Original Ugliness & Visualization of Teacher Cat’s Patent Analysis

Citation between patent documents is the information that reflects their technical relevance, including the documents cited by the applicant in the background technology of his patent application, the comparison documents used by the examiner in the examination process, and the evidence documents submitted by the third party when requesting patent invalidation.

Patent citation can be divided into Cited and quoting, also known as Backward citation and Forward citation. The corresponding patent citations are called cited documents and cited documents. Among them, the cited document refers to the reference document cited by the target patent/family, and the cited document refers to the later document cited by the target patent/family. The relationship among the target patent/family, cited documents and cited documents is shown in the table below.

By combing the citation relationship, the undertaking order of technological innovation research and development among patent documents can be established, which can help analysts reproduce the development process of patent technology. It can also be used as auxiliary information to judge the importance of a patent document by counting the cited situation of a patent document, such as the number of cited documents, the technical field of cited documents, the applicant of cited documents, etc. On this basis, we can also combine the information related to patent literature sources such as country, applicant or inventor, so as to judge the historical contribution, technical strength and competitive position of the technology source.

Case 1: the applicant who cited the most important patent US6191007 in the field of 1：FDSOI technology.

The applicant who cited the patent US6191007 the most times.

Chart Source: Zhang Maoyu. Industrial Patent Analysis Report (Volume 50) Advanced Chip Manufacturing Technology [M]. Beijing: Intellectual Property Press, 2017.

The most frequently cited patent application in the field of FDSOI technology is the patent application with publication number of US6191007 filed by Denso in 1998, which was cited 316 times, and all of them were not self-cited. The main technical direction of this patent application is technology, which is to fabricate SOI or super-wave SOI substrates by ion implantation.

The applicant who cited the patent US6191007 the most was Monolithic 3D Inc, and it can be known that the company may have made key research and development in the field of substrate technology of FDSOI following Denso’s technology. At the same time, other applicants who cited this important patent are Micron, Innovative Silicon and IBM, and these applicants are also key applicants or potentially important applicants in the field of FDSOI.

Case 2: The most influential patent applicant of microalgae related technology

The most influential patent applicant for microalgae-related technology

Chart source: WIPO patent landscape report: micro alga-related technologies

The above figure lists the most influential patent applicants for microalgae-related technologies, and provides two indicators to measure the applicant’s influence, one is the number of patent families owned by the applicant, and the other is the Citation Velocity of the applicant’s patents. The patent citation rate in this report refers to the average number of times each patent is cited by other people’s later applications every year, which excludes the applicant’s self-citation. This citation includes Patent examiners’s citation in the review process as a comparison document, and also includes other patent applicants’ use as prior art documents in the background technology of their patent application documents. The higher the number of citations, the greater the influence of the applicant in this field.

Case 3: Patent citation network of patent applicants in the field of quantum metrology and sensing

Patent citation network of patent applicants in the field of quantum metrology and sensing

Chart source: EPO landscape study on patent filing: quantum metrology and sensing

Through citation analysis, we can also see that there is a very close relationship between enterprise applicants and research institution applicants in the field of quantum metrology and sensing in technology research and development. For example, most of Lockheed Martin’s 55 patents cite the patent documents of university applicants, and 17 of them cite the patents of Melbourne University.

Original title: Patent Analysis Method | Patent Citation Analysis

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　　In practice, a large number of inventions are protected by submitting patent applications and obtaining authorization. Therefore, the writing quality of patent application documents often affects whether the patentee can successfully defend his rights and resist competitors. In this paper, the author discusses the writing skills of patent application documents from the perspective of writing patent application documents.

　　First, we should consider the appropriate scope of protection. The so-called "appropriate" scope of protection refers to obtaining as large a scope of protection as possible on the premise of complying with China’s patent law and its implementation rules.

　　The author thinks that a patent application document can "predict" the comparison documents that may be retrieved, which is based on the full retrieval of domestic and foreign patent documents in the early stage of writing the patent application document, so as to determine the appropriate level of existing technology, construct an appropriate scope of protection, and make the patent more stable.

　　In practice, the author found that many existing patent application documents only describe the technical scheme itself. The author believes that the process of writing patent application documents is a process of secondary creation, which requires the joint participation of inventors and patent agents to discuss various implementation methods to solve the technical problems involved in invention-creation, and determine the claims after summarizing and abstracting the technical characteristics of the implementation methods (upper generalization or functional limitation). And the upper generalization also needs as many examples as possible so that the claims can be supported by the specification. When judging the infringement, the functional features are interpreted as the specific embodiment disclosed in the specification and its equivalent embodiment, and the application of the equivalence rule is easy to have objections. Therefore, it is helpful to obtain a more appropriate scope of protection by excavating as many embodiments as possible in the writing stage of patent application documents.

　　Second, when writing patent application documents, we should also consider it from the perspective of being conducive to infringement judgment. For example, based on principle of universal coverage, when writing the patent application file at first, only the most necessary technical feature set that can solve the technical problems of the invention needs to be written into the independent claim, and unnecessary technical features will only limit the narrowing of the protection scope. In practice, the name of the invention, the characteristics of the use environment, the technical characteristics of the product defined by the preparation method, and the step sequence of the method claim may limit the scope of patent protection, so it should be carefully considered when using it. If there are possibly ambiguous terms in the claim and they are not explained in the specification, it may cause obstacles to the interpretation of the subsequent claims.

　　Third, the commercial prospects of patented products or methods should be considered. In the writing stage of patent application documents, patent agents may find that technical solutions can be applied to fields with more commercial prospects during the communication with inventors. For example, a technical scheme can be used in PC, but after understanding the existing technology, it is found that its application prospect in mobile terminal is very considerable, but it needs to be adjusted accordingly when applied in mobile terminal, so different technical schemes are produced, and the application strategy needs to be adjusted in time.

　　Fourth, we should consider whether patents can be easily evaded by competitors. The patent agent can work with the applicant to develop possible improved technical solutions and possible deteriorated technical solutions. The improved technical solutions can be used as a "retreat" in the patent examination stage and may prevent competitors from submitting improved solutions to patent applications. According to the Guide to Determining Patent Infringement issued by Beijing Higher People’s Court, the deteriorated technical scheme does not constitute equivalent infringement, so the deteriorated technical scheme should also be considered when writing patent application documents.

　　Fifth, it should be considered that it is conducive to obtaining evidence and safeguarding rights. If the applicant is engaged in the production of products, from the perspective of tort compensation, it may be more beneficial for the right holder to write patent application documents mainly against product manufacturers. This is because it is generally easier for sellers, importers and users of infringing products to prove the legal source of infringing products. In this case, it is advantageous to write the product and the claim of the preparation method of the product.

　　In the fields of communication, network and computer, the applicant may face multiple infringing objects, and which infringing objects he hopes to resist is an important factor in determining his claim. Different claims can be designed for different infringing objects.

　　Generally speaking, it is more beneficial to obtain evidence if you can know the technical characteristics of the product without disassembling it or using it by consumers. If you need reverse engineering to determine whether a product is infringing, you need to consider the difficulty of reverse engineering. For example, for related patents in the chemical field, the technical features that can be measured by ordinary measuring instruments or technologies are more conducive to obtaining evidence. For patents related to semiconductor and chip fields, if reverse engineering is easy to realize, components and their connection modes can be described. If reverse engineering is difficult to realize or the cost is high, it is necessary to consider whether it is necessary to change the writing method.

　　Sixth, we should consider the layout strategy. When writing patent application documents, we should also pay attention to the role of dependent claims, that is, in addition to independent claims, other novel and creative technical features can be arranged in dependent claims to prevent competitors from evading design.

　　At the same time, different levels of protection scope should be considered, and some patent application documents may be incompatible with certain technical features. At this time, independent claims with different protection scope can be considered to avoid giving up some protection scope due to modification. In addition, in some cases, the protection scope of the method claim can be different from that of the product claim, for example, the protection scope of the method claim can be greater than that of the product claim to achieve different levels of protection.

　　Chinese applicants need to consider the relevant laws and regulations of different countries when writing patent application documents if they want to arrange patents abroad. When submitting an international patent application through the Patent Cooperation Treaty (PCT), due to the relatively limited space for modification, it is especially necessary to strictly check the priority documents.

　　For example, when filing an American patent application, we should avoid too much self-admission and discussion about the existing technology. Because the U.S. Patent and Trademark Office has a strict review of Antecedent Basis, patent Enablement and Written Description, it should be extra cautious when writing priority documents. (Li Xingdi only represents the author’s personal views)
　

Author: Hongge comes from Medical Wechat WeChat official account.

　 　　 　　　Recent epidemic situation in ChinaIn the process of getting up, there are some situations that deserve our attention.the most importantIsFalse negatives in nucleic acid detection. Intercepting relevant news, it was found that 8 confirmed patients in Shijiazhuang on the 22nd were repeatedly negative for nucleic acid detection, and 5 confirmed patients in Shijiazhuang on the 24th were repeatedly negative for nucleic acid detection.

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　 　On the 22nd, there were 11 new confirmed cases in Shijiazhuang, including:

Case 1: Male, 52 years old, from Huangjiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 2: Male, 13 years old, Niujiazhuang Village. On the evening of the 21st.Nine times nucleic acid positive;

Case 3: Female, 11 years old, Zhongyao Village. On the evening of the 21st.Nine times nucleic acid positive;

Case 4: Male, 49 years old, Nanqiaozhai Village. On the evening of 21st.Ninth nucleic acid positive;

Case 5: Male, 47 years old, Niujiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 6: Female, 65 years old, Niujiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 7: Male, 11 years old, grandson of Case 6. On the evening of 21st.Ninth nucleic acid positive;

Case 11: Male, 67 years old, Xiaoguozhuang Village, husband of Case 2 on January 7th. On January 3, it was transferred to centralized isolation medical observation; On the evening of 21st.11th nucleic acid detectionFinally positive;

On the 24th, there were 7 new confirmed cases in Shijiazhuang:

Case 1: Female, 65 years old, Nanqiaozhai Village. Centralized isolation on the 11 th.Nucleic acid after 9 times, 22 positive.

