"If you dare to be overbearing, I will cut the grass and get rid of the roots." The upcoming film "Fighting Against the Black" is highly anticipated by the audience with its expression of really daring to shoot and really inspiring.

　　The film is the first film and television work to show the cases supervised by the National Anti-gang Office. It tells the story that Song Yirui, the leader of the anti-gang investigation team, led the team members to conduct an in-depth investigation of a land acquisition case, broke through layers of obstruction, and waged a fierce struggle with the evil forces behind the scenes. Finally, the hypocritical mask of corrupt officials using public office power as a criminal umbrella was uncovered, and criminals were brought to justice. Through the film, the spiritual group image of overcoming difficulties, perseverance and fearlessness is outlined, and a monument of the times is built to eliminate evils and protect the interests of the people.

　　True style, exposing the mask of evil forces

　　Film and television works on political and legal subjects need to be rigorous and professional, and more importantly, they should convey correct legal knowledge and the concept of rule of law to the audience. However, they also need to boldly explore the structural narrative and expression in line with the principle of "big things are not empty, and make artistic processing and creation on the realistic activities of political and legal affairs, so as to reach the artistic truth from the real life and inject the unique ideological connotation and artistic character into the works of rule of law. The film" Fight Against the Gangsters "has made a sample demonstration in a real style.

　　The year of 2021 is a crucial year for the CPC Central Committee and the State Council to deploy a special campaign to eliminate evils and achieve phased victory, and at the same time to promote the normalization of the campaign. Since the launch of the special campaign to eliminate evils, too many first-line cases have become rich in content for the creation of the film "Decisive Battle against Evil". The film is narrated from the first perspective of the investigation team’s handling of cases. For the first time, it presents the cases supervised by the national anti-gang office in a film-and-television way, directly attacking local evil forces, violent land acquisition, sexual assault and other social topics. In terms of creation, the film has carried out genre narrative expansion and commercialization element innovation. From script polishing, actor invitation to action scene design, it always takes into account the standards of realistic commercial genre films and the aesthetic needs of the public, and strives to bring a refreshing theme type experience to the audience. The film was staged in May 1st, 2021, which was intended to be the best gift and tribute to the national special struggle against evil in the past three years.

　　As we all know, the creation of political and legal works is difficult and heavy, which also makes many works have shortcomings: some contents do not conform to the current judicial procedures; Some contents are vulgar; Some unilaterally emphasize judicial professionalism, and the artistic quality of the works is not high, while the real style of the film "Fighting Against the Black" is to hook the hearts of the audience with details. In the film, Sun Zhibiao, a local black and evil force, led a group of thugs to violently expropriate disregard for human life, which was unforgettable. After that, similar scenes appeared, and the audience was angry from their hearts. The brutality of hanging and soaking innocent people in underworld slaughterhouses, the ugly behavior of individual grassroots leading cadres dressed up during the day and extravagant at night, the brutality of bullying girls to take drugs and engage in prostitution, the violence and nonviolence of bad elements provoking troubles among the masses and hindering the investigation, the eyeful hatred of the contractor who is cornered, the despicable trick of corrupt officials jumping off the building for fear of sin and forcing the investigation team away, the white terror of dismembering bodies at the construction site, and the cash scattered all over the office of the director … … Too many delicate treatments are concentrated, which is not common in previous works.

　　It is this design that enables the audience to have a panoramic view of the spiritual charm of the national political and legal police officers in tackling difficulties, perseverance and fearlessness in the special struggle against evil, showing their determination and action to crack down on evil forces, inspiring people through the plot of helping justice, and making the audience have a strong emotional resonance.

　　True meaning, the people are the strong backing to clean up evil forces.

　　For the vast audience, political and legal organs are curious because they are full of "mystery", not to mention the massive cases involving black and evil involving all aspects of social life. How to grasp the realistic theme? How to choose many materials? The movie "Decisive Battle Against the Gangsters" gives the answer — — At the same time, we should carry forward the spirit of the rule of law in a clear-cut manner, and at the same time focus on depicting a beautiful picture of a society ruled by law, and always believe and rely on the people to completely crush the evil forces.

　　Sometimes "justice" and "evil" are a matter of choice, and the difference and separation lie in the indulgence and persistence of human nature and the abandonment and persistence of faith. For the "umbrella" in the film, officialdom has become a fascinating vanity fair, where you can form a party for personal gain and self-interest. For Song Yirui, the leader of the anti-gang task force, officialdom is a melting pot of smelters, where they can be tempered into steel and become stronger. Two kinds of characters, two choices, two endings, the real touchstone and watershed, are still "people". That is — — Talk about the "people" as a name, or take the "people" as a support. The different fates of Cao Zhiyuan, Wei Dayong and Song Yirui also tell people that the people are always their strong backing if they sincerely serve the people. The people will eventually spit on those who do not come clean with the snake.

　　It is precisely because of trusting and relying on the people that the anti-gang task force has the political determination to resist everything. In the film, the anti-gang task force went deep into the local investigation and ran into a wall. What seems to be smiling and actively cooperating with the investigation is actually an undercurrent conspiracy. It is really painstaking to obstruct the investigation from top to bottom in the officialdom of Weihe County. The task force is in the dark, and when faced with many difficulties such as collusion, cracking down on informants, negative cooperation, smearing of public opinion, and violent intimidation, When people who don’t know the truth are bewitched by bad elements to besiege the task force, when the case handlers of the task force are beaten or even life-threatening, when Sun Zhibiao, a local evil force, throws money at the task force on the way to withdraw, and when Sun Zhibiao says, "As long as the old man is still alive, it won’t be arrogant", Jiang Wu plays the team leader and other members of the task force, and interprets the quality and value of party and government cadres and police officers handling cases in the new era with actions.

　　Taking the violent land expropriation as a clue, we can take out the grass-roots "protective umbrella" and the evil forces’ evil plots to deeply explore the current political ecological situation, explore the chronic diseases, and analyze the life philosophy behind different political choices, so that people can look back on life, reflect on human nature and seek for themselves at the same time, which should be the real value of the film "Decisive Fight Against the Black". It is in the sense of writing the ecology of the field of eliminating evils and the mentality of officialdom figures that this work has also raised the creative level of political and legal film and television works to a new height.

　　Real people, the times need more "Song Yirui"-style gang leaders.

　　Whether the typical characters can be successfully created is one of the important criteria for evaluating the success or failure of a film and television work. The TV series "Years Burning with Passion", "Bright Sword", "Happy Life of garrulous Zhang Damin" and "Soldier Assault" have successfully created unique characters such as Shi Guangrong, Li Yunlong, Zhang Damin and Xu Sanduo, which have become classics. These full and vivid screen images are also fixed in the minds of hundreds of millions of viewers. Unfortunately, there is still a lack of images of political and legal workers that impress the audience in the colorful film and television character galleries. However, the author thinks that with the release of the movie "Decisive Fight Against Gangsters", Song Yirui, the leader of the anti-gang task force played by Jiang Wu, will fill this role gap.

