US stocks opened higher and went lower on Monday. The S&P 500 Index and Nasdaq closed down by nearly 1% in intraday trading, while the Dow rose slightly by 0.09%. Brent crude oil rose by nearly 2%; New york gold futures re-entered the $1,800 mark. The strong employment data released last week made investors hold their breath for the US CPI (released on Wednesday), while the NVIDIA revenue warning dragged down the performance of the index.

　　NVIDIA, a graphics card giant, gave a pre-market performance warning on Monday, and predicted that its revenue in the second quarter would be US$ 6.7 billion, down 19% month-on-month and up only 3% year-on-year, mainly due to the sluggish performance of the game business (games+mining graphics cards) (revenue decreased by 44% month-on-month and decreased by 33% year-on-year). Overall revenue was much lower than NVIDIA’s previous forecast of $8.1 billion, and the stock closed down 6.3% (it fell over 9% in intraday trading), which also dragged down the Nasdaq. The company will hold a financial report meeting on August 24th.

　　[overnight U.S. stocks]

　　Among large-scale technology stocks, Apple fell 0.29%, Microsoft fell 0.92%, Amazon fell 0.99%, Google A fell 0.14% and Meta rose 1.88%.

　　Among the large Chinese stocks, Alibaba fell by 1.86%, Baidu by 1.03%, Netease by 0.54%, Pinduoduo by 5.13%, Weibo by 1.42%, iQiyi by 0.26%, Good Future by 4.09% and New Oriental by 8.57%.

　　[global index]

　　[global goods]

　　The main contract of crude oil in the previous period closed at 669.20 yuan per barrel overnight, up 1.72%.

　　Overnight, the Shanghai gold main contract closed up 0.73% to 391.00 yuan per gram; The main contract of Shanghai Bank closed up 3.51% to 4,518.00 yuan per kilogram.

　　[overnight news]

　　American consumers’ inflation expectations dropped significantly in July, and the inflation expectations will drop to 6.2% in the coming year.

　　The sharp drop in gasoline prices and the growing belief among Americans that the rapid rise in food and housing prices will also subside in the future, American consumers’ expectations of future inflation dropped significantly in July.

　　According to the monthly consumer expectation survey of the Federal Reserve Bank of new york, the inflation expectation of the respondents in the coming year is 6.2%, which is the largest monthly decline in the survey history; 3.2% in the next three years. Although these figures are still high compared with the historical range, they are significantly lower than the results of 6.8% and 3.6% in the June survey.

　　In August, the investor confidence index in the euro zone recorded another negative value, and the economic downturn expectation intensified.

　　According to the latest report of German market research institute Sentix, the investor confidence index in the euro zone recorded -25.2 in August, slightly rising from the previous value of -26.4, but still lower than market expectations.

　　According to the report, "the euro zone economy is still in a difficult situation. A slight rebound does not mean that the alarm is lifted, and the possibility of recession is still high."

　　EU submits "final text" on resuming the implementation of the Iranian nuclear deal.

　　On Monday, the EU submitted a "final text" on resuming the implementation of the 2015 the Iranian nuclear deal to the participants in the negotiations on resuming the implementation of the comprehensive agreement on the Iranian nuclear issue, and expected all parties to make a political decision on this "final text".

　　Borrell, the EU’s High Representative for Foreign Affairs and Security Policy, posted on social media that all the contents that can be negotiated have been negotiated and are now written into the "final text". All parties need to make political decisions on every technical issue and every detail in the "final text". If there is no objection, you can sign the agreement.

　　The United States seized a Russian oligarch’s private jet worth $90 million

　　According to CCTV news, foreign media reported that the U.S. federal prosecutor had taken action to seize Russian oligarch Andrei Skoch’s Airbus A319 worth $90 million.

　　According to reports, Andrei Sarkozy is known as "the richest man in Duma" and has been a member of the Russian National Assembly since 1999. The United States has imposed sanctions on him since 2018, claiming that Sarkozy has "long-term ties with Russian organized criminal groups". After the conflict between Russia and Ukraine broke out, the United States imposed further sanctions on Sarkozy and its assets.

　　USAID: Ukraine will receive an additional $4.5 billion in funding.

　　On August 8, local time, the United States Agency for International Development (USAID) issued a statement saying that it would provide an additional $4.5 billion to the Ukrainian government, bringing the total amount of US aid to Ukraine since the outbreak of the Russian-Ukrainian conflict in February to $8.5 billion.

　　According to the statement, the funds will flow to the Ukrainian government in batches through the coordination of the World Bank and the US Treasury Department, and the first batch of funds of 3 billion US dollars will be paid from August.

　　The strong employment report raised the Fed’s expectation of raising interest rates by 75 basis points, and then became the basic situation. Citigroup even thought that raising interest rates by 100 basis points.

　　Faced with the strong employment report released last Friday, economists from JPMorgan Chase, Evercore ISI and LH Meyer think that the Fed may raise interest rates more sharply this year, and Citigroup even expects the Fed to raise interest rates by a full percentage point in September.

　　Michael Feroli of JPMorgan Chase and Derek Tang of LH Meyer now predict that the Fed may raise interest rates by 75 basis points at its meeting on September 20-21, compared with the previous forecast of 50 basis points. Evercore analysts led by Krishna Guha expect to increase by 25 basis points this year and raise the upper limit of the target range of the federal funds rate to 3.75% by December.

　　[company news]

　　NVIDIA’s revenue in the second quarter is expected to be 6.7 billion US dollars, resulting in a 19% decline from the previous month.

　　NVIDIA said that due to the sluggish game business, revenue in the second quarter will drop by 19% from the previous quarter, only increasing by 3% year-on-year, reaching $6.7 billion, far below the company’s previous guidance of $8.1 billion, which caused the company’s share price to fall by more than 6% (once fell by more than 9% in intraday trading).

　　NVIDIA predicted that the game business revenue in the second quarter will reach 2.04 billion US dollars, down 44% from the previous month and down 33% from the same period last year. In contrast, data center business revenue will reach 3.81 billion US dollars, up 1% from the previous month and up 61% from the same period last year.

　　Federal Aviation Administration: Delivery of Boeing 787 Dreamliner will be restarted in "the next few days"

　　The Federal Aviation Administration (FAA) said on Monday that Boeing is expected to resume the delivery of its 787 Dreamliner in the next few days.

　　Since the end of 2020, the Boeing 787 Dreamliner has been found to have many quality problems, and the delivery has almost stopped.

　　The FAA said in a statement: "Boeing has made necessary changes to ensure that the 787 Dreamliner meets all certification standards. The FAA will inspect each aircraft before issuing airworthiness certificates and approving delivery. "

　　Ruixing’s revenue in the second quarter increased by 72% year-on-year, and its profit margin greatly improved, with nearly 7,200 stores.

　　Luckin Coffee’s total net income in the second quarter was 3,298.7 billion yuan, a year-on-year increase of 72.4%. There were 615 new stores in this quarter, and the total number of stores reached 7195.

　　According to the financial report, as of the second quarter, there were 4,968 self-operated stores and 2,227 affiliated stores in Luckin Coffee. Luckin Coffee’s business growth capacity continued to improve, with the same-store sales growth rate of self-operated stores reaching 41.2%. In addition, the profitability of Luckin Coffee has been further improved, with the profit rate of self-operated stores reaching 30.6%, which is significantly higher than that of 23.1% in the same period in 2021.

　　The average number of trading customers in this quarter increased by 68.6% year-on-year to 20.7 million. According to American Accounting Standards (CAAP), the operating profit of Luckin Coffee in the second quarter was 241.6 million yuan, and the operating profit rate under American Accounting Standards (GAAP) was 7.3%, while the loss in the same period in 2021 was 47.5 million yuan.

　　Alibaba: Voluntary conversion to dual major listing on the Hong Kong Stock Exchange is expected to be completed before the end of the year.

