Lingpai Luxury Car Club is located in Tianjin Port Bonded Zone. The company’s physical exhibition hall covers an area of 3,000 square meters. It is a first-class import car wholesale trading company with comprehensive strength. It has been engaged in the wholesale and retail of imported cars for fifteen years, and its business covers every province and city in China. Adhering to the sales concept of honesty first, it is professional, dedicated and dedicated to serve every customer wholeheartedly. We look forward to cooperating with you, and your satisfaction is our greatest pursuit. Car consultation hotline: 15922271117 Manager Kou (WeChat synchronization)

Tianjin’s leading luxury car club is mainly engaged in Rolls-Royce, Bentley, Porsche, Land Rover, Lexus, Mercedes-Benz, BMW and Toyota. All vehicles enjoy the lowest price for impulse repayment. During the preferential period, you can also get free car-related services or car decoration gifts when you pick up the car at the store, support the nationwide installment mortgage car-picking business, and do not charge any service fees and handling fees. You can lend money to pick up the car on the day of on-site audit. For more details, please call the 24-hour car consultation hotline: 15922271117 Manager Kou (WeChat synchronization).

23 Dodge ChallengersIn terms of the appearance of SRT Hellcat, the new car continues the American muscle car style with very tough and powerful challenger family models. At the same time, the new car has added a set of wide-body kit on the basis of the ordinary version, which is mainly aimed at widening its wheel eyebrows, and has increased by 3.5 inches (88.9mm) compared with the ordinary version, enabling the new car to use wider tires. In addition, the new car will also provide 13 different body colors, and provide a variety of body pull flowers for consumers to choose from.

23 Dodge Challenger SRT Hellcats In terms of details, the middle net and the lower air intake of the new car are also painted in black, and there is a unique logo of SRT on the side of the middle net. In terms of wheels, SRT Super Stock adopts a set of 18x11J (18 inches in diameter and 11 inches in width) rims, which are the same as those of challenger SRT Demon, and is matched with the NT05R linear acceleration special tires with 315/40 R18 specifications, so that the car has three times the grip of SRT Hellcat models. In terms of brakes, the front wheel of the new car is equipped with an upgraded Brembo four-piston caliper and a 14.2-inch front brake disc.

23 dodge challenger SRT hellcatsThe tail wing added above the rear of the car improves its stability at high speed, while the bottom spoiler and large-diameter double-outlet tail row show its powerful performance more thoroughly. The lines on the side are more rough and overbearing broken lines, which are very muscular. They are equipped with 20-inch Group2 alloy wheels and NTOS racing tires, which have excellent grip.

23 dodge challenger SRT hellcatsLooking at the front of the car, the two headlights are as sharp as eagle eyes, and the flexible lines of the whole body overflow with an aura. If you like passion, sports cars and speed, this Dodge Challenger wide-body red-eyed cat is the best choice.The aggressive front face of a muscle sports car is the most striking place, like a shark with a big mouth, which is quite powerful. The integrated taillight uses 164 LED light sources, and the tail wing improves its stability at high speed.

23 Dodge ChallengersSRT Hellcat is powered by a 6.2-liter HEMI V8 supercharged engine. Compared with the challenger Hellcat Redeye, its maximum power is increased from 807 horsepower to 818 horsepower, and the red line speed of the engine is increased from 6300rpm to 6400rpm. The transmission system is matched with a TorqueFlite 8HP90 8-speed automatic manual transmission. Dodge official said that the acceleration time of the new car from 0 to 96 km/h is 3.25 seconds, and it only takes 10.5 seconds to complete the linear acceleration of a quarter mile, but due to the new car tires, its top speed is limited to 168 mph (270 km/h).

Solemnly promise: All the models purchased in our company are imported, without unauthorized modification, and we can provide the formal goods import certificate, vehicle conformity certificate issued by the state-recognized customs, the on-board inspection list and formal invoice of imported motor vehicles, so as to ensure the normal settlement in all regions of the country. At the same time, all vehicles in our company can enjoy the three-year 100,000-kilometer warranty mandated by the state, so that you can buy comfortably and use with confidence.

Company address: Hengnuo Venture Exhibition Hall, No.98 Haibin Third Road, Tianjin Port Free Trade Zone

Sales Manager: 15922271117 Manager Kou (WeChat synchronization)

Data map: Taiyuan, Shanxi, postal workers are sorting express delivery. China News Service reporter Zhang Yunshe

　　BEIJING, Nov. 12 (Xinhua) According to the official WeChat news of the State Post Bureau, on November 11, according to the monitoring data of the State Post Bureau, postal and express delivery companies handled 535 million express mail all day, which was three times the daily processing volume since the second quarter, with a year-on-year increase of 28.6%, a record high.

　　It is estimated that the peak season of "double 11" this year will last from November 11th to 18th. During the peak period, the whole industry will handle 2.8 billion pieces of express mail. The whole industry still regards "peak-shifting delivery and balanced promotion" as the core mechanism, and strictly controls the peak delivery volume according to the delivery carrying capacity of each enterprise and the planned push volume. Through big data platforms such as postal industry safety supervision information system and e-commerce collaborative platform, the State Post Bureau will pay close attention to the whole network operation in real time, guide enterprises to control the dispatching rhythm, and moderately extend the delivery time limit of double 11.

　　In order to achieve the goals of "two noes" (no paralysis of the whole network and no explosion of important nodes) and "three guarantees" (smooth flow, safety and stability), on the basis of the existing service capacity, the whole industry temporarily hired nearly 400,000 people and 120,000 vehicles, and added more than 3.6 million square meters of processing sites and more than 3,000 sets of automatic and semi-automatic sorting equipment. Technically, unmanned warehouses, drones and unmanned vehicles have gradually achieved mass production and large-scale application. More than 200 intelligent distribution centers have been built nationwide, and many unmanned warehouses have been set up by enterprises such as SF, JD.COM, Cainiao and Suning. A large number of heavy-duty storage robots and distribution robots have been promoted and applied in different occasions, and the "illegal operation AI intelligent identification system" that automatically identifies violent sorting behavior has been put into operation in some enterprises. In urban areas, 82,000 terminal public service stations have been built nationwide, and more than 380,000 sets of intelligent express boxes have been deployed, effectively supplementing the terminal service capacity of express delivery. The establishment of 59,000 rural express public pick-up and delivery points will better meet the delivery service needs of rural residents. In terms of international business, the outlets of express delivery enterprises in more than 60 countries, overseas warehouses covering more than 50 countries and regions and new international routes will play a very positive role. In terms of after-sales, AI intelligent customer service robots that can achieve 24-hour service have been put into use in many enterprises, which will effectively improve customer service capacity during peak hours.

　　In response to the consumer’s concern about the "last mile" in rural areas in the peak season, the relevant person in charge of the State Post Bureau pointed out that up to now, express outlets have covered more than 30,000 towns and villages, and the coverage rate of express outlets in towns and villages nationwide has reached 96%, effectively improving the distribution capacity in rural areas. At the same time, the State Post Bureau specially issued the "Implementation Plan for Accelerating Express Delivery to the Countryside" this year, intensified efforts to build a terminal delivery service system consisting of home delivery, box delivery and platform delivery, and constantly promoted the integrated development of transportation and postal express delivery, and promoted the coordinated development of express delivery and rural e-commerce. In addition, since April this year, two rounds of cleaning up and rectifying illegal charges for express terminal services have been deployed nationwide, effectively safeguarding the legitimate rights and interests of farmers. On the issue of express packaging, with the help of "double 11", the industry has vigorously promoted the "9571" project of green development, continuously reduced the secondary packaging of e-commerce express mail, and deployed 27,000 standardized express packaging recycling devices at terminal service stations. At the same time, enterprises have done a lot of work in reducing the use of packaging materials, promoting electronic face sheets, circulating transfer bags and packaging recycling boxes.

Special topic: Wenchuan earthquake in Sichuan

　　Yesterday was the first small holiday after the Wenchuan Earthquake. The sky is raining, and the earthquake relief continues, but strings of zongzi, sachets, calamus and mugwort leaves convey a warm festive atmosphere in this cool weather. On the first day of the Dragon Boat Festival holiday, while many citizens were reunited with their families, many people chose to go out and enjoy the holiday. They relaxed their pent-up feelings during their travels and experienced the still beautiful Sichuan for themselves.

Yesterday morning, hundreds of married couples took photos in Hejiang Pavilion as a souvenir.

　　Yesterday was the first small holiday after the Wenchuan Earthquake. The sky is raining, and the earthquake relief continues, but strings of zongzi, sachets, calamus and mugwort leaves convey a warm festive atmosphere in this cool weather. On the first day of the Dragon Boat Festival holiday, while many citizens were reunited with their families, many people chose to go out and enjoy the holiday. They relaxed their pent-up feelings during their travels and experienced the still beautiful Sichuan for themselves.

　　Emei Mountain: The number of tourists increased year on year.

　　Yesterday, Emei Mountain Scenic Area received more than 5000 tourists. "Obviously better than our previous expectations." The relevant person in charge of Emei Mountain Scenic Area introduced. Among the tourists who came to Emei Mountain yesterday, self-driving tourists became the main force. According to the statistics of Emei Mountain digital monitoring system, the number of self-driving vehicles that came to Emei Mountain yesterday reached 1768.

　　Among them, self-driving cars from Chengdu accounted for half. "Many of them are to relax." It is understood that in addition, there are more self-driving cars from Chongqing and Zhejiang, as well as from surrounding areas such as Meishan. Wang Xiaoqing, a tourist from Chongqing, came to Mount Emei for the first time. After coming down the mountain, he said that Mount Emei was more beautiful than he expected.

　　Team tourism is also recovering. Yesterday, there were six teams coming to Emei Mountain, and three in Chengdu and Chongqing respectively. "Since we held the Chengdu-Yule Line Boutique Conference two days ago, the travel agencies in Chengdu have sent delegations every day." Emei Mountain Scenic Area said that they are very confident in the tourism market after the earthquake.

　　According to statistics, Mount Emei received a total of 5,000 tourists yesterday, a slight increase compared with the same period last year. The hotel occupancy rate is over 60% on average. It is expected that the number of tourists will reach its peak at the Dragon Boat Festival today.

　　Chengdu: Tourists enjoy the Dragon Boat Festival.

　　The first Dragon Boat Festival holiday forecast issued by Chengdu Holiday Office shows that the tourist attractions and attractions in Chengdu that are unaffected and fully open have attracted a large number of tourists. Huaxiang Rural Residence in Hongsha Village in Jinjiang District received 15,000 tourists, Huanglongxi in Shuangliu County received 12,000 tourists, and Wenjiang Northern Ecological Zone received 8,000 tourists. Although the number of tourists is less than the previous small holiday, the rapid start of the market has made these scenic spots even "unexpected".

　　It is reported that there are 65 scenic spots (spots) that have been opened and received tourists in Chengdu except Dujiangyan, Pengzhou and chongzhou city. The "Dragon Boat Festival" held in Shuangliu, Wenjiang, Qionglai and other districts (cities) and counties, such as blessing, setting off river lanterns and eating zongzi, as well as rural tours in the suburbs of the city, also attracted many tourists.

　　At the same time, the Law Enforcement Brigade of the Municipal Tourism Bureau went to the major travel agencies and scenic spots in the city to inspect the safety precautions and market order, and focused on setting safety warning signs and unblocked safety passages to ensure the tourism safety during the Dragon Boat Festival holiday.

　　Travel Agency: More people will visit Sichuan!

　　After the earthquake, many travel agencies in Sichuan closed down or were semi-closed. However, with the arrival of the Dragon Boat Festival, many travel agencies in Chengdu received their first business after the earthquake. "Although the amount is small, we see hope in it." A staff member of the Provincial Youth Travel Service introduced. Before the Dragon Boat Festival, guests kept calling for advice, which surprised them. It is understood that during the Dragon Boat Festival, many citizens in Chengdu also traveled to other provinces by participating in tour groups. These routes are mainly Yunnan, Guilin, Guizhou and East China. Although the number is small, the citizens’ willingness to travel has gradually increased, which has enhanced the confidence of travel agencies.

　　According to the analysis of a senior person in the tourism industry, the overall travel situation of the Dragon Boat Festival is definitely worse than that of previous years. There are three main reasons. First, yesterday happened to be the college entrance examination, and many parents had to accompany their children to take the exam; Second, the general rainfall yesterday affected people’s mood for traveling; Third, after the earthquake, many people want to go home to reunite with their loved ones and spend the holidays at home. He believes that with people’s lives on the right track, more people will be willing to travel. "With the joint efforts of everyone, more people will come to visit the still beautiful Sichuan!" (Reporter Tao Ying Intern Huang Lian)

Original Ugliness & Visualization of Teacher Cat’s Patent Analysis

Citation between patent documents is the information that reflects their technical relevance, including the documents cited by the applicant in the background technology of his patent application, the comparison documents used by the examiner in the examination process, and the evidence documents submitted by the third party when requesting patent invalidation.

Patent citation can be divided into Cited and quoting, also known as Backward citation and Forward citation. The corresponding patent citations are called cited documents and cited documents. Among them, the cited document refers to the reference document cited by the target patent/family, and the cited document refers to the later document cited by the target patent/family. The relationship among the target patent/family, cited documents and cited documents is shown in the table below.

By combing the citation relationship, the undertaking order of technological innovation research and development among patent documents can be established, which can help analysts reproduce the development process of patent technology. It can also be used as auxiliary information to judge the importance of a patent document by counting the cited situation of a patent document, such as the number of cited documents, the technical field of cited documents, the applicant of cited documents, etc. On this basis, we can also combine the information related to patent literature sources such as country, applicant or inventor, so as to judge the historical contribution, technical strength and competitive position of the technology source.

Case 1: the applicant who cited the most important patent US6191007 in the field of 1：FDSOI technology.

The applicant who cited the patent US6191007 the most times.

Chart Source: Zhang Maoyu. Industrial Patent Analysis Report (Volume 50) Advanced Chip Manufacturing Technology [M]. Beijing: Intellectual Property Press, 2017.

The most frequently cited patent application in the field of FDSOI technology is the patent application with publication number of US6191007 filed by Denso in 1998, which was cited 316 times, and all of them were not self-cited. The main technical direction of this patent application is technology, which is to fabricate SOI or super-wave SOI substrates by ion implantation.

The applicant who cited the patent US6191007 the most was Monolithic 3D Inc, and it can be known that the company may have made key research and development in the field of substrate technology of FDSOI following Denso’s technology. At the same time, other applicants who cited this important patent are Micron, Innovative Silicon and IBM, and these applicants are also key applicants or potentially important applicants in the field of FDSOI.

