0~7 days, 8~14 days and ≥15 days after onset. According to the guidelines on prevention and treatment of Covid-19 infection issued by National Health Commission, patients were divided into severe and mild cases.

Three groups were divided according to the sample collection time after onset, and the viral nucleic acid was quantitatively determined.The positive rate of viral nucleic acid in sputum samples was the highest in the group of 0~7 days after onset.The positive rates of severe and mild cases were 88.9% and 82.2% respectively.Followed by a nasal swab.(73.3% and 72.1% respectively),The throat swab again.(60.0% and 61.3% respectively). In mild cases, the positive rate of nasal swab and sputum samples is similar.

The positive rate of BLAF samples collected from 8 to 14 days after the onset of severe cases was 100%.However, the BALF samples of 3 mild cases were negative. In all cases, the positive rate of sputum samples was the highest in the 8~14 days after onset, which was much higher than that of nasal swab and throat swab. It is worth noting that the positive rate of throat swab in severe patients is only 50%, and that in mild patients is only 29.6%.

In the group ≥15 days after onset,The positive rates of BALF, sputum and nasal swab from severe cases were similar. In mild cases, the positive rate of sputum and nasal swab is similar, which is much higher than that of throat swab.

For the diagnosis of viral nucleic acid in COVID-19’s patients,Sputum samples are the most accurate, followed by nasal swabs. It is not recommended to collect throat swabs for diagnosis.

The difference between oropharyngeal swab and nasopharyngeal swab

anusswab

Brother Hong:

1. Oropharyngeal swab is the least painful and most acceptable, but it has to bear the consequences of high false negative results. My suggestion is to use it according to the epidemic risk in the first epidemic area.

2. The positive rate of nasopharyngeal swab is higher than that of oropharyngeal swab, which is why nasopharyngeal swab is introduced into laboratory examination in the fifth edition of Diagnosis and Treatment Plan for Pneumonia Infected by Covid-19 (the fourth edition is still pharyngeal swab). If we want to pursue accuracy, it is suggested to use it, or to use it when screening people in close contact or sub-close contact. At present, the examination of returnees in domestic reports seems to be nasopharyngeal swab method.

3. Alveolar lavage fluid can’t be used for screening in the general population, so it is suggested that hospitals with ICU should use it for screening severe pneumonia patients living in ICU for COVID-19 patients.

4. Deep expectoration seems to be the best sample, but many patients in COVID-19 have a dry cough, which may not be possible.

5、anusSwabs were used in Daxing epidemic in Beijing, which is the first time to use this method in the screening process. In some literatures,anusAlthough the positive rate of swabs is not high, as I remember, it seems to be more than 10%, but it does not seem to coincide with the patients with oropharyngeal swabs, suggesting that the virus may attack the gastrointestinal tract, and also suggesting that there may be the possibility of gastrointestinal transmission in Covid-19. Although the initial symptoms of some patients are gastrointestinal symptoms such as abdominal pain and diarrhea, there are also ACE2 receptors in the digestive tract, which is theoretically possible, but it has not been confirmed at present. So,anusMy suggestion is that swabs can only be used as a supplement to nasopharyngeal swabs, and it is better to select patients whose first symptoms are digestive tract symptoms more accurately, which is unlikely to be used as a means of large-scale screening.

Solution:It is best for National Health Commission to issue a guiding document for large-scale screening, and make detailed regulations on what population and what sampling methods to adopt under what circumstances.,When local governments encounter an outbreak in COVID-19, it’s best to ask professionals to act as consultants and make choices according to the actual situation.

Third, the consistency of sampling ability of sampling personnel affects the sampling results.

Garbage in, garbage out (garbage samples produce garbage results), which is a sentence that inspectors often say.

The sampling team is huge, and the ability of sampling personnel must be uneven. In addition, people may have such fears about sampling, which often leads to unqualified samples.

Generally, there is an internal standard in the molecular diagnostic reagent to monitor the detection process, for example, RNaseP is used as the internal standard. If both the sample response curve and the internal standard response curve displayed by the fluorescence PCR platform do not jump, it means that the quality of the collected samples may have problems or false negatives may occur due to improper experimental operation, which needs to attract the attention of medical workers. The RNaseP internal standard can monitor the sample collection and ensure the accuracy of the test results.

Note: RNaseP is ribonuclease P, which is one of the most important ribozymes in human body. It is ubiquitous in all organs, tissues and cells of human body, and can detect RNA nucleic acid fragments from human body samples, and can also be used as an internal standard.

And I privately asked the relevant person in charge of our city’s temporary inspection center. He told me that every day in our hospital, some samples were told that they needed to be re-sampled because the internal standard did not jump. Imagine that you didn’t wipe down a few cells in your throat swab collection, so will the negative of this nucleic acid be accurate?

Solution:Consistency training for nucleic acid sampling personnel will greatly reduce the human influence, and it is easier to standardize the sampling process by taking such sampling methods as nasopharyngeal swab. Our city seems to have trained the nucleic acid emergency sampling team very early. What about your city?

In addition, if in the environment of large-scale nucleic acid sampling, when testing under the standard of 5-mixed 1 and 10-mixed 1, according to the above principle of internal standard, it seems that there is no single-tube ability in the quality control of internal standard. Therefore, especially those in the emergency sampling team, we must pay attention to the standard sampling methods and remember to collect qualified samples as much as possible.

Fourth, choose the right oneSampling device

The virus preservation tube mainly consists of a sampling swab and a virus nucleic acid preservation tube (containing virus nucleic acid preservation solution). There are many kinds of virus preservation tubes on the market at present.It is very important for epidemic prevention and disease diagnosis to choose the appropriate virus preservation tube, reduce the infection risk of medical inspectors as much as possible, and keep the virus RNA stable without degradation..

The preservation solution UTM used in traditional virus collection tubes is based on Hank’s solution, with gentamicin, fungal antibiotics, BSA (V), cryoprotectant, biological buffer and amino acids added. Its main purpose is to maintain the virus activity within a certain temperature range, so that it is convenient for health and epidemic prevention departments to further isolate, culture and trace the virus and determine the pathogen. This kind of non-inactivated tube, which I call it, is good for further work, but the sameLive virus increases the infection risk of medical staff in the whole process of sample collection, transportation and testing!Personally, I think this kind of sampling tube for inactivated virus should be a better choice for disease control sampling.

And clinicalIn order to achieve the purpose of rapid detection, it is not necessary to cultivate the virus, but only to crack the virus, so as long as the integrity and stability of the virus nucleic acid can be guaranteed.nowCommonly known as inactivation tube.Many inactivation tubes in China are used.The inactivation component is guanidine salt, which is in this inactivation tube in our hospital.Guanidine salt can crack the virus, but it can’t protect the integrity of nucleic acid for a long time.The virus nucleic acid may have been degraded during the delivery of the sample to the laboratory, which will also cause a "false negative" in the detection. Many studies show that both temperature and time can affect the test results, so the COVID-19 Laboratory Testing Guide has clear requirements for samples to be tested within 24 hours after collection and transported at 4 degrees Celsius. If it is necessary to exceed 24 hours, it should be stored at -70 degrees Celsius.