　　Actor Jiang Wu, the leader of Song Yirui, is bold, resolute and upright. Such as accurately discovering the monitoring equipment in the office, seeing the new accounts of the project, and so on, all show the professionalism of the investigation team. However, this role is not a "Gao Daquan" in the traditional sense, but also a very grounded place. For example, the way of working is careless, and it is not a euphemism to communicate with leading cadres in the investigation work. He is furious at the delay of the police chief and even directly drops the computer; He was rude to the evil forces. From time to time, he came up with some Jianghu words. In the end, he personally went into battle and started hand-to-hand combat with his bare hands.

　　Actor Zhang Songwen plays the role of grassroots leading cadres, which is one of the important highlights of the movie. In the whole movie conflict, Zhang Songwen’s role has two clues alternately, and his left hand is public and his right hand is his own. How to interpret the handshaking for the cloud and cover his hands for the rain? The old drama bones interpret the classics from many details such as precise expressions and subtle eyes, and the silent contest between the grassroots leading cadres played by him and the leader of the investigation team played by Jiang Wu is the soul of the whole movie. This wonderful performance of "fist to flesh" is worth entering the cinema. No matter the positive or negative characters in the movie "Decisive Fight Against the Gangsters", there are flesh and blood, arrogant Sun Zhibiao, simple Liu Lijun and affectionate Lin Qiaoer … … They all have their own logic of thinking, their own worries, their own behaviors and their own reasons. Each character has his own story behind him, which makes the whole film more realistic and easier to accept and believe.

　　In fact, this film only shows the "tip of the iceberg" in the special struggle against evil. The data shows that since the central authorities blew the "assembly number" to eliminate evil in January 2018, the evil forces have been effectively eradicated. A total of 3,644 triad-related organizations and 11,675 criminal groups were destroyed nationwide. Through the special struggle, the arrogance of evil forces has been thoroughly cracked down, and evil crimes have been fundamentally curbed. In the past three years, the social security environment has improved significantly. Public security organs across the country cracked a total of 246,000 criminal cases involving black and evil. In 2020, the number of criminal cases nationwide decreased by 13.1% compared with that in 2017, and the number of cases of eight kinds of serious violence decreased by 30%. Through special struggles, a number of major criminal cases that have not been solved for a long time have been solved, public security chaos has been comprehensively rectified, and the social security environment has been effectively purified.

　　Standing in the new era, from the background of the creation of political and legal film and television works, the film "Decisive Fight Against the Black" dares to touch and show the most "hidden corner" of the evil forces, and strives to show the truest original appearance in the special struggle against the black and evil. This is also a reflection of the present: perhaps in the past, darkness and absurdity really existed, but now, the cold winter has gone, the future has come, and the beauty of life and the harmony of prosperity are coming to us.

It is said that the refrigerator color TV sofa is not good, but the ideal sales volume is still good, ranking first in the sales volume of the new forces, and even the asking world is not an opponent. However, with the arrival of more products, the asking world may be ready to fight the ideal battle. Recently, we obtained a group of latest spy photos of the suspected asking world M8 on the Internet, and the new car is expected to be officially unveiled at the end of this year.

According to the previous information and spy photos, the new car is unlikely to be a 5-seat version, but it has been heavily camouflaged. Moreover, from the perspective of wheelbase and front and rear design styles, this car looks special and similar in design, but its size is somewhat in line with M9, including the use of a shorter front suspension, which makes the vehicle look more slender, which can also maximize the ride performance.

Judging from the current product line, the price of the customer M9 is over 460,000, and the price of the top model of the customer M7 is 329,800. Obviously, there is a product gap between 330,000 and 460,000, and this range is also an active area. This product is very hot, so the high probability of this spy photo exposure will be the customer M8, a model located between the customer M7 and the customer M9, and it will mainly compete for the ideal L8 in the future.

Of course, if you want to benchmark the ideal L8, the refrigerator color TV and sofa are essential. More importantly, the new car is expected to continue its technological advantages, including the use of some M9 configurations, including high-end intelligent driving and HarmonyOS cockpit. The chassis is expected to adopt the Turing intelligent chassis developed by Huawei, and the products will be built by the Rubik’s Cube platform, and a large number of aluminum alloys will be used.

However, in order to meet the domestic demand, the new car may have more play in space, which can be seen from the shorter front overhang and the figure closer to MPV. If optimized properly, it is believed that if the size is close, the M8 can better solve the problem of the top leg of the third row seat, and it can also ensure that the trunk has a certain volume. Of course, in order to lower the threshold, the new car may launch a standard version of intelligent driving system without laser radar, but even so, Huawei intelligent driving is still quite capable of playing, and it also has certain advantages in the face of the ideal L8 Pro version. Therefore, on the whole, the M8 may be more like a reduced version of the M9, but the space is more spacious than the ideal L8, the advantages of intelligent driving are preserved to the maximum extent, and the price may be more close to the people. So, will you look forward to such a new car?

Special feature of 1905 film network Since the online movie was launched on April 1, the platform broadcast volume has exceeded 150 million, and the accumulated account has been nearly 35 million, which is the fastest to break the box office record of 30 million online movies. Not only that, but the film scored 6.1 points in Douban, which proved an improvement of network power.

The data of this film are higher than the box office and the number of people watching the same kind of films recently released in the cinema, such as Lost in Love (March 5), Night Watch (March 12) and April 1.

At present, among the three films, only "Lost in Love" has barely passed the box office of 5 million. As for word-of-mouth, it is a long story. So far, the three films have not been divided on any platform, which also verifies the requirement that the number of people watching movies is insufficient.

In a certain period of time, domestic horror movies meet the audience almost every week. Various "disc immortals", "chopsticks immortals", "haunted houses" and "embroidered shoes" … … They all appear as keywords in film titles or posters.

　

From propaganda to film quality, they have a unified routine: poor posters, low-level Jump scare (a common routine in horror movies) as a preview, and rough special effects in content, and many films have also played a soft pornographic edge ball.

　

This kind of film once became synonymous with bad movies.But in fact, these films have been in a state of "barbaric growth" for a long time — — As long as the film can be released and the cinema is arranged at midnight, it will have box office income to some extent. Even many films can get tens of millions at the box office.

　

Judging from the current three works, this box office achievement seems to have become a thing of the past. Looking back at the market, fewer and fewer domestic horror movies appear in the cinema. Hengye Film, which started with "releasing horror films", still has two horror-type works with "Dark Side" in the list released last year. On the contrary, more domestic horror film makers are or have changed their tracks and moved towards online platforms.

　

So, where will the next stop of domestic horror movies be?

　

01

The cinema track is slowing down.

Like the online movie "The Legend of Xing ‘anling Hunter", the horror movie that caused a certain volume in the market may be in 2017, and it won 219 million box office by virtue of the IP effect.

There are fewer and fewer horror movies in cinemas, which is not easy for creators.

