This year, Project ONE, the 50th anniversary model of AMG, received high attention. There are two main reasons: first, it is expensive, and only 275 sets are limited to production, and the price is 2.27 million euros.

Secondly, the data is too strong. This car is equipped with F1 racing car that should only appear on the track. It will be more than 1014 horsepower, and the acceleration of 100 kilometers will take 2 seconds, while the acceleration of 0 to 200 kilometers will only take 6 seconds. What’s even more incredible is that this car is only 1.6 liters, with four motors.

　　

So the question is, how does this sports car make the power so strong?

First of all, the power system of AMG Project ONE is a hybrid system consisting of a 1.6T V6 and four motors. This one originated from the F1 Championship for the 2015 season. Lewis hamilton also won the championship this year with this excellent performance.

According to the published data, 1.6T booster plus 4 motors, the total reached 746kW. One of the four motors provides pumping power for the turbine, which is 90kW. This motor does not participate in direct work to drive the whole vehicle, but provides power source for the electronic turbine. The other three motors are 120kW, which can directly provide power for the whole vehicle. This hybrid mode is a parallel mode.

　　

The advantage of parallel mode is that the energy loss is small, and each motor can drive the whole vehicle independently. In addition to transmission loss and system error, the sum can be calculated by superposition. This power system is about 746kW, minus the superposition of three motors of 360kW, so this 1.6 liter will reach 386kW.

Is it ridiculous? This is something that you can’t even think about. Generally, it takes more than 4L to achieve 386kW, but it can be achieved on a 1.6L platform, just like a 3-year-old child lifting a weight of 80kg.

The maximum NA of conventional 1.6L is only about 90kW, and the rotating speed is 6000rpm. If the rotating speed is doubled to 12000rpm, the times of doing work per unit time will be doubled. Plus, if it is increased by 40%, it will reach 252kW.

　　

So how did this model achieve 386Kw? This AMG with a F1 heart not only uses exhaust gas to drive the turbine to increase the intake density, but also uses a 90kW motor to drive the electric turbine to increase the intake density, so it is entirely possible to reach 386kW.

This is the secret weapon of Super Engine with super power, but there are many problems to be solved to make it work normally. The first is inertia force. With the increase of rotational speed, the average speed is 7-12M/S, and the acceleration can reach about 200 g, while the rotational speed of Super Engine is twice or more than that of the conventional 1.6L. If designed according to the routine, the acceleration can reach 400 g, which is a great design challenge.

How does Super Engine do to overcome such a large inertial force? First of all, this is the advantage of a V6, V-type. For the whole vehicle, it can lower the center of gravity, and the effect is better. For me, first of all, the V-shape can decompose the inertial force into two opposite directions in the horizontal plane, and the inertial force can cancel each other out. So we only need to overcome the vertical component.

　　

Secondly, 1.6L is divided into six cylinders, and the volume of each cylinder is reduced from 0.4L to 0.266L. The mass and volume of the connecting rod can be made smaller, so the rotation speed can be improved and the inertia force can be reduced.

In addition, the moment arm of is 1/2, so the Super Engine must be as short as possible, and F1 will generally set/to 2.5, so that the inertia force will be reduced at high speed.

In addition, the system, the opening and closing of the conventional camshaft drive, can no longer meet the reliability requirements at such a high speed, plus the force attenuation, the conventional steel is completely incompetent for this work. Therefore, a high-pressure nitrogen pressure tank must be equipped separately, and the pressure release gas pushing mechanism of the pressure tank can be controlled by calculating the opening and closing time of the electromagnetic valve, so that the reciprocating motion can be carried out quickly.

Super Engine rotates at 12,000 revolutions per minute, ignites 200 times per second, and opens and closes 200 times per second. The strength and reliability requirements of these core components, as well as the accuracy of ignition design, are very high, among which titanium alloy is the best choice for material selection.

　　

It needs to be emphasized here that the increase of intake density is directly proportional to the temperature in the intercooling system of this car. The intake air volume of 4.5L is inhaled in a unit time of 1.6L According to the conventional conversion, the intake pressure will reach about 3 bar, and the temperature after vortex will be much higher than that of traditional supercharging, so it is necessary to make a special design for the intercooling system to cool the intake temperature.

Generally, the service life of F1 racing car is 1000 kilometers, over after the runway is completed, which is caused by different design concepts. F1 is to pursue the ultimate speed and win the race. If the speed is designed to be above 15,000 rpm and other performance is sacrificed to improve the speed, such as reducing the weight of all parts, its reliability will not be considered, because winning the game is more important than everything else.

The service life of AMG Project ONE is 50,000 kilometers, which is much longer than that of F1′ s1,000 kilometers. I think there are two main reasons: first, the speed is reduced to about 11,000 rpm, so the use environment of parts is much milder than that of F1; Second, the use environment of the car, F1 is basically the biggest running on the track, and the maximum potential of F1 is fully exerted. However, AMG Project ONE cannot run at full speed within its life cycle, but should have its own durable working conditions.

　　

Finally, the technology of F1 events will be decentralized to the civilian field, bringing us such a high-performance product. In my opinion, this is just a high-end souvenir for the 50th anniversary of AMG, to let the world know the technology and look forward to it. However, it didn’t achieve real civilian use, 50,000 kilometers, and the conventional car was only maintained for 3 ~ 5 times, but AMG Project ONE had to change the powertrain to continue to use. In addition, the pure electric mode only lasted for 20 kilometers, which was a bit embarrassing.

Therefore, AMG Project ONE can improve the reliability and battery technology to be truly commercialized.

finish

　　　　　　 CCTV News:On September 16, 2019, the website of the State Supervision Commission of the Central Commission for Discipline Inspection released a message: Hu Hongchun, former member of the Standing Committee of Wuhan Municipal Committee, former secretary of the Working Committee of Wuhan Development Zone and former secretary of Hannan District Committee, was expelled from the Party and public office.

　　　　　　 After investigation, Hu Hongchun deviated from the party’s purpose, lost his ideals and beliefs, was disloyal and dishonest to the party, violated political discipline, transferred, concealed and destroyed stolen money, and resisted organizational review; Violation of organizational discipline, failing to truthfully explain the problem when organizing letters and inquiries; Violating the discipline of honesty, engaging in paid intermediary activities such as selling Cordyceps in violation of regulations, and accepting gifts that may affect the fair execution of official duties; Violation of work discipline, ineffective implementation of laws and regulations on the management of religious affairs, and important leadership responsibility for the illegal construction of places for religious activities and the neglect of religious Buddhism within the jurisdiction, resulting in adverse effects and major economic losses; Violate life discipline. Violation of national laws, taking advantage of his position to seek benefits for others, asking for and illegally accepting other people’s property, the amount is particularly huge, and he is suspected of accepting bribes; Abuse of power, illegal provision of assistance to criminals for parole, resulting in criminals committing a variety of illegal and criminal acts after being paroled, seriously damaging the national legal authority and judicial credibility, causing adverse social impact, suspected of abuse of power.

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　　　　　　 In this bulletin, several items are rare and attracted everyone’s attention at the first time.

　　　　　　 First of all, the item "engaging in paid intermediary activities such as selling Cordyceps in violation of regulations" is very eye-catching. According to Hu Hongchun’s public resume, in September 2004, he served as deputy secretary of Huangpi District Committee (from June 2004 to June 2007, he served as secretary of Naidong County Committee of Xizang Autonomous Region). As we all know, Xizang Autonomous Region is one of the main producing areas of Cordyceps sinensis in China.

　　　　　　 Secondly, it can be said that it is very rare for this content to appear in the notification of officials who have fallen off the horse. According to the public resume, Hu Hongchun served as member of the Standing Committee of Wuhan Municipal Committee and Minister of United Front Work Department in December 2017; In December 2018, he served as member of the Standing Committee of Wuhan Municipal Committee, Minister of United Front Work Department, Secretary of Working Committee of Wuhan Development Zone and Secretary of Hannan District Committee; Since February 2019, he will no longer serve as the head of the United Front Work Department of Wuhan Municipal Committee.

　　　　　　 According to the website of the United Front Work Department of Wuhan Municipal Committee of the Communist Party of China, the United Front Work Department of Wuhan Municipal Committee of the Communist Party of China was established in August 1950 and is the functional department in charge of the United front work of Wuhan Municipal Committee of the Communist Party of China. The main functions and tasks are to implement the line, principles and policies of the Central Committee, the Provincial Party Committee and the Municipal Party Committee on the United front, strengthen ties with democratic parties, federations of industry and commerce, personages without party affiliation and relevant people’s organizations in the city, actively carry out United front work in various fields such as non-public economy, democratic parties, ethnic religions, Hong Kong, Macao and Taiwan, overseas, non-party intellectuals and new social strata, win people’s hearts, gather strength, mobilize all positive factors, and turn negative factors into positive ones, which is formulated by the Municipal Party Committee for the realization.