And some manufacturers put forward another inactivation tube, a kind of.containNon-guanidine saltThe virus preservation tube containing protein denaturant can inactivate the virus and ensure the preservation of virus nucleic acid at room temperature.And the virus nucleic acid is stably stored for 7 days.Does not degrade.

Solution:

1, from sampling to testing, it is necessary to mark the time, so that quality control can be carried out on the preservation time, which is basically no problem in a better hospital.

2. For the front-line staff to do the corresponding training, they should know the advantages and disadvantages of various types of preservation tubes and adopt the best sampling tubes suitable for local conditions.

3. It is best for the country to recommend the selection of sampling tubes with the support of relevant experimental data.

5. Failure of reagents caused by virus mutation?

After the virus mutation in South Africa, Britain, Brazil and other places, there have been cases that turned positive after ten tests in various parts of the world, including China.The FDA recently warned that virus mutation has caused some reagents to fail, and listed several kits that may be affected by mutation. This means that virus mutation may have led to the failure of some nucleic acid detection or persistent false negative.

The FDA listed several kits that may be affected by mutation:

Accula SARS-Cov-2 detection (Mesa Biotech): If the virus mutates at the 28881st base (GGG to AAC), the detection of this kit will be affected;

TaqPath COVID-19 Combo Kit (Thermo Fisher Scientific): This kit detects three genes at the same time, and the variant B.1.1.7 appearing in Britain will affect one of the detection results;

Linea COVID-19 detection (Applied DNA Sciences): This kit detects two genes at the same time, and the variant B.1.1.7 appearing in Britain will affect one of the detection results;

Helix, an American company doing nucleic acid detection, also noticed the influence of virus mutation on detection. The company’s nucleic acid detection simultaneously detected three Covid-19 genes: ORF1ab, N, and S. Because the B.1.1.7 strain that appeared in Britain had deletion mutation in S gene, ORF1ab and N could be detected in the detection, but S gene could not be detected (4). This phenomenon is called "S gene withdrawal".

In addition, the sensitivity of reagents from different manufacturers to COVID-19 is different, and the country also organized a national evaluation of reagents last year. butIn an evaluation study on the consistency and detection ability of seven domestic novel coronavirus nucleic acid detection kits published by Chinese Journal of Laboratory Medicine in July, 2020, it was proposed that "some kits have poor detection ability for weakly positive samples,It is suggested that weak positive samples should be rechecked by kits from at least two manufacturers to ensure the accuracy of the results."

Several targets of nucleic acid detection in Covid-19 are ORF1ab gene, N gene and S gene.

In the Technical Guide for Laboratory Detection of Pneumonia Infected in novel coronavirus issued by China CDC (hereinafter referred to as the Technical Guide), the two targets of nucleic acid detection in Covid-19 are ORF1ab gene and N gene respectively.

On January 6th, the Weekly Report of China Center for Disease Control and Prevention published the results of gene sequencing analysis of two cases of Covid-19 infection in Shijiazhuang and Xingtai. According to the published results, the strain prevalent in Gaocheng, Hebei Province, is different from the strain found in other places in China recently, and is homologous to the strain reported in Russia last July, belonging to strain B.1.1.123

Coincidentally, the mutation happened at the 28881 ~ 28883 bases of the virus gene of this strain, and this is exactly the position of the forward primer of the N gene!

This also explains why there were many negative results at that time.

I guess this is one of the reasons why the criteria for judging nucleic acid positivity have also changed.The judgment position that the single target is still positive after retest is positive.

Figure/Current Criteria for Judging Positive Cases in Technical Guide

Solution:

1. Require manufacturers of nucleic acid reagents to conduct confirmatory experiments on the current mutant strains and propose technical solutions.

2, all localities should introduce at least two kinds of better quality detection reagents, for control use.

3. Information about the failure of test reagents that may be caused by mutated viruses should be effectively and widely reported in domestic laboratories.

Six, the standard implementation in the process of laboratory testing

the pastAccording to the guidelines issued by relevant institutions, the collected samples need to be inactivated at 56℃ before nucleic acid detection, which is very likely to degrade the Covid-19 nucleic acid, which will lead to the failure of normal detection and ultimately improve the false negative rate.In the early daysInactivation treatment is carried out for the sake of biological safety, to protect the staff engaged in testing from virus infection.

But later, there were many voices of doubt in the academic circles, becauseViral RNA is easily degraded by ribonuclease, because this enzyme has the highest activity at 60℃. Ribonuclease comes from two aspects, one is the sample cells, and the other is the foreign pollutants in the process of collection, preservation and transportation.

Last February, there was a similar research article.The high-temperature inactivation process before virus nucleic acid extraction significantly reduces the amount of detectable virus nucleic acid templates, which has been pre-published on the platform of scientific papers of China Academy of Sciences.

And last May,The Journal of Clinical Chemistry published the research of Chinese scholars on Covid-19’s false negative test.The study confirmed that,Thermal inactivation can cause the increase of Ct value reflected by PCR and cause false negative results.Specifically, 46.7%(7/15) of the weakly positive samples were false negative after inactivation (a surprising proportion). Another inactivation method is to inactivate the virus by dissolving the virus protein with guanidine hydrochloride. This study confirmed that guanidine hydrochloride had little effect on PCR reaction, and the false negative rate was low, although there was also a false negative rate of 13.3%(2/15).

Related address: https://academic.oup.com/clinchem/article/66/6/794/5815979

I also inquired whether there was a 56-degree inactivation step in the detection process of CDC in the United States. Although my English ability was poor, I didn’t see this step by machine translation.

Including some other documents retrieved, it is also very clear that 56-degree inactivation does have a great influence on weakly positive specimens.

No matter the Manual of Nucleic Acid Detection in Medical Institutions in novel coronavirus (Trial) on July 13th, 2020 or the Manual of Nucleic Acid Detection in Medical Institutions in novel coronavirus (Trial 2nd Edition) on December 30th, 2020, there are corresponding descriptions.For the laboratory that has been inactivated with the sampling tube containing guanidine salt, there is no need to inactivate at 56 degrees for 30 minutes.This is only true if non-inactivated sampling tubes are used.

However, I learned from the familiar laboratory leaders that this is not the case. Many laboratories still require samples to be pretreated at 56 degrees for 30 minutes regardless of whether the tubes are inactivated or not. I can understand that they are worried about hospital infection and laboratory exposure. But generally speaking, reducing the false negative rate, increasing the detection amount and taking corresponding measures to control the epidemic situation as soon as possible, I think the corresponding suggestions in the corresponding guidelines are also the best choice from the overall situation and supported by data.

Our laboratory should not control the occurrence of hospital sensation and laboratory exposure at the expense of reducing the detection rate, but should focus on stricter control of experimental steps, more cautious PPE wear and higher laboratory environment.

Solution:

1. It is suggested that the state give special instructions to laboratories at all levels on this matter.

2. It is suggested that the country should further study the preservation solution of sampling tubes, and if there is any preservation solution that can not reduce the detection rate at 56 degrees for 30 minutes, it can also be recommended.