　

"It is very difficult to make horror movies in recent years. There are many factors in it. The creation itself is’ dancing with shackles’." Zhou, a producer who has produced and developed domestic horror films, said. It seems that in the eyes of the audience, most of these films are not expensive, and eventually millions or even tens of millions of box offices can also reap good benefits. "But in fact, they really don’t make money, and some may just return to their books."

　

Although the box office performance of the series has been the benchmark in this type of film, the producer has obviously slowed down. After three years, it was officially announced that Beijing 81 No.3 will be produced in the future.

According to Lin Chaoyang, deputy general manager of Hengye Film Group, this work has been developed for more than two years, and it is expected to be officially launched this year, and Wen Juan, the screenwriter and producer of the first film, will also return this time.

　

What can’t be avoided is that the first two works of this series, although supported by first-line actors such as,, and so on, have also achieved a total box office score of over 600 million, but the word-of-mouth is not as good as one, and even the Douban score has not exceeded 5 points.

Lin Chaoyang mentioned that when they were developing this series, they would definitely re-launch the past projects. For example, they have recently paid attention to the "Legend of Hunters in Xing ‘an Mountains" with satisfactory results. "They have done a good job in folk legends and gained a large audience in the early stage." And "Beijing 81" in the early days of publicity and marketing, is also to attract the audience.

Therefore, in "Capital 81 No.3", they will want to keep the elements of oriental horror, and make greater breakthroughs in form and psychological perception while inheriting the previous style. He also revealed that in the new plot, "the emotional core is still the place we need to focus on, especially how to perfectly package the emotional and human topics into a horrible shell."

　

In addition, the same is true of The Dark Side, which appears in the same unit of Hengye’s film list.

This producer film has also been developed. Lin Chaoyang emphasized that horror and thriller are only innovations and upgrades in the form of expression, and the expression of the core of the story is the main factor that can really capture more audiences. "Suspense movies have attracted more attention in China in the past two years, and they have also been influenced by this type of TV series, and the expectations of the audience have improved a lot, so it is also the direction of key development for us."

　

02

The online track is accelerating.

From 130 films in 2016 to 5 films at present, the number of domestic horror films appearing in the cinema is getting less and less, but on the contrary, the number of online media platforms is increasing.

　

Zhou told us that after 2017, their company’s creative track for domestic horror movies slowly shifted from cinema to online platform. "At that time, we also saw the upsurge of online movies, and the traffic of horror and thriller movies on the Internet was higher than that of cinema."

　

Our research shows that the audience of domestic horror movies is still mainly in the fourth-tier cities, such as the recently released Night Watch and Lost Love, and this audience largely corresponds to the users who love online movies.

There is no denying that the internet has given this kind of film more opportunities. As another IP of this type, Zhang Zhen Storytelling has realized the "translation" from cinema to network.

　

When the first film in the series was released, it was a stunt and produced, and finally the box office exceeded 20 million, but the word-of-mouth was extremely unsatisfactory. The two also said in the publicity that they plan to invest in 10 films in this series. But when the second film was released the following year, we found that both the producer and the creative team had nothing to do with the previous film, and the box office was only 4.4 million yuan.

When many people thought that this IP disappeared in the film and television circle, in 2019, it reappeared in front of the public in the form of online movies.

　

This time, the producer Sheng Shiwen and Tencent teamed up to create The Home of Zhang Zhen’s Storytelling, The Night of Zhang Zhen’s Storytelling and The Legend of Zhang Zhen’s Storytelling Face-washing Girl once a year since 2019. However, according to the data of Cat’s Eye Professional Edition, the performance and evaluation of these works on the platform are still not brilliant.

It can be seen that the network platform will not become a refuge for inferior works. On the contrary, the recent explosion of the online video "The Legend of Xing ‘anling Hunter" has been circled by high-quality word of mouth, which is better than many similar movies in the past, both in visual effects and script structure. Although the film takes the horror story as the starting point, it finally stays in the coexistence of man and nature, making the finishing touch for the story.

Many people said after reading it that this work is actually very suitable for developing into an online drama or a series of works. When we threw this question to the relevant creator, he said, "Maybe." If it is finally formed, it may bring another dimension of thinking to domestic horror films.

　

Lin Chaoyang also mentioned that online movies have greatly improved both in content and quality in recent years, and the investment in such works has provided a good opportunity for many new companies and directors.

03

What’s the next stop for domestic horror creators?

After the epidemic, many horror film production companies have been reshuffled, and most small companies have made transformations. Head companies like Hengye Film have long been diversified in genre development according to the changes in the market and the improvement of audience aesthetics.

　

The reason for this change is that, to a large extent, after the market optimization and upgrading, the audience’s requirements for movies are getting higher and higher. In the eyes of most viewers, domestic horror films are the representatives of bad films. Even on the ticket purchasing platform with higher acceptance, the scores of these films are concentrated below 6 points, and some of them are not even scored.

　

But China doesn’t mean that there is no brilliant horror film. From the beginning of the first horror film in the film history to the later films such as "The Scared House", these works are excellent works in any dimension. Not to mention those zombie movies in Hong Kong, some of them once became the shadow of everyone’s childhood. The novel "Double Pupils" has been borrowed from Chinese literature.

　

Horror film has become a kind of film type with low cost, which can realize "small and broad" without relying on stars. Seizing the souldirectorIn the past, it was based on two filmsRed dressLittle girlThe film, which gained a lot of attention from the management, had the opportunity to create the later "Witnesses Chasing the Murder".

　

Cases like Weihao Cheng are even more common in international film circles. Directors, directors and directors are all famous for their low-budget horror films, and finally they are favored by big manufacturers.

However, it cannot be ignored that the domestic production of horror films has always been at the bottom of the "contempt chain". When communicating with other young directors at the film festival, although most people were very interested in horror films, no one would take the initiative to express their willingness to shoot this type of film.

　

On the contrary, this element is "invading" other forms of entertainment.As a script killer,Detective chinatown.Beichen, one of the series of screenwriters, also told us that there are many restrictions on the creation of horror films, so we can do more in-depth creation in script killing and escape from the secret room. At the same time, this kind of entertainment that pays attention to immersion has also circled the horror film lovers in first-and second-tier cities. Therefore, when we asked him if this type of script could be filmed, he quickly gave a negative answer.

Movies will not be absolutely replaced by other entertainment products, but in the face of the development of current horror movies, creators also suffer from the limitations of theme and content, and now more tend to integrate the themes of films.

For example, what is common is the combination of suspense, horror and adventure that are similar to the elements. Ma Kai, director of "Evil", also said in an interview that he would try to combine horror movies with comedies when he created this kind of movies in the future.

Although domestic horror films are wary of ghosts and religious elements, they can still learn from folk stories or myths and legends. Of course, this is also the best way for this type of film at present. A while ago, the movie "Seizing the Soul" was released, which weakened the elements of terror and infinitely magnified the elements of suspense and crime.