　　Alibaba announced on the Hong Kong Stock Exchange that it would voluntarily switch to dual major listing on the Hong Kong Stock Exchange, and this application has been confirmed by the Hong Kong Stock Exchange. The effective date of the major conversion is expected to be before the end of 2022.

　　Ali said that after the relevant procedures are completed, Alibaba will become a dual-listed company with american depository receipts on the new york Stock Exchange and ordinary shares on the Hong Kong Stock Exchange.

　　At that time, American-listed depositary shares and Hong Kong-listed common shares can be exchanged, and investors can continue to choose to hold Alibaba shares in one form or another.

　　Cctv news: Pay attention to the situation of valsartan in Zhejiang Huahai Pharmaceutical Company. Yesterday (July 29th), the spokesperson of National Medical Products Administration introduced the situation of trace N- nitrosodimethylamine (NDMA) impurities detected in valsartan raw materials of Zhejiang Huahai Pharmaceutical Co., Ltd.　

　　On July 6th, Zhejiang Huahai Pharmaceutical reported to National Medical Products Administration that a small amount of N- nitrosodimethylamine (NDMA) impurities were detected in the raw materials of valsartan for export, and voluntarily disclosed relevant information to the public according to relevant regulations and requirements.

　　Zhejiang Huahai Pharmaceutical Co., Ltd. immediately suspended the release and delivery of all valsartan raw materials in the domestic and international markets after detecting the impurity, and initiated the measures of voluntary recall. As of July 23, Zhejiang Huahai Pharmaceutical has completed the recall of all raw materials in China.

　　In 2012 and 2013, the current process of raw materials of this enterprise was approved by the European Drug Administration (EMA) and the US Food and Drug Administration (FDA) respectively.

　　Since July 6th, National Medical Products Administration has maintained close communication and contact with the European Drug Administration and the US Food and Drug Administration, paid close attention to the announcements and trends of risk assessment issued by international regulatory agencies, and organized experts to carry out risk assessment.

　　According to the toxicological data, the maximum daily intake limit of N- nitrosodimethylamine is 0.1μ G, which is equivalent to the provisional reference limit value of 0.3ppm by the European Drug Administration (calculated by taking 320mg valsartan daily).

　　According to the above-mentioned limit value, National Medical Products Administration conducted risk investigation on all the seven domestic manufacturers of valsartan raw materials (including Zhejiang Huahai Pharmaceutical). Except for the impurity of N- nitrosodimethylamine in valsartan raw materials of Zhejiang Huahai Pharmaceutical, the impurity detection value of N- nitrosodimethylamine in other domestic manufacturers of valsartan raw materials was lower than the limit value or was not detected.

　　There are 6 pharmaceutical manufacturers involved in the use of valsartan in Zhejiang Huahai Pharmaceutical:

　　The valsartan capsule (National Medicine Zhunzi H20103521) produced by Hunan Qianjin Xiangjiang Pharmaceutical Co., Ltd. has not yet left the factory.

　　The impurities of N- nitrosodimethylamine in the listed products of the other five manufacturers exceeded the limit, namely

　　Valsartan Hydrochlorothiazide Capsule of Chongqing Kangkeer Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20080097)

　　Valsartan dispersible tablets of Hainan Huanglong Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20050508)

　　Valsartan dispersible tablets of Harbin Sanlian Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20061058)

　　Valsartan Hydrochlorothiazide Dispersible Tablets of Jiangsu Wangao Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20090262)

　　Valsartan dispersible tablets of Shandong Yijian Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20090319)

　　The above five preparation manufacturers have stopped using the raw materials of Valsartan of Huahai Pharmaceutical and recalled relevant drugs according to regulations.

　　National Medical Products Administration has asked all provincial food and drug supervision and management departments to urge relevant preparation manufacturers to take recall measures, and disclose relevant recall information on the websites of five manufacturers, including the contact numbers of the enterprises responsible for the recall.

　　In order to facilitate the public to know in time whether the Valsartan drugs being used are within the scope of recall, five manufacturers have cooperated with information technology companies and launched the code scanning inquiry function at 22: 00 on July 26, 2018. The product traceability code can be scanned through the mobile APP to realize instant inquiry.

　　National Medical Products Administration spokesman stressed that besides the above five preparation manufacturers, other valsartan preparation products are not included in the recall.

　　At present, European Union and other multinational drug regulatory agencies believe that N- nitrosodimethylamine belongs to Class 2A carcinogen (that is, there is sufficient evidence in animal experiments, but the evidence is limited), and it may be exposed to this substance in daily life (such as preserved food). Analysis of the drugs involved this time will not cause serious health risks to patients, but for safety reasons, risk control measures such as stopping sales and recalling should be taken.

　　On July 27th, FDA issued a notice that patients taking recalled valsartan should continue to take the current drugs until doctors or pharmacists provide alternative drugs or different treatment schemes.

　　A spokesman for National Medical Products Administration reminded that patients who are taking valsartan drugs must not stop taking them without authorization, because the risk of stopping taking them without authorization is more direct and serious for patients with hypertension. Whether to stop taking medicine or change medicine must be carried out under the guidance of a doctor. You can contact a doctor to replace other drugs containing valsartan that are not involved in the recall or choose other drugs for alternative treatment.

　　National Medical Products Administration requires the relevant provincial food and drug supervision and management departments to continue to follow the relevant provisions of the Measures for the Administration of Drug Recall, urge enterprises to do a good job in product recall and protect people’s drug safety.

　　Bright picture

　　[educational perspective]

　　The epidemic has caused many inconveniences in finding jobs.

　　For most college students who will graduate in 2020, COVID-19, an unfamiliar word, will be engraved in their memories along with their tortuous job hunting experience. Because of the development of the epidemic in COVID-19, in order to protect students’ health and life safety and prevent the spread of the epidemic, the national education administrative departments and universities have taken emergency measures to limit the flow of personnel, and all kinds of campus recruitment activities have been suspended.

　　According to the practice of previous years, the coming March and April was originally the peak period for fresh college students to apply for jobs and sign contracts, but because of the epidemic, the employment and recruitment activities of college students were silent this spring.

　　The superposition of all these unfavorable factors undoubtedly affects the job selection of college graduates and the selection of talents by employers, which invisibly increases the pressure of college students’ employment.

　　For China’s economic development, the impact of the COVID-19 epidemic on the economy is bound to have a chain reaction, which will be transmitted and reflected in the employment sector — — Not only the temporary communication difficulties between graduates and enterprises and the inability to carry out recruitment activities, but also the demand for employers may be reduced. Of course, some industry sectors, such as medical and health care, environmental engineering, chemical technology and other employment needs are likely to increase.

　　The interview and employment pressure of job-seeking students has increased sharply. The silence in March and April, the peak of job hunting, dealt a heavy blow to college students’ employment signing. Because some students and employers have drawn up their initial intentions and need to go to the employer for an interview, but now the unit can’t operate normally, students can’t go out, and the recruitment and interview plans of some companies have also changed, and students are in a dilemma.

　　Stuck by the time limit, students who are pursuing further studies are in a dilemma. The postponement of the re-examination of the postgraduate entrance examination has a great influence on students. The uncertainty of whether they can pass the initial examination and whether they can be admitted after the re-examination makes most postgraduate students anxious, fearing that they may miss favorable employment opportunities after falling out of the list.

　　At the same time, taking into account epidemic prevention and employment, colleges and universities are facing multiple tests. Up to now, due to the pressure of economic adjustment, the employment rate of graduates who originally signed up to implement employment units is not optimistic. The arrival of the epidemic has made colleges and universities more pressure on epidemic prevention and teaching adjustment under the new situation than before, and the pressure on subsequent employment guidance has undoubtedly increased accordingly. The impact and impact of these pressures on local colleges and universities with the majority of local students will be less than those with scattered students’ origin and employment destination.