　　　　　　 In addition, the bulletin also mentioned a very hateful behavior of Hu Hongchun — — Abuse of power, illegal provision of help for criminal parole. We have noticed that on March 18th, 2019, Li Shengqiao, former Party Secretary and Chairman of huangpi district CPPCC, was expelled from the Party and public office. At that time, it was reported that he "took advantage of his position as secretary of the Political and Legal Committee of huangpi district, engaged in malpractices for personal gain, abused his power, provided help to criminals who violated the rules of parole, seriously damaged legal authority and judicial credibility, and caused adverse social impact, and was suspected of abusing his power". As a leading cadre in party member, Li Shengqiao lost his ideals and beliefs, deviated from the party’s purpose, abused public power, and acted as a "protective umbrella" for people involved in black and evil; The expansion of selfish desires, accepting bribes, seriously violating the party’s discipline and national laws, and being suspected of duty crimes, and failing to converge and stop after the 18 th National Congress of the Communist Party of China, the nature is bad and the circumstances are serious, which should be dealt with seriously.

　　　　　　 According to public information, from October 2001 to October 2011, Li Shengqiao served as member of the Standing Committee of huangpi district District Committee and secretary of the Political and Legal Committee of the District Committee. From October 2011 to November 2011, he served as Party Secretary of huangpi district CPPCC and Secretary of the Political and Legal Committee of the District Committee; From November 2011 to November 2016, he served as Party Secretary and Chairman of huangpi district CPPCC; Since November 2016, I have retired to the second line.

　　　　　　 In October 2001, Hu Hongchun served as member of the Standing Committee of Wuhan Huangpi District Committee and director of the office; In September 2004, he served as deputy secretary of Huangpi District Committee of Wuhan City; In November 2007, he served as deputy secretary of the Working Committee of the Wuhan Municipal Committee (bureau level); In August 2009, he served as deputy secretary and acting district head of Huangpi District Committee of Wuhan City; In December 2009, he served as deputy secretary and district head of Huangpi District Committee of Wuhan City; In September 2011, he served as secretary of Huangpi District Committee of Wuhan.

　　　　　　 On September 28, 2018, Li Shengqiao was suspected of serious violation of the law and accepted the disciplinary review and supervision investigation by the Supervision Committee of the Hubei Provincial Commission for Discipline Inspection.

　　　　　　 On March 21, 2019, Hu Hongchun was suspected of serious violation of discipline and duty, and was subject to disciplinary review and supervision investigation.

　　　　　　 The two men’s working experiences overlap, and both of them mentioned the same crime in the "double-opening" briefing, which has to be thought-provoking.

　　Cctv news: Pay attention to the situation of valsartan in Zhejiang Huahai Pharmaceutical Company. Yesterday (July 29th), the spokesperson of National Medical Products Administration introduced the situation of trace N- nitrosodimethylamine (NDMA) impurities detected in valsartan raw materials of Zhejiang Huahai Pharmaceutical Co., Ltd.　

　　On July 6th, Zhejiang Huahai Pharmaceutical reported to National Medical Products Administration that a small amount of N- nitrosodimethylamine (NDMA) impurities were detected in the raw materials of valsartan for export, and voluntarily disclosed relevant information to the public according to relevant regulations and requirements.

　　Zhejiang Huahai Pharmaceutical Co., Ltd. immediately suspended the release and delivery of all valsartan raw materials in the domestic and international markets after detecting the impurity, and initiated the measures of voluntary recall. As of July 23, Zhejiang Huahai Pharmaceutical has completed the recall of all raw materials in China.

　　In 2012 and 2013, the current process of raw materials of this enterprise was approved by the European Drug Administration (EMA) and the US Food and Drug Administration (FDA) respectively.

　　Since July 6th, National Medical Products Administration has maintained close communication and contact with the European Drug Administration and the US Food and Drug Administration, paid close attention to the announcements and trends of risk assessment issued by international regulatory agencies, and organized experts to carry out risk assessment.

　　According to the toxicological data, the maximum daily intake limit of N- nitrosodimethylamine is 0.1μ G, which is equivalent to the provisional reference limit value of 0.3ppm by the European Drug Administration (calculated by taking 320mg valsartan daily).

　　According to the above-mentioned limit value, National Medical Products Administration conducted risk investigation on all the seven domestic manufacturers of valsartan raw materials (including Zhejiang Huahai Pharmaceutical). Except for the impurity of N- nitrosodimethylamine in valsartan raw materials of Zhejiang Huahai Pharmaceutical, the impurity detection value of N- nitrosodimethylamine in other domestic manufacturers of valsartan raw materials was lower than the limit value or was not detected.

　　There are 6 pharmaceutical manufacturers involved in the use of valsartan in Zhejiang Huahai Pharmaceutical:

　　The valsartan capsule (National Medicine Zhunzi H20103521) produced by Hunan Qianjin Xiangjiang Pharmaceutical Co., Ltd. has not yet left the factory.

　　The impurities of N- nitrosodimethylamine in the listed products of the other five manufacturers exceeded the limit, namely

　　Valsartan Hydrochlorothiazide Capsule of Chongqing Kangkeer Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20080097)

　　Valsartan dispersible tablets of Hainan Huanglong Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20050508)

　　Valsartan dispersible tablets of Harbin Sanlian Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20061058)

　　Valsartan Hydrochlorothiazide Dispersible Tablets of Jiangsu Wangao Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20090262)

　　Valsartan dispersible tablets of Shandong Yijian Pharmaceutical Co., Ltd. (National Medicine Zhunzi H20090319)

　　The above five preparation manufacturers have stopped using the raw materials of Valsartan of Huahai Pharmaceutical and recalled relevant drugs according to regulations.

　　National Medical Products Administration has asked all provincial food and drug supervision and management departments to urge relevant preparation manufacturers to take recall measures, and disclose relevant recall information on the websites of five manufacturers, including the contact numbers of the enterprises responsible for the recall.

　　In order to facilitate the public to know in time whether the Valsartan drugs being used are within the scope of recall, five manufacturers have cooperated with information technology companies and launched the code scanning inquiry function at 22: 00 on July 26, 2018. The product traceability code can be scanned through the mobile APP to realize instant inquiry.

　　National Medical Products Administration spokesman stressed that besides the above five preparation manufacturers, other valsartan preparation products are not included in the recall.

　　At present, European Union and other multinational drug regulatory agencies believe that N- nitrosodimethylamine belongs to Class 2A carcinogen (that is, there is sufficient evidence in animal experiments, but the evidence is limited), and it may be exposed to this substance in daily life (such as preserved food). Analysis of the drugs involved this time will not cause serious health risks to patients, but for safety reasons, risk control measures such as stopping sales and recalling should be taken.

　　On July 27th, FDA issued a notice that patients taking recalled valsartan should continue to take the current drugs until doctors or pharmacists provide alternative drugs or different treatment schemes.

　　A spokesman for National Medical Products Administration reminded that patients who are taking valsartan drugs must not stop taking them without authorization, because the risk of stopping taking them without authorization is more direct and serious for patients with hypertension. Whether to stop taking medicine or change medicine must be carried out under the guidance of a doctor. You can contact a doctor to replace other drugs containing valsartan that are not involved in the recall or choose other drugs for alternative treatment.

　　National Medical Products Administration requires the relevant provincial food and drug supervision and management departments to continue to follow the relevant provisions of the Measures for the Administration of Drug Recall, urge enterprises to do a good job in product recall and protect people’s drug safety.

Special feature of 1905 film network When the opera meets the film, since its release, it has been evaluated with the high score of Douban 8.2 by virtue of the audience’s good reputation.

As the first 4K panoramic Cantonese opera film, it was shortlisted for the best opera film in the Golden Rooster Award for Chinese films, and also won the Golden Coconut Award for the best technology in Hainan Island International Film Festival. Through film technology, traditional Chinese opera is given a new look, and behind this, it is also inseparable from the credit of editing technology.

The editor of this film is a national first-class editor. His previous representative works include Youth Fight, Deep Sea Sword and Men’s Gang. Sun Yiqun’s mother is also an editor. She is Yang Xingyuan, the former president of China Film Editing Society, and her representative editing works are various.

Can editing technology be inherited? In this issue of Behind the Scene, Yang Xingyuan and Sun Yiqun, the editors, lead us into china national film museum to reveal the history of film film editing, and experience the technological changes of film editing together from the film age to the digital age.

Behind the scenes: Film editor Yang Xingyuan reveals the tools of "film film editing"

Film clip: "Manual sewing machine"

I have a particularly cordial feeling. I can feel the temperature of all these devices. Entering china national film museum, Yang Xingyuan knows a lot about the film editing machines in the museum.