The above zero zero always said a lot of points, mainly about how to reduce false negative conclusions, hoping to give you a reference.

It’s been many days since I wrote this afternoon, mainly considering Spring Festival travel rush. Although the scale of Spring Festival travel rush is reported to have dropped by more than 75% this year compared with previous years, the population flow is still very strong. We may face the rising trend of an epidemic after Spring Festival travel rush, and how to make the work better may be a more urgent need before us.

　　September is autumn, the temperature drops gradually, the temperature difference between day and night increases, kindergartens and schools in various places open one after another, the mobility and aggregation of people increase, and the Mid-Autumn Festival holiday and other factors are superimposed, which easily leads to the spread and popularity of many infectious diseases. Henan CDC hereby reminds the general public to pay attention to novel coronavirus infection, whooping cough, norovirus infectious diarrhea, dengue fever, school tuberculosis and food poisoning this month.

　　Key tips

　　1. novel coronavirus infection

　　The epidemic situation of COVID-19 in our province showed a fluctuating upward trend since the end of July, and it showed a fluctuating downward trend after reaching its peak in mid-August. In autumn, students start school one after another, and the Mid-Autumn Festival is approaching, the flow and gathering of people increase, and the risk of infection in COVID-19 increases. In crowded places such as public transportation and shopping malls, we should persist in personal protection to reduce the risk of virus transmission.

　　Protective measures:

　　1. Strengthen the protection of high-risk groups. Targeted measures are taken for high-risk groups such as patients with basic diseases and the elderly, so that cases can be found in time and treated effectively, and serious cases and deaths can be reduced as much as possible. Timely discover and deal with possible cluster epidemics in places where people gather, such as kindergartens, schools and old-age care institutions.

　　2. Pay attention to personal protection. Residents should wear masks in their daily trips, minimize unnecessary gatherings and keep social distance. Maintain good personal and environmental hygiene, wash hands frequently, often ventilate, pay attention to rest, pay attention to nutrition and enhance physical fitness.

　　3. Use drugs rationally and see a doctor as needed. After infection, asymptomatic infected persons and mild cases should take care of themselves at home, reduce contact with their roommates, use symptomatic drugs rationally according to relevant guidelines, do a good job in health monitoring, and go to medical institutions in time if the condition worsens.

　　2, whooping cough

　　Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis, and its typical clinical manifestations are paroxysmal, spasmodic cough and crowing inhalation roar. The disease has a long course and can last for 2-3 months, so it is called "whooping cough". It is mainly transmitted by air droplets, but also by direct contact with respiratory secretions of patients. The population is generally susceptible, and infants without immunization history are at higher risk.

　　Protective measures:

　　1. Standardize vaccination. Vaccination with DTP vaccine can reduce the risk of severe pertussis and death in infants. According to the requirements of the national immunization program for children, school-age children should be vaccinated with DTP vaccine as soon as possible, and school-age children who have not been vaccinated all the time should be replanted as soon as possible.

　　2. Seek medical attention in time. Especially when infants and young children have paroxysmal spastic cough or have their own sudden cough after similar cases around them, they should take the initiative to seek medical treatment in time to reduce the risk of epidemic spread and serious illness.

　　3. Do daily protection. Keep good hygiene habits, wash your hands frequently and ventilate frequently, cover your mouth and nose with elbows or paper towels when coughing or sneezing, and pay attention to reasonable work and rest and proper physical exercise. Try to avoid crowded and poorly ventilated public places.

　　3, norovirus infectious diarrhea

　　Norovirus is a group of non-encapsulated RNA viruses, which has the characteristics of strong infectivity, rapid spread, short immune protection time and general susceptibility of the whole population. It is the most important pathogen that causes acute gastroenteritis. It can be transmitted through polluted water and food, and can also be infected by aerosol inhalation or contact with items contaminated by virus. Shellfish such as oysters and raw fruits and vegetables are common foods that cause infection. It is easy to spread in crowded places such as schools and kindergartens. In the autumn school season, kindergartens, schools and other educational institutions should do daily protection and strengthen health monitoring.

　　Protective measures:

　　1. Maintain personal hygiene. Pay attention to washing hands frequently to prevent diseases from entering the mouth, especially before and after meals and before preparing and processing food.

　　2. Pay attention to the hygiene of diet and drinking water. Do not eat uncooked food and unpasteurized milk, shellfish and seafood such as oysters should be eaten after deep processing; Fruits and vegetables should be carefully washed before eating, and do not eat unclean fruits and vegetables; Separate raw and cooked foods to avoid cross-contamination; Ensure the safety of water sources, do not drink raw water, and the selection of bottled water should meet the hygiene standards.

　　3. Pay attention to standardization. The environment or the surface of an object polluted by the patient’s vomit or excrement should be cleaned and disinfected by trained personnel with chlorine-containing disinfectants or other effective disinfectants. In the process of handling patients’ vomit, excrement and disinfection, you must do personal protection, wear masks and rubber or disposable gloves, and carefully clean and disinfect your hands after cleaning.

　　4. Dengue fever

　　Dengue fever is an acute infectious disease caused by dengue virus. Its clinical manifestations are persistent fever, accompanied by severe headache, myalgia, joint pain, nausea, vomiting and rash. In severe cases, bleeding, shock, organ failure and even death may occur. The disease is mainly transmitted by the bite of Aedes mosquitoes. September is still the peak of mosquito activity, so we should keep good environment and room hygiene in our daily life, reduce mosquito breeding and reduce the risk of infection. At the same time, people who travel and work in dengue epidemic areas should pay attention to personal protection to prevent mosquito bites, and do a good job of self-health monitoring after returning from epidemic areas.

　　Protective measures:

　　1. Do a good job in mosquito control. Clean up the accumulated water in indoor containers such as flowerpots and drinking fountains in time, clean up domestic garbage and sanitary dead corners, and keep the room clean and tidy. Install screen doors and screens in the room, and use mosquito-repellent incense, mosquito killer and electric mosquito swatter to prevent and repel mosquitoes.

　　2. Personal protection should be done when going to dengue epidemic areas. You should wear long-sleeved clothes and trousers, spray repellent and mosquito repellent on bare skin, use mosquito nets when sleeping, and try to choose hotels with air conditioning or screens.

　　3. Do your own health monitoring. After symptoms appear, you should seek medical advice as soon as possible, and actively inform the doctor of the relevant residence history for early detection, early diagnosis and early treatment.

　　4. Use of personal protective equipment. Personal protective equipment such as mosquito nets and mosquito repellent can effectively prevent mosquito bites, thus reducing the probability of dengue virus infection. In areas with frequent mosquito activities, it is recommended to use mosquito nets or apply mosquito repellent to protect yourself.

　　5, school tuberculosis

　　Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, which can invade many organs, and pulmonary tuberculosis infection is the most common. It is mainly transmitted by respiratory droplets, and healthy people may be infected by inhaling air droplets with tuberculosis. The main symptoms are cough, expectoration lasting for more than 2 weeks, chest tightness, low fever in the afternoon, fatigue, loss of appetite, emaciation, night sweats and so on.