　　To cope with the pressure of employment, take many measures to promote Qi Li.

　　Employment must be promoted by the government, universities, employment enterprises and units, giving full play to their respective advantages in resources, channels and experience. As for the universities directly facing the above employment pressure, how to deal with this year’s new situation?

　　Colleges and universities should not panic when they serve college students’ employment under pressure.At present, we can see that under the decisive and correct decision-making and leadership of the CPC Central Committee, the understanding of COVID-19 has gradually deepened, and the fight against the epidemic has achieved initial results. The confirmed cases and suspected cases in high-incidence areas have been running at a low level, and the epidemic situation in most areas has been effectively controlled. I believe that with the support and encouragement of various supporting policies of the state, all economic construction activities will be carried out in an orderly manner. This is the biggest good news for economic activities directly related to employment.

　　College students start job hunting and employment rationally and calmly.Then, after the epidemic is controlled, the employment activities of college students that have been temporarily suspended will be restarted, and the suppressed demand for employment will be released again. Therefore, for colleges and graduates, they should gradually become rational, sober and brave from the initial panic, anxiety and sorrow, and there is no need to panic at all. They should have full confidence and calmly and objectively carry out the employment work during the epidemic period according to the arrangement of the national education administrative department.

　　Enterprises should promptly strengthen the organization of online employment recruitment activities.Before the epidemic has been completely controlled, in order to prevent large-scale gathering of people, the on-site recruitment activities of various college graduates have been suspended. In this case, colleges and universities should vigorously promote the development of online employment activities, and guide more enterprises to organize more online recruitment activities in a planned way to provide graduates with job opportunities; Students can get job information and enjoy online employment services by browsing national and provincial employment platforms, university employment networks and social recruitment websites.

　　Multi-party cooperation to explore innovative employment channels.Colleges and universities should take the initiative to coordinate relevant parties and further organize and implement grassroots projects such as the special post teacher plan, the university student village official, the three supports and one support, and the university student volunteer service plan for the western region; Encourage college students to join the army and serve national defense; Further implement preferential policies such as tuition subsidy for grassroots employment and encourage graduates to work and start businesses at the grassroots level; Establish a docking platform for school-enterprise cooperation and strengthen the docking of talent supply and demand in key areas, major projects, major projects and important fields; Further explore the employment opportunities created by the deep integration of the Internet, big data, artificial intelligence and the real economy, and support graduates to achieve multi-channel employment; Call on employers to hold campus job fairs, take recruitment tests exams, receive graduates’ resumes and practice training through the Internet and other more flexible ways.

　　Focus on strengthening the focus on helping students from difficult families.Colleges and universities must actively design and provide one-on-one assistance to poor family graduates, physically disabled graduates and other groups, and carry out targeted job promotion. It is urgent to form a team of relevant university leaders, fully grasp the latest trends of students, regional economy and professional fields, open a hotline for employment consultation and help, and develop a number of online employment guidance courses to do a good job in promoting graduates’ employment, enterprise docking and psychological counseling.

　　The epidemic will eventually pass. As long as all parties face it confidently, calmly, optimistically and scientifically, with the overall victory in the fight against the epidemic, the employment situation of college graduates in 2020 will certainly improve and usher in "spring"!

　　 (Author: Zong Cheng, a postdoctoral fellow at China Academy of Educational Sciences)

The year 2023 is of great significance to the drugs for autoimmune diseases and even to the global innovative drug market. With the expiration of patents in key markets, Hummel (adalimumab) will officially hand over the title of global sales champion for 11 years, and the first generation of "drug king" will officially end.

Due to the complex pathogenesis, the number of patients with autoimmune diseases is large and it is difficult to cure. The long-term or even lifelong demand for drugs has spawned a huge market for autoimmune drugs, which has become a hotbed for the growth of heavy drugs.

Under the demonstration effect of "drug king", major pharmaceutical companies around the world have been scrambling for layout in recent years. At present, breakthroughs have been made in the development of new drugs for potential targets such as JAK and interleukin, and the free drug track is expected to usher in a new round of competition. Local innovative drug companies try to gain a place in the domestic free drug market through differentiated distribution of indications and continuous optimization of safety.

The market for self-exempted drugs continues to grow steadily.

Autoimmune system diseases refer to diseases caused by immune response to autoantigens and self-tissue damage. Genetic defects and environmental factors are all important links in inducing autoimmune diseases. The complex disease mechanism leads to a wide variety of autoimmune diseases and a large patient base. At present, there are more than 100 known main disease types, including psoriasis, atopic dermatitis, compulsory spondylitis, rheumatoid arthritis and systemic lupus erythematosus.

As a chronic disease, autoimmune diseases usually do not directly kill people, but it is also difficult to cure them. Such as compulsory spondylitis, systemic lupus erythematosus, etc., once suffering from it, it will be difficult to reverse, which is called "undead cancer". Patients need long-term or even lifelong medication, thus giving birth to the long-term and stable growth of market demand for self-immune drugs.

Based on the financial report data of major pharmaceutical companies, in 2022, there were 22 self-disease-free drugs in the list of TOP100 drugs with global sales scale, of which 10 drugs exceeded $3 billion and the total sales exceeded $70 billion.

According to the statistics of AARDA, patients with autoimmune diseases account for 7.6%-9.4% of the global population in recent years. Jost Sullivan’s statistics show that there are nearly 500 million patients with various kinds of self-immune diseases in the world, and the global self-immune drug market will reach about 132.3 billion US dollars in 2022, which has become the second largest disease market after cancer.

Jost Sullivan predicted that by 2030, the global self-exempted drug market is expected to reach US$ 176 billion, with a compound annual growth rate of 3.6% from 2022 to 2030. Among them, the self-exempted drug market in China is expected to reach nearly US$ 25 billion in 2030, a tenfold increase compared with 2020, which is an important incremental source of global self-exempted drugs.

The "King of Medicine" made a curtain call, and new drugs rose one after another.

Treatment strategies for autoimmune diseases include inflammation alleviation and immunosuppression. Although non-steroidal anti-inflammatory drugs, corticosteroids and anti-rheumatic drugs have good anti-inflammatory effects, they are difficult to fundamentally stop the development of the disease, and they are easy to relapse after stopping taking drugs. However, traditional non-selective immunosuppressants such as cyclosporine and methotrexate are not only slow to take effect, but also lead to a higher risk of cancer. As new immunosuppressants, bio-targeted drugs can selectively suppress the immune system, ensuring the safety while improving the curative effect, which is the most promising.

Hummel is a fully humanized monoclonal antibody against TNF-α developed by AbbVie Company, which was approved by FDA in 2002 for the treatment of rheumatoid arthritis. Because of its remarkable efficacy and safety in the treatment of self-immune diseases, Hummel’s indications have been expanding since its listing, and it has gradually become the highest-selling self-immune drug, and ranked first in global drug sales in 2012. Since then, through a series of marketing and patent strategies, AbbVie has made great efforts to extend the life cycle of Hummel, and promoted the drug to become the "drug king" in the world for ten consecutive years, with accumulated sales exceeding 200 billion US dollars since its listing.

With the official expiration of the patent in the United States in 2023, the market share of self-exempted drugs controlled by Hummel was quickly robbed by many similar biological drugs. According to AbbVie’s third quarterly report in 2023, nearly 10 biologically similar drugs have entered the market. As a result, the cumulative sales of Humele in the first three quarters of 2023 was only $11.1 billion, a sharp drop of 29.1% year-on-year. Nature Reviews Drug Discovery, a well-known medical journal, predicts that the annual sales of Hummel in 2023 will be about $13.6 billion, less than 60% of Keytruda of Top1, and the first generation of drug kings will soon "abdicate".

Corresponding to the curtain call of "King of Medicine", many innovative drugs with potential targets have risen rapidly, and a new generation of heavy drugs is coming out.