Case 2: The most influential patent applicant of microalgae related technology

The most influential patent applicant for microalgae-related technology

Chart source: WIPO patent landscape report: micro alga-related technologies

The above figure lists the most influential patent applicants for microalgae-related technologies, and provides two indicators to measure the applicant’s influence, one is the number of patent families owned by the applicant, and the other is the Citation Velocity of the applicant’s patents. The patent citation rate in this report refers to the average number of times each patent is cited by other people’s later applications every year, which excludes the applicant’s self-citation. This citation includes Patent examiners’s citation in the review process as a comparison document, and also includes other patent applicants’ use as prior art documents in the background technology of their patent application documents. The higher the number of citations, the greater the influence of the applicant in this field.

Case 3: Patent citation network of patent applicants in the field of quantum metrology and sensing

Patent citation network of patent applicants in the field of quantum metrology and sensing

Chart source: EPO landscape study on patent filing: quantum metrology and sensing

Through citation analysis, we can also see that there is a very close relationship between enterprise applicants and research institution applicants in the field of quantum metrology and sensing in technology research and development. For example, most of Lockheed Martin’s 55 patents cite the patent documents of university applicants, and 17 of them cite the patents of Melbourne University.

Original title: Patent Analysis Method | Patent Citation Analysis

Read the original text

　　CCTV News:According to WeChat official account, the National Bureau of Disease Control and Prevention, on October 23rd, the National Bureau of Disease Control and Prevention released the national epidemic situation of legal infectious diseases in September 2023:

　　In September 2023 (from 0: 00 on September 1st to 24: 00 on September 30th), 879,567 cases of legal infectious diseases were reported in China (excluding Hongkong, Macao Special Administrative Region and Taiwan Province, the same below), with 2,213 deaths.

　　Nine cases of Class A infectious diseases were reported, all of which were cholera, and no deaths were reported.

　　Among the Class B infectious diseases, except novel coronavirus infection, 304,210 cases were reported and 2,213 people died, including SARS, poliomyelitis, human infection with highly pathogenic avian influenza, diphtheria and human infection with H7N9 avian influenza. The top five reported diseases are viral hepatitis, tuberculosis, syphilis, gonorrhea and dengue fever, accounting for 92.7% of the total reported cases of Class B infectious diseases.

　　In the same period, a total of 575,348 cases of Class C infectious diseases were reported, and no deaths were reported. The top three reported diseases are influenza, hand-foot-mouth disease and acute hemorrhagic conjunctivitis, accounting for 80.2% of the total reported cases of Class C infectious diseases.

Author: Hongge comes from Medical Wechat WeChat official account.

　 　　 　　　Recent epidemic situation in ChinaIn the process of getting up, there are some situations that deserve our attention.the most importantIsFalse negatives in nucleic acid detection. Intercepting relevant news, it was found that 8 confirmed patients in Shijiazhuang on the 22nd were repeatedly negative for nucleic acid detection, and 5 confirmed patients in Shijiazhuang on the 24th were repeatedly negative for nucleic acid detection.

---

　 　On the 22nd, there were 11 new confirmed cases in Shijiazhuang, including:

Case 1: Male, 52 years old, from Huangjiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 2: Male, 13 years old, Niujiazhuang Village. On the evening of the 21st.Nine times nucleic acid positive;

Case 3: Female, 11 years old, Zhongyao Village. On the evening of the 21st.Nine times nucleic acid positive;

Case 4: Male, 49 years old, Nanqiaozhai Village. On the evening of 21st.Ninth nucleic acid positive;

Case 5: Male, 47 years old, Niujiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 6: Female, 65 years old, Niujiazhuang Village. On the evening of 21st.Ninth nucleic acid positive;

Case 7: Male, 11 years old, grandson of Case 6. On the evening of 21st.Ninth nucleic acid positive;

Case 11: Male, 67 years old, Xiaoguozhuang Village, husband of Case 2 on January 7th. On January 3, it was transferred to centralized isolation medical observation; On the evening of 21st.11th nucleic acid detectionFinally positive;

On the 24th, there were 7 new confirmed cases in Shijiazhuang:

Case 1: Female, 65 years old, Nanqiaozhai Village. Centralized isolation on the 11 th.Nucleic acid after 9 times, 22 positive.

Case 2: Female, 4 years old, Nanqiaozhai Village. Centralized isolation on the 11 th.Nucleic acid after 9 times, 22 positive.

Case 3: Female, 4 years old, Mi Jie, Chang ‘an District. Centralized isolation on the 13 th.Nucleic acid after 8 times, 23 positive.

Case 4: Female, 64 years old, Xiaoguozhuang Village. Centralized isolation on the 10 th.After 11 nucleic acids, 24 positive.

Case 5: Male, 34 years old, Xiaoguozhuang Village. Centralized isolation on the 8 th.After 11 nucleic acids, 24 positive.

Case 6: 34-year-old female, Liujiazuo Village, was positive for nucleic acid on the 5th, was diagnosed as asymptomatic infection on the 6th, and was clinically confirmed on the 24th.

Case 7: A 28-year-old male, living in Yuhua District, went to work by car at Zhengding Airport on weekdays. He was diagnosed as asymptomatic infected with nucleic acid on the 5th, and was clinically confirmed on the 24th.

---

Since the outbreak of COVID-19 last year, the topic of high false negative rate of nucleic acid detection has been the focus of attention. It has been reported that the positive rate of Covid-19 detection by fluorescence quantitative RT-PCR is only 30%-50% at present, which leads to extremely high false negative rate.

For Hongge, who doesn’t know much about the test, this paper analyzes the relatively high false negative test by searching articles and documents, and summarizes some reasons to discuss with you.

First, the incidence of COVID-19 suggests that it is highly possible to collect positive samples in a proper time.

Academician Yuan Guoyong’s team conducted this cohort study in Hong Kong Princess Margaret Hospital and Queen Mary Hospital. From January 22 to February 12, 2020, 23 hospitalized patients who were diagnosed as COVID-19 by laboratory examination of nasopharyngeal or sputum specimens were screened in the two hospitals.

A total of 173 respiratory specimens were collected from 23 patients. The researchers used RT-QCPR to determine the viral load in the samples. The results showed that the median viral load of respiratory tract samples was 5.2 log10 copies /mL (interquartile range was 4.1-7.0), and only 3 patients (13%) did not detect Covid-19 RNA in saliva samples.

The researchers observed that,The viral load in saliva was the highest in the first week after the patient developed symptoms, and then gradually decreased.Eight days after the patient developed symptoms, airway extracts were collected, and there was no obvious downward trend in viral load. Of the 21 patients who did not die,Seven people (33%) could still detect viral RNA after 20 days of symptoms, but this was not related to the severity of the disease.

▲ Changes of viral load in saliva (blue line) and airway extract (red line) of all 23 patients. Abscissa D- days after symptoms appear; S/E- number of saliva/airway samples.

AprilAccording to a study published in Nature Medicine, COVID-19 patients are most infectious before symptoms appear, and they begin to shed SARS-CoV-2 2 2-3 days before the first symptoms appear.

https://doi.org/10.1038/s41591-020-0869-5

The study, led by Eric Lau of the University of Hong Kong, involved 94 patients with COVID-19 admitted to the Eighth People’s Hospital of Guangzhou, China, 50% of whom were male, with a median age of 47 years. Among them, 61 of 93 patients were mild. Specifically, the researchers collected the throat swabs of 94 COVID-19 patients who were treated in the Eighth People’s Hospital of Guangzhou, China from January 21st to February 14th. From the onset of symptoms to 23 days after onset, 414 throat swabs were collected.

The results show that the researchers areThe high viral load was detected shortly after the patient developed symptoms, and then gradually decreased to the detection limit around the 21st day.There is no significant difference in viral load among different sexes, age groups and disease severity.

In addition, the researchers also analyzed 77 samples of "transmission pairs" from public data to assess how much time passed between the onset of symptoms in each patient. It assumes that the median incubation period (the time from infection to symptoms) is 5.2 days.The research team concluded that infectivity began 2.3 days before symptoms appeared, and peaked 0.7 days before symptoms appeared.

In the sensitivity analysis, the same estimation procedure is used, but assuming that the infectious attack is unchanged 1-7 days before the symptom occurs, thenIt was found that the infectivity reached its peak 0-2 days before the onset of symptoms, and the transmission ratio before the onset of symptoms was 46% to 55%.

The study also found that,The virus may start shedding 2-3 days before the first symptoms appear.After the symptoms appear, the viral load in the patient’s body decreases faster. This is consistent with the results of two recent studies. On April 1st, teams from Munich, Germany, Berlin and Cambridge, England published the article "Viro logical assessment of hospital patients with Covid-2019" on Nature. It was found that the shedding peak of Covid-19 occurred in the early upper respiratory tract infection.This shows that virus carriers may be the most infectious when they have mild symptoms or almost no obvious symptoms.

Brother Hong:From the above two documents, we can draw a conclusion that the virus shed and spread 2-3 days before the symptoms appear after infection, and after the symptoms appear, with the passage of time,The viral load of throat swab decreases gradually, and the viral load detected within 7 days after symptoms. If symptoms have existed for more than 20 days, the reliability of negative conclusion of throat swab is poor.

Solution:We need to publicize the law of the new crown to the people and medical workers, and improve our vigilance against COVID-19. It is best for patients to see a doctor in time, and doctors can also suspect this possibility. Only at the right time can we collect high-content samples and diagnose and control them in time.

Second, accurate sampling strategy is the best means to reduce false negative results.

In February, a study published by Medrxir, a pre-printed website, collected respiratory tract samples such as nasal swab, throat swab, sputum and bronchoalveolar lavage fluid (BALF) from patients diagnosed with COVID-19, and included 213 Covid-19-infected patients admitted to the Third People’s Hospital of Shenzhen from January 11th to February 3rd, 2020, who were diagnosed by Guangdong CDC. A total of 866 respiratory tract samples, including 490 nasal swabs, 205 throat swabs, 142 sputum samples and 29 BALF samples, were collected at the time of admission and after each time point. According to the collection date, the samples were divided into 0~7 days, 8~14 days and ≥15 days after onset. According to the guidelines on prevention and treatment of Covid-19 infection issued by National Health Commission, patients were divided into severe and mild cases.

Three groups were divided according to the sample collection time after onset, and the viral nucleic acid was quantitatively determined.The positive rate of viral nucleic acid in sputum samples was the highest in the group of 0~7 days after onset.The positive rates of severe and mild cases were 88.9% and 82.2% respectively.Followed by a nasal swab.(73.3% and 72.1% respectively),The throat swab again.(60.0% and 61.3% respectively). In mild cases, the positive rate of nasal swab and sputum samples is similar.

The positive rate of BLAF samples collected from 8 to 14 days after the onset of severe cases was 100%.However, the BALF samples of 3 mild cases were negative. In all cases, the positive rate of sputum samples was the highest in the 8~14 days after onset, which was much higher than that of nasal swab and throat swab. It is worth noting that the positive rate of throat swab in severe patients is only 50%, and that in mild patients is only 29.6%.

In the group ≥15 days after onset,The positive rates of BALF, sputum and nasal swab from severe cases were similar. In mild cases, the positive rate of sputum and nasal swab is similar, which is much higher than that of throat swab.

For the diagnosis of viral nucleic acid in COVID-19’s patients,Sputum samples are the most accurate, followed by nasal swabs. It is not recommended to collect throat swabs for diagnosis.

The difference between oropharyngeal swab and nasopharyngeal swab

anusswab

Brother Hong:

1. Oropharyngeal swab is the least painful and most acceptable, but it has to bear the consequences of high false negative results. My suggestion is to use it according to the epidemic risk in the first epidemic area.

2. The positive rate of nasopharyngeal swab is higher than that of oropharyngeal swab, which is why nasopharyngeal swab is introduced into laboratory examination in the fifth edition of Diagnosis and Treatment Plan for Pneumonia Infected by Covid-19 (the fourth edition is still pharyngeal swab). If we want to pursue accuracy, it is suggested to use it, or to use it when screening people in close contact or sub-close contact. At present, the examination of returnees in domestic reports seems to be nasopharyngeal swab method.

3. Alveolar lavage fluid can’t be used for screening in the general population, so it is suggested that hospitals with ICU should use it for screening severe pneumonia patients living in ICU for COVID-19 patients.

4. Deep expectoration seems to be the best sample, but many patients in COVID-19 have a dry cough, which may not be possible.

5、anusSwabs were used in Daxing epidemic in Beijing, which is the first time to use this method in the screening process. In some literatures,anusAlthough the positive rate of swabs is not high, as I remember, it seems to be more than 10%, but it does not seem to coincide with the patients with oropharyngeal swabs, suggesting that the virus may attack the gastrointestinal tract, and also suggesting that there may be the possibility of gastrointestinal transmission in Covid-19. Although the initial symptoms of some patients are gastrointestinal symptoms such as abdominal pain and diarrhea, there are also ACE2 receptors in the digestive tract, which is theoretically possible, but it has not been confirmed at present. So,anusMy suggestion is that swabs can only be used as a supplement to nasopharyngeal swabs, and it is better to select patients whose first symptoms are digestive tract symptoms more accurately, which is unlikely to be used as a means of large-scale screening.

Solution:It is best for National Health Commission to issue a guiding document for large-scale screening, and make detailed regulations on what population and what sampling methods to adopt under what circumstances.,When local governments encounter an outbreak in COVID-19, it’s best to ask professionals to act as consultants and make choices according to the actual situation.

Third, the consistency of sampling ability of sampling personnel affects the sampling results.

Garbage in, garbage out (garbage samples produce garbage results), which is a sentence that inspectors often say.

The sampling team is huge, and the ability of sampling personnel must be uneven. In addition, people may have such fears about sampling, which often leads to unqualified samples.

Generally, there is an internal standard in the molecular diagnostic reagent to monitor the detection process, for example, RNaseP is used as the internal standard. If both the sample response curve and the internal standard response curve displayed by the fluorescence PCR platform do not jump, it means that the quality of the collected samples may have problems or false negatives may occur due to improper experimental operation, which needs to attract the attention of medical workers. The RNaseP internal standard can monitor the sample collection and ensure the accuracy of the test results.

Note: RNaseP is ribonuclease P, which is one of the most important ribozymes in human body. It is ubiquitous in all organs, tissues and cells of human body, and can detect RNA nucleic acid fragments from human body samples, and can also be used as an internal standard.

And I privately asked the relevant person in charge of our city’s temporary inspection center. He told me that every day in our hospital, some samples were told that they needed to be re-sampled because the internal standard did not jump. Imagine that you didn’t wipe down a few cells in your throat swab collection, so will the negative of this nucleic acid be accurate?

Solution:Consistency training for nucleic acid sampling personnel will greatly reduce the human influence, and it is easier to standardize the sampling process by taking such sampling methods as nasopharyngeal swab. Our city seems to have trained the nucleic acid emergency sampling team very early. What about your city?

In addition, if in the environment of large-scale nucleic acid sampling, when testing under the standard of 5-mixed 1 and 10-mixed 1, according to the above principle of internal standard, it seems that there is no single-tube ability in the quality control of internal standard. Therefore, especially those in the emergency sampling team, we must pay attention to the standard sampling methods and remember to collect qualified samples as much as possible.