Case 2: Female, 4 years old, Nanqiaozhai Village. Centralized isolation on the 11 th.Nucleic acid after 9 times, 22 positive.

Case 3: Female, 4 years old, Mi Jie, Chang ‘an District. Centralized isolation on the 13 th.Nucleic acid after 8 times, 23 positive.

Case 4: Female, 64 years old, Xiaoguozhuang Village. Centralized isolation on the 10 th.After 11 nucleic acids, 24 positive.

Case 5: Male, 34 years old, Xiaoguozhuang Village. Centralized isolation on the 8 th.After 11 nucleic acids, 24 positive.

Case 6: 34-year-old female, Liujiazuo Village, was positive for nucleic acid on the 5th, was diagnosed as asymptomatic infection on the 6th, and was clinically confirmed on the 24th.

Case 7: A 28-year-old male, living in Yuhua District, went to work by car at Zhengding Airport on weekdays. He was diagnosed as asymptomatic infected with nucleic acid on the 5th, and was clinically confirmed on the 24th.

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Since the outbreak of COVID-19 last year, the topic of high false negative rate of nucleic acid detection has been the focus of attention. It has been reported that the positive rate of Covid-19 detection by fluorescence quantitative RT-PCR is only 30%-50% at present, which leads to extremely high false negative rate.

For Hongge, who doesn’t know much about the test, this paper analyzes the relatively high false negative test by searching articles and documents, and summarizes some reasons to discuss with you.

First, the incidence of COVID-19 suggests that it is highly possible to collect positive samples in a proper time.

Academician Yuan Guoyong’s team conducted this cohort study in Hong Kong Princess Margaret Hospital and Queen Mary Hospital. From January 22 to February 12, 2020, 23 hospitalized patients who were diagnosed as COVID-19 by laboratory examination of nasopharyngeal or sputum specimens were screened in the two hospitals.

A total of 173 respiratory specimens were collected from 23 patients. The researchers used RT-QCPR to determine the viral load in the samples. The results showed that the median viral load of respiratory tract samples was 5.2 log10 copies /mL (interquartile range was 4.1-7.0), and only 3 patients (13%) did not detect Covid-19 RNA in saliva samples.

The researchers observed that,The viral load in saliva was the highest in the first week after the patient developed symptoms, and then gradually decreased.Eight days after the patient developed symptoms, airway extracts were collected, and there was no obvious downward trend in viral load. Of the 21 patients who did not die,Seven people (33%) could still detect viral RNA after 20 days of symptoms, but this was not related to the severity of the disease.

▲ Changes of viral load in saliva (blue line) and airway extract (red line) of all 23 patients. Abscissa D- days after symptoms appear; S/E- number of saliva/airway samples.

AprilAccording to a study published in Nature Medicine, COVID-19 patients are most infectious before symptoms appear, and they begin to shed SARS-CoV-2 2 2-3 days before the first symptoms appear.

https://doi.org/10.1038/s41591-020-0869-5

The study, led by Eric Lau of the University of Hong Kong, involved 94 patients with COVID-19 admitted to the Eighth People’s Hospital of Guangzhou, China, 50% of whom were male, with a median age of 47 years. Among them, 61 of 93 patients were mild. Specifically, the researchers collected the throat swabs of 94 COVID-19 patients who were treated in the Eighth People’s Hospital of Guangzhou, China from January 21st to February 14th. From the onset of symptoms to 23 days after onset, 414 throat swabs were collected.

The results show that the researchers areThe high viral load was detected shortly after the patient developed symptoms, and then gradually decreased to the detection limit around the 21st day.There is no significant difference in viral load among different sexes, age groups and disease severity.

In addition, the researchers also analyzed 77 samples of "transmission pairs" from public data to assess how much time passed between the onset of symptoms in each patient. It assumes that the median incubation period (the time from infection to symptoms) is 5.2 days.The research team concluded that infectivity began 2.3 days before symptoms appeared, and peaked 0.7 days before symptoms appeared.

In the sensitivity analysis, the same estimation procedure is used, but assuming that the infectious attack is unchanged 1-7 days before the symptom occurs, thenIt was found that the infectivity reached its peak 0-2 days before the onset of symptoms, and the transmission ratio before the onset of symptoms was 46% to 55%.

The study also found that,The virus may start shedding 2-3 days before the first symptoms appear.After the symptoms appear, the viral load in the patient’s body decreases faster. This is consistent with the results of two recent studies. On April 1st, teams from Munich, Germany, Berlin and Cambridge, England published the article "Viro logical assessment of hospital patients with Covid-2019" on Nature. It was found that the shedding peak of Covid-19 occurred in the early upper respiratory tract infection.This shows that virus carriers may be the most infectious when they have mild symptoms or almost no obvious symptoms.

Brother Hong:From the above two documents, we can draw a conclusion that the virus shed and spread 2-3 days before the symptoms appear after infection, and after the symptoms appear, with the passage of time,The viral load of throat swab decreases gradually, and the viral load detected within 7 days after symptoms. If symptoms have existed for more than 20 days, the reliability of negative conclusion of throat swab is poor.

Solution:We need to publicize the law of the new crown to the people and medical workers, and improve our vigilance against COVID-19. It is best for patients to see a doctor in time, and doctors can also suspect this possibility. Only at the right time can we collect high-content samples and diagnose and control them in time.

Second, accurate sampling strategy is the best means to reduce false negative results.

In February, a study published by Medrxir, a pre-printed website, collected respiratory tract samples such as nasal swab, throat swab, sputum and bronchoalveolar lavage fluid (BALF) from patients diagnosed with COVID-19, and included 213 Covid-19-infected patients admitted to the Third People’s Hospital of Shenzhen from January 11th to February 3rd, 2020, who were diagnosed by Guangdong CDC. A total of 866 respiratory tract samples, including 490 nasal swabs, 205 throat swabs, 142 sputum samples and 29 BALF samples, were collected at the time of admission and after each time point. According to the collection date, the samples were divided into 0~7 days, 8~14 days and ≥15 days after onset. According to the guidelines on prevention and treatment of Covid-19 infection issued by National Health Commission, patients were divided into severe and mild cases.

Three groups were divided according to the sample collection time after onset, and the viral nucleic acid was quantitatively determined.The positive rate of viral nucleic acid in sputum samples was the highest in the group of 0~7 days after onset.The positive rates of severe and mild cases were 88.9% and 82.2% respectively.Followed by a nasal swab.(73.3% and 72.1% respectively),The throat swab again.(60.0% and 61.3% respectively). In mild cases, the positive rate of nasal swab and sputum samples is similar.

The positive rate of BLAF samples collected from 8 to 14 days after the onset of severe cases was 100%.However, the BALF samples of 3 mild cases were negative. In all cases, the positive rate of sputum samples was the highest in the 8~14 days after onset, which was much higher than that of nasal swab and throat swab. It is worth noting that the positive rate of throat swab in severe patients is only 50%, and that in mild patients is only 29.6%.

In the group ≥15 days after onset,The positive rates of BALF, sputum and nasal swab from severe cases were similar. In mild cases, the positive rate of sputum and nasal swab is similar, which is much higher than that of throat swab.

For the diagnosis of viral nucleic acid in COVID-19’s patients,Sputum samples are the most accurate, followed by nasal swabs. It is not recommended to collect throat swabs for diagnosis.

The difference between oropharyngeal swab and nasopharyngeal swab

anusswab

Brother Hong:

1. Oropharyngeal swab is the least painful and most acceptable, but it has to bear the consequences of high false negative results. My suggestion is to use it according to the epidemic risk in the first epidemic area.

2. The positive rate of nasopharyngeal swab is higher than that of oropharyngeal swab, which is why nasopharyngeal swab is introduced into laboratory examination in the fifth edition of Diagnosis and Treatment Plan for Pneumonia Infected by Covid-19 (the fourth edition is still pharyngeal swab). If we want to pursue accuracy, it is suggested to use it, or to use it when screening people in close contact or sub-close contact. At present, the examination of returnees in domestic reports seems to be nasopharyngeal swab method.

3. Alveolar lavage fluid can’t be used for screening in the general population, so it is suggested that hospitals with ICU should use it for screening severe pneumonia patients living in ICU for COVID-19 patients.

4. Deep expectoration seems to be the best sample, but many patients in COVID-19 have a dry cough, which may not be possible.

5、anusSwabs were used in Daxing epidemic in Beijing, which is the first time to use this method in the screening process. In some literatures,anusAlthough the positive rate of swabs is not high, as I remember, it seems to be more than 10%, but it does not seem to coincide with the patients with oropharyngeal swabs, suggesting that the virus may attack the gastrointestinal tract, and also suggesting that there may be the possibility of gastrointestinal transmission in Covid-19. Although the initial symptoms of some patients are gastrointestinal symptoms such as abdominal pain and diarrhea, there are also ACE2 receptors in the digestive tract, which is theoretically possible, but it has not been confirmed at present. So,anusMy suggestion is that swabs can only be used as a supplement to nasopharyngeal swabs, and it is better to select patients whose first symptoms are digestive tract symptoms more accurately, which is unlikely to be used as a means of large-scale screening.

Solution:It is best for National Health Commission to issue a guiding document for large-scale screening, and make detailed regulations on what population and what sampling methods to adopt under what circumstances.,When local governments encounter an outbreak in COVID-19, it’s best to ask professionals to act as consultants and make choices according to the actual situation.