　　Tuberculosis is one of the infectious diseases that schools focus on preventing and controlling. It is the beginning season of autumn recently, and it is a high incidence period of tuberculosis. Schools, parents and students should pay attention to the prevention and control of tuberculosis.

　　Protective measures:

　　1. Strengthen campus management. It is suggested that schools should strengthen the morning check-up, afternoon check-up and late check-up of students in school, implement measures such as tracking students’ absence from class and tracing the cause, and find tuberculosis patients and suspects in school as soon as possible.

　　2. Pay attention to personal protection and improve the body’s immunity. Pay attention to window ventilation, do not spit everywhere, and cover your mouth and nose with your elbow when coughing or sneezing. Reasonable diet, balanced nutrition, combining work and rest, ensuring adequate sleep and appropriate outdoor activities, enhancing physical fitness and improving body resistance.

　　3. Standardize the whole course of treatment. The whole treatment course of pulmonary tuberculosis is 6-8 months, and the whole treatment course of drug-resistant pulmonary tuberculosis is 18-24 months. According to the doctor’s standard treatment, most tuberculosis patients can be cured.

　　6. Food poisoning

　　Food poisoning is a major disease, which is caused by nausea, vomiting, abdominal pain, diarrhea and other symptoms after eating food contaminated by toxic and harmful substances or containing toxins. In September, the high temperature and high humidity weather continued in many places in China, which also created conditions for the proliferation of bacteria. Food is more prone to spoilage. With the large number of seafood on the market, it is necessary to pay attention to the pollution of seafood by Vibrio parahaemolyticus, which is easy to cause food poisoning.

　　Protective measures:

　　1. Pay attention to food hygiene and achieve "six noes": don’t eat uncooked and thoroughly cooked food, unclean fruits and vegetables, food of unknown origin, picking and eating wild mushrooms and wild plants, and don’t buy wild mushrooms picked and sold by individuals, and don’t buy wild mushrooms at mobile stalls.

　　2. When eating out, pay attention to the selection of catering units with complete licenses and good sanitary conditions. Buy food in supermarkets or vegetable markets with health protection.

　　3. Pay attention to personal hand hygiene, wash your hands before and after meals, before and after handling raw and cooked food and its packaging, after touching pets and disposing of garbage.

Xinhua News Agency, Beijing, September 2ndQuestion: How to upgrade consumers’ enjoyment of trade-in support of overweight in various places?

Xinhua News Agency reporters Xie Xiyao, Li Xiaoting and Gong Liankang.

Recently, the "upgraded version" policy of promoting the trade-in of automobiles and home appliances at the central level has been introduced one after another. The reporter recently visited markets in Beijing, Hubei, Chongqing, Fujian and other places, and learned that all localities have introduced detailed rules for the replacement of old consumer goods in light of local actual conditions, expanded the coverage of subsidized products, upgraded subsidies, made the application process more convenient, and increased consumers’ willingness to purchase.

Government subsidies are superimposed on enterprises to make profits, and new subsidies for automobile replacement and renewal are added.

On the evening of August 27th, the reporter went to the Geely Yinhe Wuhan Star Experience Center in Hanyang District, Wuhan. The slogan of "trade-in" subsidy for cars in the store was everywhere, and many citizens went to the store to see cars and consult preferential policies.

The salesperson took the store’s best-selling model Geely Yinhe E8 as an example and calculated a "detailed account" for the reporter:

For a new car with an original price of 165,800 yuan, if the customer’s old car meets the scrapping conditions, the maximum state subsidy can be 20,000 yuan; Or transfer the car under his name, you can get a replacement subsidy of 12,000 yuan. During this period, you can also apply for a trade-in coupon of up to 2,000 yuan in Wuhan at the same time, plus a discount of more than 10,000 yuan from manufacturers and 4S stores, and the maximum superimposed discount for buying this new car can reach more than 30,000 yuan.

According to the national policy, for individual consumers who meet the provisions of the Detailed Rules for the Implementation of Vehicle Trade-in Subsidies and scrap old cars and buy new ones, the subsidy standard will be increased from 10,000 yuan for new energy passenger cars and 7,000 yuan for fuel passenger cars to 20,000 yuan and 15,000 yuan respectively. In addition to scrapping and updating, this policy will also include replacement and updating in the scope of subsidies, and support local governments to carry out replacement and updating independently.

At present, following the rhythm of national policies, local governments have successively launched trade-in schemes focusing on the local automobile market.

The national dicing and matching funds in Hubei Province are more than six times the size of the funds before the afterburner measures. The maximum subsidy for car scrapping and renewal is 20,000 yuan, and the maximum subsidy for replacement and renewal is 16,000 yuan.

Beijing has made it clear that the newly purchased new energy vehicles after replacement include not only pure electric vehicles, but also plug-in hybrid vehicles (including extended-range vehicles) and fuel cell vehicles, and all of them can enjoy replacement subsidies if they are transferred inside and outside Beijing.

Shanghai puts used cars in an important position in the trade-in policy, encourages the development of used car distribution business, and makes it clear that the average age of used cars will be reduced by one year by 2027 …

Government subsidies are superimposed on enterprises to make profits, new replacement and renewal subsidies are added, and consumers’ willingness to buy new cars is increased.

Up to now, the trade-in of consumer goods in Hubei has benefited more than 400,000 consumers, driving the sales of new cars and home appliances to 12 billion yuan. Wuhan has achieved the goal of trade-in of automobiles for the whole year ahead of schedule; As of mid-July, Hunan has received more than 8,600 applications for automobile scrapping and renewal subsidies, and more than 23,000 applications for replacement and renewal subsidies, which has driven automobile sales to exceed 5.5 billion yuan. From the release of the National New Deal to September 1st, the cumulative amount of old-for-new subsidies in Chongqing reached 9,748, and the cumulative sales of automobiles exceeded 1.837 billion yuan.

According to the data of the Ministry of Commerce, as of 10: 00 a.m. on September 1, more than 810,000 applications for car scrapping and renewal subsidies were received. From January to July, the national automobile retail sales reached 11.556 million, up 2.3% year-on-year. Among them, the retail sales of new energy passenger cars was 4.988 million, a year-on-year increase of 33.7%; The number of used cars was 10.992 million, a year-on-year increase of 6.3%.

The subsidy for home appliance replacement will be expanded, and the on-site application will be reduced immediately.

Mr. Zhou of Nanchuan District, Chongqing recently bought a Haier Class 1 energy-efficient air conditioner with a price of 2,499 yuan and enjoyed a government subsidy of 499.8 yuan for trade-in. "Government subsidies are very cost-effective, and it is very convenient to apply for money immediately." Mr. Zhou said.

On August 26th, Chongqing’s "upgraded version" green smart home appliances trade-in subsidy policy landed. On the first day of the implementation of the policy, the city issued a government subsidy of 8.165 million yuan, which directly led to the sales of home appliances of 42.6335 million yuan.