According to the global sales forecast of innovative drugs in 2023 recently released by Nature Review of Drug Discovery, the sales of self-immune biological agents Dupixent and Stelara, which target IL-4/IL-13 and IL-12/IL-23 respectively, have increased rapidly, and it is estimated that they will rank among the Top10 with sales of more than 10.6 billion US dollars.

Abbey, the owner of Hummel, is also actively looking for the next generation of self-free drugs. The sales amount of oral JAK1 inhibitor Rinvoq (upatinib) and IL-23 monoclonal antibody Skyrizi (risazhuzumab) under the company has increased rapidly in recent years. In 2022, the total sales revenue has exceeded 7 billion US dollars, and the growth rate is higher than 50%. Abbway predicts that by 2027, the combined sales revenue of these two drugs is expected to exceed the sales peak of Hummel’s $20 billion.

Domestic pharmaceutical companies compete for the next potential target.

Compared with the highly competitive innovative cancer drugs, the number of participants and innovative drugs in the self-exempt drug market is still relatively limited, and the overall market competition pattern is good. However, the huge unmet clinical needs and the continuous improvement of the diagnosis rate in China have also attracted more and more domestic innovative pharmaceutical companies to enter the drug-free track, and tried to gain a competitive advantage by virtue of differentiated layout potential targets and occupy a place in the domestic market.

So far, the targets of self-immune targeted drugs mainly focus on TNF-α, JAK, interleukin and BlyS, and the main indications are common rheumatoid arthritis, psoriasis, systemic lupus erythematosus and so on. Among them, targeted TNF-α drugs are the most classic targeted drugs for autoimmune diseases because of their early market time, mature targets and the widest range of indications. However, this track has basically been controlled by foreign-funded enterprises, and the development space of local manufacturers that follow is relatively limited. Domestic innovative drug companies have turned their research direction to JAK, interleukin and other targets.

Interleukin and its receptors are important target families in human immune regulation, and play an important role in various immune and inflammatory reactions. Psoriasis is the main indication of interleukin targeted drugs at present, and some targeted drugs have been proved to be safer than TNF-α antagonists in certain circumstances.

At present, the effective interleukin-targeting drugs listed in the world include tosilizumab targeting IL-6, ulinuzumab targeting IL-12/23, skukiyuzumab targeting IL-17A and gusechizumab targeting IL-23. Among domestic enterprises, Hengrui Pharma (600276.SH), Zhixiang Jintai (688443.SH) and Kangfang Bio (09926.HK) all have approved the listing of interleukin-targeted biological agents, and Quanxin Bio (01883.HK), Livzon Group (000513.SZ), Junshi Bio (688180.SH) and Cinda Bio.

JAK signaling pathway plays a very important role in autoimmune, tumor, hematological and other diseases, and it is one of the promising potential targets. Because the first generation of JAK inhibitors showed great toxic and side effects in the treatment process, the main research and development direction of major pharmaceutical companies is the second generation of JAK inhibitors targeting JAK1, JAK3, TYK2 and other targets with high specificity.

In clinical trials, the second generation JAK inhibitors have shown good data in terms of safety and efficacy. Among them, Upatinib, a JAK1 inhibitor listed by AbbVie, showed a better key remission index under the same safety in the head-to-head experiment of treating rheumatoid arthritis and adalimumab. In the first three quarters of 2023, the sales amount of Upatinib has reached US$ 2.71 billion, exceeding the annual performance in 2022. AbbVie expects that the drug is expected to achieve sales of more than $7.5 billion in 2025.

In view of the good performance of this target, the research on JAK-specific subunits has become one of the important directions of global innovative drug companies. Among domestic enterprises, Hengrui Pharma, Dizhe Medicine (688192.SH) and Nuocheng Jianhua (688428.SH) are in the top of the research and development progress. Among them, Nuocheng Jianhua recently disclosed that its TYK2 inhibitor ICP-488 under research has completed the first clinical administration for psoriasis patients in Phase II. ICP-332, another self-immune drug with the same target, disclosed the second phase clinical data of moderate and severe atopic dermatitis indications in December 2023. Orient securities believes that domestic JAK-targeted self-immune drugs are expected to achieve rapid volume increase after marketing through differentiated distribution of indications and optimized breakthrough in safety.

BlyS is one of the key factors in the differentiation and maturation of B lymphocytes, which is the most important effector cell of autoimmune diseases. By inhibiting BlyS, many autoimmune diseases can be treated. At present, there are two BlyS inhibitors on the market, namely, GlaxoSmithKline’s Beliyuzumab and Rongchang Bio (688331.SH)’ s Tatasip. The main indications are systemic lupus erythematosus, and the market structure is good.

Tetasip is an innovative drug of BLyS/APRIL dual-target fusion protein independently developed by Rongchang Bio. Clinical data show that the drug has the same level of efficacy and safety as Belizumab. In 2021, National Medical Products Administration conditionally approved Tatasip for the treatment of adult patients with systemic lupus erythematosus, and included it in the 2022 edition of the National Medical Insurance Catalogue; In November, 2023, the treatment of Tatasip in this indication was fully approved.

Rongchang Bio is also continuing to promote the clinical research on other indications of Tatasip, and the research on many indications such as rheumatoid arthritis, Sjogren’s syndrome and multiple sclerosis has entered the final clinical stage. In August, 2023, Tatasip was used to treat patients with rheumatoid arthritis in Phase III, and submitted an application for domestic marketing. On December 20th, the global multicenter Phase III clinical IND of Tatasip in the treatment of active primary Sjogren’s syndrome in adults was approved by the FDA of the United States, and clinical research will be carried out in many countries and regions around the world. The continuous enrichment of the clinical pipeline of Tetasip is expected to consolidate the innovative product matrix of the company and promote the continuous growth of the company’s income.

Gree Electric vision china data map

Gree Electric’s extra year-end award of 200 million yuan is actually "a Gree G3 mobile phone for employees"?

On January 31, Gree Electric issued an official statement to clarify that the company was concerned about the false news circulating on the Internet, such as "On January 28, Chairman Dong Mingzhu said at the Gree 2024 Global Dream Festival that an extra year-end bonus of 200 million yuan was actually sent to Gree mobile phones".

Gree Electric mentioned two points in the statement: First, in order to better adapt to the company’s work software, facilitate mobile office work and improve work efficiency, the company decided to provide each employee with free work mobile phones (including free communication packages), which will be distributed in batches around the Spring Festival.

Second, the year-end bonus of 200 million yuan increased by the company has nothing to do with the free work mobile phone. The scope of the increased year-end bonus does not include middle and senior cadres, and the increased part is inclined to the front-line employees.

Gree Electric said that the company reserves the right to investigate the legal responsibility of media and individuals who spread rumors and rumors according to law.

Previously, a related person in Gree Electric said, "Fake, nonsense."

On January 28th, Dong Mingzhu, Chairman and President of Gree Electric, said at the Gree 2024 Global Dream Festival that her performance reached a new high last year, creating a profit of 29 billion yuan. At the same time, she also announced that she would "give employees an extra 200 million yuan for the year-end bonus".

However, while Gree Electric’s heroic 200 million year-end bonus has aroused widespread concern, there are also questions about this year-end bonus on the Internet.

On January 30th, there were rumors on the Internet that the 200 million year-end bonus was actually "one Gree G3 mobile phone for each person" and "giving employees more G3 mobile phones with a value of 200 million". Moreover, these G3 mobile phones "can’t be sold at the price of idle fish only around 300 yuan, but the company has issued 80,000 sets at a price of 3,599 yuan".

For these rumors, Gree Electric insiders told the media: "The fake, extra 200 million bonus is not deducted by G3 mobile phone, but a real year-end bonus."

Regarding the rumor that "Gree’s year-end award is deducted with points", Gree also said that "the year-end award is not issued in the form of points".

