Collagen fell from the altar many years ago and turned red again this year.

　　Article source: Ten o’clock planting grass WeChat WeChat official account

　　Original title: I fell off the altar many years ago and turned red again this year …

　　Author: Li Ye

　　Hello ~ pretty girls, Liye is online!

　　I watched the ancient beauty variety show at home last week and found that many programs were pushing the concept of "collagen" skin care at that time.

　　This reminds Liye that in the past few years, the circle of friends purchased and sold skin care products, as long as they were labeled with [collagen], they could all become explosive products.

　　But this "collagen" wind, it didn’t take long to blow, and it declined! Because everyone found out! That’s how it works!

　　The complete collagen itself has a large molecular weight, and the transdermal rate is relatively low. Coupled with the technical limitations at that time, the collagen added in the skin care products sold is basicallyHydrolyzed collagen(Hydrolyzed collagen actually only hydrolyzes collagen into smaller forms). Although its permeability is better, it is still a macromolecule. For skin care, it has only a relatively simple moisturizing effect ♀ ~ and it is not as amazing as purchasing! Even the moisturizing effect, as I said when I bought it with the wind, is not so excellent ~

　　This over-marketing, consumers don’t pay the bill, sales decline, and the technical requirements for making collagen are really high. Many manufacturers naturally focus on ingredients that are better to make and sell, and the effect is more obvious ~

　　However, in recent years, with the technological progress, Liye found that several domestic collagen companies have made profits again, and even submitted listing applications this year. Even Huaxi Bio, a hyaluronic acid giant, is going to end up and start buying companies that produce collagen.

　　After many years, collagen is really turning red again!

　　Li Ye took a look. At present, the hot and successful research direction of collagen in the domestic market is recombinant collagen. It performs better in transdermal rate, and it has also expanded from simple moisturizing to repair field. In addition, the repair demand of consumers is increasing, and various skin care products related to recombinant collagen have become hot!

　　Many sisters may have been puzzled when they saw this. Is collagen and recombinant collagen the same thing? What’s the difference? Don’t worry, Lier, here’s the answer!

　　Natural collagen exists in all parts of our body ~ including hair, skin, nails and so on, which is essentially a kind of protein. About 70% of our skin is collagen. With its support, our skin looks more delicate and elastic. With the increase of age, collagen production slows down, the loss accelerates, and the skin loses its support, which will lead to looseness and wrinkles.

　　We have this kind of protein, and so do animals. Therefore, most of the sources of collagen in the market are still extracted from animals. However, this kind of animal-derived collagen is prone to rejection (allergy) and its safety is difficult to guarantee.

　　Recombinant collagen is a gene fragment selected from human collagen and made by gene recombination technology. It not only has a molecular weight close to our natural collagen, but also has good permeability. It can also promote the generation of collagen I and III (collagen which plays a key role in human skin) to repair skin damage, and it will be more suitable for external skin care ~

　　However, because the technical barriers of recombinant collagen are difficult to overcome, it will take many years to develop and mass-produce it. In recent years, the mass production capacity has come up, and it has been applied to skin care products, and it has gradually been recognized by everyone.

　　At present, there are two major companies that make recombinant collagen in China, Juzi Bio and Jinbo Bio. In fact, there are some similarities in composition research and development, but each product has its own characteristics. Let’s introduce it to you in detail.

　　Juzi Bio was formally founded in 2001. The initial company was only a small office in Xi ‘an High-tech Zone. But in just over 20 years, it has developed into a high-tech enterprise dominated by genetic engineering and biomaterial engineering, and cooperated with dermatology and medical beauty institutions in 3,500 hospitals all over the country.

　　Moreover, Juzi Bio is one of the drafting units of domestic YY/T 1849-2022 recombinant collagen industry standard. In this light, it is estimated that many small enterprises can only look up to big bosses (after all, everyone abides by standards and others write standards).

　　The core component of the brand, recombinant human-like collagen, was developed by the team led by Fan Daidi, the founder of Northwest University Biomedical Research Institute. In China, it can be said that it won the prize and won the China Patent Gold Award (ZL01106757.8) and the second prize of the National Technology Invention Award.

　　At present, the human-like collagen used in the product is an upgrade from the first generation of recombinant human-like collagen in 2021. It is a combined component, which contains recombinant human-like collagen, recombinant type I human collagen, recombinant type III human collagen and mini small molecular recombinant collagen peptide, and is responsible for different functions to cooperate, promote the production of collagen and repair skin.

　　Representative product

　　Recoverable beauty

　　Humanoid collagen dressing

　　198/5 tablets

　　Kefumei is a medical beauty skin care brand under Juzi Bio ~ Kefumei human collagen dressing (Shaanxi Machinery Zhun Zhun 20152640026) is its star product, and its ingredients are the above-mentioned human collagen.It can not only replenish water and collagen, but also repair the wound after medical beauty ~Many little sisters around Liye who love medical beauty use it during the recovery period.

　　Medical film cloth, although thick, is not stuffy on the upper face at all ~ very breathable! The essence is also very rich! Sometimes I play with my mobile phone while applying it, and if I forget to take it off, my face will not be pulled out!

　　The disadvantage is probably that the price is indeed more expensive than the general mask. After all, it is a mechanical dressing. If it weren’t for the demand of medical beauty or the serious bad face, the daily healthy skin use might not be too amazing and not so cost-effective

　　Kelijin

　　Humanoid collagen

　　Skin care spray

　　¥248/150ml

　　Kelijin is a high-end skin care line under the giant creature ~ This spray is very suitable for sisters who often explode their skin!