Third, the consistency of sampling ability of sampling personnel affects the sampling results.

Garbage in, garbage out (garbage samples produce garbage results), which is a sentence that inspectors often say.

The sampling team is huge, and the ability of sampling personnel must be uneven. In addition, people may have such fears about sampling, which often leads to unqualified samples.

Generally, there is an internal standard in the molecular diagnostic reagent to monitor the detection process, for example, RNaseP is used as the internal standard. If both the sample response curve and the internal standard response curve displayed by the fluorescence PCR platform do not jump, it means that the quality of the collected samples may have problems or false negatives may occur due to improper experimental operation, which needs to attract the attention of medical workers. The RNaseP internal standard can monitor the sample collection and ensure the accuracy of the test results.

Note: RNaseP is ribonuclease P, which is one of the most important ribozymes in human body. It is ubiquitous in all organs, tissues and cells of human body, and can detect RNA nucleic acid fragments from human body samples, and can also be used as an internal standard.

And I privately asked the relevant person in charge of our city’s temporary inspection center. He told me that every day in our hospital, some samples were told that they needed to be re-sampled because the internal standard did not jump. Imagine that you didn’t wipe down a few cells in your throat swab collection, so will the negative of this nucleic acid be accurate?

Solution:Consistency training for nucleic acid sampling personnel will greatly reduce the human influence, and it is easier to standardize the sampling process by taking such sampling methods as nasopharyngeal swab. Our city seems to have trained the nucleic acid emergency sampling team very early. What about your city?

In addition, if in the environment of large-scale nucleic acid sampling, when testing under the standard of 5-mixed 1 and 10-mixed 1, according to the above principle of internal standard, it seems that there is no single-tube ability in the quality control of internal standard. Therefore, especially those in the emergency sampling team, we must pay attention to the standard sampling methods and remember to collect qualified samples as much as possible.

Fourth, choose the right oneSampling device

The virus preservation tube mainly consists of a sampling swab and a virus nucleic acid preservation tube (containing virus nucleic acid preservation solution). There are many kinds of virus preservation tubes on the market at present.It is very important for epidemic prevention and disease diagnosis to choose the appropriate virus preservation tube, reduce the infection risk of medical inspectors as much as possible, and keep the virus RNA stable without degradation..

The preservation solution UTM used in traditional virus collection tubes is based on Hank’s solution, with gentamicin, fungal antibiotics, BSA (V), cryoprotectant, biological buffer and amino acids added. Its main purpose is to maintain the virus activity within a certain temperature range, so that it is convenient for health and epidemic prevention departments to further isolate, culture and trace the virus and determine the pathogen. This kind of non-inactivated tube, which I call it, is good for further work, but the sameLive virus increases the infection risk of medical staff in the whole process of sample collection, transportation and testing!Personally, I think this kind of sampling tube for inactivated virus should be a better choice for disease control sampling.

And clinicalIn order to achieve the purpose of rapid detection, it is not necessary to cultivate the virus, but only to crack the virus, so as long as the integrity and stability of the virus nucleic acid can be guaranteed.nowCommonly known as inactivation tube.Many inactivation tubes in China are used.The inactivation component is guanidine salt, which is in this inactivation tube in our hospital.Guanidine salt can crack the virus, but it can’t protect the integrity of nucleic acid for a long time.The virus nucleic acid may have been degraded during the delivery of the sample to the laboratory, which will also cause a "false negative" in the detection. Many studies show that both temperature and time can affect the test results, so the COVID-19 Laboratory Testing Guide has clear requirements for samples to be tested within 24 hours after collection and transported at 4 degrees Celsius. If it is necessary to exceed 24 hours, it should be stored at -70 degrees Celsius.

And some manufacturers put forward another inactivation tube, a kind of.containNon-guanidine saltThe virus preservation tube containing protein denaturant can inactivate the virus and ensure the preservation of virus nucleic acid at room temperature.And the virus nucleic acid is stably stored for 7 days.Does not degrade.

Solution:

1, from sampling to testing, it is necessary to mark the time, so that quality control can be carried out on the preservation time, which is basically no problem in a better hospital.

2. For the front-line staff to do the corresponding training, they should know the advantages and disadvantages of various types of preservation tubes and adopt the best sampling tubes suitable for local conditions.

3. It is best for the country to recommend the selection of sampling tubes with the support of relevant experimental data.

5. Failure of reagents caused by virus mutation?

After the virus mutation in South Africa, Britain, Brazil and other places, there have been cases that turned positive after ten tests in various parts of the world, including China.The FDA recently warned that virus mutation has caused some reagents to fail, and listed several kits that may be affected by mutation. This means that virus mutation may have led to the failure of some nucleic acid detection or persistent false negative.

The FDA listed several kits that may be affected by mutation:

Accula SARS-Cov-2 detection (Mesa Biotech): If the virus mutates at the 28881st base (GGG to AAC), the detection of this kit will be affected;

TaqPath COVID-19 Combo Kit (Thermo Fisher Scientific): This kit detects three genes at the same time, and the variant B.1.1.7 appearing in Britain will affect one of the detection results;

Linea COVID-19 detection (Applied DNA Sciences): This kit detects two genes at the same time, and the variant B.1.1.7 appearing in Britain will affect one of the detection results;

Helix, an American company doing nucleic acid detection, also noticed the influence of virus mutation on detection. The company’s nucleic acid detection simultaneously detected three Covid-19 genes: ORF1ab, N, and S. Because the B.1.1.7 strain that appeared in Britain had deletion mutation in S gene, ORF1ab and N could be detected in the detection, but S gene could not be detected (4). This phenomenon is called "S gene withdrawal".

In addition, the sensitivity of reagents from different manufacturers to COVID-19 is different, and the country also organized a national evaluation of reagents last year. butIn an evaluation study on the consistency and detection ability of seven domestic novel coronavirus nucleic acid detection kits published by Chinese Journal of Laboratory Medicine in July, 2020, it was proposed that "some kits have poor detection ability for weakly positive samples,It is suggested that weak positive samples should be rechecked by kits from at least two manufacturers to ensure the accuracy of the results."

Several targets of nucleic acid detection in Covid-19 are ORF1ab gene, N gene and S gene.

In the Technical Guide for Laboratory Detection of Pneumonia Infected in novel coronavirus issued by China CDC (hereinafter referred to as the Technical Guide), the two targets of nucleic acid detection in Covid-19 are ORF1ab gene and N gene respectively.

On January 6th, the Weekly Report of China Center for Disease Control and Prevention published the results of gene sequencing analysis of two cases of Covid-19 infection in Shijiazhuang and Xingtai. According to the published results, the strain prevalent in Gaocheng, Hebei Province, is different from the strain found in other places in China recently, and is homologous to the strain reported in Russia last July, belonging to strain B.1.1.123

Coincidentally, the mutation happened at the 28881 ~ 28883 bases of the virus gene of this strain, and this is exactly the position of the forward primer of the N gene!

This also explains why there were many negative results at that time.

I guess this is one of the reasons why the criteria for judging nucleic acid positivity have also changed.The judgment position that the single target is still positive after retest is positive.

Figure/Current Criteria for Judging Positive Cases in Technical Guide

Solution:

1. Require manufacturers of nucleic acid reagents to conduct confirmatory experiments on the current mutant strains and propose technical solutions.

2, all localities should introduce at least two kinds of better quality detection reagents, for control use.

3. Information about the failure of test reagents that may be caused by mutated viruses should be effectively and widely reported in domestic laboratories.

Six, the standard implementation in the process of laboratory testing

the pastAccording to the guidelines issued by relevant institutions, the collected samples need to be inactivated at 56℃ before nucleic acid detection, which is very likely to degrade the Covid-19 nucleic acid, which will lead to the failure of normal detection and ultimately improve the false negative rate.In the early daysInactivation treatment is carried out for the sake of biological safety, to protect the staff engaged in testing from virus infection.

But later, there were many voices of doubt in the academic circles, becauseViral RNA is easily degraded by ribonuclease, because this enzyme has the highest activity at 60℃. Ribonuclease comes from two aspects, one is the sample cells, and the other is the foreign pollutants in the process of collection, preservation and transportation.

Last February, there was a similar research article.The high-temperature inactivation process before virus nucleic acid extraction significantly reduces the amount of detectable virus nucleic acid templates, which has been pre-published on the platform of scientific papers of China Academy of Sciences.

And last May,The Journal of Clinical Chemistry published the research of Chinese scholars on Covid-19’s false negative test.The study confirmed that,Thermal inactivation can cause the increase of Ct value reflected by PCR and cause false negative results.Specifically, 46.7%(7/15) of the weakly positive samples were false negative after inactivation (a surprising proportion). Another inactivation method is to inactivate the virus by dissolving the virus protein with guanidine hydrochloride. This study confirmed that guanidine hydrochloride had little effect on PCR reaction, and the false negative rate was low, although there was also a false negative rate of 13.3%(2/15).

Related address: https://academic.oup.com/clinchem/article/66/6/794/5815979

I also inquired whether there was a 56-degree inactivation step in the detection process of CDC in the United States. Although my English ability was poor, I didn’t see this step by machine translation.

Including some other documents retrieved, it is also very clear that 56-degree inactivation does have a great influence on weakly positive specimens.

No matter the Manual of Nucleic Acid Detection in Medical Institutions in novel coronavirus (Trial) on July 13th, 2020 or the Manual of Nucleic Acid Detection in Medical Institutions in novel coronavirus (Trial 2nd Edition) on December 30th, 2020, there are corresponding descriptions.For the laboratory that has been inactivated with the sampling tube containing guanidine salt, there is no need to inactivate at 56 degrees for 30 minutes.This is only true if non-inactivated sampling tubes are used.