　

Where is the next stop for domestic horror films?We believe that it will be the result of the continuous running-in and exploration of creators and audiences. They will not disappear into the cinema absolutely, nor will they allow poor quality works to develop wantonly on the network platform.

Special topic: picture channel

　　At 9: 30 am on October 13th, the case of Shanghai Yang Jia assaulting a police officer was opened in Shanghai Higher People’s Court. The picture shows the opening information of the case published on the electronic screen of Shanghai High Court. China News Agency issued Pansofi photo

　　Today (13th) morning, the Shanghai Higher People’s Court heard the case of Yang Jia assaulting a police officer in the second instance of the Fifth Trial Chamber. About 130 people from all walks of life attended the hearing, including Yang Jia’s father, Yang Fusheng, and menstruation Wang Jingrong, and more than 30 journalists, including several Hong Kong media, also attended the hearing.

　　The lawyers defending Yang Jia are Zhai Jian, director of Shanghai Zhaijian Law Firm, and Ji Jianqing, lawyer of Shanghai Branch of Beijing Dacheng Law Firm. It is understood that Zhai Jian is good at criminal defense. In 2005, he won the title of national excellent lawyer, and in 2007, he ranked first in the first "Oriental barrister" selection. Sitting on the prosecutor’s seat are Ji Gang, director of the Public Prosecution Department of the Shanghai Municipal People’s Procuratorate, and other prosecutors.

　　At 9: 30, the presiding judge Wei Xu announced the trial.

　　With the deepening of the trial, the bloody scene that happened in Shanghai Zhabei Public Security Bureau on July 1 this year reappeared in front of people.

　　Cruel killing

　　At 9: 40 this morning, Yang Jia took eight beer bottles filled with gasoline and dropped two (unburned) beer bottles next to the gate of Zhabei Branch on Tianmu West Road, and threw five bottles at the flower bed on the west side of the gate, which burned and caught fire. After the security guard saw it, he immediately went to stop and organize the fire fighting. Yang Jia also threw a beer bottle at the security guard. While the security guard was fighting the fire, Yang held a 29-cm-long single-edged boning knife and wore a dust mask, and ran into the building through the convenience service channel of the branch office.

　　After entering the door, I saw the security guard Gu Jianming on the phone, and Yang Jia slammed his head with the handle, causing Gu’s head to be lacerated. Subsequently, Yang Jia attacked the policemen Ni Jingrong, Fang Fuxin, Zhang Yijie and Zhang Jianping at work in different places, such as the lobby aisle on the ground floor and the public security duty room, with a knife in one hand and tear gas in the other. The live TV surveillance video broadcast by the court clearly shows that in just 7 seconds, all four policemen caught off guard were stabbed to the ground.

　　Soon, Yang Jia broke into the south fire stairs from the first floor and climbed to the ninth floor. When he met Xu Wei, a policeman, Yang launched a sudden attack on Xu with a knife, and Xu fell to the ground after being stabbed in many places. Later, Yang ran to the 10th floor, raised his knife and stabbed Wang Lingyun, a policeman he met, causing injuries to Wang’s right shoulder and chest. Then, Yang ran up to the 11th floor and met Li Ke, a policeman. He stabbed Li Ke several times, and Li Ke’s chest and abdomen were hit hard. After that, Yang Jia ran to the 21st floor along the fire stairs and stabbed Wu Yuhua, a policeman waiting for the elevator. After being injured, Wu Yuhua called loudly to remind his colleagues to pay attention, while returning to the office to find counterattack weapons. Lin Wei and Li Wei, policemen who are working indoors, immediately got up and prepared to round up. Yang Jia broke into the office and rushed to Lin Wei waving a dagger. Lin Wei took advantage of the opportunity to hold the office chair and struggled to resist. Kong Zhongwei, a policeman next door, rushed in when he heard the news and hugged Yang Jia regardless of his body. Kong Zhongwei, Li Wei, Lin Wei, Wu Yuhua, and the policemen Chen Wei, Rong Kanmin and Huang Zhaoquan Qi Xin who arrived later worked together to hold Yang Jia firmly against the corner with an office chair, seize the weapon in his hand and subdue the ferocious Yang Jia.

　　The sudden tragedy eventually caused six deaths and four injuries to police and security guards.

　　In court, Yang Jia replied "unclear" or "can’t remember clearly" to the prosecutor’s questions about his murder process on July 1.

　　And the following words of lawyer Zhai Jian’s emotional questions and Yang Jia’s indifferent questions and answers made the audience ring with a buzz.

　　"Six fresh lives have died because of you. Do you think you have gone too far now?"

　　"Not too much!"

　　"Do you feel guilty?"

　　"Don’t be embarrassed!"

　　What makes Yang Jia so crazy and cruel?

　　Did the police ever beat Yang Jia?

　　According to the information provided by the police, on the evening of October 5, 2007, when Yang Jia rode an unlicensed bicycle through the Pushan intersection of Zhijiang West Road in Zhabei District, he was searched by the patrolling police of Zhijiang West Road Police Station. Yang was taken to the police station for further investigation because he refused to show his identity document and provide proof of the source of the bicycle he was riding, which caused the public to watch and affected the traffic. After finding out his true identity and bicycle rental, the police released Yang after patiently educating him, although he did not cooperate during the interrogation and repeatedly insulted the police, which hindered the normal law enforcement of the police. Afterwards, Yang repeatedly complained to the supervision department of the Municipal Public Security Bureau and Zhabei Public Security Bureau through letters and visits, e-mails, etc., and put forward unreasonable demands for dismissing the relevant police officers and compensating them for 10,000 yuan of mental damage compensation, arguing that he should not be investigated. In this regard, the police believe that the police’s law enforcement is well-founded and there is nothing improper. The inspector detachment went to Beijing twice to publicize the legal system and persuade Yang Jia, but Yang ignored them.

　　In the court, the law enforcement process recorded by the on-site police with a voice recorder was broadcast for 36 minutes. Although the background was noisy, the patient persuasion of the police and Yang Jia’s violent impulse were still like people. A live video broadcast by the court at the gate of the police station on Zhijiang West Road shows that several policemen took Yang Jia, who was active at the gate, to the back room. According to the testimony of several policemen, they were afraid that Yang Jia would run away because the case had not been ascertained. Yang Jia insisted that he was "carried into the back room by seven or eight policemen, fell to the ground, punched and kicked for two or three minutes, and his body was bruised in several places, and his clothes and trousers were torn and stained".

　　But then the prosecutor produced an e-mail complaint letter sent by Yang Jia to the Shanghai Public Security Bureau shortly afterwards, which did not mention the fact that he was beaten by the police at all. Yang Jia said that some of the contents of this email were not written by him.

　　The application for a new psychiatric evaluation was rejected.

　　On July 5, the Shanghai police entrusted the Judicial Appraisal Center of the Institute of Judicial Appraisal Science and Technology of the Ministry of Justice to conduct a judicial psychiatric appraisal of Yang Jia. The judicial appraisal book concluded that Yang Jia was "not mentally ill and had full criminal responsibility".