On the short video platform, some Gree Electric employees have already got their own year-end awards, which are divided into two parts: cash+points for products. The employee of Gree Electric’s subsidiary got a year-end bonus of 4,500 yuan in cash, and also exchanged the points for products such as rice cookers, health pots and electric fans, with a value of about 4,000 yuan.

At the Gree 2024 Global Dream Festival, Dong Mingzhu said that 2023 was the best year for Gree Electric since its founding 33 years ago, and the corporate tax revenue reached a record high. This achievement can not be separated from the hard work of every employee and the teamwork spirit.

Dong Mingzhu said that in order to let employees fully enjoy the fruits of the company’s development, he decided to give employees an extra 200 million yuan for the year-end bonus. At the same time, Dong Mingzhu also expressed the hope that the tax revenue for the country will exceed 20 billion in 2024.

Dong Mingzhu also said that Gree Electric doesn’t care about the stock price, because it doesn’t depend on the stock price to survive.

Previously, the performance forecast released by Gree Electric showed that the total operating income in 2023 is expected to be between 205 billion yuan and 210 billion yuan, up by 7.8% to 10.4% year-on-year; It is estimated that the net profit attributable to shareholders of the parent company will be between 27 billion yuan and 29.3 billion yuan, up 10.2% to 19.6% year-on-year; It is estimated that the net profit attributable to shareholders of the parent company after deducting non-recurring gains and losses will be between 26.1 billion yuan and 27.8 billion yuan, up 8.8% to 15.9% year-on-year.

As of January 31st, Gree Electric rose 0.28% to close at 35.25 yuan.

Data map: Taiyuan, Shanxi, postal workers are sorting express delivery. China News Service reporter Zhang Yunshe

　　BEIJING, Nov. 12 (Xinhua) According to the official WeChat news of the State Post Bureau, on November 11, according to the monitoring data of the State Post Bureau, postal and express delivery companies handled 535 million express mail all day, which was three times the daily processing volume since the second quarter, with a year-on-year increase of 28.6%, a record high.

　　It is estimated that the peak season of "double 11" this year will last from November 11th to 18th. During the peak period, the whole industry will handle 2.8 billion pieces of express mail. The whole industry still regards "peak-shifting delivery and balanced promotion" as the core mechanism, and strictly controls the peak delivery volume according to the delivery carrying capacity of each enterprise and the planned push volume. Through big data platforms such as postal industry safety supervision information system and e-commerce collaborative platform, the State Post Bureau will pay close attention to the whole network operation in real time, guide enterprises to control the dispatching rhythm, and moderately extend the delivery time limit of double 11.

　　In order to achieve the goals of "two noes" (no paralysis of the whole network and no explosion of important nodes) and "three guarantees" (smooth flow, safety and stability), on the basis of the existing service capacity, the whole industry temporarily hired nearly 400,000 people and 120,000 vehicles, and added more than 3.6 million square meters of processing sites and more than 3,000 sets of automatic and semi-automatic sorting equipment. Technically, unmanned warehouses, drones and unmanned vehicles have gradually achieved mass production and large-scale application. More than 200 intelligent distribution centers have been built nationwide, and many unmanned warehouses have been set up by enterprises such as SF, JD.COM, Cainiao and Suning. A large number of heavy-duty storage robots and distribution robots have been promoted and applied in different occasions, and the "illegal operation AI intelligent identification system" that automatically identifies violent sorting behavior has been put into operation in some enterprises. In urban areas, 82,000 terminal public service stations have been built nationwide, and more than 380,000 sets of intelligent express boxes have been deployed, effectively supplementing the terminal service capacity of express delivery. The establishment of 59,000 rural express public pick-up and delivery points will better meet the delivery service needs of rural residents. In terms of international business, the outlets of express delivery enterprises in more than 60 countries, overseas warehouses covering more than 50 countries and regions and new international routes will play a very positive role. In terms of after-sales, AI intelligent customer service robots that can achieve 24-hour service have been put into use in many enterprises, which will effectively improve customer service capacity during peak hours.

　　In response to the consumer’s concern about the "last mile" in rural areas in the peak season, the relevant person in charge of the State Post Bureau pointed out that up to now, express outlets have covered more than 30,000 towns and villages, and the coverage rate of express outlets in towns and villages nationwide has reached 96%, effectively improving the distribution capacity in rural areas. At the same time, the State Post Bureau specially issued the "Implementation Plan for Accelerating Express Delivery to the Countryside" this year, intensified efforts to build a terminal delivery service system consisting of home delivery, box delivery and platform delivery, and constantly promoted the integrated development of transportation and postal express delivery, and promoted the coordinated development of express delivery and rural e-commerce. In addition, since April this year, two rounds of cleaning up and rectifying illegal charges for express terminal services have been deployed nationwide, effectively safeguarding the legitimate rights and interests of farmers. On the issue of express packaging, with the help of "double 11", the industry has vigorously promoted the "9571" project of green development, continuously reduced the secondary packaging of e-commerce express mail, and deployed 27,000 standardized express packaging recycling devices at terminal service stations. At the same time, enterprises have done a lot of work in reducing the use of packaging materials, promoting electronic face sheets, circulating transfer bags and packaging recycling boxes.

Special topic: Wenchuan earthquake in Sichuan

　　Yesterday was the first small holiday after the Wenchuan Earthquake. The sky is raining, and the earthquake relief continues, but strings of zongzi, sachets, calamus and mugwort leaves convey a warm festive atmosphere in this cool weather. On the first day of the Dragon Boat Festival holiday, while many citizens were reunited with their families, many people chose to go out and enjoy the holiday. They relaxed their pent-up feelings during their travels and experienced the still beautiful Sichuan for themselves.

Yesterday morning, hundreds of married couples took photos in Hejiang Pavilion as a souvenir.

　　Yesterday was the first small holiday after the Wenchuan Earthquake. The sky is raining, and the earthquake relief continues, but strings of zongzi, sachets, calamus and mugwort leaves convey a warm festive atmosphere in this cool weather. On the first day of the Dragon Boat Festival holiday, while many citizens were reunited with their families, many people chose to go out and enjoy the holiday. They relaxed their pent-up feelings during their travels and experienced the still beautiful Sichuan for themselves.

　　Emei Mountain: The number of tourists increased year on year.

　　Yesterday, Emei Mountain Scenic Area received more than 5000 tourists. "Obviously better than our previous expectations." The relevant person in charge of Emei Mountain Scenic Area introduced. Among the tourists who came to Emei Mountain yesterday, self-driving tourists became the main force. According to the statistics of Emei Mountain digital monitoring system, the number of self-driving vehicles that came to Emei Mountain yesterday reached 1768.

　　Among them, self-driving cars from Chengdu accounted for half. "Many of them are to relax." It is understood that in addition, there are more self-driving cars from Chongqing and Zhejiang, as well as from surrounding areas such as Meishan. Wang Xiaoqing, a tourist from Chongqing, came to Mount Emei for the first time. After coming down the mountain, he said that Mount Emei was more beautiful than he expected.

　　Team tourism is also recovering. Yesterday, there were six teams coming to Emei Mountain, and three in Chengdu and Chongqing respectively. "Since we held the Chengdu-Yule Line Boutique Conference two days ago, the travel agencies in Chengdu have sent delegations every day." Emei Mountain Scenic Area said that they are very confident in the tourism market after the earthquake.

　　According to statistics, Mount Emei received a total of 5,000 tourists yesterday, a slight increase compared with the same period last year. The hotel occupancy rate is over 60% on average. It is expected that the number of tourists will reach its peak at the Dragon Boat Festival today.

　　Chengdu: Tourists enjoy the Dragon Boat Festival.