Fourth, choose the right oneSampling device

The virus preservation tube mainly consists of a sampling swab and a virus nucleic acid preservation tube (containing virus nucleic acid preservation solution). There are many kinds of virus preservation tubes on the market at present.It is very important for epidemic prevention and disease diagnosis to choose the appropriate virus preservation tube, reduce the infection risk of medical inspectors as much as possible, and keep the virus RNA stable without degradation..

The preservation solution UTM used in traditional virus collection tubes is based on Hank’s solution, with gentamicin, fungal antibiotics, BSA (V), cryoprotectant, biological buffer and amino acids added. Its main purpose is to maintain the virus activity within a certain temperature range, so that it is convenient for health and epidemic prevention departments to further isolate, culture and trace the virus and determine the pathogen. This kind of non-inactivated tube, which I call it, is good for further work, but the sameLive virus increases the infection risk of medical staff in the whole process of sample collection, transportation and testing!Personally, I think this kind of sampling tube for inactivated virus should be a better choice for disease control sampling.

And clinicalIn order to achieve the purpose of rapid detection, it is not necessary to cultivate the virus, but only to crack the virus, so as long as the integrity and stability of the virus nucleic acid can be guaranteed.nowCommonly known as inactivation tube.Many inactivation tubes in China are used.The inactivation component is guanidine salt, which is in this inactivation tube in our hospital.Guanidine salt can crack the virus, but it can’t protect the integrity of nucleic acid for a long time.The virus nucleic acid may have been degraded during the delivery of the sample to the laboratory, which will also cause a "false negative" in the detection. Many studies show that both temperature and time can affect the test results, so the COVID-19 Laboratory Testing Guide has clear requirements for samples to be tested within 24 hours after collection and transported at 4 degrees Celsius. If it is necessary to exceed 24 hours, it should be stored at -70 degrees Celsius.

And some manufacturers put forward another inactivation tube, a kind of.containNon-guanidine saltThe virus preservation tube containing protein denaturant can inactivate the virus and ensure the preservation of virus nucleic acid at room temperature.And the virus nucleic acid is stably stored for 7 days.Does not degrade.

Solution:

1, from sampling to testing, it is necessary to mark the time, so that quality control can be carried out on the preservation time, which is basically no problem in a better hospital.

2. For the front-line staff to do the corresponding training, they should know the advantages and disadvantages of various types of preservation tubes and adopt the best sampling tubes suitable for local conditions.

3. It is best for the country to recommend the selection of sampling tubes with the support of relevant experimental data.

5. Failure of reagents caused by virus mutation?

After the virus mutation in South Africa, Britain, Brazil and other places, there have been cases that turned positive after ten tests in various parts of the world, including China.The FDA recently warned that virus mutation has caused some reagents to fail, and listed several kits that may be affected by mutation. This means that virus mutation may have led to the failure of some nucleic acid detection or persistent false negative.

The FDA listed several kits that may be affected by mutation:

Accula SARS-Cov-2 detection (Mesa Biotech): If the virus mutates at the 28881st base (GGG to AAC), the detection of this kit will be affected;

TaqPath COVID-19 Combo Kit (Thermo Fisher Scientific): This kit detects three genes at the same time, and the variant B.1.1.7 appearing in Britain will affect one of the detection results;

Linea COVID-19 detection (Applied DNA Sciences): This kit detects two genes at the same time, and the variant B.1.1.7 appearing in Britain will affect one of the detection results;

Helix, an American company doing nucleic acid detection, also noticed the influence of virus mutation on detection. The company’s nucleic acid detection simultaneously detected three Covid-19 genes: ORF1ab, N, and S. Because the B.1.1.7 strain that appeared in Britain had deletion mutation in S gene, ORF1ab and N could be detected in the detection, but S gene could not be detected (4). This phenomenon is called "S gene withdrawal".

In addition, the sensitivity of reagents from different manufacturers to COVID-19 is different, and the country also organized a national evaluation of reagents last year. butIn an evaluation study on the consistency and detection ability of seven domestic novel coronavirus nucleic acid detection kits published by Chinese Journal of Laboratory Medicine in July, 2020, it was proposed that "some kits have poor detection ability for weakly positive samples,It is suggested that weak positive samples should be rechecked by kits from at least two manufacturers to ensure the accuracy of the results."

Several targets of nucleic acid detection in Covid-19 are ORF1ab gene, N gene and S gene.

In the Technical Guide for Laboratory Detection of Pneumonia Infected in novel coronavirus issued by China CDC (hereinafter referred to as the Technical Guide), the two targets of nucleic acid detection in Covid-19 are ORF1ab gene and N gene respectively.

On January 6th, the Weekly Report of China Center for Disease Control and Prevention published the results of gene sequencing analysis of two cases of Covid-19 infection in Shijiazhuang and Xingtai. According to the published results, the strain prevalent in Gaocheng, Hebei Province, is different from the strain found in other places in China recently, and is homologous to the strain reported in Russia last July, belonging to strain B.1.1.123

Coincidentally, the mutation happened at the 28881 ~ 28883 bases of the virus gene of this strain, and this is exactly the position of the forward primer of the N gene!

This also explains why there were many negative results at that time.

I guess this is one of the reasons why the criteria for judging nucleic acid positivity have also changed.The judgment position that the single target is still positive after retest is positive.

Figure/Current Criteria for Judging Positive Cases in Technical Guide

Solution:

1. Require manufacturers of nucleic acid reagents to conduct confirmatory experiments on the current mutant strains and propose technical solutions.

2, all localities should introduce at least two kinds of better quality detection reagents, for control use.

3. Information about the failure of test reagents that may be caused by mutated viruses should be effectively and widely reported in domestic laboratories.

Six, the standard implementation in the process of laboratory testing

the pastAccording to the guidelines issued by relevant institutions, the collected samples need to be inactivated at 56℃ before nucleic acid detection, which is very likely to degrade the Covid-19 nucleic acid, which will lead to the failure of normal detection and ultimately improve the false negative rate.In the early daysInactivation treatment is carried out for the sake of biological safety, to protect the staff engaged in testing from virus infection.

But later, there were many voices of doubt in the academic circles, becauseViral RNA is easily degraded by ribonuclease, because this enzyme has the highest activity at 60℃. Ribonuclease comes from two aspects, one is the sample cells, and the other is the foreign pollutants in the process of collection, preservation and transportation.

Last February, there was a similar research article.The high-temperature inactivation process before virus nucleic acid extraction significantly reduces the amount of detectable virus nucleic acid templates, which has been pre-published on the platform of scientific papers of China Academy of Sciences.

And last May,The Journal of Clinical Chemistry published the research of Chinese scholars on Covid-19’s false negative test.The study confirmed that,Thermal inactivation can cause the increase of Ct value reflected by PCR and cause false negative results.Specifically, 46.7%(7/15) of the weakly positive samples were false negative after inactivation (a surprising proportion). Another inactivation method is to inactivate the virus by dissolving the virus protein with guanidine hydrochloride. This study confirmed that guanidine hydrochloride had little effect on PCR reaction, and the false negative rate was low, although there was also a false negative rate of 13.3%(2/15).

Related address: https://academic.oup.com/clinchem/article/66/6/794/5815979

I also inquired whether there was a 56-degree inactivation step in the detection process of CDC in the United States. Although my English ability was poor, I didn’t see this step by machine translation.

Including some other documents retrieved, it is also very clear that 56-degree inactivation does have a great influence on weakly positive specimens.

No matter the Manual of Nucleic Acid Detection in Medical Institutions in novel coronavirus (Trial) on July 13th, 2020 or the Manual of Nucleic Acid Detection in Medical Institutions in novel coronavirus (Trial 2nd Edition) on December 30th, 2020, there are corresponding descriptions.For the laboratory that has been inactivated with the sampling tube containing guanidine salt, there is no need to inactivate at 56 degrees for 30 minutes.This is only true if non-inactivated sampling tubes are used.

However, I learned from the familiar laboratory leaders that this is not the case. Many laboratories still require samples to be pretreated at 56 degrees for 30 minutes regardless of whether the tubes are inactivated or not. I can understand that they are worried about hospital infection and laboratory exposure. But generally speaking, reducing the false negative rate, increasing the detection amount and taking corresponding measures to control the epidemic situation as soon as possible, I think the corresponding suggestions in the corresponding guidelines are also the best choice from the overall situation and supported by data.

Our laboratory should not control the occurrence of hospital sensation and laboratory exposure at the expense of reducing the detection rate, but should focus on stricter control of experimental steps, more cautious PPE wear and higher laboratory environment.

Solution:

1. It is suggested that the state give special instructions to laboratories at all levels on this matter.

2. It is suggested that the country should further study the preservation solution of sampling tubes, and if there is any preservation solution that can not reduce the detection rate at 56 degrees for 30 minutes, it can also be recommended.

The above zero zero always said a lot of points, mainly about how to reduce false negative conclusions, hoping to give you a reference.

It’s been many days since I wrote this afternoon, mainly considering Spring Festival travel rush. Although the scale of Spring Festival travel rush is reported to have dropped by more than 75% this year compared with previous years, the population flow is still very strong. We may face the rising trend of an epidemic after Spring Festival travel rush, and how to make the work better may be a more urgent need before us.

　　Iranian Foreign Minister Zarif. (Source: Student News Agency)

　　Overseas network September 29 th　Iranian Foreign Minister Zarif said that during his visit to new york, he had a telephone conversation with some members of the US Congress, but unfortunately, he did not hold face-to-face talks with them due to the shortened trip.

　　According to the semi-official Iranian Student News Agency (ISNA) on the 29th, Zarif told reporters when he was preparing to leave new york for Teheran that during his visit, he had talks with different groups in the United States, including some US congressmen. Zarif said that he was called by members of the US Congress. Due to the shortened itinerary, he could not coordinate these members to come to new york for face-to-face talks. He deeply regretted this. Zarif stressed that these US lawmakers have not made any demands on Iran, and Iran will not interfere in the US election. The Iranian side has held talks at the request of the other side and used these talks to show the true image of Iran.

　　Iranian President Rouhani and American President Trump. (overseas network puzzle)

　　When talking about the reports about the meeting between Rouhani and Trump, Zarif said that Trump was only trying to hold talks with Rouhani during his stay in new york this week, and Trump was unwilling to accept the lifting of sanctions as a prerequisite for the talks, so the bilateral talks could not take place. Zarif pointed out that direct talks between Trump and Rouhani have never been put on the agenda, and Iran is only willing to participate in the talks within the framework of the Iranian nuclear deal. Zarif also said that Trump did not promise to lift the sanctions after the talks, but Trump preferred to hold the talks directly and it was possible to lift the sanctions after the talks.

　　The Iranian side’s trip to the United States this time can be described as a thorn all the way. The 74th session of the United Nations General Assembly opened on September 17, 2019. Earlier, Iranian President Rouhani and Foreign Minister Zarif were delayed in obtaining American visas. Rouhani and Zarif "may cancel" their trip "if (the US) doesn’t issue visas within a few hours", Yitong News Agency reported on the 18th. On the same day, Trump said on the Iranian visa issue, "This matter does not depend on me." It was not until 19th that the Iranian delegation to the United Nations announced that the United States issued visas to the Iranian President and Foreign Minister, allowing them to attend the UN General Assembly in new york.

　　Iran said earlier that only when the United States returns to the agreement can the two sides contact. (Photo: Associated Press)

　　On the other hand, the repeated statements of the United States do not rule out the possibility of Trump meeting Rouhani during the UN General Assembly. On the 4th, after imposing additional sanctions on Iran, when asked about the possibility of meeting with Iranian leaders during the UN General Assembly, Trump said that "everything is possible". When he delivered a speech at the UN General Assembly on 24th, Trump also said that the possibility of direct dialogue with Iran was not ruled out, but the sanctions would not be lifted in advance.

　　However, the premise of the Iraqi side is that the United States must lift the sanctions before there can be talks. Iranian Foreign Minister Zarif said on the 22 nd that the premise of holding talks is that Trump promised to ease sanctions against Iran. Iranian President Rouhani also said in his speech at the general debate of the United Nations General Assembly on 25th that Iran has never bowed to foreign forces and refused to negotiate with those who imposed "the harshest sanctions in history". (Compile/Overseas Network Hou Xingchuan)

Xinhua News Agency, Beijing, September 2ndQuestion: How to upgrade consumers’ enjoyment of trade-in support of overweight in various places?

Xinhua News Agency reporters Xie Xiyao, Li Xiaoting and Gong Liankang.

Recently, the "upgraded version" policy of promoting the trade-in of automobiles and home appliances at the central level has been introduced one after another. The reporter recently visited markets in Beijing, Hubei, Chongqing, Fujian and other places, and learned that all localities have introduced detailed rules for the replacement of old consumer goods in light of local actual conditions, expanded the coverage of subsidized products, upgraded subsidies, made the application process more convenient, and increased consumers’ willingness to purchase.

Government subsidies are superimposed on enterprises to make profits, and new subsidies for automobile replacement and renewal are added.

On the evening of August 27th, the reporter went to the Geely Yinhe Wuhan Star Experience Center in Hanyang District, Wuhan. The slogan of "trade-in" subsidy for cars in the store was everywhere, and many citizens went to the store to see cars and consult preferential policies.

The salesperson took the store’s best-selling model Geely Yinhe E8 as an example and calculated a "detailed account" for the reporter:

For a new car with an original price of 165,800 yuan, if the customer’s old car meets the scrapping conditions, the maximum state subsidy can be 20,000 yuan; Or transfer the car under his name, you can get a replacement subsidy of 12,000 yuan. During this period, you can also apply for a trade-in coupon of up to 2,000 yuan in Wuhan at the same time, plus a discount of more than 10,000 yuan from manufacturers and 4S stores, and the maximum superimposed discount for buying this new car can reach more than 30,000 yuan.

According to the national policy, for individual consumers who meet the provisions of the Detailed Rules for the Implementation of Vehicle Trade-in Subsidies and scrap old cars and buy new ones, the subsidy standard will be increased from 10,000 yuan for new energy passenger cars and 7,000 yuan for fuel passenger cars to 20,000 yuan and 15,000 yuan respectively. In addition to scrapping and updating, this policy will also include replacement and updating in the scope of subsidies, and support local governments to carry out replacement and updating independently.

At present, following the rhythm of national policies, local governments have successively launched trade-in schemes focusing on the local automobile market.

The national dicing and matching funds in Hubei Province are more than six times the size of the funds before the afterburner measures. The maximum subsidy for car scrapping and renewal is 20,000 yuan, and the maximum subsidy for replacement and renewal is 16,000 yuan.

Beijing has made it clear that the newly purchased new energy vehicles after replacement include not only pure electric vehicles, but also plug-in hybrid vehicles (including extended-range vehicles) and fuel cell vehicles, and all of them can enjoy replacement subsidies if they are transferred inside and outside Beijing.