However, I learned from the familiar laboratory leaders that this is not the case. Many laboratories still require samples to be pretreated at 56 degrees for 30 minutes regardless of whether the tubes are inactivated or not. I can understand that they are worried about hospital infection and laboratory exposure. But generally speaking, reducing the false negative rate, increasing the detection amount and taking corresponding measures to control the epidemic situation as soon as possible, I think the corresponding suggestions in the corresponding guidelines are also the best choice from the overall situation and supported by data.

Our laboratory should not control the occurrence of hospital sensation and laboratory exposure at the expense of reducing the detection rate, but should focus on stricter control of experimental steps, more cautious PPE wear and higher laboratory environment.

Solution:

1. It is suggested that the state give special instructions to laboratories at all levels on this matter.

2. It is suggested that the country should further study the preservation solution of sampling tubes, and if there is any preservation solution that can not reduce the detection rate at 56 degrees for 30 minutes, it can also be recommended.

The above zero zero always said a lot of points, mainly about how to reduce false negative conclusions, hoping to give you a reference.

It’s been many days since I wrote this afternoon, mainly considering Spring Festival travel rush. Although the scale of Spring Festival travel rush is reported to have dropped by more than 75% this year compared with previous years, the population flow is still very strong. We may face the rising trend of an epidemic after Spring Festival travel rush, and how to make the work better may be a more urgent need before us.

　　September is autumn, the temperature drops gradually, the temperature difference between day and night increases, kindergartens and schools in various places open one after another, the mobility and aggregation of people increase, and the Mid-Autumn Festival holiday and other factors are superimposed, which easily leads to the spread and popularity of many infectious diseases. Henan CDC hereby reminds the general public to pay attention to novel coronavirus infection, whooping cough, norovirus infectious diarrhea, dengue fever, school tuberculosis and food poisoning this month.

　　Key tips

　　1. novel coronavirus infection

　　The epidemic situation of COVID-19 in our province showed a fluctuating upward trend since the end of July, and it showed a fluctuating downward trend after reaching its peak in mid-August. In autumn, students start school one after another, and the Mid-Autumn Festival is approaching, the flow and gathering of people increase, and the risk of infection in COVID-19 increases. In crowded places such as public transportation and shopping malls, we should persist in personal protection to reduce the risk of virus transmission.

　　Protective measures:

　　1. Strengthen the protection of high-risk groups. Targeted measures are taken for high-risk groups such as patients with basic diseases and the elderly, so that cases can be found in time and treated effectively, and serious cases and deaths can be reduced as much as possible. Timely discover and deal with possible cluster epidemics in places where people gather, such as kindergartens, schools and old-age care institutions.

　　2. Pay attention to personal protection. Residents should wear masks in their daily trips, minimize unnecessary gatherings and keep social distance. Maintain good personal and environmental hygiene, wash hands frequently, often ventilate, pay attention to rest, pay attention to nutrition and enhance physical fitness.

　　3. Use drugs rationally and see a doctor as needed. After infection, asymptomatic infected persons and mild cases should take care of themselves at home, reduce contact with their roommates, use symptomatic drugs rationally according to relevant guidelines, do a good job in health monitoring, and go to medical institutions in time if the condition worsens.

　　2, whooping cough

　　Pertussis is an acute respiratory infectious disease caused by Bordetella pertussis, and its typical clinical manifestations are paroxysmal, spasmodic cough and crowing inhalation roar. The disease has a long course and can last for 2-3 months, so it is called "whooping cough". It is mainly transmitted by air droplets, but also by direct contact with respiratory secretions of patients. The population is generally susceptible, and infants without immunization history are at higher risk.

　　Protective measures:

　　1. Standardize vaccination. Vaccination with DTP vaccine can reduce the risk of severe pertussis and death in infants. According to the requirements of the national immunization program for children, school-age children should be vaccinated with DTP vaccine as soon as possible, and school-age children who have not been vaccinated all the time should be replanted as soon as possible.

　　2. Seek medical attention in time. Especially when infants and young children have paroxysmal spastic cough or have their own sudden cough after similar cases around them, they should take the initiative to seek medical treatment in time to reduce the risk of epidemic spread and serious illness.

　　3. Do daily protection. Keep good hygiene habits, wash your hands frequently and ventilate frequently, cover your mouth and nose with elbows or paper towels when coughing or sneezing, and pay attention to reasonable work and rest and proper physical exercise. Try to avoid crowded and poorly ventilated public places.

　　3, norovirus infectious diarrhea

　　Norovirus is a group of non-encapsulated RNA viruses, which has the characteristics of strong infectivity, rapid spread, short immune protection time and general susceptibility of the whole population. It is the most important pathogen that causes acute gastroenteritis. It can be transmitted through polluted water and food, and can also be infected by aerosol inhalation or contact with items contaminated by virus. Shellfish such as oysters and raw fruits and vegetables are common foods that cause infection. It is easy to spread in crowded places such as schools and kindergartens. In the autumn school season, kindergartens, schools and other educational institutions should do daily protection and strengthen health monitoring.

　　Protective measures:

　　1. Maintain personal hygiene. Pay attention to washing hands frequently to prevent diseases from entering the mouth, especially before and after meals and before preparing and processing food.

　　2. Pay attention to the hygiene of diet and drinking water. Do not eat uncooked food and unpasteurized milk, shellfish and seafood such as oysters should be eaten after deep processing; Fruits and vegetables should be carefully washed before eating, and do not eat unclean fruits and vegetables; Separate raw and cooked foods to avoid cross-contamination; Ensure the safety of water sources, do not drink raw water, and the selection of bottled water should meet the hygiene standards.

　　3. Pay attention to standardization. The environment or the surface of an object polluted by the patient’s vomit or excrement should be cleaned and disinfected by trained personnel with chlorine-containing disinfectants or other effective disinfectants. In the process of handling patients’ vomit, excrement and disinfection, you must do personal protection, wear masks and rubber or disposable gloves, and carefully clean and disinfect your hands after cleaning.

　　4. Dengue fever

　　Dengue fever is an acute infectious disease caused by dengue virus. Its clinical manifestations are persistent fever, accompanied by severe headache, myalgia, joint pain, nausea, vomiting and rash. In severe cases, bleeding, shock, organ failure and even death may occur. The disease is mainly transmitted by the bite of Aedes mosquitoes. September is still the peak of mosquito activity, so we should keep good environment and room hygiene in our daily life, reduce mosquito breeding and reduce the risk of infection. At the same time, people who travel and work in dengue epidemic areas should pay attention to personal protection to prevent mosquito bites, and do a good job of self-health monitoring after returning from epidemic areas.

　　Protective measures:

　　1. Do a good job in mosquito control. Clean up the accumulated water in indoor containers such as flowerpots and drinking fountains in time, clean up domestic garbage and sanitary dead corners, and keep the room clean and tidy. Install screen doors and screens in the room, and use mosquito-repellent incense, mosquito killer and electric mosquito swatter to prevent and repel mosquitoes.

　　2. Personal protection should be done when going to dengue epidemic areas. You should wear long-sleeved clothes and trousers, spray repellent and mosquito repellent on bare skin, use mosquito nets when sleeping, and try to choose hotels with air conditioning or screens.

　　3. Do your own health monitoring. After symptoms appear, you should seek medical advice as soon as possible, and actively inform the doctor of the relevant residence history for early detection, early diagnosis and early treatment.

　　4. Use of personal protective equipment. Personal protective equipment such as mosquito nets and mosquito repellent can effectively prevent mosquito bites, thus reducing the probability of dengue virus infection. In areas with frequent mosquito activities, it is recommended to use mosquito nets or apply mosquito repellent to protect yourself.

　　5, school tuberculosis

　　Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, which can invade many organs, and pulmonary tuberculosis infection is the most common. It is mainly transmitted by respiratory droplets, and healthy people may be infected by inhaling air droplets with tuberculosis. The main symptoms are cough, expectoration lasting for more than 2 weeks, chest tightness, low fever in the afternoon, fatigue, loss of appetite, emaciation, night sweats and so on.

　　Tuberculosis is one of the infectious diseases that schools focus on preventing and controlling. It is the beginning season of autumn recently, and it is a high incidence period of tuberculosis. Schools, parents and students should pay attention to the prevention and control of tuberculosis.

　　Protective measures:

　　1. Strengthen campus management. It is suggested that schools should strengthen the morning check-up, afternoon check-up and late check-up of students in school, implement measures such as tracking students’ absence from class and tracing the cause, and find tuberculosis patients and suspects in school as soon as possible.

　　2. Pay attention to personal protection and improve the body’s immunity. Pay attention to window ventilation, do not spit everywhere, and cover your mouth and nose with your elbow when coughing or sneezing. Reasonable diet, balanced nutrition, combining work and rest, ensuring adequate sleep and appropriate outdoor activities, enhancing physical fitness and improving body resistance.

　　3. Standardize the whole course of treatment. The whole treatment course of pulmonary tuberculosis is 6-8 months, and the whole treatment course of drug-resistant pulmonary tuberculosis is 18-24 months. According to the doctor’s standard treatment, most tuberculosis patients can be cured.

　　6. Food poisoning

　　Food poisoning is a major disease, which is caused by nausea, vomiting, abdominal pain, diarrhea and other symptoms after eating food contaminated by toxic and harmful substances or containing toxins. In September, the high temperature and high humidity weather continued in many places in China, which also created conditions for the proliferation of bacteria. Food is more prone to spoilage. With the large number of seafood on the market, it is necessary to pay attention to the pollution of seafood by Vibrio parahaemolyticus, which is easy to cause food poisoning.

　　Protective measures:

　　1. Pay attention to food hygiene and achieve "six noes": don’t eat uncooked and thoroughly cooked food, unclean fruits and vegetables, food of unknown origin, picking and eating wild mushrooms and wild plants, and don’t buy wild mushrooms picked and sold by individuals, and don’t buy wild mushrooms at mobile stalls.