　　Defense lawyers and prosecutors have had a heated debate about whether Yang Jia has mental illness and whether it is necessary to re-evaluate his mental health.

　　Lawyer Zhai Jian believes that Yang Jia has abnormal performance and paranoid personality disorder from the aspects of cognition, impulse control, communication and emotion. Especially in 2006, he had a conflict with the police in Taiyuan, Shanxi Province, which caused three broken front teeth, bloodshot fundus and mild concussion, which probably induced abnormal brain activity. Moreover, the psychiatric appraisal done in July was only two days in time, which was a bit hasty. Therefore, he suggested that Yang Jia should be given another spiritual appraisal to show the fairness and justice of the law.

　　Prosecutor Ji Gang believes that Yang Jia’s judicial spirit appraisal is very cautious and scientific. If there is no newly discovered evidence, there is absolutely no need to re-appraise.

　　Yang Jia showed indifference in court today, so that the presiding judge once interrupted the trial and solemnly told Yang Jia, who was sitting in a chair, "Please pay attention to your sitting posture." Yang Jia said, "I personally think my spirit is normal."

　　The court subsequently announced that "the lawyer’s request for re-evaluation of Yang Jia was not sufficient and was rejected".

　　In the final statement, Yang Jia still has no remorse and thinks that he has been law-abiding and innocent for decades.

　　The trial lasted until 6: 30 pm. The court finally announced that the case would be pronounced on another day. (Reporter Liu Jian)

Editor: Wang Jiaolong

The hot weather has been going on all over the country for many days. Such heat, even if you just stand still in the sun, will soon break out in a sweat. But there are still many people who stick to their jobs at high temperatures. Protect the safety, traffic, communication, sanitation and greening of the city … Thanks to them, let our life be as usual.

A few days ago, the 2024 National Rowing Championship was held in Sichuan Water Sports Management Center. A total of 40 athletes from Hubei Province participated in 8 events with 9 boats, and successfully won 5 gold medals. The total number of gold medals ranked first in this national rowing championship, and 17 athletes were selected for the new national rowing team.

This tournament is the highest-level rowing single event in China this year. According to Group A and Group B (U23), there are 28 events including single, double, four and eight.

In the men’s single sculls final of Group B (U23), john young won the first gold medal for Hubei. In the women’s four-person single paddle event in Group A, Wu Yongmei, Lin Xinyu, Ju Rui and Yang Rongrong easily won the laurels with their superb skills; In the men’s four-person single paddle event in Group A, members Li Wenlei, Zhang Lutong, Sun Lu and Zheng Yaming struggled to win the gold medal easily. In Group B (U23) women’s quadruple sculls, the players Wang Yutong, Lu Ming, Li Yimeng and Zhao Liangyu dared to fight and live up to expectations, and then won the gold medal.

At the finale of the men’s eight-person single-oar helmsman event in Group A, Hubei players Cao Chuang, Liu Hao, Li Chun, Zhang Maolin, Yang Yue, Cong Sheng, Liu Dang, Shen Yushuang and Song Jiayi cooperated tacitly and fought hard, and finally won the gold medal.

The person in charge of Hubei Aquatic Center said that the competition in this national rowing championship was fierce. Although the Hubei team achieved more than expected results, the competition was over and everything was started all over again. Next year’s National Games will be the final test of this cycle, and the time is tight and the task is heavy. Next, the water center will comprehensively analyze and summarize the shortcomings, and put it into the winter training as soon as possible, go all out, adjust the state, and constantly improve the special skills to lay a solid foundation for the National Games.

The competition was hosted by the Water Sports Management Center of the State Sports General Administration, China Rowing Association and Sichuan Provincial Sports Bureau, and was undertaken by the Xinjin District People’s Government of Chengdu, Sichuan Water Sports Management Center and Sichuan Rowing and Kayaking Association. (From China Sports Daily, 02 edition, October 11th)

　　Xinhua News Agency, Zhengzhou, January 4th, New Media Specialist (Reporter Ma Yizhen) In response to the recent online incident of "Henan college students marrying classmates’ mothers", Weibo, the official of Henan Provincial Public Security Bureau, released a message saying that similar rumors have been spread in many places for several years and are false news.

　　Recently, a news that "Henan college students marry classmates’ mothers" attracted attention on the Internet. According to the news, a handsome 21-year-old college student married a 55-year-old divorced middle-aged aunt in a hotel in Henan. Incredibly, this middle-aged aunt is actually the biological mother of the groom’s college classmates.

　　The news also said, "It turns out that the truth behind the incident is actually like this. The groom is young and handsome, while the bride looks very young at the age of 55, just like a young girl in her twenties … …”

　　After testing, it is found that there have been similar articles since 2013, involving different places such as Guangzhou, Wuxi and Pingtan, and the pictures are the same, the story is the same, and most of the words are the same. These articles all mention that classmates and mothers use some kind of skin care products, carry out beauty treatment and so on.

　　Some experts in journalism and communication believe that, in view of the proliferation of fake news, a governance and restraint mechanism should be established, and strict control and strict investigation should be carried out through legal and administrative penalties.

　　Bright picture

　　[educational perspective]

　　The epidemic has caused many inconveniences in finding jobs.

　　For most college students who will graduate in 2020, COVID-19, an unfamiliar word, will be engraved in their memories along with their tortuous job hunting experience. Because of the development of the epidemic in COVID-19, in order to protect students’ health and life safety and prevent the spread of the epidemic, the national education administrative departments and universities have taken emergency measures to limit the flow of personnel, and all kinds of campus recruitment activities have been suspended.

　　According to the practice of previous years, the coming March and April was originally the peak period for fresh college students to apply for jobs and sign contracts, but because of the epidemic, the employment and recruitment activities of college students were silent this spring.

　　The superposition of all these unfavorable factors undoubtedly affects the job selection of college graduates and the selection of talents by employers, which invisibly increases the pressure of college students’ employment.

　　For China’s economic development, the impact of the COVID-19 epidemic on the economy is bound to have a chain reaction, which will be transmitted and reflected in the employment sector — — Not only the temporary communication difficulties between graduates and enterprises and the inability to carry out recruitment activities, but also the demand for employers may be reduced. Of course, some industry sectors, such as medical and health care, environmental engineering, chemical technology and other employment needs are likely to increase.

　　The interview and employment pressure of job-seeking students has increased sharply. The silence in March and April, the peak of job hunting, dealt a heavy blow to college students’ employment signing. Because some students and employers have drawn up their initial intentions and need to go to the employer for an interview, but now the unit can’t operate normally, students can’t go out, and the recruitment and interview plans of some companies have also changed, and students are in a dilemma.

　　Stuck by the time limit, students who are pursuing further studies are in a dilemma. The postponement of the re-examination of the postgraduate entrance examination has a great influence on students. The uncertainty of whether they can pass the initial examination and whether they can be admitted after the re-examination makes most postgraduate students anxious, fearing that they may miss favorable employment opportunities after falling out of the list.