　　The first Dragon Boat Festival holiday forecast issued by Chengdu Holiday Office shows that the tourist attractions and attractions in Chengdu that are unaffected and fully open have attracted a large number of tourists. Huaxiang Rural Residence in Hongsha Village in Jinjiang District received 15,000 tourists, Huanglongxi in Shuangliu County received 12,000 tourists, and Wenjiang Northern Ecological Zone received 8,000 tourists. Although the number of tourists is less than the previous small holiday, the rapid start of the market has made these scenic spots even "unexpected".

　　It is reported that there are 65 scenic spots (spots) that have been opened and received tourists in Chengdu except Dujiangyan, Pengzhou and chongzhou city. The "Dragon Boat Festival" held in Shuangliu, Wenjiang, Qionglai and other districts (cities) and counties, such as blessing, setting off river lanterns and eating zongzi, as well as rural tours in the suburbs of the city, also attracted many tourists.

　　At the same time, the Law Enforcement Brigade of the Municipal Tourism Bureau went to the major travel agencies and scenic spots in the city to inspect the safety precautions and market order, and focused on setting safety warning signs and unblocked safety passages to ensure the tourism safety during the Dragon Boat Festival holiday.

　　Travel Agency: More people will visit Sichuan!

　　After the earthquake, many travel agencies in Sichuan closed down or were semi-closed. However, with the arrival of the Dragon Boat Festival, many travel agencies in Chengdu received their first business after the earthquake. "Although the amount is small, we see hope in it." A staff member of the Provincial Youth Travel Service introduced. Before the Dragon Boat Festival, guests kept calling for advice, which surprised them. It is understood that during the Dragon Boat Festival, many citizens in Chengdu also traveled to other provinces by participating in tour groups. These routes are mainly Yunnan, Guilin, Guizhou and East China. Although the number is small, the citizens’ willingness to travel has gradually increased, which has enhanced the confidence of travel agencies.

　　According to the analysis of a senior person in the tourism industry, the overall travel situation of the Dragon Boat Festival is definitely worse than that of previous years. There are three main reasons. First, yesterday happened to be the college entrance examination, and many parents had to accompany their children to take the exam; Second, the general rainfall yesterday affected people’s mood for traveling; Third, after the earthquake, many people want to go home to reunite with their loved ones and spend the holidays at home. He believes that with people’s lives on the right track, more people will be willing to travel. "With the joint efforts of everyone, more people will come to visit the still beautiful Sichuan!" (Reporter Tao Ying Intern Huang Lian)

Image source: China Radio Network

CCTV News:"Family, less idle month, people twice as busy in June. At night, the south wind rises and the wheat is covered with yellow. " It’s the wheat harvest season in a year. Under the blue sky in the distance, golden wheat waves are surging. The newly harvested wheat is ground into fragrant flour and enters the kitchens of various households. ……

One out of every eight steamed buns eaten by more than 1.3 billion people in China comes from the wheat variety "Bainong Aikang 58", which is known as "the first wheat in Huanghuai". It is "Mai Da" Ru Zhengang who successfully cultivated this new wheat variety. He is the vice president of the School of Life Science and Technology of Henan University of Science and Technology, the director of the Henan Hybrid Wheat Engineering Technology Research Center, and the chief expert of wheat disease and pest resistance breeding in Henan Province.

Ru Zhengang often said: "As an agricultural science and technology worker, you can’t help farmers increase production and income. You are nothing!" His lifelong aspiration is to fill the granary of China with the power of science and technology.

Change the world with a "go against the sky wheat seed"

Food is scarce and farming is difficult. These childhood memories make Ru Zhengang have an indescribable feeling for wheat. He has always had a "wheat dream", "We must have enough food in Chinese, and the granary is full of our own wheat".

In 1981, Ru Zhengang, who graduated from agronomy, was selected by Professor Huang Guangzheng, a national expert who was famous in the breeding field at that time and won the second prize of national invention, and "pulled into" the breeding industry. Since then, it has been persistent for 36 years.

In order to find the root of the problem of wheat growth, Ru Zhengang ate and lived in the wheat field for several days. In order to ensure the accuracy of the data, he took the research team to manually thresh one by one; In order to understand the growth of wheat in various places, he traveled almost every wheat producing area in China.

In the process of breeding new wheat varieties such as "Aikang 58", Ru Zhengang explored and created a set of nearly complete scientific methods, theoretical systems and scientific research equipment and breeding platform established from it. In his breeding base, from the molecular biology laboratory to the artificial climate room, to the intelligent greenhouse, and then to the outdoor experimental field, it takes only a few minutes to be fully prepared. It is these few minutes’ path that shortens the time of wheat breeding by six years.

Ruzhengang successively cultivated and popularized many varieties such as "Bainong 62", "Bainong 64", "Bainong 160" and "Bainong Aikang 58", and the wheat varieties with stable and high yield filled the granaries of China, which also made the people happy. Ruzhengang has become an out-and-out "God of Grain".

The inspiration for scientific research propositions comes from ordinary people.

"All my scientific research topics and the inspiration and source of technological innovation come from ordinary people." Ru Zhengang traveled all over the country in most wheat fields, and no matter where he went, he never forgot to ask the villagers to "find fault" with their own seeds.

Can wheat be high-yielding and lodging-resistant? Can wheat be planted whenever it wants? The ears of wheat are big, can you make more grains? There are too many ears, can you make the straw shorter? The wheat straw is short, can it tolerate barren and drought? … … Seemingly harsh problems are thrown at him from time to time, and if Ru Zhengang gets the treasure, it will eventually turn into his most breakthrough and creative scientific research topic.

Many experts believe that the wheat yield in Huanghuai area of China has reached the "ceiling", and it is "even more difficult" to further increase the yield. Ru Zhengang’s thoughts and vision jumped to the northeast and Guangdong, Fujian and other places, hoping to find a record-breaking "artifact" in these places.

He constantly challenges himself and his limits. "Even though the frost of time has stained my temples and the knife of years has carved my forehead, why don’t I change my mind and be as heroic as yesterday?" Ru Zhengang expressed his ambition to charge for hybrid wheat breeding in poetic language.

Loving wheat is like your own daughter.

Ru Zhengang said that after 36 years of research, Wheat is actually like his daughter. It can understand his words, and he knows how it can be good, what it likes, what it doesn’t like, and how to make it happy.

"When you chat with wheat with your heart, you can feel the power of its life. Although the breeding work has to face failure 90% of the time, every improvement is an exploration of life and a spiritual enjoyment." Ru Zhengang said.

In Ru Zhengang’s view, wheat that can give people full returns, like wheat, is not wheat, but wheat of a work of art.. He wants to cultivate better wheat varieties, serve the strategic needs of modern agricultural production and national food security, and make new contributions to China’s food security and agricultural harvest. (Source: Ministry of Science and Technology)

　　The report of the 19th National Congress proposed that we should implement the new development concept and build a modern economic system.

　　In this regard, it is an important content to improve the system and mechanism of promoting consumption and enhance the basic role of consumption in economic development. In recent years, consumption has replaced investment as the first driving force of economic growth. Behind this, the innovation of payment methods brought by technical means has contributed greatly, and installment consumption is one of them. "Spend tomorrow’s money and enjoy today’s resources", whether it is life consumption such as digital electronics, home appliances and furniture, or service consumption such as training, tourism and entertainment, the tentacles of phased consumption have extended to all aspects of life.

　　Can installment consumption really make people enjoy life ahead of schedule easily? In the face of the network staging platform with spurt growth, how should consumers rationally stage and make good use of staging?

　　How hot is the market?

　　"It is no exaggeration to say that more than 90% of college students around me have used installment consumption, and food, clothing, housing and transportation, leisure and entertainment can all be solved by installment consumption."