Shanghai puts used cars in an important position in the trade-in policy, encourages the development of used car distribution business, and makes it clear that the average age of used cars will be reduced by one year by 2027 …

Government subsidies are superimposed on enterprises to make profits, new replacement and renewal subsidies are added, and consumers’ willingness to buy new cars is increased.

Up to now, the trade-in of consumer goods in Hubei has benefited more than 400,000 consumers, driving the sales of new cars and home appliances to 12 billion yuan. Wuhan has achieved the goal of trade-in of automobiles for the whole year ahead of schedule; As of mid-July, Hunan has received more than 8,600 applications for automobile scrapping and renewal subsidies, and more than 23,000 applications for replacement and renewal subsidies, which has driven automobile sales to exceed 5.5 billion yuan. From the release of the National New Deal to September 1st, the cumulative amount of old-for-new subsidies in Chongqing reached 9,748, and the cumulative sales of automobiles exceeded 1.837 billion yuan.

According to the data of the Ministry of Commerce, as of 10: 00 a.m. on September 1, more than 810,000 applications for car scrapping and renewal subsidies were received. From January to July, the national automobile retail sales reached 11.556 million, up 2.3% year-on-year. Among them, the retail sales of new energy passenger cars was 4.988 million, a year-on-year increase of 33.7%; The number of used cars was 10.992 million, a year-on-year increase of 6.3%.

The subsidy for home appliance replacement will be expanded, and the on-site application will be reduced immediately.

Mr. Zhou of Nanchuan District, Chongqing recently bought a Haier Class 1 energy-efficient air conditioner with a price of 2,499 yuan and enjoyed a government subsidy of 499.8 yuan for trade-in. "Government subsidies are very cost-effective, and it is very convenient to apply for money immediately." Mr. Zhou said.

On August 26th, Chongqing’s "upgraded version" green smart home appliances trade-in subsidy policy landed. On the first day of the implementation of the policy, the city issued a government subsidy of 8.165 million yuan, which directly led to the sales of home appliances of 42.6335 million yuan.

The reporter learned from the Chongqing Municipal Commission of Commerce that at present, the state’s pre-allocated funds to support trade-in have been issued to Chongqing, and the local governments will match the funds in proportion to jointly promote the trade-in of consumer goods.

The state has made it clear that eight types of household appliances enjoy a subsidy standard of 15% to 20% of the sales price, with a maximum subsidy of 2,000 yuan per piece. At the same time, support local governments to independently determine the varieties of subsidized "8+N" household appliances. Up to now, many places have successively issued implementation rules for the implementation of home appliance trade-in.

Chongqing has made it clear that individual consumers will enjoy 15% to 20% of the sales price of each type of household appliances when they purchase 11 types of household appliances with energy efficiency or water efficiency standards of Grade 2 or above; In terms of superimposed subsidies for enterprises, consumers can enjoy a 2% trade-in subsidy if they sell nine categories of old household appliances and buy any kind of products with energy efficiency or water efficiency of Grade 2 or above.

Beijing consumers can access the "Jingtong" applet through Alipay, WeChat, Baidu, Meituan and other channels, and receive the subsidy qualification codes of more than 10,000 household appliances in 8 categories, and enjoy preferential treatment in the payment link.

On the basis of eight types of household appliances, Guangdong has added three types of products, such as mobile phones, tablets and smart wearable devices, as well as other N-type products that are actually included in the scope of subsidies in various cities, forming an "8+3+N" product category.

From the central government to the local government, the subsidy policy has clearly defined the energy efficiency standards, and only subsidizes energy efficiency products of Grade 2 and above. "Trade-in is not a simple replacement of similar products, but a demand that tends to be higher-end, smarter, more environmentally friendly and more personalized, and supports the transformation and upgrading of household consumption through trade-in." Chen Yaoting, a professor at the Business School of Minnan Normal University, said.

Continue to open up new blocking points and smooth the resource circulation chain.

Recycling has always been a blocking point that affects trade-in consumption, and it is also the key to smooth the recycling of resources.

Fujian Quantong Resource Recycling Industrial Park, located in Zhangzhou Development Zone, Fujian Province, has a truckload of used household appliances entering the factory, weighing, unloading, acceptance, bar coding and warehousing, and then entering the dismantling process. Every day, about 2000 sets of waste household appliances are treated here in a standardized way.

Driven by the trade-in policy, Quantong has established strategic cooperation with recycling enterprises under Midea Group to realize the recycling system of products from sales, recycling to standardized dismantling.

The national policy is clear, all localities should strengthen the construction of digital platforms, learn from each other’s experience, strengthen data analysis, and timely and accurately grasp the information of the whole process of home appliances replacement, purchase and disassembly. The reporter visited and learned that under the guidance of the trade-in policy, the diversified recycling pattern of used household appliances is accelerating.

"Old household appliances are not limited to brands and years, and they can provide one-stop trade-in services such as free door-to-door dismantling of old machines and free transportation." He Yuanlin, general manager of Dahai Daming Trading Co., Ltd., a distributor of Haier Zhangzhou, said that the company is docking with dismantling enterprises with relevant qualifications, establishing a standardized recycling system for used household appliances, and at the same time promoting the development of community services for household appliances.

On September 2, Haier Zhijia Recycling Interconnection Factory was completed and put into operation in Laixi, Qingdao, with an annual dismantling capacity of 3 million units. Shijiazhuang city has perfected the comprehensive utilization system of renewable resources by the mode of "government+property+third party"; Hunan will include the recycling outlets of renewable resources such as waste household appliances into the construction of a convenient living circle for a quarter of an hour; Gree, Changhong and other home appliance companies actively adopt the "internet plus Recycling" method to provide professional old machine recycling services …

Insiders pointed out that with the increase in the number of places to promote the implementation of the old-for-new policy, it will drive the government, enterprises, platforms and other forces to join the field of recycling, and work together to improve the construction of the recycling network of used household appliances, so that consumers are "easier to get rid of the old and more willing to get new ones".

　　Now, the recommended winners and projects approved by the evaluation committee of the 2016 Shandong Science and Technology Highest Award, Natural Science Award, Technological Invention Award, Science and Technology Progress Award and International Science and Technology Cooperation Award will be publicized to the public.
　　The candidates and projects for publicity were also publicized on the websites of Shandong Provincial People’s Government (http://www.shandong.gov.cn), Shandong Provincial Department of Science and Technology (http://www.sdstc.gov.cn) and Science and Technology Information on December 6, 2016.
　　According to the relevant regulations, if there is any objection to the proposed award candidates and projects publicized, it shall be submitted in writing within 30 days from the date of publicity to the office of Shandong Science and Technology Awards Committee (located in the Science and Technology Achievements Department of the Provincial Science and Technology Department, address: No.607 Shunhua Road, Jinan High-tech Zone, zip code: 250101).