　　At the same time, taking into account epidemic prevention and employment, colleges and universities are facing multiple tests. Up to now, due to the pressure of economic adjustment, the employment rate of graduates who originally signed up to implement employment units is not optimistic. The arrival of the epidemic has made colleges and universities more pressure on epidemic prevention and teaching adjustment under the new situation than before, and the pressure on subsequent employment guidance has undoubtedly increased accordingly. The impact and impact of these pressures on local colleges and universities with the majority of local students will be less than those with scattered students’ origin and employment destination.

　　To cope with the pressure of employment, take many measures to promote Qi Li.

　　Employment must be promoted by the government, universities, employment enterprises and units, giving full play to their respective advantages in resources, channels and experience. As for the universities directly facing the above employment pressure, how to deal with this year’s new situation?

　　Colleges and universities should not panic when they serve college students’ employment under pressure.At present, we can see that under the decisive and correct decision-making and leadership of the CPC Central Committee, the understanding of COVID-19 has gradually deepened, and the fight against the epidemic has achieved initial results. The confirmed cases and suspected cases in high-incidence areas have been running at a low level, and the epidemic situation in most areas has been effectively controlled. I believe that with the support and encouragement of various supporting policies of the state, all economic construction activities will be carried out in an orderly manner. This is the biggest good news for economic activities directly related to employment.

　　College students start job hunting and employment rationally and calmly.Then, after the epidemic is controlled, the employment activities of college students that have been temporarily suspended will be restarted, and the suppressed demand for employment will be released again. Therefore, for colleges and graduates, they should gradually become rational, sober and brave from the initial panic, anxiety and sorrow, and there is no need to panic at all. They should have full confidence and calmly and objectively carry out the employment work during the epidemic period according to the arrangement of the national education administrative department.

　　Enterprises should promptly strengthen the organization of online employment recruitment activities.Before the epidemic has been completely controlled, in order to prevent large-scale gathering of people, the on-site recruitment activities of various college graduates have been suspended. In this case, colleges and universities should vigorously promote the development of online employment activities, and guide more enterprises to organize more online recruitment activities in a planned way to provide graduates with job opportunities; Students can get job information and enjoy online employment services by browsing national and provincial employment platforms, university employment networks and social recruitment websites.

　　Multi-party cooperation to explore innovative employment channels.Colleges and universities should take the initiative to coordinate relevant parties and further organize and implement grassroots projects such as the special post teacher plan, the university student village official, the three supports and one support, and the university student volunteer service plan for the western region; Encourage college students to join the army and serve national defense; Further implement preferential policies such as tuition subsidy for grassroots employment and encourage graduates to work and start businesses at the grassroots level; Establish a docking platform for school-enterprise cooperation and strengthen the docking of talent supply and demand in key areas, major projects, major projects and important fields; Further explore the employment opportunities created by the deep integration of the Internet, big data, artificial intelligence and the real economy, and support graduates to achieve multi-channel employment; Call on employers to hold campus job fairs, take recruitment tests exams, receive graduates’ resumes and practice training through the Internet and other more flexible ways.

　　Focus on strengthening the focus on helping students from difficult families.Colleges and universities must actively design and provide one-on-one assistance to poor family graduates, physically disabled graduates and other groups, and carry out targeted job promotion. It is urgent to form a team of relevant university leaders, fully grasp the latest trends of students, regional economy and professional fields, open a hotline for employment consultation and help, and develop a number of online employment guidance courses to do a good job in promoting graduates’ employment, enterprise docking and psychological counseling.

　　The epidemic will eventually pass. As long as all parties face it confidently, calmly, optimistically and scientifically, with the overall victory in the fight against the epidemic, the employment situation of college graduates in 2020 will certainly improve and usher in "spring"!

　　 (Author: Zong Cheng, a postdoctoral fellow at China Academy of Educational Sciences)

　　BEIJING, Beijing, June 14 (Reporter Du Yan) Today, the Beijing Municipal Bureau of Human Resources and Social Security released a centralized adjustment plan for relevant social security benefits in Beijing in 2019, including pensions for enterprise retirees, basic pensions for urban and rural residents and welfare pensions, and regular treatment for work-related injury insurance, benefiting nearly 3.5 million people in the city.

　　Beijing issued a centralized adjustment plan for social security benefits in 2019, including pensions for enterprise retirees, basic pensions and welfare pensions for urban and rural residents, and regular treatment for work-related injury insurance. Photo courtesy of Beijing Human Resources and Social Security Bureau

　　Pensions for retired employees were paid in place on June 15th.

　　According to national requirements, since January 1, 2019, Beijing has continued to adjust the basic pension for enterprise retirees (including those who have retired and retired), with an increase of about 5%. After the adjustment, the per capita growth will be around 220 yuan, and the average pension level will reach 4,157 yuan per month, which is the 27th consecutive increase of enterprise retirees’ pensions in Beijing.

　　It is understood that the basic old-age insurance for enterprise employees in Beijing operated smoothly in 2018. In that year, the fund income was 234.24 billion yuan, the expenditure was 146.39 billion yuan, and the balance was 87.85 billion yuan.

　　This adjustment is aimed at retirees who have gone through retirement procedures and received monthly pensions before the end of 2018. It is expected to benefit 2.57 million people, and the pensions will be reissued from January this year and distributed to the retirees of enterprises on June 15.

　　It is reported that this adjustment will ensure that those with low level of treatment can appropriately increase the basic pension by adopting the way of high-profile for the lowest and low-key for the highest. At the same time, in order to give consideration to fairness, if a few retirees are lower than the next file after adjusting their pensions in absolute amount, the difference will be made up.

　　Appropriately tilt to senior retirees.

　　For retirees with early retirement time and older age, since 2007, Beijing has been moderately inclined to senior retirees when adjusting the basic pension for enterprise retirees. In 2019, we will continue to adhere to this practice, and the senior retirees who have reached the age of 65 or above before the end of 2018 will once again enjoy the four grades of preferential policies from 40 yuan to 70 yuan after adjustment according to the above-mentioned basic pension adjustment methods. That is, retirees aged 65 to 69 will increase their 40 yuan every month; 70 to 74 years old, each person will increase 50 yuan every month; Each person aged 75 to 79 will add 60 yuan every month; 70 yuan will be increased every month for each person over 80 years old.

　　On this basis, for retirees over 65 who have paid for 30 years, the 5 yuan will be increased every month, so as to reflect the further preference for retirees with early retirement time, continuous service and long payment period.

　　Beijing issued a centralized adjustment plan for social security benefits in 2019, including pensions for enterprise retirees, basic pensions and welfare pensions for urban and rural residents, and regular treatment for work-related injury insurance. Photo courtesy of Beijing Human Resources and Social Security Bureau

　　Separate adjustment of retirement benefits for old workers who participated in revolutionary work before the founding of New China.