　　"With children at home, the requirements for environmental sanitation are relatively high. My British Dyson vacuum cleaner was made of JD.COM white stripes. I often shop in JD.COM, and I can avoid paying interest by installments with coupons. It is much more economical to installment this year than to use a bank credit card. " Hao Yihang, an employee of a large state-owned enterprise in Beijing, is a fan of JD.COM IOUs. In his words, the slogan of "Consumption by stages, so that youth does not leave blank" attracts young people. The service of "Shopping first, paying later" and "30 days interest-free and staging at will" makes life consumption zero obstacles. "Consumption by stages is so cool!"

　　It reduces the pressure of one-time payment, and the relaxed shopping experience of "installment consumption" makes people happy. Hao Yihang said that Apple’s upcoming iPhone X, which he also intends to buy in stages, will not cause economic pressure and keep up with the trend. Staging consumption can make the monthly salary diversified and meet more new consumption needs.

　　The application method is flexible, the application procedure is convenient, there is no need for mortgage guarantee, and the approval speed is fast. With these characteristics, installment consumption quickly wins the favor of young people. The group represented by "post-90 s" grew up in the era of rapid development of the Internet, and accepted new technologies, new things and new products with a high degree. Pursuing efficiency and enjoying the present are their main consumption concepts, and this group is the main force of phased consumption.

　　"It is no exaggeration to say that more than 90% of college students around me have used installment consumption, and food, clothing, housing and transportation, leisure and entertainment can all be solved through installment consumption." Wang Peng is a junior in a university in Beijing. As early as when he first entered school, he began to use installment consumption, which was very convenient.

　　"This year, the money I signed up for the TOEFL training class was solved by stages. A TOEFL class costs more than 30 thousand yuan, and I ask my parents directly. I’m a little embarrassed. After using the staging platform, I will take out some money from the living expenses to repay the loan on schedule every month. Although there is some interest, I think it is worthwhile. " Wang Peng said that installment consumption is very common among college students, ranging from buying computers and mobile phones, education and training, to recharging phone bills and purchasing tickets for movies. They all like to choose installment.

　　In the past two years, the installment consumption platform has developed rapidly, especially the "internet plus installment consumption" platform has made up for the shortcomings of the traditional financial industry and served the groups that it failed to cover. Recently, the industry has welcomed the "regular army", banks have returned to the field of campus installment consumer credit, and the market is gradually standardizing. According to the forecast of relevant institutions, in the past five years, the average annual growth rate of installment consumption loans exceeded 20%.

　　How tempting is it?

　　Some merchants deliberately weaken the intermediary fees and induce consumers with the gimmick of "low threshold, zero interest and zero down payment", while the handling fee and service fee behind the products are actually higher than the interest.

　　"I obviously bought a 5799 yuan mobile phone, but the final repayment was more than 1700 yuan, which means that I spent nearly 8000 yuan on this mobile phone. Although the mobile phone was used more than one year in advance, it also paid a price. " Speaking of installment consumption, Zhao Xiaoxian, a chef in a restaurant in Hefei, Anhui Province, felt quite helpless. "It is very difficult for migrant workers like me who have no stable income to apply for bank credit cards. Online merchants lied to me that installment consumption threshold is low, procedures are convenient and interest is low. However, in the final calculation, the handling fees are higher than the interest. "

　　Dong Ximiao, a senior researcher at Chongyang Financial Research Institute of Renmin University of China, believes that the staged consumer market is developing rapidly, but the good and the bad are mixed, and many services are falsely advertised. The main purpose of staging business on the consumer platform is to expand users’ staging consumption, but the way to expand customers mainly comes from offline, and salesmen are easy to cheat and induce consumers for the sake of performance. Some merchants deliberately weaken the intermediary fees, and basically induce consumers with the gimmick of "low threshold, zero interest and zero down payment", while the handling fee and service fee behind the products are actually higher than the interest, which makes consumers feel miserable.

　　"The development of bank credit card business is relatively mature, and both the bank’s own risk control system and regulatory regulations are relatively perfect. However, the staged market has outstanding problems such as false propaganda and induced sales promotion in a fierce competitive environment. " Dong Ximiao said.

　　The installment consumption business of traditional commercial banks is standardized, mainly for consumers with stable income. Consumers have lower risk in using it and can effectively protect their rights and interests. The market gap that traditional commercial banks can’t cover has inspired the rise of Internet staging platforms, which have low thresholds and are aimed at social groups such as students and migrant workers. Coupled with the lag of regulatory policies, some disadvantages of installment consumption are constantly emerging.

　　For example, it is inevitable that unqualified consumers will default in time on the staging platform. Salespeople usually "salute before soldiers", but the effect of "collection" will be linked to performance. Because there is no standardized and legalized collection supervision policy at present, there are different kinds of violent collection behaviors in the staged market in reality.

　　The risk of disclosure of personal information makes installment consumption a safety hazard. Many people have encountered the problem of "receiving a collection message without a loan" and "being registered under an assumed name without registration". Most people will choose to ignore it, but doing so may affect consumers’ credit information and bring inconvenience to life and work.

　　In addition, from the consumer’s own point of view, staged consumption increases irrational consumption behavior. The amount of payment is reduced when the installment is consumed, which makes people have the illusion of spending less. The risk monitoring measures of many platforms are not in place, which may easily lead to credit problems such as overdue default by unqualified consumers.

　　How hard is it to choose?

　　By means of digital management and information sharing, we will strengthen the construction of credit system and prevent multi-head lending. Consumers should abandon vanity, comparison and blind obedience.

　　Behind the popularity of installment consumption, how can we rationally use and manage installment consumption?

　　Dong Ximiao believes that from the perspective of regulators, we should continue to carry out the special rectification of Internet finance and increase the cleaning and rectification of various stages of consumption platforms. For the platform with disorderly operation and chaotic management, if it fails to pass the filing in accordance with the regulations, measures should be taken to resolutely close it.

　　"At present, China’s credit information market still needs to be further improved, and the problem of long-term lending in the industry has not been completely solved. I believe that after the sharing of credit information data at the national level in the future, the whole industry will develop more healthily and orderly." Dong Ximiao said.

　　Credit data is an important link in risk control of phased consumption platform. Companies such as Taobao, JD.COM, Ctrip, etc., which have mastered the consumption scenes of hundreds of millions of users, have a large user base and many data resources, and can keenly capture the credit rating of users, and the cost of risk control is low. It is difficult for other financial platforms to accurately judge consumers’ credit information "Facebook".

　　"Now, for installment consumption, we have to put a lot of energy into risk prevention and control. It can be said that if the risk control is done well, the operating cost will be reduced, and the platform installment consumption interest rate will be reduced accordingly, thus attracting more quality customers." Gao Sheng, the public relations director of Staged Music Mall, said, "For example, we are now using artificial intelligence technology to develop ‘ Hawkeye ’ The intelligent risk control engine has more than 6,000 risk control model data variables, which can greatly improve the efficiency of risk control audit. "

　　Dong Ximiao suggested strengthening the construction of credit infrastructure, consolidating and enriching the credit information system by means of digital management and information sharing, improving the risk identification ability and risk prevention efficiency of installment consumption business, and enabling institutions and customers to enjoy more convenience in inclusive finance.

　　Banks and internet platforms should further improve or establish their own risk assessment and monitoring systems, objectively evaluate users’ consumption levels, and reasonably set credit lines; Staging consumption business institutions and platforms should correctly carry out marketing propaganda, put an end to false propaganda and induced propaganda, and set up necessary punishment mechanisms.

　　For consumers, we should carefully choose between bank credit card and installment payment platform, and try to choose a bank credit card with a more formal and perfect management system. If you choose the internet installment consumption platform, you should carefully check how to calculate the installment consumption interest, handling fee and service fee to prevent being charged with high interest and service fee.

　　"Installment consumption is a form of prepayment. If the repayment is overdue, it will not only increase the overdue interest, but also affect their credit rating, and even some financial institutions will terminate the installment business." Dong Ximiao said that consumers should abandon the bad mentality of vanity, comparison and blind obedience, carefully weigh whether the purchase of goods is reasonable, and formulate reasonable consumption and repayment plans to avoid over-consumption and over-consumption.