　

Facing a splicing machine full of historical colors, Yang Xingyuan introduced that Premier Zhou Enlai cared about film splicing and specially entrusted Tianjin No.2 Optical Instrument Factory to develop this splicing machine for them, also known as the four-way sound painting machine.

From the end of the 1960s to the end of the 1990s, this was the only tool for their editors, and the frequency was controlled in the frequency of 24 squares by hand. "My editing of Man to Middle Age, Zhou Enlai and Armageddon was cut out by such a machine."

The process of film editing is particularly complicated. After the film is finished, it should be washed in the studio, and then printed into samples with the negative, and the editor and the director and other producers will jointly review it.

　

When editing, the sound and picture of the sample should be synchronized with the negative, so the first step of editing is not to cut, but to arrange, and each of the specific scenes, shots and sound tapes in all the shooting materials should be completely recorded first, otherwise the material synchronized with the negative can not be found later.

　

"So it’s not easy to start editing. All this work has to be done before you can enter the creative stage." Yang Xingyuan said that it is more difficult at the stage of revision. For example, if there are ten films and one place is revised, these ten films will have to be hand-cranked from beginning to end on the film receiver. "After shaking it down, it is a lot of films, and then it is lifted one by one. At that time, the state positioned the editor as a light manual worker. "

Recalling the editing work of "Zhou Enlai", at that time, the version of mixed editing of picture and sound was completed, but the director had to modify the picture temporarily. "I was so angry that I wouldn’t change it for you, but he personally took a dozen films upstairs and asked me to change it." In order to make the film better, Yang Xingyuan said that even if the editing process was not easy at that time, it still had to be modified.

In the past, when editing technology was underdeveloped, a small machine supported the creation of many excellent classic films. Sun Yiqun recalled, "At that time, my mother stayed up late at night, so I slept next to her with a small quilt. I always wanted to shake this film, and my mother was particularly afraid that I would destroy it. She said that if you broke it, the consequences would be unimaginable."

Nowadays, computer technology is very simple to operate the effects of transition editing, such as fade-in, fade-out, cut-in and cut-out, overlapping, etc., but it is very troublesome in the film age. It is necessary for the editor to make specific marks on the film with a special pen, and then let the special effects producers use optical skills to make them on the film.

　

The complicated and exquisite technology of film film editors bears the heavy history of China films.

"For example, there are seven kinds of scenes to record a dialogue and an action now. I think the workload is very heavy. There are more than 200 shots as soon as I open the folder, but it is much more complicated than us to hear these things that the predecessors are editing. My mother sewed by hand at that time, and now it is equivalent to using an electric sewing machine. "

　

Hearing his mother’s introduction to film editing technology, Sun Yiqun felt a lot. "Now we have mastered new technologies and brought us convenience, while the older generation got through it like that and admired it."

Digital editing: White Snake’s secret recipe

The era of film editing has ended, and digital computer technology has been fully popularized. Nowadays, Sun Yiqun’s editing work is no longer just a simple operation technology, but also needs to integrate his own ideas at the creative level.

　

Talking about her latest film White Snake, Sun Yiqun said that in editing skills, she paid special attention to the balance between drama and film.

"There are many stylized things in traditional Chinese opera. Actors often communicate with the audience and the camera, which breaks the spatial illusion that the film has carefully established." Therefore, she will especially avoid editing the lens that highlights the "fourth wall" and choose more pictures of actors communicating with each other.

　

When the traditional Chinese opera performance is put on the movie screen, it is easy to have a magnifying effect. In addition, it is 4K quality, and any tiny expression of the actor can be clearly captured. When editing, Sun Yiqun will also avoid the scenes that will appear exaggerated on the big screen.

"The hand, eye, body and steps of an opera actor, his figure is a very important aspect of expression. If I edit excessively or even choose inappropriate scenery, it will destroy the good rhythm of the opera, so I still have to pick up its rhythm and grasp it well." How to find a moderate point is a difficult part of this editing.

　

Sun Yiqun is also worried that if the aria is too long, it will affect the audience’s desire to watch. Among them, there is a scene of "Broken Bridge and Residual Snow", in which lady white snake complains to Xu Xian after suffering, and the recorded aria is very long. She took the initiative to discuss the reduction with the director. "Otherwise, it would ruin lady white snake’s image and become a dissatisfied housewife." Finally, after coordination and careful cutting, it was cut for more than 30 minutes.

White Snake reinterprets classic stories and boldly tries new editing techniques of combining drama with film. Yang Xingyuan feels that today’s editors have a higher pursuit than the older generation. "They need to have the ability to master the lens and handle the structure, not the things we have learned. Those things have passed. They can put more energy into creation. "

Two generations of editing methods

Yang Xingyuan was originally an actor, but later transferred to Changying and changed to editing. "Having been an actor for more than ten or twenty years, I can still understand the performance and rhythm, and this accumulation will be useful. I just thought I could learn to edit and play my little role."

　

Thanks to her experience as an actor, Yang Xingyuan switched to editing, and she can better handle the rhythm of performances and shots.

　

When cutting "Man to Middle Age", because Lu Wenting and Yang Xingyuan are both of the same generation, Yang Xingyuan said that she edited the character completely according to the character and her own feelings. "Lu Wenting went to see the child, and the editor must understand how she looked at it in order to impress the audience. So I chose her to post it in the nearest place to watch the child sleeping, so that I can understand the psychological feelings of this character. "

With more than 40 years of experience in behind-the-scenes editing, Yang Xingyuan concluded that editors should think about editing from three angles.

　

The first is the director. "I must know what he wants to do, what he wants to show and what he wants to give to the audience." Then there is the character, "to understand the character’s mentality and his various things."

Then there is the audience. "You must know what the audience wants to see and where his interest lies. I can’t say that I am an old lady now. My rhythm is slow, so I don’t appreciate the audience’s appreciation ability. I also deal with the film according to my rhythm and speed, and the audience will definitely stop watching it. "

Daughter Sun Yiqun did a lot of work that had nothing to do with art. Later, her mother thought she should learn a skill, so she taught her to edit and took her into the business. The two later jointly edited the TV series Behind the Vanity.

　

"They always ask why the play they cut is not good-looking. I said that because you cut the process, it is not a play." Sun Yiqun believes that a good editing is to "pick up" the scene and find the eye of the scene, while a bad editing is to exert an average force. "If the scene and the scene are not more energetic, it will not work."

　

In her view, editing and scriptwriting have a lot in common, they all want to tell stories, and they all want to think about how to make this story vivid, interesting and arresting.

From Yang Xingyuan to Sun Yiqun, from film editing to digital editing, the editors of mother and daughter have great enthusiasm for this art, which has been passed down from generation to generation not only for the iterative upgrade of film editing skills, but also for the consistent dedication, concentration, lean and innovative craftsmanship as editors.

The year 2023 is of great significance to the drugs for autoimmune diseases and even to the global innovative drug market. With the expiration of patents in key markets, Hummel (adalimumab) will officially hand over the title of global sales champion for 11 years, and the first generation of "drug king" will officially end.

Due to the complex pathogenesis, the number of patients with autoimmune diseases is large and it is difficult to cure. The long-term or even lifelong demand for drugs has spawned a huge market for autoimmune drugs, which has become a hotbed for the growth of heavy drugs.

Under the demonstration effect of "drug king", major pharmaceutical companies around the world have been scrambling for layout in recent years. At present, breakthroughs have been made in the development of new drugs for potential targets such as JAK and interleukin, and the free drug track is expected to usher in a new round of competition. Local innovative drug companies try to gain a place in the domestic free drug market through differentiated distribution of indications and continuous optimization of safety.

The market for self-exempted drugs continues to grow steadily.

Autoimmune system diseases refer to diseases caused by immune response to autoantigens and self-tissue damage. Genetic defects and environmental factors are all important links in inducing autoimmune diseases. The complex disease mechanism leads to a wide variety of autoimmune diseases and a large patient base. At present, there are more than 100 known main disease types, including psoriasis, atopic dermatitis, compulsory spondylitis, rheumatoid arthritis and systemic lupus erythematosus.

As a chronic disease, autoimmune diseases usually do not directly kill people, but it is also difficult to cure them. Such as compulsory spondylitis, systemic lupus erythematosus, etc., once suffering from it, it will be difficult to reverse, which is called "undead cancer". Patients need long-term or even lifelong medication, thus giving birth to the long-term and stable growth of market demand for self-immune drugs.

Based on the financial report data of major pharmaceutical companies, in 2022, there were 22 self-disease-free drugs in the list of TOP100 drugs with global sales scale, of which 10 drugs exceeded $3 billion and the total sales exceeded $70 billion.