The reporter learned from the Chongqing Municipal Commission of Commerce that at present, the state’s pre-allocated funds to support trade-in have been issued to Chongqing, and the local governments will match the funds in proportion to jointly promote the trade-in of consumer goods.

The state has made it clear that eight types of household appliances enjoy a subsidy standard of 15% to 20% of the sales price, with a maximum subsidy of 2,000 yuan per piece. At the same time, support local governments to independently determine the varieties of subsidized "8+N" household appliances. Up to now, many places have successively issued implementation rules for the implementation of home appliance trade-in.

Chongqing has made it clear that individual consumers will enjoy 15% to 20% of the sales price of each type of household appliances when they purchase 11 types of household appliances with energy efficiency or water efficiency standards of Grade 2 or above; In terms of superimposed subsidies for enterprises, consumers can enjoy a 2% trade-in subsidy if they sell nine categories of old household appliances and buy any kind of products with energy efficiency or water efficiency of Grade 2 or above.

Beijing consumers can access the "Jingtong" applet through Alipay, WeChat, Baidu, Meituan and other channels, and receive the subsidy qualification codes of more than 10,000 household appliances in 8 categories, and enjoy preferential treatment in the payment link.

On the basis of eight types of household appliances, Guangdong has added three types of products, such as mobile phones, tablets and smart wearable devices, as well as other N-type products that are actually included in the scope of subsidies in various cities, forming an "8+3+N" product category.

From the central government to the local government, the subsidy policy has clearly defined the energy efficiency standards, and only subsidizes energy efficiency products of Grade 2 and above. "Trade-in is not a simple replacement of similar products, but a demand that tends to be higher-end, smarter, more environmentally friendly and more personalized, and supports the transformation and upgrading of household consumption through trade-in." Chen Yaoting, a professor at the Business School of Minnan Normal University, said.

Continue to open up new blocking points and smooth the resource circulation chain.

Recycling has always been a blocking point that affects trade-in consumption, and it is also the key to smooth the recycling of resources.

Fujian Quantong Resource Recycling Industrial Park, located in Zhangzhou Development Zone, Fujian Province, has a truckload of used household appliances entering the factory, weighing, unloading, acceptance, bar coding and warehousing, and then entering the dismantling process. Every day, about 2000 sets of waste household appliances are treated here in a standardized way.

Driven by the trade-in policy, Quantong has established strategic cooperation with recycling enterprises under Midea Group to realize the recycling system of products from sales, recycling to standardized dismantling.

The national policy is clear, all localities should strengthen the construction of digital platforms, learn from each other’s experience, strengthen data analysis, and timely and accurately grasp the information of the whole process of home appliances replacement, purchase and disassembly. The reporter visited and learned that under the guidance of the trade-in policy, the diversified recycling pattern of used household appliances is accelerating.

"Old household appliances are not limited to brands and years, and they can provide one-stop trade-in services such as free door-to-door dismantling of old machines and free transportation." He Yuanlin, general manager of Dahai Daming Trading Co., Ltd., a distributor of Haier Zhangzhou, said that the company is docking with dismantling enterprises with relevant qualifications, establishing a standardized recycling system for used household appliances, and at the same time promoting the development of community services for household appliances.

On September 2, Haier Zhijia Recycling Interconnection Factory was completed and put into operation in Laixi, Qingdao, with an annual dismantling capacity of 3 million units. Shijiazhuang city has perfected the comprehensive utilization system of renewable resources by the mode of "government+property+third party"; Hunan will include the recycling outlets of renewable resources such as waste household appliances into the construction of a convenient living circle for a quarter of an hour; Gree, Changhong and other home appliance companies actively adopt the "internet plus Recycling" method to provide professional old machine recycling services …

Insiders pointed out that with the increase in the number of places to promote the implementation of the old-for-new policy, it will drive the government, enterprises, platforms and other forces to join the field of recycling, and work together to improve the construction of the recycling network of used household appliances, so that consumers are "easier to get rid of the old and more willing to get new ones".

The 14th Press Conference on Epidemic Prevention and Control in COVID-19, Hainan Province.
(February 19, 2020)

Ru Yingying:

Hello, ladies and gentlemen! At present, the epidemic prevention and control work has reached a very critical period. In order to further strengthen the popularization of protection knowledge and ensure the safety of those who return to work and resume production, the Information Office of Hainan Province held the 14th news conference on the epidemic prevention and control work in COVID-19, Hainan Province, and invited Mr. Sun Shaoke, deputy director of the Provincial Big Data Administration, Mr. Chen Jianhong, spokesman of the Provincial Health and Wellness Committee, and Mr. Jin Yuming and Mr. He Bin, chief physicians of the Provincial Center for Disease Control and Prevention, to answer your questions around the theme of "knowledge of epidemic prevention and control in different industries and populations".

First of all, please ask Chen Jianhong, spokesman of the Provincial Health and Wellness Committee, to report the latest epidemic situation.

Chen Jianhong:

First, the latest epidemic situation

From 00: 00 to 12: 00 on February 19th, 2020, novel coronavirus was reported by Hainan Province, and there were no newly confirmed cases, severe cases, deaths and discharged cases.

By 12: 00 on February 19th, Hainan Province had reported 163 confirmed cases, 9 severe cases, 4 deaths and 79 discharged cases in novel coronavirus. Among the confirmed cases, there are 34 cases in Haikou, 54 cases in Sanya, 15 cases in Danzhou, 3 cases in Wenchang, 6 cases in qionghai city, 13 cases in Wanning, 3 cases in Dongfang, 9 cases in Chengmai, 6 cases in Lingao, 7 cases in Changjiang, 4 cases in Lingshui, 3 cases in Ding ‘an, 3 cases in Baoting, 2 cases in Ledong and 1 case in Qiongzhong.

By 12: 00 on February 19th, 5,280 close contacts had been tracked, 4,196 people had been released from medical observation, and 1,084 people were still under centralized medical observation.

Second, the daily epidemiological risk warning (February 19)

In recent years, the number of newly diagnosed cases in our province has remained low continuously, and the number of discharged cases has increased significantly. However, due to the recent resumption of work and other factors, if the prevention and control measures are not in place, there may be epidemic fluctuations in the future. The prevention and control suggestions are as follows:

1 prevention and control departments at all levels should strengthen the epidemic monitoring and related prevention and control measures after the resumption of work. In particular, key areas such as Haikou and Sanya should strengthen prevention and control.

2. Try to go to work at the wrong time, arrange shifts flexibly, prohibit gatherings and dinners, implement a meal sharing system, clean up the working and living environment, reduce the living density and strengthen ventilation.

Ru Yingying:Next, please answer the questions that journalists and netizens care about.

Q:Our province launched the health code system on February 18th. Could you tell us something about it?

Sun Shaoke:

Thank you for your question. I will break your question down into twelve sub-questions to answer.

(1) What is Hainan Health Code?

Hainan Health One Code System is a personal two-dimensional code generated by comparing and verifying the health data declared by residents or people returning to work, combined with epidemic prevention big data information.

(2) What is the meaning of "three colors" of Hainan health code?