　　Shandong Province Science and Technology Highest Award (1 person)
　　Hu Dunxin, male, academician of China Academy of Sciences and researcher of Institute of Oceanography of China Academy of Sciences. Three undercurrents, such as the Mindanao undercurrent (MUC) in the tropical western Pacific Ocean, were discovered, revealing the subsurface circulation opposite to the surface circulation. Breaking through the restricted area of submarine observation, successfully deploying/recovering the deepest submarine in the western boundary current area of the world ocean at the depth of 6100 meters in the western Pacific Ocean, and obtaining valuable scientific data for four consecutive years; The discovery of "East China Sea Cold Vortex" initiated the study of mesoscale vortex on the continental shelf in China; The scientific law of "where there is upwelling on the shelf, the seabed deposit must be soft mud" is discovered, and its mechanism is expounded dynamically. It reveals the non-wind-induced mechanism of upwelling along the coast of Zhejiang Province and corrects the traditional wind-induced mechanism. It is the first to study the continental shelf ocean flux (carbon cycle) in the world, and draws an important conclusion that "the East China Sea is a sink of atmospheric carbon dioxide".
　　Organized and launched the international cooperation plan of "Northwest Pacific Ocean Circulation and Climate Experiment (NPOCE)", which was launched in 2010 and participated by 19 units from 8 countries; Invited to lead 17 scientists at home and abroad to publish review articles in Nature: Pacific Western Boundary Currents and Their Roles in Climate; Led the establishment of JGOFS and LOICZ committees in China, and initiated the research on ocean flux and land-sea interaction in China.
　　He has presided over 1 major project of National Natural Fund, 4 key national funds, 2 major projects of Chinese Academy of Sciences and 4 973 projects. Won 2 national defense science and technology progress awards and 3 Chinese Academy of Sciences awards.
Shandong Natural Science Award
First prize (2 items)
　　1. Basic research and sensing mechanism of paper chip microfluidic based on structural control and photoelectric properties.
　　Completed by: Yu Jinghua (Jinan University)
　　Ge Shenguang (Jinan University)
　　Yan Mei (Jinan University)
　　Huang Jiadong (Jinan University)
　　2. Surface interface regulation of nano-carbon materials and its physical property enhancement mechanism.
　　Completed by: Xue Qingzhong (China Shiyou University (East China))
　　Xing Wei (China Shiyou University (East China))
　　Shu Shuping (Shandong University of Technology)
　　Zheng Qingbin (China Shiyou University (East China))
　　Yan Zifeng (China Shiyou University (East China))
Second prize (7 items)
　　1. Analysis and regulation of polymer multilayer structure
　　Completed by: Zhang Jianming (Qingdao University of Science and Technology)
　　Duan Yongxin (Qingdao University of Science and Technology)
　　Yan Shouke (beijing university of chemical technology)
　　Yuan Yuan (Qingdao University of Science and Technology)
　　Zhang Tongping (Qingdao University of Science and Technology)
　　2. Rapid identification, accurate identification and biological activity study of halogenated compounds in marine red algae.
　　Completed by: Wang Bingui (Institute of Oceanography, China Academy of Sciences)
　　Ji Naiyun (Yantai Institute of Coastal Zone, Chinese Academy of Sciences)
　　Li Ke (Institute of Oceanography, China Academy of Sciences)
　　Li Xiaoming (Institute of Oceanography, China Academy of Sciences)
　　Duan Xiaojuan (Institute of Oceanography, China Academy of Sciences)
　　3. Study on analytical methods of typical pollutants in complex environmental media.
　　Completed by: Chen Lingxin (Yantai Institute of Coastal Zone, Chinese Academy of Sciences)
　　Li Jinhua (Yantai Institute of Coastal Zone, Chinese Academy of Sciences)
　　Wang Yunqing (Yantai Institute of Coastal Zone, Chinese Academy of Sciences)
　　Chen Zhaopeng (Yantai Institute of Coastal Zone, Chinese Academy of Sciences)
　　4. Study on ultra-sensitive Qualcomm single molecule detection of disease-related biomarkers.
　　Completed by: Zhang Chunyang (Shandong Normal University, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences)
　　Wang Lijuan (Shandong Normal University, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences)
　　Hu Juan (Shandong Normal University, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences)
　　Zhangyan (Shandong Normal University, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences)
　　5. Molecular mechanism of brain iron redistribution in Parkinson’s disease and intervention strategy of dopaminergic neuron injury.
　　Completed by: Xie Junxia (Qingdao University)
　　Jiang Hong (Qingdao University)
　　Shi Limin (Qingdao University)
　　Wang Jun (Qingdao University)
　　Ma Zegang (Qingdao University)
　　6. Stabilization control of nonlinear systems
　　Completed by: Zhang Xianfu (Shandong University)
　　Ma Shuping (Shandong University)
　　Zhu Shuqian (Shandong University)
　　7. Molecular mechanism of oyster genome analysis and intertidal adaptation.
　　Completed by: Zhang Guofan (Institute of Oceanography, China Academy of Sciences)
　　Li Li (Institute of Oceanography, China Academy of Sciences)
　　Xu Fei (Institute of Oceanography, China Academy of Sciences)
　　Zhang Linlin (Institute of Oceanography, China Academy of Sciences)
　　Guo Ximing (Institute of Oceanography, China Academy of Sciences)
Third prize (2 items)
　　1. Research on the theory and application of several kinds of differential equation problems.
　　Completed by: Xinguang Zhang (Yantai University)
　　Liu Lishan (Qufu Normal University)
　　Zhang Xiaoyan (Shandong University)
　　Jiang Jiqiang (Qufu Normal University)
　　2. Nano-materials assembly and analysis of pollutant detection and treatment mechanism.
　　Completed by: Ai Shiyun (Shandong Agricultural University)
　　Yin Huanshun (Shandong Agricultural University)
　　Fan Hai (Shandong Agricultural University)
　　Zhu Lusheng (Shandong Agricultural University)
　　Su Xiurong (Shandong Agricultural University)
Shandong Technological Invention Award
First prize (5 items)
　　1. The establishment of molecular breeding technology and the cultivation of new varieties of scallop.
　　Completed by: Bao Zhenmin (China Ocean University)
　　Julian Waghann (China Ocean University)
　　Hu Xiaoli (China Ocean University)
　　Li Hengde (Chinese Academy of Fishery Sciences)
　　Liu Guangmou (Weihai Changqing Ocean Technology Co., Ltd.)
　　Wang Youting (Yantai Haiyi Miaoye Co., Ltd.)
　　2. Development and application of ultrasonic logging tool.
　　Completed by: Cao Maoyong (Shandong University of Science and Technology)
　　Fandi (Shandong University of Science and Technology)
　　Liang Huibin (Shandong University of Science and Technology)
　　Wang Yi (Shandong University of Science and Technology)
　　Jiang Hao (Shandong University of Science and Technology)
　　Sun Nongliang (Shandong University of Science and Technology)
　　3. R&D and industrial application of key technologies for trehalose production
　　Completed by: Wang Ruiming (Qilu University of Technology)
　　Wang Tengfei (Qilu University of Technology)
　　Liu Zongli (Baolingbao Biology Co., Ltd.)
　　Zhaowei (Shandong Fuyang Biology Science and Technology Co., Ltd.)
　　Li Piwu (Qilu University of Technology)
　　Ma Chunling (Qilu University of Technology)
　　4. Complete sets of technologies and equipment for industrialization of seaweed fiber preparation
　　Completed by: Xia Yanzhi (Qingdao University)
　　Zhu Ping (Qingdao University)
　　Zhang Chuanjie (wuhan textile University)
　　Quanfengyu (Qingdao University)
　　Wang Bingbing (Qingdao University)
　　Sui Shuying (Qingdao University)
　　5. Creation and application of nano-seed alloy series products and heat-resistant high-strength light metal materials.
　　Completed by: Liu Xiangfa (Shandong University)
　　Wu Yuying (Shandong University)
　　Nie Jinfeng (Shandong University)
　　Bianxiufang (Shandong University)
　　Sun Qianqian (Shandong Lvmei Melting Body Technology Co., Ltd.)
　　Yao Tao (Rizhao Jingang Piston Co., Ltd.)
Second prize (7 items)
　　1. Key technologies of data center operating system for cloud computing.
　　Completed by: Zhang Dong (Inspur Electronic Information Industry Co., Ltd.)
　　Liu Zhengwei (Inspur Electronic Information Industry Co., Ltd.)
　　Yan Bingheng (Inspur Electronic Information Industry Co., Ltd.)
　　Qi Kaiyuan (Inspur Electronic Information Industry Co., Ltd.)
　　Samuel Kwok (Inspur Electronic Information Industry Co., Ltd.)
　　Liu Junpeng (Inspur Electronic Information Industry Co., Ltd.)
　　2. The supporting theory and key technology of gob-side entry without coal pillar.
　　Completed by: Tan Yunliang (Shandong University of Science and Technology)
　　Zhao Tongbin (Shandong University of Science and Technology)
　　Liu Student (Shandong University of Science and Technology)
　　Yu Fenghai (Shandong University of Science and Technology)
　　Ning Jianguo (Shandong University of Science and Technology)
　　Gu Shitan (Shandong University of Science and Technology)
　　3. Energy-saving rubber continuous mixing technology
　　Completed by: Wang Chuansheng (Qingdao University of Science and Technology)
　　Bian Huiguang (Qingdao University of Science and Technology)
　　Li Li (Qingdao University of Science and Technology)
　　Fu Ping (Qingdao University of Science and Technology)
　　Shen Bo (Qingdao University of Science and Technology)
　　Wang Xiaobo (Qingdao University of Science and Technology)
　　4. Photovoltaic crystalline silicon material tailings metallurgical regeneration manufacturing technology and industrialization
　　Completed by: Tan Yi (Dagong (Qingdao) New Energy Materials Technology Research Institute Co., Ltd.)
　　Jiang Dachuan (Dagong (Qingdao) New Energy Material Technology Research Institute Co., Ltd.)
　　Li Pengting (Dalian University of Technology)
　　Guo Xiaoliang (Dagong (Qingdao) New Energy Material Technology Research Institute Co., Ltd.)
　　Shi Shuang (Dalian University of Technology)
　　Hu Zhigang (Qingdao Longsheng Jinggui Technology Co., Ltd.)
　　5. Key technology, equipment and application of nano-particle aerosol jet micro-lubrication grinding
　　Completed by: Li Changhe (Qingdao University of Technology)
　　Zhang Naiqing (Shanghai Jinzhao Energy Saving Technology Co., Ltd.)
　　Hou Yali (Qingdao University of Technology)
　　Zhang Yanbin (Qingdao University of Technology)
　　Mao Cong (Changsha University of Science and Technology)
　　Wu Qidong (Shanghai Jinzhao Energy Saving Technology Co., Ltd.)
　　6. Sewage and surface water heat pump heating and cooling based on dredging heat exchange.
　　Completed by: Wu Ronghua (Qingdao Kechuanglan New Energy Co., Ltd.)
　　Chi Fang (Qingdao Kechuanglan New Energy Co., Ltd.)
　　Wang Gang (Qingdao Kechuanglan New Energy Co., Ltd.)
　　Sun Dexing (Qingdao Kechuanglan New Energy Co., Ltd.)
　　Yang Qirong (Qingdao University)
　　Xu Long (Qingdao Kechuanglan New Energy Co., Ltd.)
　　7. Key technologies and applications of early detection of cardiovascular diseases.
　　Completed by: Liu Changchun (Shandong University)
　　Wang Xinpei (Shandong University)
　　Liu Chengyu (Shandong University)
　　Li Peng (Shandong University)
　　Yang Lei (Ji ‘nan Hui Yi Rong Gong Technology Co., Ltd.)
　　Zhang Ming (Ji ‘nan Huiyi Ronggong Technology Co., Ltd.)
Shandong province science and technology progress award
First prize (17 items)
　　1. Cultivation, processing and utilization of new sweet potato varieties for Jishu series.
　　Completed by: Crop Research Institute of Shandong Academy of Agricultural Sciences
　　Sishui lifeng foods co., ltd
　　Jiangsu normal university
　　Completed by: Zhang Liming, Wang Qingmei, Zheng Yuanlin, Zhang Haiyan, Hou Fuyun, Li Aixian, Kong Xiankui, Xie Beitao, Wang Baoqing, Dong Shunxu, Song Huadong and Duan Wenxue.
　　2. Creation and application of double-balanced slow-release fertilizer for million-ton crops.
　　Completed by: Jin Zhengda Ecological Engineering Group Co., Ltd.
　　Shandong Agricultural University
　　shandong agricultural resource and environmental science research institute
　　National Agricultural Technology Extension Service Center
　　Completed by: Zhang Min, Chen Hongkun, Yang Li, john young, Zhang Qiang, Zhang Yufeng, Wang Huaili, Chen Haining, Wan Lianbu, Chen Deqing, Liu Zhiguang and Wang Min.
　　3. Agricultural multi-source information integration and accurate service technology
　　Completed by: Institute of Science and Technology Information, Shandong Academy of Agricultural Sciences
　　China Agricultural University
　　Beijing Agricultural Information Technology Research Center
　　Completed by: Li Daoliang, Ruan Huaijun, Wu Huarui, Fu Zetian, Feng Wenjie, Li Jingling, Chloe Wang, Liu Yanzhong, Zhao Jia, Sun Xiang, Wang Fengyun and Chen Yingyi.
　　4. Application support platform for modern service industry
　　Completed by Shandong Zhongchuang Software Engineering Co., Ltd.
　　Peking University
　　Beihang University
　　national university of defense technology
　　institute of software chinese academy of sciences
　　Shandong zhongchuang software commercial middleware co., ltd
　　Completed by: Jing Xinhai, Shi Dianxi, Cao Donggang, Wang Wei, Zhao Yongwang, Ding Bo, Gao Longlin, feng han, Liu Min, He Zhongsheng, Wang Huan, Bao Dong.
　　5. Development and application of broadband electromagnetic signal receiving, analysis and identification technology and equipment
　　Completed by: Shandong University
　　China electronics technology group company no.41 institute
　　Completed by: Xu Jianhua, Wang Hongjun, Xiang Changbo, Han Min, Wang Feng, Du Huiwen, Sun Weifeng, Juck Zhang, Xiong Hailiang, Du Yitao, Zhang Zhi and Zhao Yongzhi.
　　6. New NMR logging technology and industrial application of tight clastic reservoir.
　　Completed by: China Shiyou University (East China)
　　Exploration and Development Research Institute of China Petroleum and Natural Gas Co., Ltd.
　　Suzhou Niumai Analytical Instrument Co., Ltd.
　　Completed by: Fan Yiren, Zhou Cancan, Ge Xinmin, Hu Falong, Li Chaoliu, Deng Shaogui, Yang Peiqiang, Wu Fei, Li Changxi, Zhang Yingli, Xing Donghui, Fan Zhuoying.
　　7. Comprehensive utilization of engineering technology by chemical decomposition of industrial by-product gypsum
　　Completed by: Shandong Lubei Enterprise Group Corporation
　　Completed by: Lv Tianbao, Zhai Hongxuan, Yuan Jinliang, Wang Shucai, Bao Shutao, Wu Jianmin, Feng Xiangyi, Wang Detang, Gao Qiang, Wang Tongyong.
　　8. Development and industrialization demonstration of green synthesis technology of fine chemicals
　　Completed by: Shandong Institute of Chemical Technology
　　institute of chemistry chinese academy of sciences
　　Completed by: Feng Weichun, Yue Tao, Xing Wenguo, Chen Qi, Liu Li, Wang Hao, Zhou Ti, Yang Xu, Zhang Jian and Wei Feng.
　　9. Shot peening technology and equipment for metal surface
　　Completed by Shandong Kaitai Group Co., Ltd.
　　Jinan university
　　Shandong University
　　Completed by: Wang Shouren, Wang Ruiguo, Liu Ruwei, Li Cong, Yang Xuefeng, Wang Yanjun, Zhai Yongzhen, Zhang Xiao, Wang Yongjie and Zhang Laibin.
　　10. Key technologies for prediction, early warning and risk control of major water inrush disasters in deep and long tunnels.
　　Completed by: Shandong University
　　Hohai University
　　Highway Science Research Institute of Ministry of Transport
　　institute of mechanics, chinese academy of sciences
　　Shandong province traffic planning and design institute
　　China Railway 19th Bureau Group Co., Ltd.
　　Anhui Wan Tai Geophysical Technology Co., Ltd.
　　Completed by: Li Liping, Yang Weimin, Du Xiaotong, Zhang Ganqing, Chen Xuguang, Shi Shaoshuai, Wan Li, Lu Wei, Bao Zuojun, Feng Chun, Liu Guoqiang and Liu Qiang.
　　11. Complete sets of new technologies for building safety detection, appraisal and reinforcement.
　　Completed by: Shandong Institute of Building Science.
　　China construction science research institute
　　qingdao technological university
　　Weifang changda construction group co., ltd
　　Ji ‘nan Sijian (Group) Co., Ltd.
　　Shandong huasen concrete co., ltd
　　Completed by: Cui Shiqi, Cheng Bo, Shang Huaishuai, Di Xiaotan, Kong Xuwen, Cui Hongtao, Xie Huidong, Jiang Liping, Xing Qingyi, Zhang Lianyue, Mei Zuoyun and Wang Zifu.
　　12. Key technologies of automobile advanced power and on-board energy system and their application in new energy vehicles.
　　Completed by: Institute of Automation, Shandong Academy of Sciences
　　Tsinghua University
　　Zhongtong bus holding co., ltd
　　Completed by: Wang Qinpu, Li Liang, Wang Zhixue, Li Lei, Liu Yuanyang, Jerry Lee, Yang Chao, Zhang Yun, Wang Bo, He Dongmei, Song Jinxiang and Wang Li.