　　In addition to human-like collagen, it also contains sodium hyaluronate to strengthen moisturizing; Smithsonite extract delays skin oxidation; β -glucan promotes repair. No alcohol, no essence, no irritating preservatives added, very friendly to sensitive muscles ~

　　Spray out, very fine, there will be no water droplets on my face, gently soft, directly absorbed into the skin! It has the effect of soothing and cooling immediately ~ it won’t dry after ten minutes, and it can also be used directly as make-up water in summer.

　　Moreover, it is a "binary spray tank", which does not need to be filled with compressed gas with explosion risk, and can continuously spray water mist only through the compression force of the air in the aluminum tank when the inner bag is filled with liquid.

　　However, for an office worker like me who stays in an air-conditioned room all day and wants to spray a few times at any time and place, it is consumed too quickly, and 150ml will be used up soon. It’s really not as extravagant as some cabbage prices.

　　Established on March 28th, 2008, Jinbo Bio is a biomaterial enterprise driven by systematic innovation and research of functional proteins. Its unique skill is recombinant type Ⅲ humanized collagen (patent number ZL201811438582.6)~

　　As mentioned above, type ⅲ collagen is a kind of protein which is rich in human body in infancy, and it has a good repairing effect! Part of keeping skin elastic depends on it! But this kind of protein, after growing up, gradually lost! Therefore, supplementing type ⅲ collagen is a key to fight against skin aging ~

　　The recombinant humanized collagen III of Jinbo Bio is very similar to the human collagen III, and has the triple helix structure of human collagen, so it has good biocompatibility on the epidermis, and it is not easy to be sensitized when applied externally to the skin. Last March, it became the first recombinant humanized collagen III raw material in China (registration number: M2021001-000).

　　In scientific research, its team is also very strong. Chinese Academy of Sciences, Tsinghua University, Fudan University, Sichuan University, the Second Affiliated Hospital of Chongqing Medical University and other scientific research institutions have established long-term cooperative relations, and have successively established Fudan-Jinbo Joint Research Center for Functional Proteins, Sichuan University-Jinbo Joint Laboratory for Functional Proteins and Functional Protein Clinical Transformation Center. Compared with Fumei, it pays more attention to the field of medical beauty, and its products are more inclined to the efficacy skin care in the field of anti-aging (mostly cosmetic skin care products).

　　Representative product

　　164.88 muscle frequency active protein facial essence stock solution

　　¥419/25ml

　　Muscle frequency is the brand of Jinbo Bio’s main stock solution and mask ~ the representative product is this 164.88 muscle frequency active protein facial essence stock solution.

　　The main product is the recombinant humanized collagen III, plus a drop of water, hyaluronic acid and sodium polyglutamate, and there are no other ingredients ~ the formula is very simple! So it is also very gentle to use!

　　When Liye first used it, she felt as if it was the same as mineral water, and she was still suspicious! Is this the legendary type III humanized collagen? It’s so insensitive!

　　But it took about two or three days! The surprise happened! Liye loves her chin and nose, which are red with acne, and most of them have disappeared! Unfortunately, the anti-aging effect doesn’t seem to be obvious.

　　It’s really expensive, too. It’s more than 400 yuan. When Liye’s face was rotten, she ran out in a few weeks! And it’s really too much trouble to use, because it’s sterile and has to be put in the refrigerator after opening. Harm, it is recommended that the budget treasures rush!

　　Heavy source jinbo protein-polypeptide essence

　　¥429/35ml

　　Chongyuan is the sister brand of Muscle Frequency, and the R&D team is also a heavyweight of Chinese Academy of Sciences and Fudan University ~

　　This essence focuses on brightening ~ So in addition to recombinant humanized collagen type III and sodium hyaluronate, nonapeptide -1 is also added.

　　Octapopeptide -1 is a bionic peptide, which can match with MC1 receptor in pigment cells, thus preventing tyrosinase from being further activated and reducing pigment production.

　　However, in order to keep the ingredients simple and gentle, these ingredients are good for sensitive muscles, but if they are used alone, it is easy for the face to dry again in a few minutes. It is still recommended to match it with a more moisturizing essence/cream.

　　The effect is mainly reflected in improving dull and delicate skin ~ for example, you can open a bottle and apply it after staying up late, which can save you from anxiety ~ As for whitening, Liye doesn’t exist after using it. If it is not to try collagen ingredients, it may not be as fast as buying a bottle of brightening essence directly!

　　Although the technology of recombinant collagen has been developed, the scale of mass production is still much smaller than that of components that have been widely used, such as hyaluronic acid (the production capacity of recombinant collagen giant Gianzi Bio is about 10.9 tons in 2021, and the production capacity of hyaluronic acid giant Huaxi Bio is 470 tons in 2021).

　　This has also caused the overall price of recombinant collagen skin care products on the market is still high ~ a mask/dressing is also more than 30 yuan to start. Unlike hyaluronic acid skin care products, there are many choices from parity to expensive price.

　　On the other hand, in terms of skin care efficacy, recombinant collagen skin care products are still reflected in many repair fields, and it is estimated that more technology research and development are needed for anti-aging.

　　However, Liye feels that with the increasing high-end skin care research and development technology and the increasing demand for skin care by Chinese people, there will still be companies like Huaxi Bio joining the collagen track in the future ~ Domestic brands looking forward to developing collagen can add more efforts and bring us more surprises!