A green code indicates that there are no symptoms at present. According to local management requirements, you can check the bright code of body temperature. The yellow code and the red code do not meet the traffic conditions for epidemic control, and they can travel normally only after being converted into green codes.

(3) What are the differences between the green code, the yellow code and the red code?

Health codes are divided into three colors: red, yellow, green, yellow and red.

1. When the access control at the bayonet or the enterprise returns to work, the green code personnel can pass by the code and go to work normally. Those who receive the red code and the yellow code need to be isolated according to the regulations and make a daily health punch card. When the conditions are met, they will be turned into green codes.

2. In principle, the "red code" personnel who entered Qiong shall be advised to return or delayed to Qiong. "Yellow code" personnel shall be observed at home or in centralized isolation according to regulations. Display "green code", and pass the release after bright code and temperature measurement.

(4) How to apply for a green health code?

Users don’t have a health code by default. Please apply for it through government service APP, government big data WeChat official account, Coconut City Minyun, Alipay and WeChat scan code, and punch in your daily health card. The system will automatically assign you a health code of corresponding color according to your health information.

(5) How can the red code/yellow code be converted into green code?

Code red and code yellow personnel must punch in the registration information for 14 consecutive days and meet the relevant conditions before they can turn into green codes.

(6) What are the functions and functions of Hainan health code?

Hainan health code can be applied and popularized in multiple scenarios, which can improve work efficiency and control quality. In management scenarios such as grid worker’s door-to-door inspection, community gate inspection, unit enterprise’s return to work registration, road traffic checkpoint inspection, fever clinic, fever medicine purchase, etc., people’s personal health code can be directly scanned, information can be collected without contact, reporting is convenient, and data can be shared and utilized, which is conducive to rapid epidemic prevention work.

(seven) the scope of application of Hainan health code?

Hainan health code is applicable to those who are in Hainan and those who are waiting to enter Hainan.

(eight) Hainan health code which occasions need to be used?

During the epidemic prevention and control period, the health code can be used as an electronic passport for work, study and life in Joan. Please take the initiative to show it to cooperate with the inspection when necessary. In addition, the health code can also be used in scenes such as hospitals, pharmacies and enterprises returning to work and production.

(9) What is the significance of Hainan health code for enterprises to resume work and production?

Grasp the real-time health status of employees through employee health codes, effectively arrange work for different people, and reduce the risk of epidemic spread caused by gathering; At the same time, it is also conducive to effectively evaluating the risk of enterprises’ resumption of production and work, better balancing the relationship between epidemic prevention and control and enterprises’ resumption of production through health code, and promoting the orderly development of social economy.

(10) Where can I register to check the health code?

The health code system has been provided in platforms such as Hainan Government Service APP, Hainan Government Big Data WeChat official account, Coconut City Minyun, Alipay, etc. Citizens can scan the code and log in through Alipay, Coconut City Minyun APP, WeChat, mobile browser and other channels.

(11) Can health codes only be used by Hainan natives? Can I use it from other places?

The health registration function is used for personal self-help online health status report. No matter local residents, people who have returned to Qionglai from other provinces or Hubei Province, they can register their own health by punching in the health registration function of the health code.

(12) How to consult if there are problems in the use of health codes?

Members of the public can call the Hainan 12345 government service hotline to ask questions related to health codes.

Q:Yesterday, our province issued "Ten Measures for Migrant Workers to Work in Provincial Key Projects and Key Projects during the Epidemic Prevention and Control Period", and construction sites in our province will start one after another. How to do a good job in epidemic prevention and control after the construction sites resume work?

He Bin:

After the construction site resumes work, all parties involved in the construction should implement the main responsibility of prevention and control, strictly do a good job in epidemic prevention and control, and file a record for future reference.

(1) Personnel control requirements.

1, completes the personnel registration;

2, do a good job in all field personnel temperature detection;

3. Do a good job in reporting the causes of absenteeism;

4. Make emergency response.

(2) Requirements for control on the construction site.

1. The construction enterprise shall set up temperature detection points at the entrance and exit of the construction site, and all personnel must have temperature detection when entering the construction site. Persons with body temperature greater than or equal to 37.3℃ should be sent to the isolation observation dormitory in time for further isolation observation. After resting in the isolation observation dormitory for 10 minutes, if the body temperature is still greater than or equal to 37.3℃, appropriate protective measures should be taken and sent to the fever clinic designated by the health department in time. All personnel entering the site should wear masks and take personal protective measures. Decentralize pre-shift education, technical disclosure and other activities to reduce personnel gathering and meetings.

2. According to the relevant technical requirements, carry out ventilation, disinfection and epidemic prevention work on the construction site, office and living areas (site canteens, dormitories, toilets and other places) and other personnel activities.

3, strict implementation of food procurement, processing, storage and other health standards, not illegal slaughter, disposal of wild animals, and effectively protect food safety. The canteen on the construction site can take measures such as separate meals and wrong meals, and it is forbidden for people to have dinner.

4, do a good job in the classification of domestic waste, in strict accordance with the requirements of the disposal of discarded masks and other medical protective equipment waste.

5, the construction site should be related to health and epidemic prevention education into the approach and daily pre-job education, fully launch the publicity and education of novel coronavirus related knowledge, take measures such as posting health and epidemic prevention advertisements in a prominent position in the construction site and living quarters, and improve the prevention and control awareness of field personnel.

6, the implementation of epidemic prevention and control work to implement the daily system and emergency reporting system.

Q:How do migrant workers and other migrant workers do personal protection?

He Bin:

(a) before returning to the city, to carry out temperature measurement, to ensure that there is no abnormal increase in body temperature.

(2) Measure your body temperature before going to work every day on weekdays and make records. If you have symptoms such as fever and cough, you should be isolated in time and seek medical treatment.

(three) when many people work together in the workplace, each person should wear a mask.

(4) Wear masks on the way to the workplace, and keep a certain distance between people.

(five) collective dormitory ventilation frequently, the distance between beds is more than 1 meter, daily cleaning, timely cleaning of garbage, and thorough cleaning and cleaning of the dormitory every week.

(6) Take meals at the wrong time to avoid dinner. Clean the restaurant thoroughly after each meal, with no food residue on the dining table and no sanitary corner on the ground, and remove the kitchen garbage in time. Clean and disinfect the used tableware in time.

(seven) keep the public toilet ventilated. Sanitary cleaning shall be carried out at any time every day, and the floor and walls shall be kept clean. There shall be no dirt in the sink and no feces and dirt accumulation in the urinal. Disinfect urinals every day.

(eight) wear a mask when traveling daily, and do not litter or spit when going out. When sneezing, cover your nose and mouth with paper towels, or use elbows and arms to keep a certain distance from others, and do not move in crowded places. Do a good job of hand hygiene after going out and returning.

Q:How to prevent and control the epidemic situation in the collective office after returning to work?

Jin Yuming:

(a) staff should do a good job of health monitoring, if there are suspicious symptoms of novel coronavirus infection (including fever, cough, sore throat, chest tightness, dyspnea, fatigue, nausea and vomiting, diarrhea, conjunctivitis, muscle aches, etc.), don’t go to work sick, you should report to the unit in time and go to the fever clinic for investigation.