According to the statistics of AARDA, patients with autoimmune diseases account for 7.6%-9.4% of the global population in recent years. Jost Sullivan’s statistics show that there are nearly 500 million patients with various kinds of self-immune diseases in the world, and the global self-immune drug market will reach about 132.3 billion US dollars in 2022, which has become the second largest disease market after cancer.

Jost Sullivan predicted that by 2030, the global self-exempted drug market is expected to reach US$ 176 billion, with a compound annual growth rate of 3.6% from 2022 to 2030. Among them, the self-exempted drug market in China is expected to reach nearly US$ 25 billion in 2030, a tenfold increase compared with 2020, which is an important incremental source of global self-exempted drugs.

The "King of Medicine" made a curtain call, and new drugs rose one after another.

Treatment strategies for autoimmune diseases include inflammation alleviation and immunosuppression. Although non-steroidal anti-inflammatory drugs, corticosteroids and anti-rheumatic drugs have good anti-inflammatory effects, they are difficult to fundamentally stop the development of the disease, and they are easy to relapse after stopping taking drugs. However, traditional non-selective immunosuppressants such as cyclosporine and methotrexate are not only slow to take effect, but also lead to a higher risk of cancer. As new immunosuppressants, bio-targeted drugs can selectively suppress the immune system, ensuring the safety while improving the curative effect, which is the most promising.

Hummel is a fully humanized monoclonal antibody against TNF-α developed by AbbVie Company, which was approved by FDA in 2002 for the treatment of rheumatoid arthritis. Because of its remarkable efficacy and safety in the treatment of self-immune diseases, Hummel’s indications have been expanding since its listing, and it has gradually become the highest-selling self-immune drug, and ranked first in global drug sales in 2012. Since then, through a series of marketing and patent strategies, AbbVie has made great efforts to extend the life cycle of Hummel, and promoted the drug to become the "drug king" in the world for ten consecutive years, with accumulated sales exceeding 200 billion US dollars since its listing.

With the official expiration of the patent in the United States in 2023, the market share of self-exempted drugs controlled by Hummel was quickly robbed by many similar biological drugs. According to AbbVie’s third quarterly report in 2023, nearly 10 biologically similar drugs have entered the market. As a result, the cumulative sales of Humele in the first three quarters of 2023 was only $11.1 billion, a sharp drop of 29.1% year-on-year. Nature Reviews Drug Discovery, a well-known medical journal, predicts that the annual sales of Hummel in 2023 will be about $13.6 billion, less than 60% of Keytruda of Top1, and the first generation of drug kings will soon "abdicate".

Corresponding to the curtain call of "King of Medicine", many innovative drugs with potential targets have risen rapidly, and a new generation of heavy drugs is coming out.

According to the global sales forecast of innovative drugs in 2023 recently released by Nature Review of Drug Discovery, the sales of self-immune biological agents Dupixent and Stelara, which target IL-4/IL-13 and IL-12/IL-23 respectively, have increased rapidly, and it is estimated that they will rank among the Top10 with sales of more than 10.6 billion US dollars.

Abbey, the owner of Hummel, is also actively looking for the next generation of self-free drugs. The sales amount of oral JAK1 inhibitor Rinvoq (upatinib) and IL-23 monoclonal antibody Skyrizi (risazhuzumab) under the company has increased rapidly in recent years. In 2022, the total sales revenue has exceeded 7 billion US dollars, and the growth rate is higher than 50%. Abbway predicts that by 2027, the combined sales revenue of these two drugs is expected to exceed the sales peak of Hummel’s $20 billion.

Domestic pharmaceutical companies compete for the next potential target.

Compared with the highly competitive innovative cancer drugs, the number of participants and innovative drugs in the self-exempt drug market is still relatively limited, and the overall market competition pattern is good. However, the huge unmet clinical needs and the continuous improvement of the diagnosis rate in China have also attracted more and more domestic innovative pharmaceutical companies to enter the drug-free track, and tried to gain a competitive advantage by virtue of differentiated layout potential targets and occupy a place in the domestic market.

So far, the targets of self-immune targeted drugs mainly focus on TNF-α, JAK, interleukin and BlyS, and the main indications are common rheumatoid arthritis, psoriasis, systemic lupus erythematosus and so on. Among them, targeted TNF-α drugs are the most classic targeted drugs for autoimmune diseases because of their early market time, mature targets and the widest range of indications. However, this track has basically been controlled by foreign-funded enterprises, and the development space of local manufacturers that follow is relatively limited. Domestic innovative drug companies have turned their research direction to JAK, interleukin and other targets.

Interleukin and its receptors are important target families in human immune regulation, and play an important role in various immune and inflammatory reactions. Psoriasis is the main indication of interleukin targeted drugs at present, and some targeted drugs have been proved to be safer than TNF-α antagonists in certain circumstances.

At present, the effective interleukin-targeting drugs listed in the world include tosilizumab targeting IL-6, ulinuzumab targeting IL-12/23, skukiyuzumab targeting IL-17A and gusechizumab targeting IL-23. Among domestic enterprises, Hengrui Pharma (600276.SH), Zhixiang Jintai (688443.SH) and Kangfang Bio (09926.HK) all have approved the listing of interleukin-targeted biological agents, and Quanxin Bio (01883.HK), Livzon Group (000513.SZ), Junshi Bio (688180.SH) and Cinda Bio.

JAK signaling pathway plays a very important role in autoimmune, tumor, hematological and other diseases, and it is one of the promising potential targets. Because the first generation of JAK inhibitors showed great toxic and side effects in the treatment process, the main research and development direction of major pharmaceutical companies is the second generation of JAK inhibitors targeting JAK1, JAK3, TYK2 and other targets with high specificity.

In clinical trials, the second generation JAK inhibitors have shown good data in terms of safety and efficacy. Among them, Upatinib, a JAK1 inhibitor listed by AbbVie, showed a better key remission index under the same safety in the head-to-head experiment of treating rheumatoid arthritis and adalimumab. In the first three quarters of 2023, the sales amount of Upatinib has reached US$ 2.71 billion, exceeding the annual performance in 2022. AbbVie expects that the drug is expected to achieve sales of more than $7.5 billion in 2025.

In view of the good performance of this target, the research on JAK-specific subunits has become one of the important directions of global innovative drug companies. Among domestic enterprises, Hengrui Pharma, Dizhe Medicine (688192.SH) and Nuocheng Jianhua (688428.SH) are in the top of the research and development progress. Among them, Nuocheng Jianhua recently disclosed that its TYK2 inhibitor ICP-488 under research has completed the first clinical administration for psoriasis patients in Phase II. ICP-332, another self-immune drug with the same target, disclosed the second phase clinical data of moderate and severe atopic dermatitis indications in December 2023. Orient securities believes that domestic JAK-targeted self-immune drugs are expected to achieve rapid volume increase after marketing through differentiated distribution of indications and optimized breakthrough in safety.

BlyS is one of the key factors in the differentiation and maturation of B lymphocytes, which is the most important effector cell of autoimmune diseases. By inhibiting BlyS, many autoimmune diseases can be treated. At present, there are two BlyS inhibitors on the market, namely, GlaxoSmithKline’s Beliyuzumab and Rongchang Bio (688331.SH)’ s Tatasip. The main indications are systemic lupus erythematosus, and the market structure is good.

Tetasip is an innovative drug of BLyS/APRIL dual-target fusion protein independently developed by Rongchang Bio. Clinical data show that the drug has the same level of efficacy and safety as Belizumab. In 2021, National Medical Products Administration conditionally approved Tatasip for the treatment of adult patients with systemic lupus erythematosus, and included it in the 2022 edition of the National Medical Insurance Catalogue; In November, 2023, the treatment of Tatasip in this indication was fully approved.

Rongchang Bio is also continuing to promote the clinical research on other indications of Tatasip, and the research on many indications such as rheumatoid arthritis, Sjogren’s syndrome and multiple sclerosis has entered the final clinical stage. In August, 2023, Tatasip was used to treat patients with rheumatoid arthritis in Phase III, and submitted an application for domestic marketing. On December 20th, the global multicenter Phase III clinical IND of Tatasip in the treatment of active primary Sjogren’s syndrome in adults was approved by the FDA of the United States, and clinical research will be carried out in many countries and regions around the world. The continuous enrichment of the clinical pipeline of Tetasip is expected to consolidate the innovative product matrix of the company and promote the continuous growth of the company’s income.

Gree Electric vision china data map

Gree Electric’s extra year-end award of 200 million yuan is actually "a Gree G3 mobile phone for employees"?

On January 31, Gree Electric issued an official statement to clarify that the company was concerned about the false news circulating on the Internet, such as "On January 28, Chairman Dong Mingzhu said at the Gree 2024 Global Dream Festival that an extra year-end bonus of 200 million yuan was actually sent to Gree mobile phones".