　　2. When eating out, pay attention to the selection of catering units with complete licenses and good sanitary conditions. Buy food in supermarkets or vegetable markets with health protection.

　　3. Pay attention to personal hand hygiene, wash your hands before and after meals, before and after handling raw and cooked food and its packaging, after touching pets and disposing of garbage.

　　Cctv news(Reporter Li Wenxue): According to the requirements of the "Class B and B Tube" general plan notice of the comprehensive group of the State Council Joint Prevention and Control Mechanism and the "novel coronavirus Infection Prevention and Control Plan (10th Edition)", on January 9th, the Harbin Leading Group Command issued a notice on optimizing and adjusting the nucleic acid detection strategy, requiring that no nucleic acid should be done unless necessary, at least one 24-hour nucleic acid detection point should be set up in all districts and counties, and personnel of key institutions should carry out antigen or nucleic acid detection.

　　According to the notice, it is required to insist on not doing nucleic acid unless necessary, and no longer carry out nucleic acid screening for all staff. Community residents are "willing to check and check" as needed. The cost of nucleic acid testing for personnel and medical personnel in key institutions such as nursing homes and welfare homes shall be borne by the competent department of industry according to the requirements of "who is in charge, who is responsible and who pays"; Other people will pay for nucleic acid testing from January 10, 2023.

　　All districts and counties (cities) should rely on community health service centers or township hospitals to set up enough convenient nucleic acid detection points, and at least one 24-hour nucleic acid detection point should be set up to facilitate the needs of the public. All nucleic acid detection points should be set in place before January 10. All districts and counties (cities) shall set up at least one testing point that can provide Chinese and English nucleic acid testing reports to meet the needs of citizens for nucleic acid testing abroad.

　　Medical institutions should carry out antigen or nucleic acid detection for outpatients (emergency) with fever and respiratory infection symptoms, hospitalized patients with severe and high risk, and symptomatic medical staff.

　　During the epidemic period, the staff in places where vulnerable people are concentrated, such as pension institutions and social welfare institutions, will carry out full-time nucleic acid testing twice a week, and the people who are cared for will carry out antigen or nucleic acid testing twice a week. The testing of agency staff and people who are cared for will be carried out alternately every other day, or it can be carried out according to the requirements of the competent authorities of the industry. Nucleic acid detection of people in other industries shall be carried out in accordance with the requirements of the competent department of industry.

　　The elderly aged 65 and above, long-term hemodialysis patients, severe diabetes patients and other high-risk community residents, infants under 3 years old and other people need to carry out antigen testing after symptoms such as fever and respiratory infection, or go to convenient nucleic acid testing points set up in the community for nucleic acid testing. Just as residents are infected, other people can carry out antigen testing every day for 3 consecutive days.

　　After other residents have symptoms such as fever and respiratory infection, they can carry out antigen testing on their own as needed, or go to convenient nucleic acid testing points set up in the community for nucleic acid testing.

　　Foreigners enter the gathering place of vulnerable people, check the negative certificate of nucleic acid test within 48 hours and carry out antigen test on the spot; Enter all kinds of business premises, commercial stores, government agencies, enterprises and institutions, and no longer check the negative certificate of nucleic acid detection.

Compared with previous years, this year’s 618 is still a lot of excitement. As the first mega-event promotion node after the lifting of the epidemic control, it is also the 20th anniversary of the founding of JD.COM. At the party on June 18th, the new CEO of JD.COM, Xu Ran, Chairman of Gree Electric, Dong Mingzhu and others all attended.

At the party, Dong Mingzhu also announced that Gree Electric will cooperate with JD.COM in all categories, and strive to bring better products to users. At the party, Dong Mingzhu, as always, advertised his products:"Gree has been striving to provide better products. After all, only Gree’s air conditioners in the world don’t blow people."

Source: Gree

When it comes to air conditioning, the best-selling brands in everyone’s impression are traditional white goods manufacturers such as Gree, Midea and TCL, among which Gree is famous for focusing on the air conditioning market. It is estimated that many people still remember the advertising words "Gree, master the core technology".

There is a saying that Gree air conditioners do sell well. In JD.COM’s air conditioner sales list, Gree is the manufacturer with the most products in the top ten, and only two air conditioners with a price of more than 3,000 yuan are Gree. In Tmall’s hot-selling list, Gree is also on the list.

What did Dong Mingzhu say: "Gree air conditioners don’t blow people"? Does Gree really rely on this to win the recognition of users?

Air conditioning doesn’t blow people, what black technology?

For Xiao Lei, who lives in the south, air conditioning is a life-saving tool in summer. Since April in Guangzhou, the temperature may be higher than 30 degrees, and in the next six months, it is basically normal for the highest temperature to exceed 30 degrees. It can be said that the time of blowing air conditioning is close to half a year.

Friends who often blow air conditioners know that although the air conditioner is good, it is uncomfortable to blow it too much, especially when the air outlet of the air conditioner is facing you. Even in hot summer, as long as the operation of the air conditioner is still normal, you will start looking for the air conditioner in less than 10 minutes to see if you can change the wind direction of the air conditioner and stop blowing it on your head.

The cold air of air conditioner blowing directly on the human body will cause the somatosensory temperature to drop rapidly, and it only takes a short time for you to feel the coldness like winter in summer. Many netizens even bluntly said that direct air-conditioning blowing will give them headaches. Sometimes they forget to adjust the air-conditioning wind direction before going to bed, and get up the next day with a headache and a cold.

Source: VEER

Gree’s propaganda really poked a lot of people’s pain points. After all, if you can make yourself sleep more comfortably at the same price, why not?

Generally speaking, the design of "not blowing people" is called "soft wind" in the industry, and there are many brands promoting the function of soft wind. Xiaomi, TCL and other brands all have products featuring the function of "soft wind". Generally speaking, it is realized by the design of soft wind plate and upper blowing. As long as the air duct is changed, the demand of "air conditioning does not blow people" can be easily realized.

However,What Dong Mingzhu wants to say is obviously more than this. What she said "air conditioning doesn’t blow people" may be more a summary of Gree air conditioning’s technical strength, product design and user demand.Technically speaking, the long-term cold air blowing directly is largely due to the lack of refrigeration capacity of air conditioners, which leads to the inability to cool the room quickly and has to extend the cooling time.

Source: VEER

The "core technology" that Gree has been promoting actually refers to Gree’s air conditioning compressor technology. As the core of air conditioning, the performance of the compressor itself directly determines the cooling and heating effects of air conditioning. In some real-life tests, Gree’s air conditioners are indeed among the best in cooling speed.

Simply put, just let the room reach the set temperature in a short time, then the air conditioner can enter the maintenance mode with low power consumption, and only need to keep the room temperature with low air volume. If the cold wind blows for a short time, it will naturally not give people a strong coolness, which coincides with the requirement of "not blowing people".

More efficient air-conditioning compressor, with the design of flexible air plate and upper air outlet, makes Gree air-conditioning give users a better experience when cooling. Perhaps this is what Dong Mingzhu said, "Only Gree’s air conditioners don’t blow people", and behind it is also the confidence in Gree’s technology and products.

However, whether Gree air conditioners sell well is because they don’t blow people, I’m afraid there is still a question mark.

Which air conditioners are more popular in this 618?

Writing here, Xiao Lei can’t help wondering, what are the most popular air conditioners in 618? What are the functions of the new air conditioner now? Judging from the total sales list of JD.COM, the top three are Gree, Xiaomi and Midea, and their prices are all below 3,000 yuan, all of which are 1.5-horse hanging air conditioners.

Source: JD.COM

Judging from the total sales record of the list, Gree and Xiaomi are cliff-leading, both of which have sold more than 200,000 pieces. It is not an exaggeration to say that these two products are the most popular air conditioners of 618. On the product introduction page,After a brief summary, Xiao Lei found that the selling points of the two are actually very similar: silence, rapid refrigeration, frequency conversion and power saving, and self-cleaning..

The biggest difference between the two is that Xiaomi, who has been deeply involved in the field of smart home appliances, has added a remote Zhilian function to his air conditioner, which can be remotely controlled through apps such as Mijia, which is much more convenient than traditional air conditioners, even if he forgets to turn off the air conditioner when going out, he can also remotely operate it. Gree, on the other hand, doesn’t support it, and it needs the help of an additional infrared remote control gateway.

Generally speaking, the functions of the two air conditioners are very similar. In the past two years, the internal and external machines with special functions were self-cleaning. Now, they have become the standard of two thousand yuan air conditioners, which makes people feel a little overwhelmed by the air conditioning industry. Moreover, in Internet home appliance brands, intelligent interconnection has become a standard product, but traditional home appliance manufacturers often only carry intelligent interconnection systems on high-end product lines.

Looking at other products in the list, the functions are basically the same, and the main selling points are very similar. As for the biggest reason to guide users to make choices, I am afraid it is price and brand power. In terms of price, it can be seen that except Gree, most of the hot-selling air conditioners are between 2,000 and 3,000 yuan, while Xiaomi is the cheapest 1.5 air conditioners on the list with a bottom of 1,879 yuan.

Basically, at present, when users choose air conditioners, they still value power saving, power, durability, etc., and have low requirements for some new functions.Of course, there are also some products with "new functions" in the list. For example, Haier’s Jingyue series is equipped with intelligent light sense sleep protection function, which will automatically adjust the buzzer and indicator brightness of the air conditioner after turning off the lights to ensure that the user’s sleep is not disturbed.

Source: JD.COM

From the actual experience, it may be a function that is better than nothing for most people, but it is of great significance to some sensitive friends with poor sleep quality. In addition, in this year’s air-conditioning market, there are many more products advertised with functions such as "fresh air" and "plasma sterilization", and some high-end users will also consider the extra skills of air-conditioning.