(2) If suspicious symptoms of novel coronavirus infection are found, the staff should register and ask them to go to the nearest fever clinic for investigation.

(three) public goods and public contact items or parts should be cleaned and disinfected regularly.

(four) to maintain air circulation in the office. Ensure the normal operation of the air conditioning system or exhaust fan, clean the air conditioning filter regularly, and strengthen the ventilation by opening the window.

(five) the bathroom should be equipped with enough hand sanitizer to ensure the normal work of water supply facilities such as faucets.

(six) keep the environment clean, clean up the garbage in time.

Q:How do students protect themselves during the winter vacation and on the way back to school?

Jin Yuming:

(1) During the winter vacation.

1. Students who have a history of residence or travel in epidemic-prone areas (such as Wuhan) have been under medical observation at home or in designated places for 14 days since leaving the epidemic-prone areas.

2. Students from all over the country should stay at home as much as possible, reducing visits to relatives and friends, gatherings and dinners, and activities in crowded public places, especially in places with poor air mobility.

3. Students are advised to monitor their health every day and report to the designated person in charge of the community or school as required.

4. At the end of the winter vacation, students can return to school normally if they have no suspicious symptoms. If you have any suspicious symptoms, you should report them to the school or the guardian, and seek medical treatment in time, and then go back to school after recovery.

(2) On the way back to school

1. Wear medical surgical masks all the time when taking public transport.

2, keep hand hygiene at any time, reduce contact with tools of public goods and parts.

3. Do a good job in health monitoring during the trip, and take the initiative to measure your body temperature when you feel feverish.

4. Pay attention to the health status of the surrounding passengers and avoid close contact with people with suspicious symptoms.

5. If there are suspicious symptoms during the trip, you should take the initiative to put on a medical surgical mask, try to avoid contact with other people, and seek medical attention in time according to your condition.

6. If you need to see a doctor in a medical institution during the trip, you should take the initiative to tell the doctor about the travel and residence history of the relevant disease-endemic areas and cooperate with the doctor to carry out relevant investigations.

7. Keep the travel ticket information properly to cooperate with the investigation of possible close contacts.

Q:What are the suggestions for kindergartens (or schools) to prepare for returning to school after the outbreak?

Jin Yuming:

(1) Students who have lived or traveled in areas with high epidemic rates (such as Wuhan) before returning to school are advised to stay at home for 14 days before returning to school.

(2) Students should monitor their body temperature and health status every day after returning to school, try to reduce unnecessary going out and avoid contact with other people.

(3) When students are in close contact with other teachers and students, they should wear medical surgical masks correctly to minimize the scope of activities.

(IV) Schools should closely monitor students’ health status, measure their body temperature twice a day, and make records of absence, leaving early and taking leave. If suspicious symptoms are found among students, they should immediately report to the epidemic management personnel, and cooperate with medical and health institutions to do a good job in the management and disinfection of close contacts.

(5) Schools should try to avoid organizing large-scale collective activities. In classrooms, dormitories, libraries, activity centers, canteens, auditoriums, teachers’ offices, toilets and other activity areas, it is recommended to strengthen ventilation and cleaning, and equip them with hand sanitizers and hand disinfectants.

(six) the school to carry out online teaching, make-up classes for students who missed classes due to illness, for those who delayed the exam due to illness, make-up exams should be arranged and should not be recorded in the file.

Q:At present, farmers’ markets in our province have also resumed business one after another. How can farmers’ markets do a good job in epidemic prevention and control?

He Bin:

(a) the management department of farmers’ market should attach great importance to the prevention and control of epidemic situation, establish the working mechanism of epidemic situation prevention and control, formulate the prevention and control plan, refine the prevention and control measures, implement the prevention and control personnel, put the responsibilities in place, and divide the work among people.

(two) the management department of the farmer’s market should grasp the out-going situation and health status of all operators and relevant staff in the market 14 days before rework. People from high-incidence areas (such as villages, communities and streets with confirmed cases in Hubei Province) must be observed in isolation for 14 days before they can start business and rework. Other migrant workers who have passed the temperature and health examination can do business and rework.

(three) operators and staff in the market daily health monitoring, the establishment of body temperature monitoring register. Operators should maintain personal hygiene when providing services, wash their hands frequently and wear masks all the time.

(4) Strictly implement the system of inspection and acceptance of incoming goods and claiming tickets and certificates. Operators in farmers’ markets shall not purchase food and food raw materials that have no source or do not meet the requirements, and it is strictly forbidden to purchase and use meat and its products that have died of illness or the cause of death is unknown, and that have failed quarantine; It is forbidden to slaughter live livestock and poultry in captivity, to trade live poultry, to purchase and sell wild animals and their products.

(5) Market operators should carry out a general cleaning after the daily closing of their stalls, and clean the countertops, floors, sewers and storefronts with water to keep the stalls clean and tidy, so as to ensure that no sanitary corner is formed. Regularly spray and disinfect sewers, floors around stores, countertops, appliances and chopping boards. When cleaning and disinfecting, wear long water shoes, masks and waterproof gloves, and do a good job in personal hygiene protection. Pay attention to the ventilation of the place (mechanical ventilation is used when necessary). Public toilets should be kept clean and equipped with soap, hand sanitizer or alcohol-containing hand sanitizer to ensure the normal use of water supply facilities such as faucets. Strengthen garbage classification management, set up garbage bins with discarded masks, remove garbage in time, and keep the environment clean and hygienic.

(6) Do a good job in rodent control and pest control. Strengthen the management of garbage in farmers’ markets, require garbage transport vehicles and hand-propelled garbage collection vehicles to be stored and transported in a closed manner, and improve the level of garbage collection, transportation and treatment; Install anti-rat, anti-mosquito and anti-fly facilities. Ensure that the control level of rats, mosquitoes, flies and cockroaches (vectors) in the market meets the requirements of national standards.

(seven) the entrance of the farmer’s market to test the temperature of customers, if necessary, to re-test, to remind passengers to wear masks. People with fever reaching or exceeding 37.3℃ are not allowed to enter.

Q:How to ensure epidemic prevention and production and life in rural areas?

He Bin:

(a) have been to Hubei, relatives and friends from Hubei should promptly inform the village committee, family members, relatives and friends or their own fever, cough, chest tightness and other unwell symptoms, to report early, timely diagnosis and treatment. Wear a mask when going to crowded places, and wear a mask when coughing or having a fever. This is the simplest and most effective protective measure.

(two) clean up the sanitary corner, timely removal of garbage, do a good job in environmental sanitation, prevent mosquito and fly diseases. Do not spit everywhere, cover your nose and mouth with paper towels when coughing or sneezing, and wash your hands after handling.

(3) Wash your hands with soap or hand sanitizer for at least 15 seconds after coughing or sneezing, preparing food, defecating before and after meals, touching animals or handling animal droppings, and going out and returning home, paying attention to scrubbing every part in place.