Gree Electric mentioned two points in the statement: First, in order to better adapt to the company’s work software, facilitate mobile office work and improve work efficiency, the company decided to provide each employee with free work mobile phones (including free communication packages), which will be distributed in batches around the Spring Festival.

Second, the year-end bonus of 200 million yuan increased by the company has nothing to do with the free work mobile phone. The scope of the increased year-end bonus does not include middle and senior cadres, and the increased part is inclined to the front-line employees.

Gree Electric said that the company reserves the right to investigate the legal responsibility of media and individuals who spread rumors and rumors according to law.

Previously, a related person in Gree Electric said, "Fake, nonsense."

On January 28th, Dong Mingzhu, Chairman and President of Gree Electric, said at the Gree 2024 Global Dream Festival that her performance reached a new high last year, creating a profit of 29 billion yuan. At the same time, she also announced that she would "give employees an extra 200 million yuan for the year-end bonus".

However, while Gree Electric’s heroic 200 million year-end bonus has aroused widespread concern, there are also questions about this year-end bonus on the Internet.

On January 30th, there were rumors on the Internet that the 200 million year-end bonus was actually "one Gree G3 mobile phone for each person" and "giving employees more G3 mobile phones with a value of 200 million". Moreover, these G3 mobile phones "can’t be sold at the price of idle fish only around 300 yuan, but the company has issued 80,000 sets at a price of 3,599 yuan".

For these rumors, Gree Electric insiders told the media: "The fake, extra 200 million bonus is not deducted by G3 mobile phone, but a real year-end bonus."

Regarding the rumor that "Gree’s year-end award is deducted with points", Gree also said that "the year-end award is not issued in the form of points".

On the short video platform, some Gree Electric employees have already got their own year-end awards, which are divided into two parts: cash+points for products. The employee of Gree Electric’s subsidiary got a year-end bonus of 4,500 yuan in cash, and also exchanged the points for products such as rice cookers, health pots and electric fans, with a value of about 4,000 yuan.

At the Gree 2024 Global Dream Festival, Dong Mingzhu said that 2023 was the best year for Gree Electric since its founding 33 years ago, and the corporate tax revenue reached a record high. This achievement can not be separated from the hard work of every employee and the teamwork spirit.

Dong Mingzhu said that in order to let employees fully enjoy the fruits of the company’s development, he decided to give employees an extra 200 million yuan for the year-end bonus. At the same time, Dong Mingzhu also expressed the hope that the tax revenue for the country will exceed 20 billion in 2024.

Dong Mingzhu also said that Gree Electric doesn’t care about the stock price, because it doesn’t depend on the stock price to survive.

Previously, the performance forecast released by Gree Electric showed that the total operating income in 2023 is expected to be between 205 billion yuan and 210 billion yuan, up by 7.8% to 10.4% year-on-year; It is estimated that the net profit attributable to shareholders of the parent company will be between 27 billion yuan and 29.3 billion yuan, up 10.2% to 19.6% year-on-year; It is estimated that the net profit attributable to shareholders of the parent company after deducting non-recurring gains and losses will be between 26.1 billion yuan and 27.8 billion yuan, up 8.8% to 15.9% year-on-year.

As of January 31st, Gree Electric rose 0.28% to close at 35.25 yuan.

CCTV News:The Spring Festival is coming, and it is the choice of many families to take family photos in the photo studio. The reporter recently visited the Beijing market and found that the passenger flow of many photo studios has increased significantly, and some places even have to make an appointment many days in advance.

Reporter:I am now in Dabei photo studio on Qianmen Street in Beijing. The staff told me that with the approach of the Spring Festival, more and more customers come here to take photos, especially the family photos are selling more and more hot.

Beijing consumers:Once a year, I added this family of five, and I took my parents with me. It was also the first time to take a photo with my baby.

Beijing consumers:Want to take a picture of her (mother) every year, (she) is a little nervous.

In the photo studio, the staff told reporters that in recent days, family photos, black and white and color headshots are still the main products in the store, and most customers are coming from this classic nostalgia.

Beijing consumers:We were born in the 1980s, and there weren’t many color photos at the beginning. It’s quite retro to bring children to take pictures.

Meng Qingyi, manager of Beijing Dabei Photography Front Store:At the end of the year, the passenger flow still increased. Usually, we take more than 200 photos (every day), but now we can take between 300 and 400 photos, mainly because we have more photos.

Reporter:Different from the traditional photo studio, we see more young people in this fast and fashionable photo studio in Xidan, Beijing. For them, taking a photo at the end of the year is the pursuit of a sense of ritual in life.

Beijing consumers:We want to shoot something academic, or something related to the New Year.

Beijing consumers:This suit is also suitable for the occasion, just in line with the new year atmosphere.

The reporter learned that with the continuation of Christmas and New Year’s products and the launch of family photo products in the Spring Festival, there are more choices of products in the photo studio at present. The price of a single person ranges from 300 to 500, and the daily reception volume has also increased by about 20% compared with usual.

Wang Xinwei, manager of a fast fashion photo studio in Beijing:Many customers choose to take a photo at the festival just to increase the sense of ceremony and send a circle of friends. Basically, every day is a full state, and weekends are full. The best sellers are Weiyang and Chiying in the national tide. Because it is red and Chinese style, customers will have more choices.

Notice on printing and distributing the vaccination work plan to deal with the recent infection situation in Covid-19
Guo Wei Ming Dian [2023] No.46

All provinces, autonomous regions, municipalities directly under the Central Government and Xinjiang Production and Construction Corps should respond to the joint prevention and control mechanism (leading group and headquarters) of novel coronavirus infection, and the State Council should respond to the members of the vaccination coordination group of the joint prevention and control mechanism of novel coronavirus infection:

The "Work Plan for Vaccination in Response to Recent Infections in Covid-19" is hereby printed and distributed to you, please conscientiously implement it according to the actual situation.

The State Council responds to novel coronavirus infection.Comprehensive group of epidemic prevention and control mechanism
April 6, 2023

(Information disclosure form: voluntary disclosure)

Respond to the recent Covid-19 infection epidemic.Vaccination work plan

In order to thoroughly implement the decision-making arrangements of the CPC Central Committee and the State Council, effectively respond to the recent epidemic situation in Covid-19, and ensure and safeguard people’s health, this work plan is formulated in combination with the epidemic situation, vaccine research and development, immune effect evaluation, population immunity level and other factors.

First, the target population

At this stage, the focus of vaccination is to fill the gap in immune level for different target groups and further reduce the risk of severe illness and death. The target population is as follows:

(a) people who are not infected and have not completed the established immunization program. Including uninfected people aged 3-17 who have not completed basic immunization, uninfected people aged over 18 who have not completed the first dose of booster immunization, and uninfected people aged over 18 who have not completed the second dose of booster immunization (high-risk people with infection, elderly people over 60 years old, people with serious basic diseases and people with low immunity).

(two) people who have been infected and have not completed basic immunization.

Second, the time interval and vaccine selection

(1) Time interval.

The uninfected target population completes the follow-up vaccination according to the established immunization program and its time interval requirements. Among them, for people over 18 who have completed basic immunization, the interval of the first dose of booster immunization is adjusted to more than 3 months.

People who have been infected and have not completed basic immunization can be vaccinated with one dose after 3 months of infection.

(2) vaccine selection.

Shenzhou cell recombinant Covid-19 tetravalent S trimer protein vaccine and Unacon Covid-19 mRNA vaccine have been included in emergency use, which can be used for intensive immunization of people over 18 years old.

The vaccines used for basic immunization of uninfected target population shall be implemented with reference to the relevant requirements in the previous period. In order to strengthen immunization, it is recommended to use Shenzhou cell recombinant Covid-19 tetravalent S trimer protein vaccine and Unacon Covid-19 mRNA vaccine. Other recombinant protein vaccines or virus vector vaccines that have been approved for conditional marketing or emergency use can also be selected for sequential enhanced immunization.

People over the age of 18 who have been infected and have not completed basic immunization are recommended to use Shenzhou cell recombinant Covid-19 tetravalent S trimer protein vaccine and Unacon Covid-19 mRNA vaccine, or choose other recombinant protein vaccines or virus vector vaccines that have been approved for conditional marketing or emergency use. For people aged 3-17 who have been infected and have not completed basic immunization, the vaccines used for vaccination shall be implemented according to the relevant requirements of the previous period.

Follow-up will be based on the progress of vaccine research and development, approval, combined with the epidemic situation, virus variation and other conditions, timely research and adjustment of vaccination strategies.

Third, ensure vaccination safety

All localities should continue to give priority to vaccination safety, and organize vaccination implementation in strict accordance with the requirements of the Code for Vaccination Work. Local health departments should implement the "four haves" requirement that vaccination units should have emergency personnel stationed in general hospitals at or above the second level, emergency equipment and medicines, 120 ambulances on duty, and green channels for treatment in general hospitals at or above the second level to ensure vaccination safety. Inoculation units should do a good job in vaccination information registration and vaccine flow management, and update the vaccination records in the immunization planning information system and vaccination vouchers in a timely and accurate manner.