　　The insiders believe that for platforms with relatively standardized operations, the principle of "same business, same supervision" should be adopted to implement penetrating supervision, safeguard the legitimate rights and interests of financial consumers and protect the security of personal information. At the same time, we will strengthen the monitoring of the installment business it provides in terms of loan purposes and capital flow. Consumers should also enhance their risk awareness, strengthen the study of financial consumption and network security knowledge, and not disclose personal information at will to improve their ability to identify and prevent bad businesses.

　　What are the installment consumption platforms? (link)

　　In the past two years, staged consumption platforms have mushroomed, with different application scenarios and different characteristics.

　　JD.COM White Strip: the first Internet consumer financial product in the industry. You can enjoy a deferred payment period of up to 30 days or a payment by installments of up to 24 days if you use white bars for payment on JD.COM website. In recent years, JD.COM White Bar has been integrated into more consumption scenes, gradually covering the fields of renting, tourism, decoration, education, wedding and so on, extending from credit purchase service to providing credit consumption loans to provide credit consumption services for more consumers.

　　Ant Flower Garden: Born in the e-commerce department, it mainly supports multi-scene shopping. Its main application scenarios are Taobao and Tmall. Recently, it has also settled in most e-commerce shopping platforms, such as Amazon, Suning and local life service websites, such as word of mouth, Meituan, public comment, etc., and also involved some overseas shopping websites.

　　Staging music: Staging music in the staged shopping mall under Lexin Group is a new consumption platform of "e-commerce+finance". The shopping mall consumption scene involves 3C digital, outdoor sports, beauty care, eating, drinking and having fun, etc. It is the official authorized distributor of Apple mobile phones. The platform provides phased consumption services for mainstream consumer groups such as young people and white-collar workers.

　　Consumer finance company: it is a non-bank financial institution that provides unsecured and unsecured consumer loans. According to the "2017 Internet Consumer Finance Development Report and Outlook" by Suning Financial Research Institute, there are currently 22 licensed consumer finance companies in China, of which banks account for more than 90%. Consumer finance companies have offline channels, and offline outlets basically involve the whole country. Many licensed financial consumer companies have launched in-store consumption business to expand the financial consumer market. With the development of internet finance in recent years, many consumer finance companies have begun to cooperate with e-commerce platforms to develop online consumer credit business.

　　(Song Chao)

Notice on printing and distributing the vaccination work plan to deal with the recent infection situation in Covid-19
Guo Wei Ming Dian [2023] No.46

All provinces, autonomous regions, municipalities directly under the Central Government and Xinjiang Production and Construction Corps should respond to the joint prevention and control mechanism (leading group and headquarters) of novel coronavirus infection, and the State Council should respond to the members of the vaccination coordination group of the joint prevention and control mechanism of novel coronavirus infection:

The "Work Plan for Vaccination in Response to Recent Infections in Covid-19" is hereby printed and distributed to you, please conscientiously implement it according to the actual situation.

The State Council responds to novel coronavirus infection.Comprehensive group of epidemic prevention and control mechanism
April 6, 2023

(Information disclosure form: voluntary disclosure)

Respond to the recent Covid-19 infection epidemic.Vaccination work plan

In order to thoroughly implement the decision-making arrangements of the CPC Central Committee and the State Council, effectively respond to the recent epidemic situation in Covid-19, and ensure and safeguard people’s health, this work plan is formulated in combination with the epidemic situation, vaccine research and development, immune effect evaluation, population immunity level and other factors.

First, the target population

At this stage, the focus of vaccination is to fill the gap in immune level for different target groups and further reduce the risk of severe illness and death. The target population is as follows:

(a) people who are not infected and have not completed the established immunization program. Including uninfected people aged 3-17 who have not completed basic immunization, uninfected people aged over 18 who have not completed the first dose of booster immunization, and uninfected people aged over 18 who have not completed the second dose of booster immunization (high-risk people with infection, elderly people over 60 years old, people with serious basic diseases and people with low immunity).

(two) people who have been infected and have not completed basic immunization.

Second, the time interval and vaccine selection

(1) Time interval.

The uninfected target population completes the follow-up vaccination according to the established immunization program and its time interval requirements. Among them, for people over 18 who have completed basic immunization, the interval of the first dose of booster immunization is adjusted to more than 3 months.

People who have been infected and have not completed basic immunization can be vaccinated with one dose after 3 months of infection.

(2) vaccine selection.

Shenzhou cell recombinant Covid-19 tetravalent S trimer protein vaccine and Unacon Covid-19 mRNA vaccine have been included in emergency use, which can be used for intensive immunization of people over 18 years old.

The vaccines used for basic immunization of uninfected target population shall be implemented with reference to the relevant requirements in the previous period. In order to strengthen immunization, it is recommended to use Shenzhou cell recombinant Covid-19 tetravalent S trimer protein vaccine and Unacon Covid-19 mRNA vaccine. Other recombinant protein vaccines or virus vector vaccines that have been approved for conditional marketing or emergency use can also be selected for sequential enhanced immunization.

People over the age of 18 who have been infected and have not completed basic immunization are recommended to use Shenzhou cell recombinant Covid-19 tetravalent S trimer protein vaccine and Unacon Covid-19 mRNA vaccine, or choose other recombinant protein vaccines or virus vector vaccines that have been approved for conditional marketing or emergency use. For people aged 3-17 who have been infected and have not completed basic immunization, the vaccines used for vaccination shall be implemented according to the relevant requirements of the previous period.

Follow-up will be based on the progress of vaccine research and development, approval, combined with the epidemic situation, virus variation and other conditions, timely research and adjustment of vaccination strategies.

Third, ensure vaccination safety

All localities should continue to give priority to vaccination safety, and organize vaccination implementation in strict accordance with the requirements of the Code for Vaccination Work. Local health departments should implement the "four haves" requirement that vaccination units should have emergency personnel stationed in general hospitals at or above the second level, emergency equipment and medicines, 120 ambulances on duty, and green channels for treatment in general hospitals at or above the second level to ensure vaccination safety. Inoculation units should do a good job in vaccination information registration and vaccine flow management, and update the vaccination records in the immunization planning information system and vaccination vouchers in a timely and accurate manner.

Fourth, strengthen organization and implementation

(1) Strengthening the responsibility of territorial subjects. All localities should implement the responsibility of territorial management, attach great importance to and co-ordinate the vaccination work in Covid-19. It is necessary to strengthen the guidance of vaccination work within the jurisdiction and fully grasp the progress of the work. Relevant local departments should strengthen docking and do a good job of coordination.

(two) to play the role of the competent department of industry. The competent departments of relevant industries should guide the units where the personnel in this industry work to actively cooperate with local unified arrangements and jointly do a good job in organizing and mobilizing.

(3) Strengthen supervision and guidance. It is necessary to closely track and monitor the progress of vaccination in various places, and find and study and solve related problems in time. Improve the traceability system of vaccine flow, improve the safety supervision mechanism of vaccine chain, continuously strengthen the whole process management and safety precautions, and effectively ensure the efficient and smooth transportation of vaccines.

(4) Do a good job in publicity and guidance. All localities and relevant departments should, according to the needs of work, formulate targeted publicity measures for vaccination work, focus on the purpose and significance of vaccination, respond to social concerns, sum up and popularize typical experiences and practices, actively guide the target population to take the initiative to vaccinate, and especially guide and improve the vaccination rate of the elderly population.

Note: People aged 3-17 can only use Covid-19 inactivated vaccine of Sinopharm Zhongsheng Beijing Company, Beijing Kexing Company, Sinopharm Zhongsheng Wuhan Company and Zhifeilong Kema recombinant Covid-19 vaccine (CHO cells).