In the high-end air-conditioning market, air-conditioning is no longer a simple appliance for cooling and heating. Some users also hope that it can also serve as a new fan, air purifier and other products to keep indoor air clean. The pursuit of health by users is becoming a new direction in the high-end air-conditioning market.

In addition, intelligent voice control, modular customization and other functions have begun to appear one after another. In the high-end market, these new designs and functions are good ways to attract users.

However, on the whole, most manufacturers are still doing "icing on the cake" before there is a big change in the air-conditioning market today. And in most cases, a 2000-3000 yuan on-hook can meet the cooling/heating needs of the room. As for those extra functions, to be honest, it is not as attractive as reducing the price in 500 yuan.

Five zang-organs health-preserving method-Shugan method

2020-06-24 11:51:22.0 Source: China Fitness Qigong Association

　 　 　 Liver belongs to wood, which is the official of a general, and forms the liver system with gallbladder, eyes, tendons and claws.

　 　 　 First, the physiological function of liver

　 　 　 The main physiological functions of the liver are: dispersing and storing blood.

　 　 　 1. The liver governs the drainage: the drainage refers to the dredging, and the drainage refers to the smoothness, which means that the liver can dredge the qi, and it has the movements of ascending, descending, exiting and entering, and circulates all over the body everywhere to maintain the physiological functions of the human body. The function of main drainage is embodied in the following two aspects:

　 　 　 (1) Emotion: The emotional activities of the human body are mainly dominated by the heart and the liver. The difference is that the heart storing the spirit refers to the occurrence of mental disorders and various emotional lesions when the mind is in charge of the mental consciousness. The function of the liver governing the discharge refers to regulating emotional activities and helping to think about problems. When this function is normal, people feel comfortable, optimistic and thoughtful. When it is abnormal, it is emotionally disordered, which is mostly manifested as qi depression and rage. Depression of liver qi can be seen as sullen, suspicious and thoughtful, sad and crying, hypochondriac breast swelling and pain, irregular menstruation. Hyperactivity of liver qi can be seen as impatience, dizziness and hypochondriac pain. Liver dysfunction and emotional abnormality are mutually causal. Liver dysfunction and emotional abnormality turn into depression or hyperactivity, and emotional failure leads to liver disease, which is dysfunction, while rage and qi stagnation both hurt the liver. Therefore, the characteristics of the liver are: being happy (feeling comfortable) and being depressed.

　 　 　 (2) Digestion: Digestion is the function of the spleen and stomach, and the drainage of the liver can help the spleen and stomach digest, which is manifested in two aspects: on the one hand, it helps the spleen and stomach to rise and fall. Normal qi movement changes are spleen ascending to clear, stomach descending to turbid. If the drainage of the liver is normal, the qi can be regulated smoothly, so the spleen can be cleared and the stomach can be turbid. If the liver’s drainage is abnormal, the qi will be disordered, and the stomach will drop when the liver’s qi invades the stomach, which is vomiting and belching in the upper body, and abdominal distension and pain in the middle; When liver-qi invades the spleen, the spleen loses its elevation, which is dizziness in the upper part and diarrhea in the lower part. On the other hand, it secretes and excretes bile: bile is secreted by the liver, which is yellow in color and bitter in taste and discharged into the intestine to help digestion. Normal liver drainage, normal bile secretion and excretion, normal digestion; The liver loses its function of dispersing qi, and bile secretion and excretion are abnormal. If it overflows into the stomach, it will cause yellow mouth, bitter water and epigastric pain. If it cannot be discharged into the intestine, abdominal distension will occur. In addition, the liver governs the discharge, which has a close influence on women’s menstruation.

　 　 　 2. The liver holds blood: it means that the liver has the function of storing and regulating blood.

　 　 　 (1) Storage of blood: The liver is known as the "treasury of blood". The liver looks like a warehouse, and there is a saying in Su Wen Wu Zang Gen Pian: "The blood lying in the old man belongs to the liver". Modern medical research has proved that the liver can increase blood flow by 25% when people lie still, and the whole liver system, including venous system, can store 55% of the whole body blood volume.

　 　 　 (2) Regulate the circulating blood volume: Only the blood of human tissues can play a normal role. When the activities of tissues and organs are strengthened, more blood supply is needed, and conversely, less blood supply is needed. At this time, liver blood can be re-divided. If there is insufficient blood stored in the liver, the leader will not be raised and he will feel dizzy; If you are not surplus, you will see less menstrual flow or amenorrhea; I can’t nourish the collaterals, and my limbs are numb.

　 　 　 Liver-governing and blood-storing cooperate with each other in physiology and affect each other in pathology. liver blood deficiency can cause disorder of blood-releasing, resulting in depression or irritability. Conversely, liver depression and qi stagnation can cause blood stasis (chest and hypochondrium, tingling, amenorrhea, lump) when the mood is abnormal; In great anger, the liver qi goes up against the qi, and blood can be seen bleeding with the surge of qi.

　 　 　 Second, self-guided massage for liver disease intervention

　 　 　 It consists of qigong exercises and massage. When exercising and recovering, you can do qigong first and then massage.

　 　 　 (A) Fitness Qigong movements

　 　 　 1. save your fist and glare to increase your strength

　 　 　 Key points of action: move your body’s center of gravity to the right, move your left foot to the left, squat down with your legs slowly and knees in a stance, and at the same time, hold your hands firmly, with your fist eyes up and look ahead. The left fist rushes forward slowly and forcefully, shoulder-high, with the fist eye facing up; Stare, depending on the direction of the left fist. Left arm pronation, left fist changing palm, tiger mouth down, visual left palm. The left arm is rotated outward, and the elbow joint is slightly bent. At the same time, the left palm is wrapped to the left, and the palm is turned up and then held, with the thumb included, and the left fist is visually observed. The elbow of the left fist is recovered to the waist, the fist eye is up, and the front is visible. The right potential action is the same as the left potential action, and the potential is left and right once, which is done three times in total.

The role of the achievement method: "the main muscle of the liver, enlighten the eyes." The expression "glaring" in this formula can stimulate the liver meridian, make the liver blood full, relieve the diarrhea of the liver qi, and strengthen the bones and muscles. Squatting with two legs and grasping the ground with ten toes, fist-saving with both hands, wrist-twisting, and finger-grasping with force step by step can stimulate the hands and feet at Shu points and Du Meridian in Yang the twelve meridians, Yin San. At the same time, the muscles and tendons of the whole body are stimulated by static stretching, and long-term exercise can make the muscles and muscles of the whole body firm and increase their strength.

　 　 　 2. Qinglong probe claw

　 　 　 Zuo Qinglong explores the claw potential: the feet are shoulder-width apart, the hands are firmly grasped, the elbows are flexed to the waist, the fist wheel is attached to Zhangmen point, and the fist center is upward; Look down front. Then the right fist changes to palm, the right arm is straight, and it abducts to the right from below, slightly lower than the shoulder, and the palm is up; Move your eyes. The right arm bends elbow and wrist, the right palm turns into a "dragon claw", the fingertips are left, and they extend horizontally to the left side of the body through the chin, and the eyes move easily; The trunk then turns to the left about 90; Look at the direction pointed by the right palm. The "right claw" changes its palm, and then the body bends forward to the left, and the palm is pressed down to the outside of the left foot; Look down. The trunk bends from left to right, and drives the right hand to draw an arc to the outside of the right knee or right foot through the left knee or left foot. The arm is rotated outward, the palm is forward, and the grip is firm; Look down with your eyes. The upper body is lifted and upright; The right fist is raised with the upper body and closed at Zhangmen point, with the heart of the fist upward; Look down front. Right Qinglong claw-probing potential: It is the same as left Qinglong claw-probing potential, but in the opposite direction.

　 　 　 Function of achievement method: "Two threats belong to the liver", which can alternately open and close the two threats by turning around, probing left and right paws and bending forward, so as to achieve the effects of soothing the liver, regulating qi and regulating emotions; It can improve the activity function of waist and lower limb muscles.

　 　 　 3. The formula of "shh"

　 　 　 Action points: release your hands, palm up, little finger lightly attached to your waist, and receive it back to your waist; Look down front. Keep your feet still and turn your body 90 to the left; At the same time, the right palm slowly goes out from the waist to the left, to about shoulder height, and with the word "shh" spoken; Eyes gradually open, visual right palm out direction. The right palm draws back the waist along the original road; At the same time, the body turns back to the front; Look down front. The left and right movements are the same, but in the opposite direction. So wear the palm three times left and right. This type utters the word "shh" six times.

Function of achievement method: Shuzi formula can dredge liver qi, prevent and treat liver diseases, eye diseases, chest tightness, loss of appetite, dizziness and other symptoms, and can intervene reproductive system and gynecological diseases.