Fourth, strengthen organization and implementation

(1) Strengthening the responsibility of territorial subjects. All localities should implement the responsibility of territorial management, attach great importance to and co-ordinate the vaccination work in Covid-19. It is necessary to strengthen the guidance of vaccination work within the jurisdiction and fully grasp the progress of the work. Relevant local departments should strengthen docking and do a good job of coordination.

(two) to play the role of the competent department of industry. The competent departments of relevant industries should guide the units where the personnel in this industry work to actively cooperate with local unified arrangements and jointly do a good job in organizing and mobilizing.

(3) Strengthen supervision and guidance. It is necessary to closely track and monitor the progress of vaccination in various places, and find and study and solve related problems in time. Improve the traceability system of vaccine flow, improve the safety supervision mechanism of vaccine chain, continuously strengthen the whole process management and safety precautions, and effectively ensure the efficient and smooth transportation of vaccines.

(4) Do a good job in publicity and guidance. All localities and relevant departments should, according to the needs of work, formulate targeted publicity measures for vaccination work, focus on the purpose and significance of vaccination, respond to social concerns, sum up and popularize typical experiences and practices, actively guide the target population to take the initiative to vaccinate, and especially guide and improve the vaccination rate of the elderly population.

Note: People aged 3-17 can only use Covid-19 inactivated vaccine of Sinopharm Zhongsheng Beijing Company, Beijing Kexing Company, Sinopharm Zhongsheng Wuhan Company and Zhifeilong Kema recombinant Covid-19 vaccine (CHO cells).

　　Cctv newsAt 15: 00 on April 20th, the State Council Press Office held a press conference to introduce the development of industry and informatization in the first quarter of 2023 and answer questions from reporters.

　　Zhao Zhiguo, chief engineer and spokesperson of the Ministry of Industry and Information Technology, said that overall, the development of industry and information technology achieved a smooth start in the first quarter, showing a trend of stabilization and improvement.

　　First, the industrial economy has maintained a stable operation. It mainly presents three characteristics. First, industrial production has steadily picked up. In the first quarter, the added value of industrial enterprises above designated size increased by 3% year-on-year, which was 0.3 percentage points higher than that in the fourth quarter of last year, reversing the continuous downward trend since October last year. According to the data of China Association of Automobile Manufacturers, the production and sales of automobiles in March increased by 15.3% and 9.7% respectively, and the production and sales of new energy vehicles increased by 44.8% and 34.8% respectively. Second, investment in manufacturing industry continued to grow steadily. In the first quarter, manufacturing investment increased by 7% year-on-year, which was 1.9 percentage points higher than the national fixed assets investment, and maintained a rapid growth rate on the basis of a high base for two consecutive years. Third, the role of industrial provinces is obvious. The industrial growth rate of Hebei, Shandong, Jiangsu and other major industrial provinces is significantly higher than the national level. Since March, the industrial economy of Guangdong, Zhejiang and other provinces has picked up.

　　Second, the advanced manufacturing industry is developing well. Vigorously develop advanced manufacturing industry and promote the high-end, intelligent and green development of manufacturing industry. Solidly promote the industrial base reconstruction project and major technical equipment research projects, and make significant progress in some areas. ARJ21 has safely transported more than 6.55 million passengers and has recently been put into overseas commercial operation. Delivered the world’s largest 24188 TEU super-large container ship, and the first domestic extracorporeal membrane oxygenation machine (ECMO) was successfully developed and certified for listing. Deeply implement intelligent manufacturing engineering and promote the digital transformation of the industry. The three functional systems of industrial internet network, platform and security were completed, and the scale of core industries exceeded 1.2 trillion yuan. Accelerate the transformation and development of green and low-carbon industries. Accelerate the development of new energy vehicles, photovoltaics and other emerging industries. In the first quarter, the investment in fixed assets of high-tech manufacturing industry increased by 15.2% year-on-year, and the output of new energy vehicles, solar cells and other emerging products increased by 22.5% and 53.2% respectively.

　　Third, the empowerment effect of the information and communication industry is constantly emerging. We will fully consolidate new infrastructure and strongly support high-quality economic and social development. In the first quarter, telecom business revenue increased by 7.7% year-on-year. Steadily promote the construction of "double Gigabit" network, with the cumulative number of 5G base stations exceeding 2.64 million, and the number of Gigabit access users exceeding 100 million. Continue to deepen the application of convergence, and 5G is fully integrated into 52 national economic categories. Improve the ability of application services, further enhance the supply of mobile Internet application services, and accelerate the demonstration and promotion of excellent cases of aging and barrier-free transformation of Internet applications. Coordinate development and security, introduce policies to promote the development of data security industry, strengthen the security protection of key information infrastructure in the industry, and ensure the safe and stable operation of basic telecommunications networks.

　　Fourth, the industrial development environment has been further optimized. Adhere to the better combination of effective market and promising government, and strive to create a good ecology conducive to industrial development. In-depth implementation of the "14 th Five-Year Plan" in the field of industry and information technology, and organization and formulation of work plans for steady growth of key industries such as automobiles and electronics. Focusing on the "urgent difficulties and worries" of small and medium-sized enterprises, together with relevant departments, we have issued a series of policy measures to help stabilize growth and adjust structural strength, and started the cultivation of the fifth batch of "little giants" that specialize in specialty and innovation. Convene the 2023 Working Meeting of the Inter-Ministerial Joint Conference on Reducing the Burden of Enterprises in the State Council. Deepen the precise docking of industry and finance, and the national industry-finance integration platform has helped enterprises to raise more than 500 billion yuan.

　　Of course, we must also see that there are still some difficulties and challenges in the current industrial economic development, but the fundamentals of China’s industrial economic development have not changed for a long time, and we are full of confidence in this. In the next step, we will adhere to the guidance of Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, thoroughly implement the decision-making arrangements of the CPC Central Committee and the State Council, strengthen our confidence, be determined to innovate, stabilize the development of key industries, support leading enterprises and specialized new enterprises, work hard to draw long boards, forge new boards and fill short boards, promote the sustained stabilization and improvement of the industrial economy in the second quarter, and accelerate the development of the information and communication industry, thus laying a solid foundation for achieving the objectives and tasks for the whole year.

The 14th Press Conference on Epidemic Prevention and Control in COVID-19, Hainan Province.
(February 19, 2020)

Ru Yingying:

Hello, ladies and gentlemen! At present, the epidemic prevention and control work has reached a very critical period. In order to further strengthen the popularization of protection knowledge and ensure the safety of those who return to work and resume production, the Information Office of Hainan Province held the 14th news conference on the epidemic prevention and control work in COVID-19, Hainan Province, and invited Mr. Sun Shaoke, deputy director of the Provincial Big Data Administration, Mr. Chen Jianhong, spokesman of the Provincial Health and Wellness Committee, and Mr. Jin Yuming and Mr. He Bin, chief physicians of the Provincial Center for Disease Control and Prevention, to answer your questions around the theme of "knowledge of epidemic prevention and control in different industries and populations".

First of all, please ask Chen Jianhong, spokesman of the Provincial Health and Wellness Committee, to report the latest epidemic situation.

Chen Jianhong:

First, the latest epidemic situation

From 00: 00 to 12: 00 on February 19th, 2020, novel coronavirus was reported by Hainan Province, and there were no newly confirmed cases, severe cases, deaths and discharged cases.

By 12: 00 on February 19th, Hainan Province had reported 163 confirmed cases, 9 severe cases, 4 deaths and 79 discharged cases in novel coronavirus. Among the confirmed cases, there are 34 cases in Haikou, 54 cases in Sanya, 15 cases in Danzhou, 3 cases in Wenchang, 6 cases in qionghai city, 13 cases in Wanning, 3 cases in Dongfang, 9 cases in Chengmai, 6 cases in Lingao, 7 cases in Changjiang, 4 cases in Lingshui, 3 cases in Ding ‘an, 3 cases in Baoting, 2 cases in Ledong and 1 case in Qiongzhong.

By 12: 00 on February 19th, 5,280 close contacts had been tracked, 4,196 people had been released from medical observation, and 1,084 people were still under centralized medical observation.

Second, the daily epidemiological risk warning (February 19)

In recent years, the number of newly diagnosed cases in our province has remained low continuously, and the number of discharged cases has increased significantly. However, due to the recent resumption of work and other factors, if the prevention and control measures are not in place, there may be epidemic fluctuations in the future. The prevention and control suggestions are as follows:

1 prevention and control departments at all levels should strengthen the epidemic monitoring and related prevention and control measures after the resumption of work. In particular, key areas such as Haikou and Sanya should strengthen prevention and control.