　　13. Key technologies and clinical application to improve the long-term curative effect of osteosarcoma.
　　Completed by: jinan military area command General Hospital of Chinese People’s Liberation Army.
　　Completed by: Yu Xiuchun, Xu Ming, Arqie, Bing Wang, Yu Chen, Chang Zhengqi, Song Ruoxian and Xu Songfeng.
　　14. The key technology and system construction of prevention and treatment of juvenile low vision with integrated traditional Chinese and western medicine.
　　Setting: Institute of Ophthalmology, Shandong University of Traditional Chinese Medicine
　　The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine
　　Jiangsu Provincial Hospital of Traditional Chinese Medicine
　　Affiliated Hospital of Shandong University of Traditional Chinese Medicine
　　Completed by: Bi Hongsheng, Wu Jianfeng, Xie Xiaofeng, Jiang Wenjun, Hu Yuanyuan, Bi Ailing, Wang Xingrong, Chen Rong, Wang Yuliang, Wang Jingbo, Guo Junguo and Guo Dadong.
　　15. Construction and application of new preparation system of montelukast sodium and its preparation based on key technologies of industrialization.
　　Completed by: Lunanbeite Pharmaceutical Co., Ltd.
　　Lunan pharmaceutical group co., ltd
　　Shandong new age drug co., ltd
　　Completed by: Zhang Guimin, Feng Qiguo, Jiang Qingcheng, Zhang Zicheng, Shi Jianghua, Zhu Yaoliang, Xu Chuanjin, Cui Jian, Feng Xiaoliang, Ma Qingwen, Wang Haixin and Wang Zengxue.
　　16. Key technologies for separation and preparation of natural products and development of national standard samples.
　　Completed by: Shandong Analysis and Testing Center
　　Beijing Physical and Chemical Analysis and Testing Center
　　China National Institute of Standardization
　　Quantum Hi-Tech (China) Biology Co., Ltd.
　　Completed by: Wang Xiao, Duan Wenjuan, Liu Feng, Zhang Jinghua, Wang Daijie, Xi Xingjun, Geng Yanling, Yu Jinqian, Liu Jianhua, Ji Wenhua, Shi Xingang, Wei Yuanan.
　　17 intelligent dyeing and finishing technology and equipment technology innovation platform
　　Completed by: Shandong Kangpingna Group Co., Ltd.
Second prize (58 items)
　　1. Breeding, demonstration and popularization of drought-resistant and salt-tolerant wheat varieties Qingmai 6 and Qingmai 7.
　　Completed by: Qingdao Agricultural University
　　Completed by: Lin Qi, Mu Ping, Zhang Yumei, Lan Jinhao, Shi Changhai, Zhang Hongsheng, Liu Yiguo, Wang Jianlin, Han Wei.
　　2. Creation of excellent peanut mutants and cultivation of new varieties.
　　Completed by: Biotechnology Research Center of Shandong Academy of Agricultural Sciences.
　　Shandong Weifang Academy of Agricultural Sciences
　　Shandong shengfeng seed industry technology co., ltd
　　Completed by: Wang Xingjun, Fu Chun, Xia Han, Lu Chengkai, Hou Lei, Zhao Chuanzhi, Zhao Shuzhen, Gao Xiaoyong, Jiang Yansheng.
　　3. Creation of stress-resistant pepper rootstock male sterile line, breeding and application of new varieties.
　　Completed by: Shandong Agricultural University
　　Chinese Academy of Agricultural Sciences Institute of Vegetables and Flowers
　　Shandong Agricultural Engineering College
　　Beijing agricultural college
　　Completed by: Ai Zhenzhen, Wei Youying, Zheng Huamei, Wang Shaohui, He Chaoxing, Duan Xi, Wang Hongtao, Jiang Fei, Li Qingming.
　　4. Breeding and efficient cultivation techniques of high-quality watermelon and melon series new varieties in protected facilities
　　Completed by: Vegetable and Flower Research Institute of Shandong Academy of Agricultural Sciences.
　　Shandong Shouguang Sanmu Seedling Co., Ltd.
　　Shandong shangdao biology science and technology co., ltd
　　Weifang chuangke seedling co., ltd
　　Shenxian county jiefeng vegetables technology service co., ltd
　　Completed by: Jiao Zigao, Liu Shusen, Wang Chongqi, Dong Yumei, Sun Lihua, Xiao Shouhua, Li Wendong, Wei Jiapeng and Sun Jianlei.
　　5. Integration and demonstration of key technologies for industrialization of new humic acid slow-release fertilizer
　　Completed by: Shandong Agricultural University Fertilizer Technology Co., Ltd.
　　Completed by: Ma Xuewen, Ding Fangjun, Wu Qinquan, Chen Shigeng, Ge Yuming, Meng Qingyu, Chen Weimin, Gu Duanyin and Chen Dayin.
　　6. Key technologies and applications of recycling waste from breeding industry in Huanghuaihai region.
　　Completed by: Institute of Agricultural Resources and Environment, Shandong Academy of Agricultural Sciences
　　Shandong Agricultural University
　　Shandong province agriculture sustainable development institute
　　Hebei academy of agriculture and forestry Institute of Genetic Physiology
　　Hebei academy of agriculture and forestry Institute of Agricultural Resources and Environment
　　Shijiazhuang goldsun biology organic fertilizer co., ltd
　　Shandong gufengyuan biotechnology group co., ltd
　　Completed by: Guo Honghai, Ning Tangyuan, Han Jiandong, Wang Zhanwu, Li Xinhua, Wang Liying, Sui Xueyan, Dong Xiaoxia, Tian Shensi.
　　7. Key technologies and industrialization of preparation of antioxidant and anti-inflammatory active substances in fruits and vegetables.
　　Completed by: Institute of Agricultural Products, Shandong Academy of Agricultural Sciences
　　Qufu normal university
　　Dongying Guangyuan Biotechnology Co., Ltd.
　　Shandong yuhuang grain and edible oil foods co., ltd
　　Completed by: Cheng Anwei, Wang Wenliang, Sun Jinyue, Li Guoliang, Liu Lina, Liu Chao, Gong Zhiqing, Dai Hualei, Fan Wenjing.
　　8. Nutritional needs of meat geese and efficient utilization technology of feed
　　Completed by: Qingdao Agricultural University
　　Shandong province animal epidemic disease prevention Yu control center
　　Qingdao puxing biology science and technology co., ltd
　　Shandong zhongke Jiayi biology engineering co., ltd
　　Shandong jiurui agriculture group co., ltd
　　Shandong tianpu sunshine group co., ltd
　　Completed by: Wang Baowei, Li Wenli, Ge Wenhua, Zhang Mingai, Yue Bin, Lian Ailing, Lu Guangzhou, Pan Yulin, Sun Zuowei.
　　9. Key technologies of high-quality forage and efficient production and application of precision livestock raising.
　　Completed by: Shandong Provincial Animal Husbandry Station
　　Shandong Academy of Agricultural Sciences Institute of Agricultural Quality Standards and Detection Technology
　　shandong agricultural resource and environmental science research institute
　　Shandong Agricultural University
　　Shandong Shuang Jia Nong Zhuang technology co., ltd
　　Laoling Guoyu agriculture machinery equipment co., ltd
　　Completed by: Zhai Guiyu, Jiang Huixin, Wang Yanqin, Zhang Guiguo, liu junhua, Shen Yixin, Liu Dong, Zhang Junqiang and Wang Mingtang.
　　10. Physiological and ecological response mechanism and supporting cultivation techniques of cold resistance of tea trees.
　　Completed by: Qingdao Agricultural University
　　Shandong province guocha technology popularizing station
　　Completed by: Ding Zhaotang, Wang Yu, Yusheng Li, Zhang Yunwei, Sun Haiwei, Ding Deen, Ma Dexin, Wang Yi, Bi Caihong.
　　11. Obstacle mechanism of poplar plantation continuous cropping and key technologies for long-term productivity maintenance
　　Completed by: Shandong Agricultural University
　　Shandong province forestry science study institute
　　Taian Taishan forestry science study institute
　　Ningyang County, Shandong Province State-owned Gao Qiao Forest Farm
　　Shandong changnong agriculture technology co., ltd
　　Completed by: Wang Huatian, Wang Yanping, Dong Yufeng, Jiang Yuezhong, Kong Linggang, Liu Fude, Zhang Guangcan, Wang Zongqin and Huang Qilun.
　　12. Development and industrialization of high quality, efficient and environment-friendly flounder compound feed.
　　Completed by: Qingdao Qihao Biotechnology Co., Ltd.
　　Chinese Marine University
　　Qingdao agricultural university
　　Completed by: Chen Jinghua, Zhang Wenbing, Xu Wei, Xiao Lindong and Lu Wei.
　　13 aquatic collagen and collagen peptide research, technology development and industrialization
　　Completed by: China Ocean University
　　Shandong dongfang ocean technology co., ltd
　　Completed by: Li Bafang, Hou Hu, Zhao Xue, Liu Yuntao, Lin Lin, Zhuang Yongliang, Yan Mingyan, Liu Zunying and Xue Yong.
　　14. Key technologies of water resources regulation of groundwater system and water search in poor water areas
　　Completed by: Shandong Institute of Geology and Mineral Engineering.
　　Jinan university
　　China University of Geosciences，Wuhan
　　Shandong province lunan geology engineering survey institute
　　Shandong University of Science and Technology
　　Completed by: Kang Fengxin, Zhang Zhongxiang, Xu Junxiang, Xing Liting, Bu Hua, Cheng Xiuming, Peng Hao, Feng Jianguo and Li Changsuo.
　　15. The upper level integrated measurement and control system
　　Completed by: Shandong Institute of Aerospace Electronic Technology
　　Beijing Institute of Technology
　　Completed by: Yang Zhiqun, Wang Yongqing, Ji Chunguo, Zhang Xinkui, Guo Shiyou, Gong Changhui, Yang Na, Zhang Ju and Wang Qiang.
　　16. Key technologies and applications of ultra-high definition liquid crystal display controlled by deep dynamic backlight.
　　Completed by Qingdao hisense electric Co., Ltd.
　　Completed by: Cao Jianwei, Liu Weidong, Zhang Yuxin, Gao Shang, Xu Aichen, Li Minhua, Song Zhicheng, Zhong Qiang and Li Fulin.
　　17. Research and application technology of spatial structure evolution mechanism of overlying strata in coal mine stope
　　Completed by: Shandong University of Science and Technology
　　Shandong Dongshan Wang Lou Coal Mine Co., Ltd.
　　Tengzhou Jixiang (Group) Jisuo Coal Mine
　　Tengzhou dongda mining industry co., ltd
　　Completed by: Han Zuozhen, Wen Zhijie, Shi Yongkui, Xiao Qinghua, Lu Guozhi, Tang Jianquan, Zhu Huaizhi, Huiyong Yin and Wang Chunguang.
　　18. Safe and efficient mining technology for high-magnification filling of underwater broken deposits
　　Completed by: Sanshandao Gold Mine of Shandong Gold Mining (Laizhou) Co., Ltd.
　　Central South University
　　Chongqing University
　　Henan Polytechnic University
　　Completed by: Zhang Hongxun, Peng Kang, Wang Jianbo, Liu Zhixiang, Cavin Wang, Liu Kewei, Zhang Xiaogang, Yin Tubing and Sun Hongzhou.
　　19. Metallogenic regularity of precious and nonferrous metal deposits in Jiaodong and major breakthroughs in prospecting.
　　Completed by: Shandong Third Institute of Geology and Mineral Exploration.
　　Jilin University
　　the institute of geology,chinese academy of geological sciences
　　Completed by: Ding Zhengjiang, Sun Fengyue, Liu Jianhui, Liu Fulai, Zhang Junjin, Li Guohua, Zhang Yingchuan, Ji Pan and Zhang Pijian.
　　20. Complete sets of high-efficiency oil and gas recovery technologies and their applications
　　Completed by: Qingdao Safety Engineering Research Institute of China Petrochemical Company Limited.
　　Completed by: Zhang Weihua, Zhang Jianzhong, Tao Bin, Shan Xiaowen, Zhang Hongxing, Zou Bing, Wang Zhenzhong, Guang Xu and Wu Fengbang.
　　21. Endogenous microbial flooding technology to improve oil recovery of medium and high temperature reservoirs
　　Completed by: Petroleum Engineering Technology Research Institute of Shengli Oilfield Branch of China Petrochemical Co., Ltd.
　　Completed by: Li Ximing, Wang Weidong, Song Yongting, Zhang Shaodong, Sun Gangzheng, Cao Yanying, Hu Jing, Li Caifeng, Tamia Liu.
　　22. The key technology and application of special modified starch for food.
　　Completed by: Qilu University of Technology
　　Zhucheng xingmao corn development co., ltd
　　Jiangnan University/ Southern Yangtze University
　　Completed by: Cui Bo, Qiu Lizhong, Tian Yaoqi, Yu Bin, Bian Xiliang, Sun Chunrui, Tan Yiping, Qiu Hongwei, Hou Zhaohua.
　　23. Key technologies and industrialization of green and efficient biological manufacturing of sodium gluconate
　　Completed by: Shandong Kaixiang Biochemical Co., Ltd.
　　Shandong province food fermentation industry research and design institute
　　Completed by: Tian Yanjun, Cui Guangshui, Zhang Jiaxiang, Li Guiling, Han Yanlei, Ji Hongyan, Zhang Lihe, Shiping Li and Hu Zongzhi.
　　24. Research and development and industrialization of refining technology for high-value biomass products
　　Completed by: Shandong Sun Paper Co., Ltd.
　　Qilu university of technology
　　Completed by: Ying Guangdong, Yang Guihua, Liu Zehua, Ji Xingxiang, Liu Yanbo, Qiao Jun, Zhang Wei, Lu Qinghui, Zhai Bingyan.
　　25. Development and application of new technology for preparation of high charge density resin neutral sizing emulsion.
　　Completed by: Qingdao University of Science and Technology
　　Qingdao haiwang paper industry co., ltd
　　Completed by: Song Xiaoming, Chen Fushan, Leng Yuxi, Liu Danfeng, Wang Songlin, Gao Shanshan, Zhou Jiazhong.
　　26. Innovation and application of key technologies for green preparation of special modified starch and special syrup for food.
　　Completed by: Qingdao Agricultural University
　　Shandong Luzhou Food Group Co., Ltd.
　　Shandong University
　　Institute of Biology, Shandong Academy of Sciences
　　Luzhou Biotechnology (Shandong) Co., Ltd.
　　Completed by: Sun Qingjie, Zhao Yubin, Liu Yuchun, Xiong Liu, Liang Quanfeng, Yang Junhui, Chen Haihua, Liang Caifeng and Yang Jie.
　　27. Popularization and industrialization of key technologies for low formaldehyde and high quality non-ironing finishing of cotton fiber products
　　Completed by Lutai Textile Co., Ltd.
　　Wuhan textile university
　　Completed by: Xu Weilin, Lu Wenquan, Wang Yunli, Geng Caihua, Shen Xiaolin, Zhang Shougang, Huang Yanhua, Cui Weigang, Tian Lili.
　　28. Development and industrialization of key technologies of HT-L large-scale dry pulverized coal pressurized gasification.
　　Completed by: Shandong Runyin Biochemical Co., Ltd.
　　Aerospace Changzheng Chemical Engineering Co., Ltd.
　　Completed by: Zhang Chengsheng, Han Shugang, Zhang Daofu, Li Sihua, Wang Zhiyong, Wang Aiyun, Chen Zhenwei, Jiang Congbin, Xin Wei.
　　29. Combined process of hydrogen supply and viscosity reduction-deep pyrolysis for inferior heavy oil
　　Completed by: China Shiyou University (East China)
　　Jiangshan union chemical industry group co., ltd
　　Completed by: Dong Liu, Nathan Wang, Guo Aijun, Yin Changlong, Chen Kun, Wei Yongsheng, Zhang Hongyu, Lv Renqing, Lou Bin.
　　30. Coking furnace technology with high severity and low coking rate
　　Completed by: China Shiyou University (East China)
　　China Petrochemical Company Limited Jinling Branch
　　Completed by: Xiao Jiazhi, Yang Junwei, Shen Guoping, Zhang Longli, Wang Lanjuan, Qian Zhongjian and Shan Honghong.
　　31. Synthesis technology and industrialization of triazine ring, the key intermediate of ceftriaxone.
　　Completed by: Shandong Huihai Pharmaceutical Chemical Co., Ltd.
　　Jinan university
　　Completed by: Zheng Gengxiu, Mou Yingke, Jiang Fuyuan, Zhang Zhongzheng, Zhang Shifeng, Guo Gang, Hou Xuhui.
　　32. A new functional ceramic material for manufacturing TFT-LCD liquid crystal glass substrate of 8.5 generation.
　　Completed by Zibo Gongtao Refractory Co., Ltd.
　　Completed by: Zhang Ying, Li Zhijun, Zhang Qishan, Li Yuqiang, Jiang Xugui, Wu Guanghui and Sun Wenli.
　　33. Development and application of new technologies for green and high-performance light-load commercial vehicle tires.
　　Completed by: Shandong Linglong Tire Co., Ltd.
　　Completed by: Wang Feng, Li Ming, Sui Haitao and Chen Xuemei.
　　34. Synthesis of series modified acrylic emulsion and its application in waterborne environmental protection coatings.
　　Completed by: Qingdao University of Science and Technology
　　Ocean chemical industry research institute co., ltd
　　Shandong Lehua Paint Industry Co., Ltd.
　　Qingdao Xuanwei coating material co., ltd
　　Completed by: Li Shaoxiang, Wang Huajin, Hou Peimin, Chen Xilei, Wang Zhaoan, Li Guangjun, Zhao Wei, Wang Xiao, Zhang Feng.
　　35. Preparation and industrialization of nano-montmorillonite composite polyurethane cathodic electrophoretic resin
　　Completed by: Qingdao University of Science and Technology
　　Wuhan kelier new material co., ltd
　　Completed by: Li Zaifeng, Li Zailiang, Li Jinyan and Li Cuiping.
　　36. Preparation technology of high performance magnesium alloy materials and components for locomotive lightweight.
　　Completed by Weihai Wan Feng Magnesium Technology Development Co., Ltd.
　　Shandong Academy of Sciences Institute of New Materials
　　Completed by: Zhu Xunming, Tang Shouqiu, Zhou Jixue, Duan Junpeng, Zhao Dongqing, Xu Guosong, Liu Yunteng, Liu Dan and Li Weihong.
　　37. Manufacturing technology and equipment of new aluminum alloy piston with high temperature and pressure resistance.
　　Completed by: Shandong Binzhou Bohai Piston Co., Ltd.
　　Completed by: Zhang Guohua, Feng Zengjian, Mou Jundong, Zhu Junkui, Gai Shaolei, Yunqing Xun, Gao Xiaobo, Gao Zhanyu and Wang Shili.
　　