　　At present, the old workers who participated in revolutionary work before the founding of New China are generally over 80 years old, and the state stipulates that they can enjoy 100% retirement benefits. This adjustment will still be made according to the previous year’s method, that is, those who participated in the revolutionary work from July 7, 1937 to September 2, 1945 will receive an increase of 365 yuan per person per month; Those who took part in revolutionary work from September 3, 1945 to September 30, 1949 received an increase of 335 yuan per person per month. On the basis of the adjustment of the above two standards, they also enjoy the preferential policy for senior retirees, and this adjustment is generally increased by 405 to 440 yuan/month.

　　At the same time, it is guaranteed that the retired military cadres, former industrial and commercial personnel and senior professional and technical personnel of enterprises will not be lower than the average level of pensions in the city after adjustment. If the basic pension of the above-mentioned population is lower than the adjusted average pension level of the whole city of 4157 yuan/month, it will be replenished to the average level. At the same time, senior retirees who have reached the age of 65 or above before the end of 2018 also enjoy the preferential policy for senior retirees.

　　According to the national regulations, those who retire from Beijing institutions before the end of 2018 will also adjust the basic pension according to the combination of quota adjustment, hook adjustment and appropriate tilt, and will be paid in place before the end of June.

　　More than 880,000 urban and rural residents have increased their pensions in 100 yuan every month.

　　According to national requirements, Beijing will continue to implement the normal adjustment mechanism of basic pension and welfare pension in 2019. From January 1st this year, these two pension standards will be adjusted, and the 100 yuan will be increased per person per month for the groups enjoying basic pension and welfare pension. This treatment adjustment has benefited 888,800 urban and rural residents and is expected to be distributed before the end of June.

　　According to reports, those who have received the basic pension of urban and rural residents’ basic old-age insurance and the old-age security welfare pension before December 31, 2018 will adjust the old-age security treatment standard for urban and rural residents from January 1, 2019, and increase the 95 yuan per person per month; In order to further reflect the preferential policy for the elderly, 10 yuan will be added to those who have reached the age of 65 or above before December 31, 2018. The per capita basic pension for those who have received benefits has reached 810 yuan, and the per capita welfare pension has reached 725 yuan.

　　In addition, since January 1, 2019, those who are eligible to receive basic old-age insurance benefits for urban and rural residents on a monthly basis will have a basic pension standard of 800 yuan per person per month; The old-age security welfare pension standard is 715 yuan per person per month.

　　Continue to adjust the regular treatment of industrial injury insurance.

　　According to the regulations of the state, since 2001, the disability allowance for those who have been disabled due to work-related injuries and the pension for the dependent relatives of those who have died due to work have been adjusted year by year in Beijing.

　　This year, Beijing will continue to adjust the regular treatment of work-related injury insurance. The scope of adjustment is for work-related injuries (excluding retirees receiving basic pensions) who enjoyed disability allowance before December 31, 2018 (inclusive), and workers and deceased people who enjoyed the pension for supporting relatives. It will benefit 15,000 people and will be implemented from January 1, 2019. The specific adjustment scheme is as follows:

　　According to the level of disability, each person will increase each month: the first level of disability will increase by 380 yuan, the second level of disability will increase by 360 yuan, the third level of disability will increase by 340 yuan, and the fourth level of disability will increase by 320 yuan. The employing unit shall increase the disability allowance for the five or six injured workers who have not arranged for work, and the increase per person per month shall not be lower than that in 200 yuan.

　　Adjust the pension for dependent relatives. The adjustment of the pension for dependent relatives of workers and deceased persons will increase 200 yuan per person per month. (End)

The year 2023 is of great significance to the drugs for autoimmune diseases and even to the global innovative drug market. With the expiration of patents in key markets, Hummel (adalimumab) will officially hand over the title of global sales champion for 11 years, and the first generation of "drug king" will officially end.

Due to the complex pathogenesis, the number of patients with autoimmune diseases is large and it is difficult to cure. The long-term or even lifelong demand for drugs has spawned a huge market for autoimmune drugs, which has become a hotbed for the growth of heavy drugs.

Under the demonstration effect of "drug king", major pharmaceutical companies around the world have been scrambling for layout in recent years. At present, breakthroughs have been made in the development of new drugs for potential targets such as JAK and interleukin, and the free drug track is expected to usher in a new round of competition. Local innovative drug companies try to gain a place in the domestic free drug market through differentiated distribution of indications and continuous optimization of safety.

The market for self-exempted drugs continues to grow steadily.

Autoimmune system diseases refer to diseases caused by immune response to autoantigens and self-tissue damage. Genetic defects and environmental factors are all important links in inducing autoimmune diseases. The complex disease mechanism leads to a wide variety of autoimmune diseases and a large patient base. At present, there are more than 100 known main disease types, including psoriasis, atopic dermatitis, compulsory spondylitis, rheumatoid arthritis and systemic lupus erythematosus.

As a chronic disease, autoimmune diseases usually do not directly kill people, but it is also difficult to cure them. Such as compulsory spondylitis, systemic lupus erythematosus, etc., once suffering from it, it will be difficult to reverse, which is called "undead cancer". Patients need long-term or even lifelong medication, thus giving birth to the long-term and stable growth of market demand for self-immune drugs.

Based on the financial report data of major pharmaceutical companies, in 2022, there were 22 self-disease-free drugs in the list of TOP100 drugs with global sales scale, of which 10 drugs exceeded $3 billion and the total sales exceeded $70 billion.

According to the statistics of AARDA, patients with autoimmune diseases account for 7.6%-9.4% of the global population in recent years. Jost Sullivan’s statistics show that there are nearly 500 million patients with various kinds of self-immune diseases in the world, and the global self-immune drug market will reach about 132.3 billion US dollars in 2022, which has become the second largest disease market after cancer.

Jost Sullivan predicted that by 2030, the global self-exempted drug market is expected to reach US$ 176 billion, with a compound annual growth rate of 3.6% from 2022 to 2030. Among them, the self-exempted drug market in China is expected to reach nearly US$ 25 billion in 2030, a tenfold increase compared with 2020, which is an important incremental source of global self-exempted drugs.

The "King of Medicine" made a curtain call, and new drugs rose one after another.

Treatment strategies for autoimmune diseases include inflammation alleviation and immunosuppression. Although non-steroidal anti-inflammatory drugs, corticosteroids and anti-rheumatic drugs have good anti-inflammatory effects, they are difficult to fundamentally stop the development of the disease, and they are easy to relapse after stopping taking drugs. However, traditional non-selective immunosuppressants such as cyclosporine and methotrexate are not only slow to take effect, but also lead to a higher risk of cancer. As new immunosuppressants, bio-targeted drugs can selectively suppress the immune system, ensuring the safety while improving the curative effect, which is the most promising.