2. Try to go to work at the wrong time, arrange shifts flexibly, prohibit gatherings and dinners, implement a meal sharing system, clean up the working and living environment, reduce the living density and strengthen ventilation.

Ru Yingying:Next, please answer the questions that journalists and netizens care about.

Q:Our province launched the health code system on February 18th. Could you tell us something about it?

Sun Shaoke:

Thank you for your question. I will break your question down into twelve sub-questions to answer.

(1) What is Hainan Health Code?

Hainan Health One Code System is a personal two-dimensional code generated by comparing and verifying the health data declared by residents or people returning to work, combined with epidemic prevention big data information.

(2) What is the meaning of "three colors" of Hainan health code?

A green code indicates that there are no symptoms at present. According to local management requirements, you can check the bright code of body temperature. The yellow code and the red code do not meet the traffic conditions for epidemic control, and they can travel normally only after being converted into green codes.

(3) What are the differences between the green code, the yellow code and the red code?

Health codes are divided into three colors: red, yellow, green, yellow and red.

1. When the access control at the bayonet or the enterprise returns to work, the green code personnel can pass by the code and go to work normally. Those who receive the red code and the yellow code need to be isolated according to the regulations and make a daily health punch card. When the conditions are met, they will be turned into green codes.

2. In principle, the "red code" personnel who entered Qiong shall be advised to return or delayed to Qiong. "Yellow code" personnel shall be observed at home or in centralized isolation according to regulations. Display "green code", and pass the release after bright code and temperature measurement.

(4) How to apply for a green health code?

Users don’t have a health code by default. Please apply for it through government service APP, government big data WeChat official account, Coconut City Minyun, Alipay and WeChat scan code, and punch in your daily health card. The system will automatically assign you a health code of corresponding color according to your health information.

(5) How can the red code/yellow code be converted into green code?

Code red and code yellow personnel must punch in the registration information for 14 consecutive days and meet the relevant conditions before they can turn into green codes.

(6) What are the functions and functions of Hainan health code?

Hainan health code can be applied and popularized in multiple scenarios, which can improve work efficiency and control quality. In management scenarios such as grid worker’s door-to-door inspection, community gate inspection, unit enterprise’s return to work registration, road traffic checkpoint inspection, fever clinic, fever medicine purchase, etc., people’s personal health code can be directly scanned, information can be collected without contact, reporting is convenient, and data can be shared and utilized, which is conducive to rapid epidemic prevention work.

(seven) the scope of application of Hainan health code?

Hainan health code is applicable to those who are in Hainan and those who are waiting to enter Hainan.

(eight) Hainan health code which occasions need to be used?

During the epidemic prevention and control period, the health code can be used as an electronic passport for work, study and life in Joan. Please take the initiative to show it to cooperate with the inspection when necessary. In addition, the health code can also be used in scenes such as hospitals, pharmacies and enterprises returning to work and production.

(9) What is the significance of Hainan health code for enterprises to resume work and production?

Grasp the real-time health status of employees through employee health codes, effectively arrange work for different people, and reduce the risk of epidemic spread caused by gathering; At the same time, it is also conducive to effectively evaluating the risk of enterprises’ resumption of production and work, better balancing the relationship between epidemic prevention and control and enterprises’ resumption of production through health code, and promoting the orderly development of social economy.

(10) Where can I register to check the health code?

The health code system has been provided in platforms such as Hainan Government Service APP, Hainan Government Big Data WeChat official account, Coconut City Minyun, Alipay, etc. Citizens can scan the code and log in through Alipay, Coconut City Minyun APP, WeChat, mobile browser and other channels.

(11) Can health codes only be used by Hainan natives? Can I use it from other places?

The health registration function is used for personal self-help online health status report. No matter local residents, people who have returned to Qionglai from other provinces or Hubei Province, they can register their own health by punching in the health registration function of the health code.

(12) How to consult if there are problems in the use of health codes?

Members of the public can call the Hainan 12345 government service hotline to ask questions related to health codes.

Q:Yesterday, our province issued "Ten Measures for Migrant Workers to Work in Provincial Key Projects and Key Projects during the Epidemic Prevention and Control Period", and construction sites in our province will start one after another. How to do a good job in epidemic prevention and control after the construction sites resume work?

He Bin:

After the construction site resumes work, all parties involved in the construction should implement the main responsibility of prevention and control, strictly do a good job in epidemic prevention and control, and file a record for future reference.

(1) Personnel control requirements.

1, completes the personnel registration;

2, do a good job in all field personnel temperature detection;

3. Do a good job in reporting the causes of absenteeism;

4. Make emergency response.

(2) Requirements for control on the construction site.

1. The construction enterprise shall set up temperature detection points at the entrance and exit of the construction site, and all personnel must have temperature detection when entering the construction site. Persons with body temperature greater than or equal to 37.3℃ should be sent to the isolation observation dormitory in time for further isolation observation. After resting in the isolation observation dormitory for 10 minutes, if the body temperature is still greater than or equal to 37.3℃, appropriate protective measures should be taken and sent to the fever clinic designated by the health department in time. All personnel entering the site should wear masks and take personal protective measures. Decentralize pre-shift education, technical disclosure and other activities to reduce personnel gathering and meetings.

2. According to the relevant technical requirements, carry out ventilation, disinfection and epidemic prevention work on the construction site, office and living areas (site canteens, dormitories, toilets and other places) and other personnel activities.

3, strict implementation of food procurement, processing, storage and other health standards, not illegal slaughter, disposal of wild animals, and effectively protect food safety. The canteen on the construction site can take measures such as separate meals and wrong meals, and it is forbidden for people to have dinner.

4, do a good job in the classification of domestic waste, in strict accordance with the requirements of the disposal of discarded masks and other medical protective equipment waste.

5, the construction site should be related to health and epidemic prevention education into the approach and daily pre-job education, fully launch the publicity and education of novel coronavirus related knowledge, take measures such as posting health and epidemic prevention advertisements in a prominent position in the construction site and living quarters, and improve the prevention and control awareness of field personnel.

6, the implementation of epidemic prevention and control work to implement the daily system and emergency reporting system.

Q:How do migrant workers and other migrant workers do personal protection?

He Bin:

(a) before returning to the city, to carry out temperature measurement, to ensure that there is no abnormal increase in body temperature.

(2) Measure your body temperature before going to work every day on weekdays and make records. If you have symptoms such as fever and cough, you should be isolated in time and seek medical treatment.

(three) when many people work together in the workplace, each person should wear a mask.

(4) Wear masks on the way to the workplace, and keep a certain distance between people.

(five) collective dormitory ventilation frequently, the distance between beds is more than 1 meter, daily cleaning, timely cleaning of garbage, and thorough cleaning and cleaning of the dormitory every week.

(6) Take meals at the wrong time to avoid dinner. Clean the restaurant thoroughly after each meal, with no food residue on the dining table and no sanitary corner on the ground, and remove the kitchen garbage in time. Clean and disinfect the used tableware in time.

(seven) keep the public toilet ventilated. Sanitary cleaning shall be carried out at any time every day, and the floor and walls shall be kept clean. There shall be no dirt in the sink and no feces and dirt accumulation in the urinal. Disinfect urinals every day.

(eight) wear a mask when traveling daily, and do not litter or spit when going out. When sneezing, cover your nose and mouth with paper towels, or use elbows and arms to keep a certain distance from others, and do not move in crowded places. Do a good job of hand hygiene after going out and returning.

Q:How to prevent and control the epidemic situation in the collective office after returning to work?

Jin Yuming:

(a) staff should do a good job of health monitoring, if there are suspicious symptoms of novel coronavirus infection (including fever, cough, sore throat, chest tightness, dyspnea, fatigue, nausea and vomiting, diarrhea, conjunctivitis, muscle aches, etc.), don’t go to work sick, you should report to the unit in time and go to the fever clinic for investigation.

(2) If suspicious symptoms of novel coronavirus infection are found, the staff should register and ask them to go to the nearest fever clinic for investigation.

(three) public goods and public contact items or parts should be cleaned and disinfected regularly.

(four) to maintain air circulation in the office. Ensure the normal operation of the air conditioning system or exhaust fan, clean the air conditioning filter regularly, and strengthen the ventilation by opening the window.

(five) the bathroom should be equipped with enough hand sanitizer to ensure the normal work of water supply facilities such as faucets.

(six) keep the environment clean, clean up the garbage in time.

Q:How do students protect themselves during the winter vacation and on the way back to school?

Jin Yuming:

(1) During the winter vacation.

1. Students who have a history of residence or travel in epidemic-prone areas (such as Wuhan) have been under medical observation at home or in designated places for 14 days since leaving the epidemic-prone areas.