　　38. Key equipment and intelligent high-speed automation system of robot stamping automatic line
　　Completed by: Jinan Otto Automation Co., Ltd.
　　Qilu university of technology
　　Jinan university
　　Completed by: Shan Dongri, He Ruilin, Hou Meng, water, Chen Naijian, Wang Zhenyu, Lin Fei, Ma Wenshuai and Zhang Jian.
　　39. Research and engineering application of key technologies of high-lift and high-power mine emergency multistage pump
　　Completed by: Shandong Xingyuan Mining Equipment Group Co., Ltd.
　　Jiangsu university
　　Completed by: Pan Bo, Li Wei, Zhou Ling, Shi Weidong, Pan Shuhuai, Huang Jun, Qiao Shoubin, Wang Chuan and Qu Bing.
　　40. Development and application of ECO Shuang Yuan dual-mode variable flow control technology in inverter air conditioner.
　　Completed by Hisense (Shandong) Air Conditioning Co., Ltd.
　　Completed by: Chen Xinghu, Kang Yue, Niu Jianyong, Yin Development, Liu Jintao, Zheng Xueli, Wu Lintao, Zhao Yukai and Dr. Jianbing Chen.
　　41. Key technologies and industrialization of high-performance medium-sized and high-speed diesel engines
　　Completed by Weichai Power Co., Ltd.
　　Completed by: Zhang Jiyuan, Guo Shenggang, Wang Jinbo, Wang Zhijian, Li Jianwen, Sun Jianwei, Wang Yibao, Han Feng and Li Wenguang.
　　42. Interconnection technology of charging infrastructure for the popularization of electric vehicles
　　Completed by: State Grid Shandong Electric Power Company
　　Guodian nanrui technology co., ltd
　　Xuji power supply co., ltd
　　State Grid Shandong Electric Power Company Electric Power Science Research Institute
　　Shandong luneng intelligent technology co., ltd
　　Completed by: Jiang Bin, Liu Jidong, Zhang Huadong, Dong Xinsheng, Li Yunting, Li Hongmei, Zhang Jian, Fu Mengchao and Chen Liangliang.
　　43. Research and application of key technologies for energy saving and stable operation of large-scale double-suction centrifugal pump
　　Completed by Shandong Shuanglun Co., Ltd.
　　Jiangsu university
　　Completed by: Wang Jiabin, Pei Ji, Yuan Shouqi, Zhang Xuesen, Si Qiaorui, Li Xiupeng, Yu Wenchao, Wang Wenjie and Yao Chunguang.
　　44. Thermochemical conversion technology of biomass based on pyrolysis and gasification.
　　Completed by: Institute of Energy, Shandong Academy of Sciences
　　Ji ‘nan Boiler Group Co., Ltd.
　　Completed by: Sun Rongfeng, Liu Zuo, Yan Guihuan, Zhang Weijie, Fan Xiaoxu, Guan Haibin, Jiang Jianguo, Wang Haifeng and Li Xiaoxia.
　　45. Road structural performance and material response law, life cycle integrated design and engineering application
　　Completed by: Highway Bureau of Shandong Provincial Department of Transportation
　　Tongji University
　　Shandong province traffic science study institute
　　Shandong Province Highway Construction (Group) Co., Ltd.
　　Shandong huarui road material technology co., ltd
　　Qilu communications development group co., ltd
　　Shandong Taihe highway engineering co., ltd
　　Completed by: Guo Zhongyin, Li Yingyong, Ma Shijie, Wei Jincheng, Xue Zhichao, Li Shaohui, Xin Xing, Yu Sixin, Chen Baoqiang.
　　46. Core technology, equipment development and demonstration project of kitchen waste recycling based on anaerobic digestion
　　Completed by: Shandong Shifang Environmental Protection Energy Co., Ltd.
　　Tsinghua University
　　Completed by: Wang Kaijun, Gan Hainan, Zuo Jiane, Duan Mingxiu, Liu Xiaoji, Zhang Guanglan, Gong Hui, Tang Yutong and Xu Heng.
　　47. Key technologies and applications of integrated centralized control platform for urban water supply quality security and optimal dispatching.
　　Completed by: Shandong Public Holding Co., Ltd.
　　Shandong province analysis test center
　　Shandong Province Computing Center (National Supercomputing Ji ‘nan Center)
　　Research Center for Eco-Environmental Sciences， Chinese Academy of Sciences
　　Jinan university
　　Completed by: Chen Qingfeng, Ma Geng, Li Lu, Shan Baoqing, Wang Tieyu, Fu Ying, Zhang Rangyong, Liu Wei and Deng Gang.
　　48. Epidemiological investigation and prevention demonstration of rare diseases
　　Completed by: Shandong Medical Biotechnology Research Center
　　Completed by: Han Jinxiang, Cui Asia, Lu Yanqin, Zhou Xiaoyan, Luan Jing, Zhang Yanjun, Ma Lu Yu, Xu Shuangqing, Liu Xiao.
　　49. Clinical application of cardiovascular CT precision technology
　　Completed by: Shandong Institute of Medical Imaging
　　Completed by: Wang Ximing, Cheng Zhaoping and Duan Yanhua.
　　50. Molecular pathological techniques and clinical application in diagnosis and treatment of neuromuscular diseases
　　Completed by: Qilu Hospital of Shandong University
　　Completed by: Yan Chuanzhu, Lin Pengfei, Li Wei, Wen Bing, Lou Jianwei, Shan Jingli, Ji Kungan.
　　51. Individualized targeted therapy for malignant tumors based on molecular biological information.
　　Completed by: Shandong Institute of Cancer Prevention and Treatment.
　　Completed by: Hu Man, Zhang Yan, Liu Ningbo, Han Anqin, Yang Yanqin, Liu Xijun, Chen Dawei and Fan Bingjie.
　　52. Pathogenesis, diagnosis and treatment technology and application of hepatitis B cirrhosis
　　Completed by: Shandong Provincial Hospital
　　Shenyang military area command General Hospital of Chinese People’s Liberation Army
　　Completed by: Zhu Qiang, Qin Chengyong, Li Jie, Qi Xingshun, Zhao Xinya, Ren Wanhua, Shi Yongjun and Liang Tiejun.
　　53. Application of DNA methylation biomarkers in molecular diagnosis of hepatitis B related diseases.
　　Completed by: Qilu Hospital of Shandong University
　　Completed by: Wang Kai, Fan Yuchen, Han Liyan, Fan Xiaopeng, Wang Bing, Zhao Jing, Li Feng, Qi Zhaoxia and Sun Fengkai.
　　54. Guided vector of bone marrow mesenchymal stem cells based on the mechanism of proliferation, invasion and migration of lung cancer cells
　　Completed by: Qilu Hospital of Shandong University
　　Completed by: Tian Hui, Li Lin, Li Shuhai, Lu Ming and Qi Lei.
　　55. Reconstruction of cardiac autonomic nerve and clinical application of Guizhi decoction in its intervention and adjustment.
　　Setting: Affiliated Hospital of Shandong University of Traditional Chinese Medicine.
　　Completed by: Li Xiao, Jiang Ping, Jiang Yuehua, Lin Haiqing, Wei Qin, Ma Dufang, Yang Jinlong, Yan Wang and Wang Yongcheng.
　　56. Construction and scale industrialization of preparation system of glipizide based on key technology of industrialization.
　　Completed by Disha Pharmaceutical Group Co., Ltd.
　　Weihai disen pharmaceutical co., ltd
　　Shanghai pharmaceutical industry research institute
　　Completed by: Duo Yueying, Zhang Fuli, Liu Bingpeng, Chang Xiujuan, Long Lianqing, Cong Rigang, Wang Guan, Fu Yumai and Feng Meijun.
　　57. Construction and scale industrialization of a new preparation system for a new generation of fluoroquinolones broad-spectrum antibacterial drugs.
　　Completed by: Shandong Luoxin Pharmaceutical Group Co., Ltd.
　　Shandong yuxin drug co., ltd
　　Shandong luoxin pharmaceutical group hengxin drug co., ltd
　　Completed by: Li Minghua, Sun Song, Liu Wenqi, Zuo Cuiyong, Lu Lili, Cui Campus, Zhang Xianzhen, Li Junguang and Li Xiuzhen.
　　58. Standardization of quality standards for Chinese herbal medicines and decoction pieces in Shandong Province
　　Completed by: Shandong Institute of Food and Drug Inspection
　　Shandong province traditional Chinese medicine research institute
　　Linyi food medicines inspection testing center
　　Zibo Food & Drug Inspection Testing Center
　　Ji’ nan food medicines inspection testing center
　　Binzhou food medicines inspection testing center
　　Jining food medicines inspection testing center
　　Completed by: Xu Lihua, Lin Yongqiang, Hu Defu, Wang Bing, Lin Lin, Li Qiyan, Wang Yutuan, Yin Ningning, Kun Wang.
　　
　　Third prize (35 items)
　　1. Breeding of new maize variety Tiantai 33 and research and application of its supporting cultivation techniques.
　　Completed by Shandong Tiantai Seed Industry Co., Ltd.
　　Shandong zhongnong Tiantai seed industry co., ltd
　　Completed by: Liu Ning, Feng Shangzong, Peng Meixiang, Li Chunxiang, Shi Xuhai and Kong Jinhua.
　　2. Creation and application of new apple varieties with high pollination efficiency.
　　Completed by: Shandong Agricultural University
　　Completed by: Shen Xiang, Yin Chengmiao, Hu Yanli, Wu Shujing, Wang Rong and Chen Xuesen.
　　3. Development and application of fruit tree nutrition package technology in Jin Duo.
　　Completed by: Shandong Jin Duo Agricultural Science and Technology Co., Ltd.
　　Completed by: Yang Jinduo, Wei Chunzhi, Han Jiliang, Li Guangsheng, Guo Yuanxin and Yang Yadong.
　　4. Creation of several genetic engineering vaccines for livestock and poultry virus diseases and optimization of production technology.
　　Completed by: Qingdao Xinde Pharmaceutical Co., Ltd.
　　Harbin Veterinary Institute, Chinese Academy of Agricultural Sciences
　　Shandong xinde animal vaccine co., ltd
　　Qingdao agricultural university
　　Shandong xinde technology co., ltd
　　Completed by: Li Mingyi, Tian Guobin, Liu Yang, Li Guimei, Wang Dana, Ge Dong.
　　5. Key technologies for prevention and control of foot-and-mouth disease, classical swine fever and highly pathogenic porcine blue ear disease.
　　Completed by Shandong Animal Disease Prevention and Control Center.
　　China Animal Health and Epidemiology Center
　　Lanzhou Veterinary Institute of China Academy of Agricultural Sciences
　　Weifang nuoda drug co., ltd
　　Qingdao dongbao national engineering technology research center co., ltd
　　Completed by: Li Yungang, Li Xiaocheng, Zhang Qiang, Wu Faxing and Zhang Faren, in Qinghai.
　　6. Genetic development of main characters of walnut and breeding of anthracnose resistant varieties
　　Completed by: Shandong Agricultural University
　　Completed by: Yang Keqiang, Liu Huixiang, Liu Xia, Wang Cancan.
　　7. Real-time monitoring system for ultra-long-distance intrusion security based on laser Rayleigh interference technology.
　　Completed by: Weihai Beiyang Photoelectric Information Technology Co., Ltd.
　　Weihai Beiyang electric group co., ltd
　　Completed by: Sun Zhongzhou, Ji Shenghua, Wang Jianqiang, Shi Zhenguo, Liang Mingming and Zhang Yongchen.
　　8. Highly trusted mobile computing platform system based on domestic key software and hardware.
　　Completed by: Shandong Chaoyue CNC Electronics Co., Ltd.
　　Completed by: Zhao Ruidong, Feng Lei, Li Changzhi, Zhao Bin, Chai Pingping and Niu Yufeng.
　　9. Key technologies and industrialization of high-quality semiconductor silicon carbide substrate
　　Completed by: Shandong Tianyue Advanced Materials Technology Co., Ltd.
　　Completed by: Gao Yuqiang, Zong Yanmin, Wang Xijie, Liang Qingrui, Yu Guojian, Gao Chao.
　　10. Mechanism and prediction technology of gas content in coal and gas outburst.
　　Completed by: Shandong University of Science and Technology
　　China Mining University
　　Completed by: Wang Gang, Yang Yongliang, Li Weimin, Liu Zhen, Li Jianhua and Ni Guanhua.
　　11. Dynamic mineralization and multi-information prospecting prediction of typical gold deposits in northwest Jiaodong.
　　Completed by: Hedong Gold Mine of Zhaojin Mining Co., Ltd.
　　Central South University
　　Changsha Wu Wei di ke survey technology co., ltd
　　Completed by: Wang Peishou, Yang Bin, Xi Zhenzhu, Shine Wong, Wang Yanlei, Wang Changtao.
　　12. Development and application of key technologies for collaborative heat transfer enhancement of high-power frequency conversion controller.
　　Completed by Hisense (Shandong) Air Conditioning Co., Ltd.
　　Completed by: Zhao Keke, Zhao Xifeng, Wang Zhigang, Li Benwei, Wang Zongliang and Yin Xianxin.
　　13. Key technologies and industrialization of ultra-low CO safe, environmentally friendly and comfortable gas water heaters
　　Completed by: Qingdao Economic and Technological Development Zone Haier Water Heater Co., Ltd.
　　tianjin chengjian university
　　Completed by: Li Jian, Sun Jingyan, Liu Fengguo, Zheng Tao, Cao Guanzhong and Feng Qing.
　　14. Key technologies and applications of large-scale preparation of biological preservatives.
　　Completed by: Shandong Academy of Pharmacy
　　Shandong furuida biology science and technology co., ltd
　　Shandong furuida medicine group company
　　Shandong University
　　Shandong Academy of Biomedical Sciences
　　Completed by: Ling Peixue, Zhu Xiqiang, Liu Fei, Su Yishan, Li Haijun and Zhang Xiaoyuan.
　　15. Development and industrial application of super cotton-like polyester/cotton fiber blended non-ironing fabric
　　Completed by Lufeng Weaving and Dyeing Co., Ltd.
　　China textile science research institute
　　China Petrochemical Yizheng Chemical Fiber Co., Ltd.
　　Shandong university of technology
　　Completed by: Zhang Zhanqi, Lian Zhijun, Xu Qiusheng, Wang Fangshui, Qi Yuanzhang and Fu Zhongjun.
　　16. Creation and industrialization of key technologies of green, low-consumption and high-simulation microfiber artificial leather
　　Completed by Shandong Tongda Island New Materials Co., Ltd.
　　Shaanxi university of science and technology
　　Completed by: Wang Lezhi, Qiang Taotao, Zheng Yonggui, Ma Jinmei, Zhang Fengjie and Wang Xiaolei.
　　17. Development of disperse dyes with high alkali resistance
　　Completed by: Penglai Jiaxin Dyestuff Chemical Co., Ltd.
　　Completed by: Wang Zhe, Zhang Shansheng, Wang Shuxiang, Jing Lili, Kang Hongwei and Geng Ningning.
　　18. Development and application of efficient synthesis technology for recycling 2-naphthalene series products
　　Completed by: Zaozhuang Tairui Fine Chemical Co., Ltd.
　　Completed by: Yang Yudong, Zhou Zhihui, Liu Shuyin, Meng Qingwei and Zhao Mingxia.
　　19. High purity industrial zinc sulfide
　　Completed by Weifang Dayao New Material Co., Ltd.
　　Completed by: Wang Qiang, Li Bo and Li Jun.
　　20. Preparation technology and application of high-performance high-frequency microwave and conductive shielding film materials
　　Completed by Shandong Jinding Electronic Material Co., Ltd.
　　Completed by: Geng Guoling, Zou Wei, Wu Tianxiang, Ouyang Yanhui, Zhuo Feng
　　21. Research, development and industrialization of high-precision copper thin soft strip
　　Completed by: Zhongse Obote Copper and Aluminum Co., Ltd.
　　Completed by: Wang Shijie, Zhang Jianhua, Guo Lili, Xu Bingjun, Liu Chenliang and Jing Yan.
　　22. The key technology and application of ultra-heavy CNC moving gantry boring and milling turning center (lathe)
　　Completed by: Weihai east china numerical control Co., Ltd.
　　Completed by: Qiu Yuliang, Liu Bingwen, Qin Zhixu, Che Zhongwei, Zheng Shuguang and yan wang.
　　23. CTL-2.5× 1850 automatic numerical control pendulum cutting line
　　Completed by: Jinan No.2 Machine Tool Group Co., Ltd.
　　Completed by: Zhao Jinrong, Wen Zhiquan, Wang Yanling, Zhang Faxin, Qu Shihui and Li Shuanqiang.
　　24. Mechanism, defense technology and application of disaster magnetic storm affecting the safe operation of power grid
　　Completed by: Electric Power Research Institute of State Grid Shandong Electric Power Company
　　Nanjing nanrui group company
　　North China Electric Power University
　　Completed by: Xue Yusheng, Liu Lianguang, Sun Shumin, wei li, Xue Feng and Cui Xiaodan.
　　25. Key technologies and applications of super-long and long-span subsea tunnel construction.
　　Completed by: Qingdao Guoxin Jiaozhou Bay Transportation Co., Ltd.
　　Shandong University
　　Central South University
　　China Railway Second Bureau 2 nd Engineering Co., Ltd.
　　Completed by Qu Liqing, Zhou Shuming, Xue Yiguo, Wang Xinghua, Guo Yongjian, Zhang Jianyang.
　　26. R&D and application of key technologies and equipment for 10,000-ton super-large caisson construction
　　Completed by: No.2 Engineering Co., Ltd. of China Communications No.1 Navigation Bureau.
　　Completed by: Zhang Baochang, Fu Dawei, Zhao Jianming, Feng Haibao, Ma Zongtian and Lu Lianzhou.
　　27. Innovation and application of stress myocardial perfusion and coronary vein imaging technology
　　Completed by: Yantai Yuhuangding Hospital
　　Completed by: Yang Jun, Ma Heng, Jing Liu and Sun Chunjuan.
　　28. Four-dimensional images and functional images guide precise radiotherapy for chest tumors.
　　Completed by: Shandong Institute of Cancer Prevention and Treatment.
　　Completed by: Li Jianbin, Zhang Yingjie, Wang Jinzhi, Shao Qian, Min Xu and Ma Zhifang.
　　29. The application of molecular imaging and pathology in the era of precise tumor treatment.
　　Completed by: Shandong Institute of Cancer Prevention and Treatment.
　　Completed by: Meng Xue, Xu Yaping, Wang Shijiang, Han Shumei, Teng Feifei and Jiang Liyang.
　　30. Key technologies for diagnosis, immunization and targeted therapy of endometrial cancer.
　　Completed by: Qilu Hospital of Shandong University
　　Completed by: Jiang Jie, Kong Beihua, Zhang Guiyu, Cui Baoxia and Qiu Chunping.
　　31. The establishment, transformation and application of the characteristic theory and key technology of TCM in treating diabetes.
　　Setting: Affiliated Hospital of Shandong University of Traditional Chinese Medicine.
　　The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine
　　Completed by: Xu Yunsheng, Peng Wei, Huang Yanqin, Ding Qianqian, Wang Sumei and Zhang Xiujuan.
　　32. Basic research and clinical application of "strengthening tendons and binding bones" in the treatment of lumbar instability diseases
　　Completed by: Wendeng osteopathy hospital of Shandong province.
　　Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
　　Shandong province Wendeng osteopathy technology development co., ltd
　　Completed by: Yang Yongjun, Zhou Jiping, Wang Yongjun, Tan Yuanchao, Tang Dezhi and Liang Qianqian.
　　33. Development and industrialization of cefminox sodium bulk drug
　　Completed by: Qilu Antie (Linyi) Pharmaceutical Co., Ltd.
　　Completed by: Fu Ling, Zhao Weiliang, Tang Fei, Xu Hongfei, Zhang Baona.
　　34. Efficient biological transformation and industrialization of L-aspartic acid and L-alanine
　　Completed by: Yantai Hengyuan Biological Co., Ltd.
　　Shandong province food fermentation industry research and design institute
　　Completed by: Ma Yuyue, Zhao Xiangying, Jiang Zengyan, Qiao Jun, Jiang Guozheng and Yang li Ping.
　　35. Development and application of new ion chromatograph and establishment of quality control system
　　Completed by: Shandong Institute of Metrology
　　Qingdao shenghan chromatography technology co., ltd
　　Completed by: Lin Zhenqiang, Xu Aihua, Guo Bo, Zhang Xizhi, Cui Chenglai and Sui Feng.
　　
　　Shandong International Science and Technology Cooperation Award (3 persons)
　　1. Heinz Rolf Stoke
　　Country: Germany
　　Cooperation unit: Yantai Hilde New Materials Co., Ltd.
　　2. William Mathias Vindis
　　Country: Germany
　　Partner: Shandong Haizhibao Ocean Technology Co., Ltd.
　　3. Shaq alzas Land
　　Country: United Kingdom
　　Partner: Qingdao Russell Biotechnology Co., Ltd.