Hummel is a fully humanized monoclonal antibody against TNF-α developed by AbbVie Company, which was approved by FDA in 2002 for the treatment of rheumatoid arthritis. Because of its remarkable efficacy and safety in the treatment of self-immune diseases, Hummel’s indications have been expanding since its listing, and it has gradually become the highest-selling self-immune drug, and ranked first in global drug sales in 2012. Since then, through a series of marketing and patent strategies, AbbVie has made great efforts to extend the life cycle of Hummel, and promoted the drug to become the "drug king" in the world for ten consecutive years, with accumulated sales exceeding 200 billion US dollars since its listing.

With the official expiration of the patent in the United States in 2023, the market share of self-exempted drugs controlled by Hummel was quickly robbed by many similar biological drugs. According to AbbVie’s third quarterly report in 2023, nearly 10 biologically similar drugs have entered the market. As a result, the cumulative sales of Humele in the first three quarters of 2023 was only $11.1 billion, a sharp drop of 29.1% year-on-year. Nature Reviews Drug Discovery, a well-known medical journal, predicts that the annual sales of Hummel in 2023 will be about $13.6 billion, less than 60% of Keytruda of Top1, and the first generation of drug kings will soon "abdicate".

Corresponding to the curtain call of "King of Medicine", many innovative drugs with potential targets have risen rapidly, and a new generation of heavy drugs is coming out.

According to the global sales forecast of innovative drugs in 2023 recently released by Nature Review of Drug Discovery, the sales of self-immune biological agents Dupixent and Stelara, which target IL-4/IL-13 and IL-12/IL-23 respectively, have increased rapidly, and it is estimated that they will rank among the Top10 with sales of more than 10.6 billion US dollars.

Abbey, the owner of Hummel, is also actively looking for the next generation of self-free drugs. The sales amount of oral JAK1 inhibitor Rinvoq (upatinib) and IL-23 monoclonal antibody Skyrizi (risazhuzumab) under the company has increased rapidly in recent years. In 2022, the total sales revenue has exceeded 7 billion US dollars, and the growth rate is higher than 50%. Abbway predicts that by 2027, the combined sales revenue of these two drugs is expected to exceed the sales peak of Hummel’s $20 billion.

Domestic pharmaceutical companies compete for the next potential target.

Compared with the highly competitive innovative cancer drugs, the number of participants and innovative drugs in the self-exempt drug market is still relatively limited, and the overall market competition pattern is good. However, the huge unmet clinical needs and the continuous improvement of the diagnosis rate in China have also attracted more and more domestic innovative pharmaceutical companies to enter the drug-free track, and tried to gain a competitive advantage by virtue of differentiated layout potential targets and occupy a place in the domestic market.

So far, the targets of self-immune targeted drugs mainly focus on TNF-α, JAK, interleukin and BlyS, and the main indications are common rheumatoid arthritis, psoriasis, systemic lupus erythematosus and so on. Among them, targeted TNF-α drugs are the most classic targeted drugs for autoimmune diseases because of their early market time, mature targets and the widest range of indications. However, this track has basically been controlled by foreign-funded enterprises, and the development space of local manufacturers that follow is relatively limited. Domestic innovative drug companies have turned their research direction to JAK, interleukin and other targets.

Interleukin and its receptors are important target families in human immune regulation, and play an important role in various immune and inflammatory reactions. Psoriasis is the main indication of interleukin targeted drugs at present, and some targeted drugs have been proved to be safer than TNF-α antagonists in certain circumstances.

At present, the effective interleukin-targeting drugs listed in the world include tosilizumab targeting IL-6, ulinuzumab targeting IL-12/23, skukiyuzumab targeting IL-17A and gusechizumab targeting IL-23. Among domestic enterprises, Hengrui Pharma (600276.SH), Zhixiang Jintai (688443.SH) and Kangfang Bio (09926.HK) all have approved the listing of interleukin-targeted biological agents, and Quanxin Bio (01883.HK), Livzon Group (000513.SZ), Junshi Bio (688180.SH) and Cinda Bio.

JAK signaling pathway plays a very important role in autoimmune, tumor, hematological and other diseases, and it is one of the promising potential targets. Because the first generation of JAK inhibitors showed great toxic and side effects in the treatment process, the main research and development direction of major pharmaceutical companies is the second generation of JAK inhibitors targeting JAK1, JAK3, TYK2 and other targets with high specificity.

In clinical trials, the second generation JAK inhibitors have shown good data in terms of safety and efficacy. Among them, Upatinib, a JAK1 inhibitor listed by AbbVie, showed a better key remission index under the same safety in the head-to-head experiment of treating rheumatoid arthritis and adalimumab. In the first three quarters of 2023, the sales amount of Upatinib has reached US$ 2.71 billion, exceeding the annual performance in 2022. AbbVie expects that the drug is expected to achieve sales of more than $7.5 billion in 2025.

In view of the good performance of this target, the research on JAK-specific subunits has become one of the important directions of global innovative drug companies. Among domestic enterprises, Hengrui Pharma, Dizhe Medicine (688192.SH) and Nuocheng Jianhua (688428.SH) are in the top of the research and development progress. Among them, Nuocheng Jianhua recently disclosed that its TYK2 inhibitor ICP-488 under research has completed the first clinical administration for psoriasis patients in Phase II. ICP-332, another self-immune drug with the same target, disclosed the second phase clinical data of moderate and severe atopic dermatitis indications in December 2023. Orient securities believes that domestic JAK-targeted self-immune drugs are expected to achieve rapid volume increase after marketing through differentiated distribution of indications and optimized breakthrough in safety.

BlyS is one of the key factors in the differentiation and maturation of B lymphocytes, which is the most important effector cell of autoimmune diseases. By inhibiting BlyS, many autoimmune diseases can be treated. At present, there are two BlyS inhibitors on the market, namely, GlaxoSmithKline’s Beliyuzumab and Rongchang Bio (688331.SH)’ s Tatasip. The main indications are systemic lupus erythematosus, and the market structure is good.

Tetasip is an innovative drug of BLyS/APRIL dual-target fusion protein independently developed by Rongchang Bio. Clinical data show that the drug has the same level of efficacy and safety as Belizumab. In 2021, National Medical Products Administration conditionally approved Tatasip for the treatment of adult patients with systemic lupus erythematosus, and included it in the 2022 edition of the National Medical Insurance Catalogue; In November, 2023, the treatment of Tatasip in this indication was fully approved.

Rongchang Bio is also continuing to promote the clinical research on other indications of Tatasip, and the research on many indications such as rheumatoid arthritis, Sjogren’s syndrome and multiple sclerosis has entered the final clinical stage. In August, 2023, Tatasip was used to treat patients with rheumatoid arthritis in Phase III, and submitted an application for domestic marketing. On December 20th, the global multicenter Phase III clinical IND of Tatasip in the treatment of active primary Sjogren’s syndrome in adults was approved by the FDA of the United States, and clinical research will be carried out in many countries and regions around the world. The continuous enrichment of the clinical pipeline of Tetasip is expected to consolidate the innovative product matrix of the company and promote the continuous growth of the company’s income.