　 　 　 4. Wind swings lotus leaves

　 　 　 Action points: Left-handed action: the left foot is open to the side, the two feet are parallel, the distance is about shoulder width, and the legs bend their knees and squat; The waist is turned from right to left by 45 degrees, and the hands are changed from ring grip to tiger’s mouth grip stick, the palms are down, and a flat circle is drawn to the left and front through the abdomen; Stand naturally with your legs stretched out; Hold the staff in both hands, roll the wrist and collect the staff in an arc on the left side of the abdomen; Look at the lower left front. Both legs remain the same; Turn the waist to the right, and the staff will move the lower abdomen horizontally from left to right, with the right hand leading the staff to the back of the right shoulder and the left hand holding the staff to the right rib; Then both legs bend their knees and squat; The waist turns positive, and the left and right hands are crossed to the right and left respectively, and the right arm overlaps the chest at the top and the left arm at the bottom; Look ahead. Stretch your knees with your legs and stand naturally; The left hand holding the stick draws a flat circle from the front of the waist to the left rear of the body, and reaches the extension line to the left from the rear edge of the left heel. The left hand is about waist high, and the right arm is naturally straightened and attached to the right ear. The upper body bends to the left, and the stick stands obliquely and stops at the left rear of the body. Then both hands and fingers naturally straighten, hold the staff, and pause; Look at the direction of the staff. Keep your legs still; The body is upright, the head is raised, the staff is raised upward to the top of the head in an arc shape, the wrist is straight, the fingers are upward, the arms are naturally straight, and the eyes are above; Immediately, the legs bend their knees, the staff falls to the chest, and then it is rubbed down from the breasts to the abdomen, and the palms of both hands are down; Close your left foot and right foot together, stand naturally, hold the staff in both hands and put it in front of your abdomen; Look ahead. Right-handed and left-handed movements are the same, but the left and right directions are opposite. This formula is done once for one left and one right, and it is done twice in total.

　 　 　 Function of achievement method: The body bends sideways, which can effectively stimulate the channels such as gallbladder meridian, pulse impulse and Ren Du meridian, help to soothe the liver and benefit the gallbladder, suppress the hyperactivity of liver yang, and promote the smooth operation of qi and blood in the whole body. According to the practice and theory of chiropractic, the left and right flexion of the spine can prevent or adjust the asymmetry and imbalance of the physiological bending of the spine, and effectively avoid the adverse changes in the shape of the spine.

　 　 　 5. Friction potential

　 　 　 Action points: straighten your legs, lift your arms horizontally from side to side, palm down, fingertips outward, cooperate with inhalation, and look ahead. Move the center of gravity to the right, buckle the left foot by 45, move the center of gravity to the left, slightly bend the left foot, straighten the right leg and tilt the palm toe, take the heel of the right foot as the fulcrum, turn the body about 90, and turn the body right at the same time. The center of gravity leans backward and leans forward to drive the two-arm cube to swing the arm, with the left arm up/forward/down to the tip of the right foot, the left fingertip forward and downward, and the left elbow slightly flexes, at the same time, the right arm is downward. Bend your right arm, put your right palm under your armpit, step back about 30 with your right foot, and move your center of gravity backward. Push the root of your right palm along the midline of your armpit, swing forward in an arc, and lift your left palm up to your armpit in an arc. At the same time, your right foot retreats into a left imaginary step, and your body turns left. With exhalation, look at the direction of your right hand. Step back with your left foot, turn your body right, push your left palm forward, lift your right palm up to your right armpit, and take four steps back. At the end of the fourth step backwards and rib rubbing, the right foot tilts up, leans forward, presses the tip of the right foot under the left palm, and lifts the right arm to the back. Get up, buckle your right foot, tilt your left foot abduction, turn left, and drive your two arms to swing three-dimensionally. Bend over, stick the right palm to the left toe, lift the left arm to the back, cooperate with exhalation, and look at the front and bottom. This formula takes four steps back on the left and four steps back on the right. The actions are the same and the directions are opposite. Do it again on the left and right. When you make the last move on the right side, buckle your left foot, keep your right heel inside, get up and turn positive, drive your arms to extend horizontally, then embrace them upward, inhale, bend your knees and press them with your palms down, which is the same height as your navel.With exhalation, look at the front and bottom.

　 　 　 Function of achievement method: The rubbing rib potential can enhance the flexibility of shoulder joint and lower limbs by swinging arms, climbing feet and flexing legs, and can promote the function of dispersing the liver and transporting the spleen by massaging the big acupoints on both sides and twisting the spine left and right. This type of action requires high physical coordination, which can be improved through practice.

　 　 　 (B) Tuina method

　 　 　 1. Wide-chested method: Sit, put the virtual palm of your right hand above your right breast, slap it with appropriate force and gradually move it to the other side, and go back and forth for 10 times. Then cross your palms and cling to the top and bottom of the breast, and rub them back and forth 29 times. Later, two palms are stuck under two armpits, from the upper side of the waist down to the ilium, and pushed back and forth, with heat as the degree.

　 　 　 2. Sparse intercostal space: Sit, with two palms under your armpits, fingers open, and the gap between fingers and ribs is the same width. First, push the right palm to the left to the sternum, then push it to the sternum with the left palm to the right, from top to bottom, alternately push it to the umbilical level, and repeat 10 times. Pay attention to the fingers should be close to the ribs, and the force should be uniform, especially if the chest ribs have a warm feeling.

　 　 　 3. Straighten the triple energizer: Sit or lie down, with two hands and four fingers crossed, press horizontally on the Shanzhong point, and press with two palms on the inner side of both breasts. From top to bottom, push slightly to the end of the abdomen, counting 20 times.

　 　 　 4. Dial Yanglingquan: when sitting, press two thumbs on Yanglingquan point (the point where human tendons meet) on both sides, and the other four fingers are assisted. Press and knead this point for 1 minute first, and then pluck the tendons at this point 3-5 times with force, so as to feel sore and numb.

　 　 　 5. Binocular movement: Keep your gaze straight, keep your head straight and your waist straight. First, slowly rotate your eyes clockwise for 10 times, then stare forward for a moment, and then operate counterclockwise as usual.

　 　 　 Third, nourishing the liver and taking medicine

　 　 　 Traditional Chinese Medicine: Radix Codonopsis, Ganoderma, Colla Corii Asini, Radix Paeoniae Alba, Radix Angelicae Sinensis, Carapax Trionycis, Carapax et Plastrum Testudinis and Bupleuri Radix.

　 　 　 Food: crucian carp, lean pork, animal liver, chicken, shellfish, fungus, medlar, mung bean, banana, kiwi fruit, strawberry, etc.

　 　 　 Ganzao Buxue Decoction: pork liver 30g, duck liver 30g, spinach 100g, dried jujube 20g, water fungus 15g, seasoning: ginger 5g, salt 2g, slicing both pork liver and duck liver; Wash spinach and cut into sections; Put the liver, jujube and auricularia auricula into a pot, add appropriate amount of water and cook for 30 minutes on low heat; Add spinach, salt and ginger and cook for 5 minutes. It has the functions of invigorating qi and liver, replenishing essence and blood. It is suitable for dizziness, fatigue, dysphoria, irritability, etc. caused by liver blood deficiency.

　 　 　 Chrysanthemum honey drink: 50g chrysanthemum, 20ml water, simmer for 30 minutes, filter, add appropriate amount of honey, and mix well before drinking. Has the effects of nourishing liver, improving eyesight, promoting fluid production, quenching thirst, clearing heart fire and strengthening brain, and is suitable for blurred vision, vexation, aphtha, etc. caused by liver fire.

　　According to the spirit of the Notice on Adjusting Relevant Measures for Epidemic Prevention and Control in Our City (No.58 [2022] of Great Epidemic), all citizens will carry out nucleic acid testing twice a week from September 20th, and fulfill the requirements of normalized nucleic acid testing, which does not leak one person, but should be thoroughly checked. The relevant matters are hereby notified as follows:

　　First, the centralized sampling time for normalized nucleic acid detection is from 6: 00 to 18: 00 every Tuesday and Friday.

　　Two, the normalization of nucleic acid detection by the district, city and county (pilot area) unified organization, full participation. Please follow the arrangement of the street (township) and community (village) where you are located, go to the nearby sampling point at the wrong peak, wear a mask throughout the sampling, keep a distance of more than 1 meter from others, and do not talk or gather.

　　Three, all kinds of key populations in accordance with the requirements of the city headquarters to determine the frequency of nucleic acid detection, in the designated time to participate in the sampling and testing of nucleic acid sampling points of key populations.

　　Nucleic acid detection is an important means of epidemic prevention and control. The general public should take the initiative to participate in the detection, actively cooperate with the "site code" inspection, and jointly build a barrier for epidemic prevention and control to protect the hard-won epidemic prevention achievements!

According to the data released by China National Intellectual Property Administration on January 16th, by the end of 2023, the number of effective invention patents in China (excluding Hong Kong, Macao and Taiwan) was 4.015 million, up by 22.4% year-on-year, and China became the first country in the world with the number of effective invention patents exceeding 4 million. According to relevant sources, through the data of intellectual property rights in 2023, we can see that the innovation activities of enterprises remain active, the innovation in the digital economy is strong, and new consumption growth points such as "trendy products" of domestic products are accelerating, and China’s economic vitality continues to generate.

High-value invention patents account for more than 40%

On January 16th, Hu Wenhui, deputy director of China National Intellectual Property Administration, introduced at the press conference held by the State Council Office that it took 31 years for the effective number of invention patents in China (excluding Hong Kong, Macao and Taiwan) to reach the first 1 million, and it only took one and a half years to break through the fourth 1 million. Among the more than 4 million valid invention patents, high-value invention patents account for more than 40%. China has become a veritable intellectual property power, and continues to make important contributions to global innovation and development.

From the perspective of enterprises, by the end of 2023, there were 427,000 enterprises with effective invention patents in China, an increase of 72,000 over the previous year. Domestic enterprises have 2.909 million valid invention patents, accounting for 71.2%, exceeding 70% for the first time, and the status of innovation subject is further highlighted.

In terms of fields, according to the statistics of 35 technical fields classified by the World Intellectual Property Organization, by the end of 2023, the top three technical fields of effective invention patents in China were information technology management methods, computer technology and basic communication programs, which increased by 59.4%, 39.3% and 30.8% respectively year-on-year, far higher than the domestic average growth level. "This shows that China has maintained a high degree of innovation in the field of digital technology and continued to empower and increase efficiency for the high-quality development of the digital economy. Hu Wenhui said.