When the hybrid car developed into the second half, it was not the user’s taste that became higher, but the user’s eyesight became awkward. It is increasingly found that price is not the only indicator of hybrid cars, and cars with high performance, high intelligence and high safety are worthy of the money in their pockets. Cars are not toys. They will be replaced and eliminated after buying for one or two years, but will bring long-term high-value travel experience. Therefore, cars manufactured with high standards are worth starting with.

The 2025 LECK 08EM-P, which was launched on August 8, is a high-value hybrid SUV choice worthy of users’ travel and life in terms of strength and quality.

Between low price and high value, there are always people who prefer the latter.

In the former automobile market, there were always people who thought that low price was king. As users became more aware of automobiles, they tended to be more value-oriented.

The 2025 LECK 08EM-P has six models: 120 long battery life Plus version, 120 long battery life Pro version, 120 long battery life version, 245 long battery life Pro version, 245 long battery life Halo version and 220 four-wheel drive performance Halo version. The battery life in pure electric mode adopts stricter CLTC working conditions. CLTC is based on the actual driving conditions in China, including urban, suburban and high-speed driving conditions, and the battery life test is more in line with it. On the surface, the LEICK 08EM-P with a low battery life of 120km seems to be equivalent to the 121km Tang DM-i, but the Tang DM-i still uses a relatively loose NEDC working condition count. In terms of comprehensive endurance, the LECK 08EM-P with CLTC working condition of 1400km is obviously more realistic than the Tang DM-i with NEDC working condition of 1100km.

?On the power system level, the Lectra 08EM-P super extended-range electric system consists of P1 and P3 motors +P4 motor +1.5T electric hybrid engine, which together form a high-performance architecture. Specifically, the P1+P3 motor architecture is a rear-wheel drive model, and the P1+P3+P4 motor architecture is a four-wheel drive model. Logically, the engine generates electricity for P1 motor, and the rear-drive vehicle is driven by P3 motor, with a maximum power of 160 kW and a peak torque of 350 N m.. The four-wheel drive model is driven by P3+P4 motor, and the peak power of P4 motor is 156 kW. The comprehensive maximum power of the system is 436 kW, the comprehensive maximum torque is 905 N·m, and the acceleration of 100 kilometers is only 4.6 seconds.

The DHT three-speed transmission of LINKE 08EM-P can realize the flexible switching between engine and motor, and bring more accurate power distribution under different road conditions. In the specific operation experience, the driver of the 08EM-P can choose the appropriate gear in different road environments and match the power with different intensities, thus bringing a precise sense of control. And the shifting logic is very clear, and the power acceleration is not all of a sudden, but a linear acceleration experience.

In contrast, Tang DM-i’s CVT gearbox has the advantages of strong ride comfort, but its disadvantages are also quite obvious: first, CVT gearbox is prone to cold protection problems, and it may take a long time to start in cold environment, which may also lead to the inability of vehicles to speed up effectively. Secondly, the transmission belt of CVT gearbox is fragile and easy to be damaged in harsh driving environment, which requires more frequent maintenance and replacement, and the actual vehicle maintenance cost is higher. Thirdly, CVT gearbox will obviously feel the lack of power on vehicles with strong power, especially on uphill sections, which is one of the reasons why BYD plug-in and hybrid vehicles have not adopted the strategy of high power.

In the era of intelligent flooding, Linke 08EM-P has implemented the user’s needs.

At present, the new energy vehicle market has entered the era of intelligent flooding, which is manifested in the stacking of non-vehicle intelligent configurations, such as the "refrigerator color TV sofa" that people often vomit. On the aspect of integrated intelligence, LEEK 08EM-P upgraded the car system to OTA version 1.6.0. The overall intelligent cockpit performance of the car is different from the current flood era. It follows the principle of "making the car practical and intelligent to the extreme" and implements the needs of users.

If you are installed with the identity of "Leader 08EM-P Owner" now, you don’t need a physical key to get on the bus, and your Apple mobile phone, watch and proximity can open the door for you, realizing a feeling of unlocking/locking, and making your travel life more scientific and technological. When you sit in the driver’s seat, you don’t need to look down at your mobile phone or central control screen navigation when driving, because there is the largest 92-inch AR-HUD mass-produced in the industry, which directly presents three-lane information, AR navigation, ADAS assistance and other information on the front windshield. In terms of car experience, the LYNK Flyme Auto car system of LINKE 08EM-P is the first to take the Antola 1000 Pro computing platform, which integrates two 7nm "Longying No.1" chips independently developed in the industry, and the computing power of a single chip is comparable to that of Qualcomm 8155 car chip, and it has larger running and storage memory, which is smoother and faster in car startup and functional experience.

When you want to watch the video on a big screen, use the 15.4-inch ultra-clear full screen of LTPS LCD display technology, which has a picture quality of 2.5K and a color gamut as high as 85%, which can show more colors. The sound quality experience is even more impressive. As the only SUV model equipped with Harman Kardon 23 plus WANOS panoramic sound within 200,000, the Lectra 08EM-P has brought a million-level extreme sound experience at a price of 200,000. In terms of sound surround telepresence, the top "sky sound" surround channel is added to the Lectra 08EM-P cockpit, which enhances the depth and telepresence of the sound image compared with the two-channel stereo, and it seems to be surrounded by sound when sitting on it. In addition, the car system is equipped with WANOS Panoramic Audio APP, with its high-quality panoramic audio-visual entertainment resources to realize audio-visual synchronization, which can bring you and your family a more immersive and shocking audio-visual experience.

On the intelligent voice level, Aicy voice assistant can support four-tone recognition, which has higher understanding and execution ability, not only supports custom wake-up words, but also can customize a variety of images to make the dialogue more vivid and interesting. Crucially, Aicy voice assistant can realize multiple rounds of communication according to the context of the whole context, which really brings an intelligent experience of "seeing and speaking".

Not only that, LINKE 08EM-P also has innovative functions of sentry mode and car wash mode. Sentinel mode In the parking scene, vehicles can monitor suspicious targets by looking around the fisheye camera, rely on the acceleration sensor to detect the risk of collision, and give a double flash warning to the outside world in time. It can also record and store suspicious scenes and notify the owner. When the car wash mode is turned on, the vehicle will close the window, trunk, charging cap, fuel cap, wiper, etc., and disable the approaching vehicle to unlock and leave the vehicle, effectively preventing water seepage and ensuring vehicle safety.

In intelligent driving, LEEK 08EM-P is equipped with Lynk Co-Pilot Navi intelligent navigation assistance system, which not only performs sensitive and fast in daily adaptive cruising, overtaking, going up and down ramps and other road conditions, but also has various lane-changing functions such as autonomous lane change and voice control lane change, taking into account more scenes. It is worth mentioning that when the Lectra 08EM-P encounters a big car, it will take the initiative to avoid it, deliberately widen the front and rear distance from the big car, and in the process of overtaking, pull the horizontal distance from the big car, reduce the parallel time, relieve the driver’s driving fatigue and pressure, and ensure driving safety.

In terms of road perception, LEEK 08EM-P supports 10 perception cameras and 5 millimeter-wave radars, and relies on centimeter-level precision maps to guide navigation. Together with two black sesame intelligent Huashan A1000 chips with a cost-effective ratio of up to 116 TOPS, it realizes the algorithmic arrangement of road environment and helps vehicles realize the intelligent driving performance of L2+ high-order parking.

Whoever ignores security is the enemy of users.

Consumers want cars with lower prices, but irrational price wars will only harm the interests of users in the end. Some brands take the lead in setting off price involution, which seems to be more cost-effective. In fact, they cut corners on invisible core components and car-making technology, and use iron oil tanks, ultra-thin and ultra-short front and rear anti-collision beams, and chopsticks-slender chassis suspension, which bring great hidden dangers to the safety of the whole vehicle. Such cost-effective is not the price that users want, and such brands can also be regarded as the enemies of users.

In sharp contrast with such a brand model, the price of the Lexus 08EM-P, which is already quite ahead in terms of three-electric system and intelligence, starting from 179,800 yuan may not be cheap, but it is also within the reasonable price of high-value plug-in SUV. Crucially, LEEK 08EM-P is a benchmark in vehicle safety.

The LEICK 08EM-P is made of thermoformed steel with the maximum pressure of 2000MPa, and the proportion of high-strength steel and aluminum alloy in white body is as high as 75%. It is equipped with aerospace-grade 7 series aluminum alloy front crash beam, and the integrated thermoformed boron steel door knocker and superelastic honeycomb filling technology are adopted for the first time, which can alleviate more impact energy, and the performance of materials exceeds that of brand luxury cars.

In addition, the car is equipped with an extended head air curtain with a length of 2000mm, which runs through the ABC column and covers the whole window area. After bouncing off, the pressure can be maintained for 6 seconds, which brings longer personnel protection. Adding 120L super-large passenger airbag can further ensure the safety of the passenger’s head. Finally, in terms of battery safety that people are most concerned about, Linke 08EM-P adopts the first integrated DP1180 bottom guard plate with the tensile strength of 1200MPa, which far exceeds the safety standard of the national standard, and can realize 50ms high-voltage power failure due to collision and bid farewell to the natural danger of battery fire.

Based on its solid performance in safety, LEEK 08EM-P obtained the first domestic certification of "60km/h side impact protection of new energy passenger cars with superimposed side pillars" issued by China Automotive Research Institute.

Jianghu car review:

In the just-concluded platform test, the Lectra 08EM-P stood out among 35 models, and won the first lap time of SUV with 2 minutes and 19.87 seconds, which fully reflected the excellent handling performance of CMA Evo architecture. The 2025 Lectra 08EM-P is not the first model of Lectra 08EM-P. Since it was launched one year ago, the cumulative sales volume has exceeded 80,000, and its high-value travel quality has been recognized by users. Its brand, Linke, also rolled off the production line for the millionth vehicle in less than six years, becoming the fastest high-end automobile brand in China and the truly recognized high-end automobile brand in China. The Lexus 08-EM-P, which is built with heart, advanced technology and solid materials, is a high-end new energy SUV choice that most people can’t avoid.