(4) Open the doors and windows regularly to keep the air circulating at home. Exercise more, drink more water, get enough sleep, mix food with meat and vegetables, separate raw food from cooked food, and try to improve your immunity.

(five) livestock and poultry should be kept in captivity, cleaned and disinfected, and vaccinated in time. Do not hunt, kill, process, sell or eat wild animals and their products.

(six) support the work of township and village cadres, and cooperate with the registration and verification of epidemic prevention. Poverty alleviation cadres in the province, especially those at the grassroots level, should guide and help the poor to implement prevention and control measures to ensure that no one is left behind.

(7) Crowd gathering places are risky, so it is necessary to visit relatives and friends less, gather for dinner less, go to markets less, and go to crowded places less. Don’t attend village temple fairs, public meetings, etc.

(eight) if the body is abnormal or in close contact with the confirmed sick person, don’t hide it for fear of isolation. As long as the patients are found and isolated in time, the epidemic situation can be contained quickly. Don’t panic too much and don’t believe in rumors.

(nine) to develop good hygiene habits, don’t litter, especially the worn masks and related protective equipment. If it is possible, it should be centralized and harmless, and if it can’t be centralized, it should be burned by itself.

(ten) don’t refuse to check the temperature of the temporary epidemic prevention checkpoint. In response to the government’s call, migrant workers returned to the city in an orderly manner as required. Migrant workers should not bring live birds and other animals when they return to the city.

(eleven) the plan of the year lies in the spring, the epidemic situation should be prevented, and the production should not stop. We should do a good job in spring field management, spring ploughing and animal husbandry production.

Q:Can I order takeout during epidemic prevention?

Jin Yuming:

It is suggested that the take-away restaurant will distribute the containers containing food outside, and increase the frequency on the basis of the usual cleaning and disinfection requirements to disinfect the delivery staff’s vehicles. Do a good job of cleaning, disinfection and protection, and the possibility of virus transmission through take-away is relatively low. Be sure to wear a mask when taking takeout. It is suggested to carry out non-contact delivery, and inform the delivery staff to put the goods at the designated place, without the need for both parties to sign face to face. When taking takeout, you can bring disposable gloves, or use paper towels to separate your hands from the packaging bag. After taking the takeaway, you can remove the layers of packaging under the protection of gloves or paper towels and throw them into the trash can. Then use the soapbox flowing water to absorb it at the first time, or use antibacterial hand gel containing alcohol to clean your hands. However, we still suggest cooking by yourself and bringing meals. If you go to a restaurant or order takeout, it is recommended to order hot food instead of cold food; If possible, reheat the food before eating to ensure it is cooked thoroughly; Always remember to maintain hand hygiene, wash your hands before and after meals and after touching easily contaminated items.

Ru Yingying:thank you This concludes today’s press conference.

Many people have had this feeling that their chest suddenly "thumped" as if their heart had stopped. This situation is likely to be premature beats.

Premature beat is that a heartbeat rhythm is advanced, and there is a long interval after beating ahead. Some patients with less premature beats have no obvious feeling, but occasionally feel some discomfort or slight palpitation in the chest. If premature beats occur frequently, it will cause symptoms such as palpitation, shortness of breath, chest tightness and fatigue, and even worsen the original heart disease, which requires active treatment.

Western medicine treatment of premature beats is mainly "anti-"

For the treatment of premature beats, the traditional western medicine treatment method is to choose antiarrhythmic drugs, which only aim at a certain level and a certain part of arrhythmia, ignoring the interaction between factors at the same level and the interaction between different levels, and then aiming at the single cause of arrhythmia, blindly adopting the "anti-"treatment method can not solve the fundamental problem. Moreover, the side effects of antiarrhythmic drugs are increasingly obvious, which not only has serious extracardiac toxicity and leads to liver and kidney damage, but also may cause more complicated arrhythmia and even worsen the original arrhythmia symptoms. Another point is that western medicine can not effectively treat bradyarrhythmia, so there is no good way to treat arrhythmia such as sinus bradycardia with ventricular premature beats.

The treatment of premature beats with traditional Chinese medicine focuses on "regulating" 　 　 　 　 　 　 　 　 　 　 　 　 　

Shensong Yangxin capsule, a traditional Chinese medicine, has realized the thinking change from "resistance" to "modulation" in clinical treatment of premature beats. "Modulation" is the whole regulation, which takes the integration of various factors and mechanisms for regulating premature beats as the core, and starts from the interrelation among molecules, cells, tissues, the whole heart and even the whole human body, so as to regulate the autonomic nervous function of the heart, block multi-ion channels, improve the metabolism of myocardial cells, and restore the whole function of the heart, and has a good curative effect on all kinds of premature beats.

In the evidence-based medical research of Shensong Yangxin Capsule, which was attended by more than 500 doctors from 36 3A hospitals in China, 188 cases of non-organic ventricular premature beats and 671 cases of organic ventricular premature beats caused by heart diseases such as coronary heart disease and myocarditis were treated with Shensong Yangxin Capsule. Compared with the curative effect of slow heart rhythm, the results of 24-hour dynamic electrocardiogram examination show that Shensong Yangxin capsule has a good therapeutic effect on both non-organic ventricular premature beats and organic ventricular premature beats, and its curative effect is significantly better than that of slow heart rhythm, and there is no adverse cardiac reaction. By taking Shensong Yangxin Capsule, the symptoms such as palpitation, shortness of breath, chest tightness, fatigue, dizziness and sweating disappeared.

In addition, the curative effect of Shensong Yangxin Capsule on sinus bradycardia with ventricular premature beats and heart failure with ventricular premature beats has also been confirmed by evidence-based medical research.

A randomized, double-blind, placebo-controlled, multi-center clinical study of Shensong Yangxin Capsule in the treatment of sinus bradycardia with ventricular premature beats, which was jointly participated by 33 3A hospitals in China, showed that the number of premature beats in the treatment group decreased by 1827 times /24 hours, the rate of decrease of premature beats was 71.01%, the heart rate increased by 6.25 times/minute, and the heart rate percentage increased by 11.38%. The research results show that Shensong Yangxin Capsule can improve ventricular premature beats safely and effectively, and at the same time, it can increase sinus heart rate, thus screening out effective and safe therapeutic drugs for patients with sinus bradycardia and ventricular premature beats at home and abroad.

Evidence-based medical research on Shensong Yangxin Capsule in the treatment of heart failure with ventricular premature beats was completed by 31 domestic 3A hospitals for two years. The results confirmed that Shensong Yangxin Capsule can significantly reduce the number of patients with 24-hour ventricular premature beats and significantly improve the decline rate of 24-hour ventricular premature beats on the basis of standardized treatment of chronic heart failure. At the same time, it can increase the left ventricular ejection fraction, improve the cardiac function classification, reduce the plasma concentration of pro-brain natriuretic peptide (NT-ProBNP), increase the walking distance of 6 minutes, improve the quality of life of patients, and have good safety.

Based on the research results of Shensong Yangxin Capsule in treating premature beats, Shensong Yangxin Capsule was recommended by China Expert Consensus of Ventricular Arrhythmia in 2020.

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