From the regional perspective, by the end of 2023, the effective number of invention patents in Yangtze River Delta, Beijing-Tianjin-Hebei and Guangdong-Hong Kong-Macao Greater Bay Area were 1.308 million, 703,000 and 672,000 respectively, accounting for 65.6% of the domestic total, up 21.1%, 21.0% and 23.2% respectively, and the leading role of innovation in key areas was remarkable.

Hu Wenhui said that China National Intellectual Property Administration will continue to improve the quality and efficiency of examination, vigorously promote the transformation and application of patents, accelerate the realization of patent value, better stimulate the innovation vitality of the whole society and help high-quality economic and social development.

The annual output value of geographical indication products exceeds 800 billion yuan.

According to the data of China National Intellectual Property Administration, in 2023, 13 geographical indication products were approved, and 201 geographical indications were registered as collective trademarks and certification trademarks. 5,842 business entities approved to use special geographical indications.

Hu Wenhui introduced that by the end of 2023, China had approved a total of 2,508 geographical indication products, and 7,277 geographical indications were registered as collective trademarks and certification trademarks, with a total of 26,000 business entities specializing in geographical indications and an annual output value of geographical indication products exceeding 800 billion yuan.

With the continuous development in China, China’s geographical indication products have accelerated their entry into the international market and are favored by more overseas consumers. Wen Guo, Director of the Intellectual Property Protection Department of China National Intellectual Property Administration, said that this year is the third year since the signing of the Agreement on the Protection and Cooperation of Geographical Indications between China and Europe. Since the entry into force of the agreement, many products have been selected into the list of mutual recognition and mutual protection of geographical indications between China and Europe, and the mutual recognition and mutual protection products have won the reputation and affirmation of European consumers for their unique quality characteristics. For example, after Liuyang Fireworks was listed as a product of mutual recognition and mutual insurance, the export volume climbed year after year, reaching 7.06 billion yuan in 2023, accounting for 19% of its total output value, setting a new high.

"The international popularity of China’s geographical indication products is getting higher and higher." Wen Guo said that the number of enterprises that approved the use of special geographical indications has quadrupled to 73 since the wine at the eastern foot of Helan Mountain was selected into the mutual recognition and mutual insurance list. The wines of more than 60 wineries in the producing areas have won more than 1,100 awards in various international wine competitions, and their products are exported to more than 40 countries and regions.

Cultivate new consumption growth points such as domestic products "trendy products"

Hu Wenhui said that the development of "fashionable goods" of domestic products is inseparable from the all-round assistance of intellectual property rights, especially the need to make good use of the trademark system to strengthen brand protection and realize brand value. China National Intellectual Property Administration has thoroughly implemented the trademark brand strategy, vigorously promoted the trademark brand construction, and helped to cultivate new consumption growth points such as "fashionable goods" of domestic products.

-Strengthen policy support. Taking the construction of "a thousand enterprises with thousands of standards" and "a hundred cities with hundreds of products" and trademark brand guidance stations as the starting point, we encourage local and enterprises to strengthen trademark brand construction, support the innovation and upgrading of traditional brands, and actively cultivate emerging brands. Recently, the first batch of 1,105 enterprise trademark brands and 285 regional trademark brands were approved to participate in the trademark brand value promotion action of "Thousands of Enterprises and Hundred Cities", and China National Intellectual Property Administration will give guidance and support in enhancing the trademark brand ability and brand value.

-Improve the service level. Promote the construction of more than 3,900 trademark brand guidance stations nationwide, with an average annual service of more than 400,000 enterprises. We will continue to promote trademark pledge financing to benefit enterprises. In 2023, the national trademark pledge financing amount reached 176.91 billion yuan, up 63.5% year-on-year, which helped enterprises effectively alleviate the financial difficulties in the process of brand development.

-Strengthen brand protection. We will continue to push forward the revision process of the Trademark Law, strengthen the protection of legitimate prior rights of trademark brands and well-known trademarks, conscientiously guide foreign-related intellectual property disputes when domestic products go out to sea, resolutely crack down on all kinds of behaviors such as being next to famous brands, hitchhiking and rubbing hot spots, and boost the confidence of brand development and the sense of gaining business entities.

Hu Wenhui said that China National Intellectual Property Administration will continue to promote the brand value promotion of "Thousands of Enterprises and Hundreds of Cities" to help form more influential national brands and internationally renowned brands, create more "fashionable products" of domestic products and expand the scale of brand consumption. (Reporter Qiu Haifeng)

The revised budget law requires the establishment and improvement of a "regular evaluation and withdrawal mechanism" for special transfer payments. Where the market competition mechanism can effectively regulate matters, "special transfer payments shall not be established". In addition to the matters shared by the lower and higher levels of government, the higher level shall not require the lower level to support the special transfer payment.

The issue of fiscal transfer payment has always been a major focus of public concern about the revision of the budget law. In the previous deliberations of the budget law, members of the Standing Committee often pointed out that the proportion of special transfer payments is relatively large, even higher than that of general transfer payments. Then, what kind of provisions does the revised budget law make for the financial transfer payment system, especially the special transfer payment? After the implementation of the budget law on January 1, 2015, how much will it restrict the problems of low efficiency, lack of effective supervision and misappropriation of some special funds? Some highlights of the new budget law on fiscal transfer payment can answer these questions.

The reporter learned that transfer payment is an activity that governments at all levels transfer financial funds through certain forms and channels to supplement public goods and provide free expenses. It is also an important means for China to make up for the financial gap brought about by the financial system characteristics of "highly decentralized expenditure and centralized taxation". It seems that the central government’s transfer payment to local finance is far away from the people, and many livelihood funds such as education, medical care and social security, which are actually related to the well-being of the people, come from transfer payment. Too much special transfer payment will encourage the local atmosphere of "running the department to make money", lead to corruption and waste, and increase the burden of local supporting facilities, which will become a difficult problem for reform. However, there is no corresponding regulation and management in the current budget law, which also brings some problems, such as fund abuse, "running out of money" and inefficient use of funds.

Therefore, the revised budget law stipulates the financial transfer payment, and clarifies the legal status of the transfer payment for the first time, which is a great progress. In particular, the revision of the budget law is consistent with the policy tone of "increasing the general and reducing the special" proposed by the central government, emphasizing the exit mechanism of special transfer payments and legalizing the follow-up management of special transfer payments, which has become the highlight of the revision of the budget law. The revised budget law clearly stipulates the financial transfer payment system. According to the law, the state implements the financial transfer payment system. Financial transfer payment should be standardized, fair and open, with the main goal of promoting the equalization of basic public services between regions. Financial transfer payment includes the transfer payment from the central government to the local government and the transfer payment from the local higher-level government to the lower-level government, with the general transfer payment as the main body to balance the basic financial resources between regions and be arranged and used by the lower-level government as a whole.

The law also stipulates that special transfer payments can be set up to handle specific matters in accordance with laws, administrative regulations and the provisions of the State Council. Establish and improve the regular evaluation and withdrawal mechanism of special transfer payments. For matters that can be effectively regulated by the market competition mechanism, no special transfer payment shall be established. When arranging special transfer payments, the higher-level government shall not require the lower-level government to bear matching funds. However, in accordance with the provisions of the State Council, matters that should be shared by the higher and lower governments are excluded.

Moreover, the new budget law also makes detailed provisions on the budget preparation of transfer payments, and the general transfer payments are prepared according to a unified method. At present, the general transfer payment from the central government to the local government has been compiled according to the formula method, and the basic principles and methods have been formulated by the relevant departments of the central government, with a unified and open calculation formula. "All regions can know how many general transfer payments there are according to the same standards and methods. This way, the central budget can enter the local budget as soon as possible. " Liu Shangxi, deputy director of the Institute of Fiscal Science of the Ministry of Finance, said.

In terms of special transfer payment, the previous special transfer payment generally determined a special project first, and then assigned to provinces, cities and counties, and then operated after the budget was approved. Liu Shangxi said, "Because the special transfer is related to various departments, it is difficult to get in place in supervision, management and performance appraisal, and even lead to corruption." In this regard, the new budget law requires sub-regional and sub-project preparation. First, tell what projects to do, how much money is needed, where the money will be used specifically, and where it will be allocated. It must be clear in advance, and you can’t wait until the budget is compiled to find the project with money.

On August 31st, when answering a reporter’s question about financial transfer payment, Finance Minister Lou Jiwei said that comprehensive measures are needed to solve the problem of financial transfer payment, which has been comprehensively stipulated in the budget law. For example, the new budget law clearly requires that the budget must be complete and open. Except for confidential information, it should be made public in principle. "Openness is the best sunshine", because some special transfer payments have repeated objectives and little effect. The Third Plenary Session of the 18th CPC Central Committee proposed to clean up, integrate and standardize the special transfer payment. By opening the budget, some special transfer payments can be reduced, which is conducive to the merger of similar items. ?

For another example, the new budget law requires the establishment of a cross-year budget balance system, and it is necessary to make medium-and long-term budget planning. In the past, we used to make budgets on an annual basis, and fiscal revenue and expenditure, including income system and expenditure policy, are medium-and long-term policy tools. Therefore, the implementation of medium-and long-term planning, rolling budget and rolling planning can make the policy have long-term consideration, demonstrate scientifically, reduce fragmentation and randomness, and also help reduce special transfer payments.

"The next step is to standardize integration in accordance with the requirements put forward by the Third Plenary Session of the 18th CPC Central Committee. Generally speaking, the goal is clear, the means are clear, and don’t cut it too thin. Distinguish between the responsibilities of the central and local governments, and the central and local governments jointly arrange expenditures. The part of the special transfer payment that belongs to the local responsibilities is gradually cancelled and becomes a general transfer payment. Entrust local matters to minimize. " Lou Jiwei said. By taking the above measures, "special transfer payments will be reduced and general transfer payments will increase." (Text/reporter Wang Ping)