2. Students from all over the country should stay at home as much as possible, reducing visits to relatives and friends, gatherings and dinners, and activities in crowded public places, especially in places with poor air mobility.

3. Students are advised to monitor their health every day and report to the designated person in charge of the community or school as required.

4. At the end of the winter vacation, students can return to school normally if they have no suspicious symptoms. If you have any suspicious symptoms, you should report them to the school or the guardian, and seek medical treatment in time, and then go back to school after recovery.

(2) On the way back to school

1. Wear medical surgical masks all the time when taking public transport.

2, keep hand hygiene at any time, reduce contact with tools of public goods and parts.

3. Do a good job in health monitoring during the trip, and take the initiative to measure your body temperature when you feel feverish.

4. Pay attention to the health status of the surrounding passengers and avoid close contact with people with suspicious symptoms.

5. If there are suspicious symptoms during the trip, you should take the initiative to put on a medical surgical mask, try to avoid contact with other people, and seek medical attention in time according to your condition.

6. If you need to see a doctor in a medical institution during the trip, you should take the initiative to tell the doctor about the travel and residence history of the relevant disease-endemic areas and cooperate with the doctor to carry out relevant investigations.

7. Keep the travel ticket information properly to cooperate with the investigation of possible close contacts.

Q:What are the suggestions for kindergartens (or schools) to prepare for returning to school after the outbreak?

Jin Yuming:

(1) Students who have lived or traveled in areas with high epidemic rates (such as Wuhan) before returning to school are advised to stay at home for 14 days before returning to school.

(2) Students should monitor their body temperature and health status every day after returning to school, try to reduce unnecessary going out and avoid contact with other people.

(3) When students are in close contact with other teachers and students, they should wear medical surgical masks correctly to minimize the scope of activities.

(IV) Schools should closely monitor students’ health status, measure their body temperature twice a day, and make records of absence, leaving early and taking leave. If suspicious symptoms are found among students, they should immediately report to the epidemic management personnel, and cooperate with medical and health institutions to do a good job in the management and disinfection of close contacts.

(5) Schools should try to avoid organizing large-scale collective activities. In classrooms, dormitories, libraries, activity centers, canteens, auditoriums, teachers’ offices, toilets and other activity areas, it is recommended to strengthen ventilation and cleaning, and equip them with hand sanitizers and hand disinfectants.

(six) the school to carry out online teaching, make-up classes for students who missed classes due to illness, for those who delayed the exam due to illness, make-up exams should be arranged and should not be recorded in the file.

Q:At present, farmers’ markets in our province have also resumed business one after another. How can farmers’ markets do a good job in epidemic prevention and control?

He Bin:

(a) the management department of farmers’ market should attach great importance to the prevention and control of epidemic situation, establish the working mechanism of epidemic situation prevention and control, formulate the prevention and control plan, refine the prevention and control measures, implement the prevention and control personnel, put the responsibilities in place, and divide the work among people.

(two) the management department of the farmer’s market should grasp the out-going situation and health status of all operators and relevant staff in the market 14 days before rework. People from high-incidence areas (such as villages, communities and streets with confirmed cases in Hubei Province) must be observed in isolation for 14 days before they can start business and rework. Other migrant workers who have passed the temperature and health examination can do business and rework.

(three) operators and staff in the market daily health monitoring, the establishment of body temperature monitoring register. Operators should maintain personal hygiene when providing services, wash their hands frequently and wear masks all the time.

(4) Strictly implement the system of inspection and acceptance of incoming goods and claiming tickets and certificates. Operators in farmers’ markets shall not purchase food and food raw materials that have no source or do not meet the requirements, and it is strictly forbidden to purchase and use meat and its products that have died of illness or the cause of death is unknown, and that have failed quarantine; It is forbidden to slaughter live livestock and poultry in captivity, to trade live poultry, to purchase and sell wild animals and their products.

(5) Market operators should carry out a general cleaning after the daily closing of their stalls, and clean the countertops, floors, sewers and storefronts with water to keep the stalls clean and tidy, so as to ensure that no sanitary corner is formed. Regularly spray and disinfect sewers, floors around stores, countertops, appliances and chopping boards. When cleaning and disinfecting, wear long water shoes, masks and waterproof gloves, and do a good job in personal hygiene protection. Pay attention to the ventilation of the place (mechanical ventilation is used when necessary). Public toilets should be kept clean and equipped with soap, hand sanitizer or alcohol-containing hand sanitizer to ensure the normal use of water supply facilities such as faucets. Strengthen garbage classification management, set up garbage bins with discarded masks, remove garbage in time, and keep the environment clean and hygienic.

(6) Do a good job in rodent control and pest control. Strengthen the management of garbage in farmers’ markets, require garbage transport vehicles and hand-propelled garbage collection vehicles to be stored and transported in a closed manner, and improve the level of garbage collection, transportation and treatment; Install anti-rat, anti-mosquito and anti-fly facilities. Ensure that the control level of rats, mosquitoes, flies and cockroaches (vectors) in the market meets the requirements of national standards.

(seven) the entrance of the farmer’s market to test the temperature of customers, if necessary, to re-test, to remind passengers to wear masks. People with fever reaching or exceeding 37.3℃ are not allowed to enter.

Q:How to ensure epidemic prevention and production and life in rural areas?

He Bin:

(a) have been to Hubei, relatives and friends from Hubei should promptly inform the village committee, family members, relatives and friends or their own fever, cough, chest tightness and other unwell symptoms, to report early, timely diagnosis and treatment. Wear a mask when going to crowded places, and wear a mask when coughing or having a fever. This is the simplest and most effective protective measure.

(two) clean up the sanitary corner, timely removal of garbage, do a good job in environmental sanitation, prevent mosquito and fly diseases. Do not spit everywhere, cover your nose and mouth with paper towels when coughing or sneezing, and wash your hands after handling.

(3) Wash your hands with soap or hand sanitizer for at least 15 seconds after coughing or sneezing, preparing food, defecating before and after meals, touching animals or handling animal droppings, and going out and returning home, paying attention to scrubbing every part in place.

(4) Open the doors and windows regularly to keep the air circulating at home. Exercise more, drink more water, get enough sleep, mix food with meat and vegetables, separate raw food from cooked food, and try to improve your immunity.

(five) livestock and poultry should be kept in captivity, cleaned and disinfected, and vaccinated in time. Do not hunt, kill, process, sell or eat wild animals and their products.

(six) support the work of township and village cadres, and cooperate with the registration and verification of epidemic prevention. Poverty alleviation cadres in the province, especially those at the grassroots level, should guide and help the poor to implement prevention and control measures to ensure that no one is left behind.

(7) Crowd gathering places are risky, so it is necessary to visit relatives and friends less, gather for dinner less, go to markets less, and go to crowded places less. Don’t attend village temple fairs, public meetings, etc.

(eight) if the body is abnormal or in close contact with the confirmed sick person, don’t hide it for fear of isolation. As long as the patients are found and isolated in time, the epidemic situation can be contained quickly. Don’t panic too much and don’t believe in rumors.

(nine) to develop good hygiene habits, don’t litter, especially the worn masks and related protective equipment. If it is possible, it should be centralized and harmless, and if it can’t be centralized, it should be burned by itself.

(ten) don’t refuse to check the temperature of the temporary epidemic prevention checkpoint. In response to the government’s call, migrant workers returned to the city in an orderly manner as required. Migrant workers should not bring live birds and other animals when they return to the city.

(eleven) the plan of the year lies in the spring, the epidemic situation should be prevented, and the production should not stop. We should do a good job in spring field management, spring ploughing and animal husbandry production.

Q:Can I order takeout during epidemic prevention?

Jin Yuming:

It is suggested that the take-away restaurant will distribute the containers containing food outside, and increase the frequency on the basis of the usual cleaning and disinfection requirements to disinfect the delivery staff’s vehicles. Do a good job of cleaning, disinfection and protection, and the possibility of virus transmission through take-away is relatively low. Be sure to wear a mask when taking takeout. It is suggested to carry out non-contact delivery, and inform the delivery staff to put the goods at the designated place, without the need for both parties to sign face to face. When taking takeout, you can bring disposable gloves, or use paper towels to separate your hands from the packaging bag. After taking the takeaway, you can remove the layers of packaging under the protection of gloves or paper towels and throw them into the trash can. Then use the soapbox flowing water to absorb it at the first time, or use antibacterial hand gel containing alcohol to clean your hands. However, we still suggest cooking by yourself and bringing meals. If you go to a restaurant or order takeout, it is recommended to order hot food instead of cold food; If possible, reheat the food before eating to ensure it is cooked thoroughly; Always remember to maintain hand hygiene, wash your hands before and after meals and after touching easily contaminated items.

Ru Yingying:thank you This concludes today’s press conference.